Detailed information for compound 1205726

Basic information

Technical information
  • TDR Targets ID: 1205726
  • Name: 2-(4-dimethylaminophenyl)-N-(thiophen-2-ylmet hyl)pyrimidin-4-amine
  • MW: 310.417 | Formula: C17H18N4S
  • H donors: 1 H acceptors: 2 LogP: 3.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)c1nccc(n1)NCc1cccs1)C
  • InChi: 1S/C17H18N4S/c1-21(2)14-7-5-13(6-8-14)17-18-10-9-16(20-17)19-12-15-4-3-11-22-15/h3-11H,12H2,1-2H3,(H,18,19,20)
  • InChiKey: MIQLOUNCEHLUCT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-dimethylaminophenyl)-N-(2-thienylmethyl)pyrimidin-4-amine
  • 2-(4-dimethylaminophenyl)-N-(2-thienylmethyl)-4-pyrimidinamine
  • dimethyl-[4-[4-(2-thienylmethylamino)pyrimidin-2-yl]phenyl]amine
  • PCOP-464292
  • NCGC00011379

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0105 0.0222 0.0222
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0134 0.0299 0.0414
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0359 0.0894 0.3312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0226 0.0226
Schistosoma mansoni zinc finger protein 0.0147 0.0334 0.0376
Plasmodium falciparum glutathione reductase 0.0359 0.0894 0.3312
Toxoplasma gondii thioredoxin reductase 0.1035 0.2683 1
Brugia malayi Probable ClpP-like protease 0.0316 0.0781 0.0882
Echinococcus granulosus dnaJ subfamily B 0.0905 0.2338 0.3311
Loa Loa (eye worm) acetyltransferase 0.0317 0.0784 0.0885
Echinococcus granulosus single minded 2 0.0043 0.006 0.0075
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0089 0.0032
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0316 0.0781 0.11
Schistosoma mansoni methyl-cpg binding protein mbd 0.0117 0.0255 0.0285
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0032 0.0116
Loa Loa (eye worm) glutathione reductase 0.1035 0.2683 0.305
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0105 0.0222 0.0802
Giardia lamblia GTOR 0.0134 0.0299 0.329
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0207 0.0493 0.0653
Mycobacterium ulcerans aldehyde dehydrogenase 0.0249 0.0603 0.6683
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.043 0.0479
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0316 0.0781 0.2893
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0095 0.0197 0.6491
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0207 0.0493 0.0653
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0036 0.0032
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.1176 0.1326
Mycobacterium ulcerans hypothetical protein 0.0095 0.0197 0.204
Schistosoma mansoni hypothetical protein 0.0095 0.0197 0.0218
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Brugia malayi ubiquitin conjugating enzyme protein 13 0.004 0.0052 0.005
Echinococcus multilocularis protein patched 0.005 0.0078 0.008
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0085 0.0111
Brugia malayi glutathione reductase 0.1035 0.2683 0.305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.043 0.06
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0197 0.0197
Schistosoma mansoni smad1 5 8 and 0.0034 0.0033 0.003
Trypanosoma brucei NADH dehydrogenase 0.0095 0.0197 0.0707
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0018 0.004
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0381 0.0374
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Schistosoma mansoni myst-related protein 0.0024 0.0008 0.0001
Echinococcus granulosus GPCR family 2 0.0175 0.0407 0.0568
Schistosoma mansoni lamin 0.0033 0.0031 0.0027
Loa Loa (eye worm) hypothetical protein 0.0313 0.0772 0.0871
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0381 0.0381
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0095 0.0197 0.022
Leishmania major hypothetical protein, conserved 0.0024 0.0007 0.0026
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0109 0.0233 0.2011
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0085 0.0291
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0109 0.0233 0.0844
Plasmodium vivax ataxin-2 like protein, putative 0.013 0.0288 0.1049
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0095 0.0197 0.204
Echinococcus granulosus Protein patched homolog 1 0.005 0.0078 0.01
Loa Loa (eye worm) hypothetical protein 0.0095 0.0197 0.0216
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0227 0.0312
Echinococcus granulosus lamin 0.0033 0.0031 0.0033
Plasmodium falciparum thioredoxin reductase 0.0359 0.0894 0.3312
Trichomonas vaginalis mercuric reductase, putative 0.0359 0.0894 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0018 0.0015
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0031 0.0027
Loa Loa (eye worm) hypothetical protein 0.0146 0.033 0.0368
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.061 0.061
Echinococcus granulosus thioredoxin glutathione reductase 0.1041 0.2699 0.3824
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.043 0.06
Schistosoma mansoni hypothetical protein 0.0049 0.0073 0.0076
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.0051
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0095 0.0197 0.204
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0085 0.0085
Entamoeba histolytica thioredoxin reductase, putative 0.0095 0.0197 0.6491
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0095 0.0197 0.022
Schistosoma mansoni glutamate synthase 0.0095 0.0197 0.0218
Mycobacterium tuberculosis Conserved protein 0.0054 0.0087 0.006
Loa Loa (eye worm) hypothetical protein 0.0316 0.0781 0.0882
Schistosoma mansoni SET domain protein 0.0038 0.0045 0.0044
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0138 0.0148
Brugia malayi MH2 domain containing protein 0.0034 0.0033 0.003
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0087 0.079
Giardia lamblia PHD finger protein 15 0.0028 0.002 0.0141
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0134 0.0299 1
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0405 0.0405
Brugia malayi Smad1 0.0034 0.0033 0.003
Trichomonas vaginalis bromodomain containing protein, putative 0.0024 0.0007 0.0007
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0095 0.0197 0.0707
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0156 0.0156
Trichomonas vaginalis bromodomain containing protein, putative 0.0024 0.0007 0.0007
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0316 0.0781 0.8644
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0095 0.0197 0.0269
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0359 0.0894 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0073 0.0075
Echinococcus multilocularis thioredoxin glutathione reductase 0.1041 0.2699 0.3055
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.004 0.0052 0.005
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0095 0.0197 0.1571
Brugia malayi PHD-finger family protein 0.0028 0.002 0.0014
Echinococcus multilocularis dual specificity protein kinase clk2 0.0147 0.0332 0.0369
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0089 0.0328
Leishmania major cytochrome p450-like protein 0.0028 0.0018 0.0065
Brugia malayi N-terminal motif family protein 0.0195 0.046 0.0516
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0095 0.0197 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Echinococcus granulosus cpg binding protein 0.0111 0.0237 0.0327
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0138 0.015
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0025
Echinococcus granulosus methyl CpG binding domain protein 2 0.0117 0.0255 0.0352
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.0547 0.0615
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0128 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0019 0.0019
Toxoplasma gondii selenide, water dikinase 0.0095 0.0197 0.0707
Leishmania major protein kinase, putative 0.0147 0.0332 0.1237
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0095 0.0197 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.0051
Schistosoma mansoni lamin 0.0033 0.0031 0.0027
Leishmania major hypothetical protein, conserved 0.0467 0.1181 0.4403
Leishmania major hypothetical protein, conserved 0.013 0.0288 0.1072
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.0052 0.0052
Brugia malayi PAS domain containing protein 0.0059 0.01 0.0106
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0138 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0041 0.0052 0.0051
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0208 0.0208
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0134 0.0299 0.0332
Toxoplasma gondii aldehyde dehydrogenase 0.0249 0.0603 0.2227
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0128 0.0119
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0128 0.0138
Onchocerca volvulus 0.0038 0.0045 0.0038
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trypanosoma cruzi ISWI complex protein 0.0105 0.0223 0.0807
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0085 0.0291
Brugia malayi MH1 domain containing protein 0.0034 0.0033 0.003
Entamoeba histolytica disulphide oxidoreductase, putative 0.0095 0.0197 0.6491
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0085 0.0291
Brugia malayi Bromodomain containing protein 0.0528 0.1343 0.1522
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0138 0.0149
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0095 0.0197 0.0197
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0147 0.0332 0.1215
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0031 0.0027
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0049 0.0047
Mycobacterium tuberculosis Probable oxidoreductase 0.2624 0.6887 1
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.004 0.0052 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0095 0.0197 0.2136
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0481 0.1217 0.452
Schistosoma mansoni hypothetical protein 0.0058 0.0099 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0197 0.0707
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0175 0.0175
Leishmania major trypanothione reductase 0.1035 0.2683 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0138 0.0488
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.019 0.0208
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0087 0.0298
Loa Loa (eye worm) MH2 domain-containing protein 0.0492 0.1246 0.1412
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0156 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0226 0.0226
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.0076 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0012 0.0012
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0045 0.0064 0.008
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.0052 0.0391
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0085 0.0085
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.0197 0.0466 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0332 0.0374
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0095 0.0197 0.1571
Loa Loa (eye worm) hypothetical protein 0.0264 0.0643 0.0724
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0136 0.0136
Echinococcus multilocularis protein dispatched 1 0.0057 0.0097 0.0101
Schistosoma mansoni aldehyde dehydrogenase 0.0249 0.0603 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis glutamate synthase, putative 0.0095 0.0197 0.0197
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0089 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0007 0.00000019829
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0064 0.021
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0034 0.003
Schistosoma mansoni gabp alpha 0.0073 0.0138 0.015
Loa Loa (eye worm) hypothetical protein 0.0288 0.0705 0.0796
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0213 0.0508 0.0577
Schistosoma mansoni ets-related 0.0221 0.053 0.0602
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0095 0.0197 0.0269
Plasmodium vivax ferrodoxin reductase, putative 0.0095 0.0197 0.0707
Trichomonas vaginalis rotamase, putative 0.0034 0.0034 0.0034
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0147 0.0332 0.1215
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Plasmodium vivax acyl-CoA synthetase, putative 0.0041 0.0052 0.0168
Schistosoma mansoni bromodomain containing protein 0.0042 0.0056 0.0056
Trypanosoma cruzi NADH dehydrogenase, putative 0.0095 0.0197 0.0707
Mycobacterium ulcerans aldehyde dehydrogenase 0.0249 0.0603 0.6683
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.019 0.026
Echinococcus granulosus tumor protein p63 0.0996 0.2579 0.3653
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0095 0.0197 0.022
Echinococcus granulosus geminin 0.0695 0.1783 0.2522
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0147 0.0332 0.1215
Brugia malayi hypothetical protein 0.0313 0.0772 0.0871
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0159 0.5211
Echinococcus granulosus lamin dm0 0.0033 0.0031 0.0033
Plasmodium falciparum protein serine/threonine kinase-1 0.0147 0.0332 0.1215
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0095 0.0197 0.0707
Trypanosoma brucei AAA ATPase, putative 0.0024 0.0007 0.000001137
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0359 0.0894 0.3312
Brugia malayi Ets-domain containing protein 0.0073 0.0138 0.0148
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0226 0.0226
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Giardia lamblia Thioredoxin reductase 0.0095 0.0197 0.2136
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0085 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0136 0.0136
Chlamydia trachomatis thioredoxin reductase 0.0095 0.0197 0.1716
Loa Loa (eye worm) hypothetical protein 0.0062 0.0108 0.0115
Brugia malayi Pre-SET motif family protein 0.334 0.878 1
Echinococcus granulosus smad 0.0034 0.0033 0.0037
Brugia malayi CHE-14 protein 0.005 0.0078 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0552 0.1406 0.1595
Trichomonas vaginalis lymphoid specific helicase, putative 0.0024 0.0007 0.0007
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.004 0.0052 0.0051
Mycobacterium ulcerans dehydrogenase 0.0095 0.0197 0.204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0299 0.0299
Echinococcus granulosus Smad4 0.0034 0.0033 0.0037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.1035 0.2683 0.3854
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0032 0.0832
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0095 0.0197 0.0707
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0128 0.1257
Trichomonas vaginalis hypothetical protein 0.0024 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0046 0.0067 0.2037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.0051
Echinococcus multilocularis Niemann Pick C1 protein 0.0168 0.0388 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0095 0.0197 0.0269
Loa Loa (eye worm) hypothetical protein 0.0054 0.0089 0.0093
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0117 0.0255 0.8493
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0138 0.0513
Mycobacterium ulcerans aldehyde dehydrogenase 0.0249 0.0603 0.6683
Schistosoma mansoni hypothetical protein 0.0695 0.1783 0.2044
Schistosoma mansoni hypothetical protein 0.0049 0.0073 0.0076
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.0426 0.0477
Echinococcus granulosus microtubule associated protein 2 0.2685 0.7046 1
Entamoeba histolytica protein kinase rad3, putative 0.0025 0.0012 0.0151
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0316 0.0781 0.8668
Entamoeba histolytica ankyrin repeat protein, putative 0.0024 0.0007 0.0000018193
Brugia malayi MAP kinase sur-1 0.0053 0.0085 0.0089
Schistosoma mansoni jumonji domain containing protein 0.0074 0.014 0.0153
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0033 0.0037
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0481 0.1217 0.1392
Echinococcus granulosus hypothetical protein 0.0145 0.0328 0.0456
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0134 0.0299 0.1113
Brugia malayi Bromodomain containing protein 0.0052 0.0082 0.0086
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0054 0.0087 0.0087
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0134 0.0299 0.109
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0092 0.0316
Schistosoma mansoni jumonji/arid domain-containing protein 0.0053 0.0084 0.0089
Brugia malayi Cytochrome P450 family protein 0.004 0.0051 0.005
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0054 0.0087 0.006
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0032 0.0091
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0045 0.0064 0.021
Echinococcus multilocularis Niemann Pick C1 protein 0.0117 0.0255 0.0281
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0095 0.0197 0.6491
Loa Loa (eye worm) hypothetical protein 0.0486 0.1232 0.1395
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0033 0.003
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.004 0.0052 0.0165
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0054 0.0089 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0208 0.0208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0359 0.0894 0.3312
Schistosoma mansoni glutamate synthase 0.0095 0.0197 0.0218
Brugia malayi hypoxia-induced factor 1 0.0182 0.0426 0.0477
Plasmodium vivax thioredoxin reductase, putative 0.1035 0.2683 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) transcription factor SMAD2 0.0492 0.1246 0.1412
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0051 0.005
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0087 0.079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0089 0.0062
Loa Loa (eye worm) hypothetical protein 0.0172 0.0399 0.0446
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0208 0.0208
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0064 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.061 0.061
Schistosoma mansoni hypothetical protein 0.0142 0.032 0.036
Mycobacterium ulcerans glutamate synthase subunit beta 0.0095 0.0197 0.204
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0247 0.0599 0.0671
Trypanosoma brucei ISWI complex protein 0.0105 0.0223 0.0807
Plasmodium falciparum glutathione reductase 0.1035 0.2683 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0025 0.0012 0.0016
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0024 0.0007 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.0084 0.0088
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.043 0.0479
Brugia malayi Cytochrome P450 family protein 0.0028 0.0018 0.0012
Trichomonas vaginalis bromodomain containing protein, putative 0.0024 0.0007 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.043 0.0481
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0067 0.0557
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0085 0.0316
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0085 0.0088
Schistosoma mansoni smad 0.0034 0.0033 0.003
Brugia malayi SET domain containing protein 0.0038 0.0045 0.0043
Schistosoma mansoni rotamase 0.0034 0.0034 0.003
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0249 0.0603 0.2247
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0085 0.0088
Brugia malayi hypothetical protein 0.0107 0.0227 0.0251
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0134 0.0299 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0089 0.0806
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0359 0.0894 1
Leishmania major hypothetical protein, conserved 0.0095 0.0197 0.0731
Trypanosoma brucei protein kinase, putative 0.0053 0.0085 0.0291
Echinococcus granulosus L aminoadipate semialdehyde 0.0164 0.0378 0.0527
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0552 0.1406 0.1595
Brugia malayi Cytochrome P450 family protein 0.0028 0.0018 0.0012
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0018 0.004
Trichomonas vaginalis bromodomain containing protein, putative 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0164 0.0378 0.0423
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0025 0.001 0.001
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0316 0.0781 0.872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0064 0.0064
Echinococcus multilocularis expressed protein 0.0034 0.0034 0.003
Brugia malayi hypothetical protein 0.013 0.0288 0.032
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus granulosus fetal alzheimer antigen falz 0.016 0.0369 0.0514
Toxoplasma gondii NADPH-glutathione reductase 0.0359 0.0894 0.3312
Echinococcus granulosus expressed conserved protein 0.011 0.0236 0.0325
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Schistosoma mansoni zinc finger protein 0.0105 0.0223 0.0248
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0045 0.0064 0.0065
Echinococcus granulosus glutamate synthase 0.0095 0.0197 0.0269
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0164 0.0378 0.0427
Treponema pallidum oxidoreductase 0.0095 0.0197 0.1571
Schistosoma mansoni jumonji/arid domain-containing protein 0.0053 0.0084 0.0089
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0014
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0109 0.0233 0.0844
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.005 0.0078 0.008
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0095 0.0197 0.0216
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0316 0.0781 0.8668
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0316 0.0781 0.0879
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0138 0.0186
Plasmodium vivax glutathione reductase, putative 0.1035 0.2683 1
Onchocerca volvulus 0.0164 0.0378 0.0371
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0095 0.0197 0.0269
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0105 0.0222 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.0175 0.0407 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0226 0.0226
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0134 0.0299 0.109
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.061 0.0687
Giardia lamblia Kinase, CMGC CLK 0.0147 0.0332 0.3667
Brugia malayi bHLH-PAS transcription factor 0.0043 0.006 0.006
Leishmania major hypothetical protein, conserved 0.0095 0.0197 0.0731
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0316 0.0781 0.2893
Mycobacterium tuberculosis Probable reductase 0.2361 0.619 0.8981
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0359 0.0894 0.3312
Echinococcus multilocularis peregrin 0.0052 0.0082 0.0085
Trypanosoma brucei PAB1-binding protein , putative 0.013 0.0288 0.1049
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0089 0.0328
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0095 0.0197 0.0707
Loa Loa (eye worm) CXXC zinc finger family protein 0.0092 0.0189 0.0207
Loa Loa (eye worm) hypothetical protein 0.0117 0.0255 0.0282
Echinococcus multilocularis lamin dm0 0.0033 0.0031 0.0027
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0085 0.0291
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0227 0.0253
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0057 0.0056
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0041 0.0052 0.0051
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0095 0.0197 0.0707
Schistosoma mansoni hypothetical protein 0.0905 0.2338 0.2683
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0024 0.0007 0.0007
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0095 0.0197 0.0707
Loa Loa (eye worm) programmed cell death 8 0.0095 0.0197 0.0216
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0089 0.0032
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0012 0.0016
Entamoeba histolytica hypothetical protein 0.0024 0.0008 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0481 0.1217 0.1373
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0381 0.0381
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0306 0.0754 0.0851
Schistosoma mansoni hypothetical protein 0.0175 0.0407 0.046
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0054 0.0089 0.0806
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.004 0.0052 0.0052
Brugia malayi PHD-finger family protein 0.0184 0.0431 0.0483
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0095 0.0197 0.0707
Echinococcus granulosus Niemann Pick C1 protein 0.0117 0.0255 0.0352
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0032 0.0091
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Plasmodium vivax serine/threonine kinase-1, putative 0.0147 0.0332 0.1215
Onchocerca volvulus 0.0033 0.0031 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0359 0.0894 0.3312
Trypanosoma cruzi target of rapamycin kinase 3 0.0107 0.0227 0.082
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0025 0.0012 0.0006
Schistosoma mansoni peptidase Clp (S14 family) 0.0316 0.0781 0.0891
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0067 0.0557
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0095 0.0197 0.0707
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0018 0.0012
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0054 0.0087 0.079
Toxoplasma gondii bromodomain-containing protein 0.0024 0.0007 0.00000019829
Treponema pallidum thioredoxin reductase (trxB) 0.0095 0.0197 0.1571
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0085 0.088
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0197 0.0197
Leishmania major protein kinase, putative 0.0147 0.0332 0.1237
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.004 0.0052 0.1517
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0024 0.0007 0.00000034526
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0095 0.0197 0.0707
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0095 0.0197 0.0707
Brugia malayi Pre-SET motif family protein 0.0481 0.1217 0.1378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0136 0.0136
Schistosoma mansoni cpg binding protein 0.0092 0.0189 0.0209
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0012 0.0016
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0099 0.0104
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0164 0.0378 0.0423
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0147 0.0332 0.1215
Schistosoma mansoni myst-related protein 0.0024 0.0008 0.0001
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0095 0.0197 0.6491
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0598 0.1527 0.175
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0381 0.0381
Schistosoma mansoni hypothetical protein 0.0378 0.0944 0.1078
Trichomonas vaginalis glutathione reductase, putative 0.0359 0.0894 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0598 0.1527 0.1725
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0024 0.0007 0.0007
Plasmodium vivax SET domain containing protein 0.0043 0.0059 0.0194
Trichomonas vaginalis bromodomain containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0299 0.0299
Loa Loa (eye worm) phosphatidylinositol 3 0.0134 0.0299 0.0332
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0095 0.0197 0.204
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0028 0.0019 0.0045
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0109 0.0233 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0136 0.0136
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0107 0.0227 0.082
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.061 0.061
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.061 0.061
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0105 0.0222 0.0802
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.2624 0.6887 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0099 0.013
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0359 0.0894 0.102
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0064 0.021
Echinococcus granulosus histone acetyltransferase KAT2B 0.0292 0.0718 0.101
Onchocerca volvulus Alhambra homolog 0.0028 0.002 0.0012
Echinococcus granulosus intermediate filament protein 0.0033 0.0031 0.0033
Giardia lamblia Glutamate synthase 0.0095 0.0197 0.2136
Brugia malayi hypothetical protein 0.0197 0.0466 0.0523
Schistosoma mansoni cpg binding protein 0.0111 0.0237 0.0265
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0085 0.0291
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0095 0.0197 0.0215
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0381 0.0381
Mycobacterium ulcerans hypothetical protein 0.0054 0.0089 0.0806
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0359 0.0894 0.3312
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0134 0.0299 0.0336
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0359 0.0894 0.3312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0481 0.1217 0.1392
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.004 0.0052 0.005
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0316 0.0781 0.2893
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0197 0.0197
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.01 0.0105
Echinococcus granulosus peptidase Clp S14 family 0.0207 0.0493 0.069
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0288 0.1049
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0024 0.0007 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.334 0.878 1
Brugia malayi Fli-1 protein 0.0221 0.053 0.0596
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0107 0.0227 0.0844
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0156 0.0156
Brugia malayi follicle stimulating hormone receptor 0.0228 0.0547 0.0615
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0159 0.0568
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.002 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0359 0.0894 0.3312
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0095 0.0197 0.022
Loa Loa (eye worm) hypothetical protein 0.005 0.0078 0.008
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.0052 0.0165
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.2624 0.6887 1
Mycobacterium ulcerans monoxygenase 0.0095 0.0197 0.204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0012 0.0012
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0423 0.1064 0.1502
Schistosoma mansoni aldehyde dehydrogenase 0.0249 0.0603 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0182 0.0182
Trypanosoma cruzi trypanothione reductase, putative 0.1035 0.2683 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0249 0.0603 0.0814
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0138 0.0488
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0552 0.1406 0.1595
Schistosoma mansoni hypothetical protein 0.0028 0.002 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0018 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.043 0.0481
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0012 0.0005
Echinococcus multilocularis microtubule associated protein 2 0.2685 0.7046 0.799
Schistosoma mansoni bromodomain containing protein 0.0448 0.113 0.1292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.043 0.0486
Schistosoma mansoni smad1 5 8 and 0.0034 0.0033 0.003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.2361 0.619 0.8981
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0033 0.003
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0095 0.0197 0.204
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0067 0.0222
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0018 0.004
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.002 0.0047
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0359 0.0894 0.3312
Schistosoma mansoni smad1 5 8 and 0.0034 0.0033 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0064 0.0064
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0249 0.0603 0.0846
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0095 0.0197 0.0707
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0067 0.0222
Loa Loa (eye worm) bromodomain containing protein 0.0129 0.0286 0.0317
Mycobacterium ulcerans ferredoxin reductase 0.0095 0.0197 0.204
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0095 0.0197 0.0215
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0012 0.0006
Brugia malayi Thioredoxin reductase 0.1035 0.2683 0.305
Brugia malayi PHD-finger family protein 0.0028 0.0018 0.0012
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0359 0.0894 0.333
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0067 0.003
Brugia malayi acetyltransferase, GNAT family protein 0.0317 0.0784 0.0885
Trypanosoma cruzi ISWI complex protein 0.0105 0.0223 0.0807
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0147 0.0332 0.1215
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0067 0.0173
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0012 0.0005
Loa Loa (eye worm) Smad1 0.0034 0.0033 0.003
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0147 0.0332 0.1215
Toxoplasma gondii LsmAD domain-containing protein 0.013 0.0288 0.1049
Onchocerca volvulus 0.0313 0.0772 0.0765
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0288 0.1049
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0033 0.003
Brugia malayi intermediate filament protein 0.0033 0.0031 0.0027
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.046 0.0453
Echinococcus multilocularis expressed conserved protein 0.011 0.0236 0.026
Trichomonas vaginalis rotamase, putative 0.0033 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0107 0.0227 0.7543
Echinococcus granulosus zinc finger protein 0.0147 0.0334 0.0465
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0089 0.0093
Onchocerca volvulus 0.0095 0.0197 0.0189
Echinococcus multilocularis GPCR, family 2 0.0175 0.0407 0.0454
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0359 0.0894 0.333
Trichomonas vaginalis set domain proteins, putative 0.3801 1 1
Schistosoma mansoni hypothetical protein 0.0107 0.0227 0.0253
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0332 0.0374
Mycobacterium ulcerans hypothetical protein 0.0054 0.0087 0.079
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0095 0.0197 0.0197
Trypanosoma brucei trypanothione reductase 0.1035 0.2683 1
Echinococcus multilocularis zinc finger protein 0.0147 0.0334 0.0371
Onchocerca volvulus 0.0092 0.0189 0.0181
Brugia malayi hypothetical protein 0.0084 0.0166 0.0181
Echinococcus multilocularis peptidase Clp (S14 family) 0.0207 0.0493 0.0551
Loa Loa (eye worm) PHD-finger family protein 0.0142 0.032 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0381 0.0381
Toxoplasma gondii histone lysine methyltransferase SET1 0.0216 0.0516 0.19
Mycobacterium ulcerans NADH dehydrogenase 0.0095 0.0197 0.204
Echinococcus multilocularis tumor protein p63 0.0996 0.2579 0.2919
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0032 0.0091
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0359 0.0894 0.333
Loa Loa (eye worm) hypothetical protein 0.0054 0.0089 0.0093
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.006 0.006
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0095 0.0197 0.019
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0085 0.0085
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0359 0.0894 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0461 0.1165 0.1644
Leishmania major NADH dehydrogenase, putative 0.0095 0.0197 0.0731
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0095 0.0197 0.0707
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0316 0.0781 0.872
Leishmania major phosphatidylinositol 3-kinase, putative 0.0045 0.0064 0.0235
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.004 0.0052 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Mycobacterium ulcerans putative regulatory protein 0.0043 0.006 0.0477
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0012 0.0005
Plasmodium falciparum thioredoxin reductase 0.1035 0.2683 1
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.004 0.0052 0.0191
Leishmania major hypothetical protein, conserved 0.0105 0.0223 0.083
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0095 0.0197 0.204
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0175 0.0407 0.0454
Echinococcus granulosus histone lysine methyltransferase setb 0.0598 0.1527 0.2159
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0359 0.0894 1
Schistosoma mansoni cellular tumor antigen P53 0.0146 0.033 0.0372
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus granulosus Niemann Pick C1 protein 0.0168 0.0388 0.0541
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0087 0.0323
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.061 0.061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0089 0.2785
Schistosoma mansoni hypothetical protein 0.0105 0.0223 0.0248
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0067 0.0222
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0359 0.0894 0.3312
Plasmodium falciparum bromodomain protein 1 0.0024 0.0007 0.00000019829
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0423 0.1064 0.12
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.01 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0089 0.0806
Loa Loa (eye worm) hypothetical protein 0.0195 0.046 0.0516
Schistosoma mansoni hypothetical protein 0.0175 0.0407 0.046
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0095 0.0197 0.0215
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0012 0.0016
Brugia malayi jmjC domain containing protein 0.0053 0.0084 0.0088
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0095 0.0197 0.0707
Schistosoma mansoni microtubule-associated protein tau 0.2685 0.7046 0.8104
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0067 0.0222
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0012
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0067 0.0222
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0134 0.0299 0.109
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0288 0.1049
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0249 0.0603 0.0676
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0263 0.0642 0.0723
Loa Loa (eye worm) hypothetical protein 0.0552 0.1406 0.1595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0064 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0175 0.0407 0.0456
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0316 0.0781 0.2893
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0046 0.0067 0.0084
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0067 0.0247
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0359 0.0894 0.1238
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0095 0.0197 0.0216
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.2361 0.619 0.8981
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0159 0.1715
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0095 0.0197 0.0269
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0095 0.0197 0.019
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0134 0.0299 0.109
Brugia malayi ATPase, AAA family protein 0.0024 0.0007 0.00000034674
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0197 0.0197
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0359 0.0894 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0175 0.0407 0.0456
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0378 0.0944 0.1067
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0041 0.0052 0.0063
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0095 0.0197 0.0215
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0089 0.0806
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0138 0.0148
Onchocerca volvulus 0.0481 0.1217 0.121
Entamoeba histolytica hypothetical protein 0.0107 0.0227 0.7543
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0134 0.0299 0.1113
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0197 0.0707
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0381 0.0381
Echinococcus multilocularis musashi 0.0033 0.0031 0.0027
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0138 0.0488
Treponema pallidum NADH oxidase 0.0359 0.0894 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0119 0.026 0.0291
Brugia malayi Ets-domain containing protein 0.0073 0.0138 0.0148
Schistosoma mansoni hypothetical protein 0.0049 0.0073 0.0076
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0024 0.0007 0.00000043214
Schistosoma mansoni hypothetical protein 0.0175 0.0407 0.046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0359 0.0894 0.3312
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.061 0.0687
Trypanosoma cruzi hypothetical protein, conserved 0.0467 0.1181 0.4388
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0095 0.0197 0.1571
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0598 0.1527 0.175
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0025 0.0012 0.0151
Echinococcus multilocularis 0.0145 0.0328 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0359 0.0894 0.1259
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.0052 0.005
Echinococcus multilocularis lamin 0.0033 0.0031 0.0027
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0359 0.0894 0.101
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Onchocerca volvulus 0.0146 0.033 0.0323
Echinococcus multilocularis cpg binding protein 0.0111 0.0237 0.0261
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0359 0.0894 0.3312
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0078 0.0078
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.016 0.0369 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0172 0.0399 0.0446
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0014
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0095 0.0197 0.0731
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0095 0.0197 0.0215
Entamoeba histolytica hypothetical protein 0.0107 0.0227 0.7543
Trichomonas vaginalis apoptosis inducing factor, putative 0.0095 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0049 0.0073 0.0076
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0316 0.0781 0.8644
Echinococcus granulosus peregrin 0.0052 0.0082 0.0107
Entamoeba histolytica hypothetical protein 0.0107 0.0227 0.7543
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0095 0.0197 0.6491
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0025 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0147 0.0332 0.037
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0085 0.0085
Schistosoma mansoni sulfide quinone reductase 0.0095 0.0197 0.0218
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0128 0.0137
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0095 0.0197 0.204
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0105 0.0222 0.0222
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0175 0.0407 0.0454
Mycobacterium tuberculosis Probable dehydrogenase 0.2361 0.619 0.8981
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.2361 0.619 0.8978
Onchocerca volvulus 0.0054 0.0089 0.0081
Brugia malayi Bromodomain containing protein 0.0271 0.0661 0.0745
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0045 0.0064 0.021
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0095 0.0197 0.0269
Schistosoma mansoni Smad4 0.0034 0.0033 0.003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0247 0.0599 0.084
Brugia malayi MH2 domain containing protein 0.0034 0.0033 0.003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.2361 0.619 0.8981
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) histone methyltransferase 0.0046 0.0067 0.0068
Echinococcus multilocularis geminin 0.0695 0.1783 0.2015
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0054 0.0089 0.0062
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0095 0.0197 0.022
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.1176 0.166
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0147 0.0332 0.037
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus granulosus sterol regulatory element binding protein 0.005 0.0078 0.01
Trichomonas vaginalis hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.061 0.061
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0095 0.0197 0.0731
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0085 0.009
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0359 0.0894 0.3312
Onchocerca volvulus 0.0043 0.006 0.0052
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0138 0.0185
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0227 0.025
Echinococcus multilocularis fetal alzheimer antigen, falz 0.016 0.0369 0.041
Leishmania major hypothetical protein, conserved,predicted bromodomain protein 0.0024 0.0007 0.0026
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0046 0.0067 0.0067
Trypanosoma cruzi trypanothione reductase, putative 0.0359 0.0894 0.3312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0064 0.0064
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0147 0.0332 0.1215
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0095 0.0197 0.0707
Onchocerca volvulus 0.0033 0.0031 0.0024
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0117 0.0255 0.0281
Echinococcus multilocularis smad 0.0034 0.0033 0.003
Toxoplasma gondii target of rapamycin (TOR), putative 0.01 0.0208 0.0751
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.004 0.0052 0.0063
Mycobacterium ulcerans hypothetical protein 0.0054 0.0087 0.079
Loa Loa (eye worm) hypothetical protein 0.0145 0.0328 0.0366
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0049 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0147 0.0332 0.0332
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0116 0.0124
Plasmodium falciparum ferrodoxin reductase-like protein 0.0095 0.0197 0.0707
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0089 0.0093
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0207 0.0493 0.0625
Schistosoma mansoni hypothetical protein 0.0695 0.1783 0.2044
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0085 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0381 0.0381
Plasmodium vivax hypothetical protein, conserved 0.0028 0.002 0.0047
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0138 0.0148
Echinococcus multilocularis sterol regulatory element binding protein 0.005 0.0078 0.008
Brugia malayi jmjC domain containing protein 0.0093 0.019 0.0209
Toxoplasma gondii hypothetical protein 0.0109 0.0233 0.0844
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.002 0.0014
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0095 0.0197 0.0707
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0226 0.0226
Leishmania major hypothetical protein, conserved 0.0024 0.0007 0.0026
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0359 0.0894 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0033 0.003
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0054 0.0089 0.0806
Echinococcus multilocularis dnaJ subfamily B 0.0905 0.2338 0.2645
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0138 0.4479
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0208 0.0208
Trichomonas vaginalis glutamate synthase, putative 0.0095 0.0197 0.0197
Schistosoma mansoni cpg binding protein 0.0111 0.0237 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0136 0.0136
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0359 0.0894 0.3312
Echinococcus granulosus neuropeptide s receptor 0.0465 0.1176 0.166
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0128 0.0171
Echinococcus granulosus histone acetyltransferase KAT2B 0.0105 0.0222 0.0305
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0208 0.0208
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0095 0.0197 0.0707
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.004 0.0052 0.0165
Schistosoma mansoni methyl-cpg binding protein mbd 0.0117 0.0255 0.0285
Schistosoma mansoni intermediate filament proteins 0.0033 0.0031 0.0027
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0263 0.0642 0.0723
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0359 0.0894 0.3312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.043 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0136 0.0136
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0089 0.0093
Plasmodium vivax SET domain protein, putative 0.0481 0.1217 0.452
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0055
Leishmania major DNA-binding protein, putative,predicted bromodomain protein 0.0024 0.0007 0.0026
Entamoeba histolytica acyl-coA synthetase, putative 0.0054 0.0089 0.2785
Brugia malayi Latrophilin receptor protein 2 0.0175 0.0407 0.0456
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.00000034674
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0018 0.0012
Schistosoma mansoni sulfide quinone reductase 0.0095 0.0197 0.0218
Brugia malayi glutamate synthase 0.0095 0.0197 0.0216
Echinococcus granulosus dual specificity protein kinase clk2 0.0147 0.0332 0.0462
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0128 0.0139
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0089 0.2785
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0095 0.0197 0.022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0027
Brugia malayi MH1 domain containing protein 0.0034 0.0033 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0208 0.0208
Trichomonas vaginalis bromodomain containing protein, putative 0.0024 0.0007 0.0007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0031 0.0027
Echinococcus multilocularis citrate lyase subunit beta protein 0.0054 0.0087 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Schistosoma mansoni fkbp-rapamycin associated protein 0.0025 0.0012 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0247 0.0247
Echinococcus granulosus lysine specific demethylase 5A 0.0053 0.0084 0.0109
Echinococcus granulosus mixed lineage leukemia protein mll 0.0041 0.0052 0.0063
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0095 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.004 0.004
Echinococcus multilocularis L aminoadipate semialdehyde 0.0164 0.0378 0.0421
Entamoeba histolytica hypothetical protein 0.0025 0.0012 0.0151
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0197 0.0197
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0025 0.0012 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0012 0.0012
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.002 0.0047
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0175 0.0407 0.0568
Brugia malayi F/Y-rich N-terminus family protein 0.0068 0.0125 0.0134
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0317 0.0784 0.0894
Trypanosoma brucei ubiquitin-protein ligase, putative 0.004 0.0052 0.0165
Loa Loa (eye worm) thioredoxin reductase 0.1035 0.2683 0.305
Plasmodium falciparum acyl-CoA synthetase 0.0041 0.0052 0.0168
Leishmania major hypothetical protein, conserved 0.0095 0.0197 0.0731
Brugia malayi Niemann-Pick C1 protein precursor 0.0117 0.0255 0.0282
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.1176 0.1326
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0095 0.0197 0.019
Echinococcus granulosus expressed protein 0.0034 0.0034 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0095 0.0197 0.0707
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0085 0.0089
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0095 0.0197 0.0197
Schistosoma mansoni single-minded 0.0059 0.01 0.0107
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0063 0.0112 0.0392
Schistosoma mansoni glutamate synthase 0.0095 0.0197 0.0218
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0095 0.0197 0.6491
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Brugia malayi CXXC zinc finger family protein 0.0092 0.0189 0.0207
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0359 0.0894 0.3312
Schistosoma mansoni hypothetical protein 0.0175 0.0407 0.046
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3354 0.8818 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0045 0.0064 0.0235
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0087 0.0298
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0467 0.1181 0.4388
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0095 0.0197 0.0215
Loa Loa (eye worm) hypothetical protein 0.0598 0.1527 0.1732
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0359 0.0894 0.3312
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0208 0.0208
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.2361 0.619 0.8981
Trypanosoma cruzi NADH dehydrogenase, putative 0.0095 0.0197 0.0707
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0386 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0085 0.0291
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0359 0.0894 0.333
Echinococcus granulosus citrate lyase subunit beta protein 0.0054 0.0087 0.0113
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0405 0.0405
Schistosoma mansoni patched 1 0.005 0.0078 0.0081
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0317 0.0784 0.0881
Echinococcus multilocularis Smad4 0.0034 0.0033 0.003
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0359 0.0894 0.1006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0041 0.0052 0.0009
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0197 0.0197
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0134 0.0299 0.0331
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.004 0.0052 0.005
Giardia lamblia NADH oxidase lateral transfer candidate 0.0359 0.0894 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0018 0.0012
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0095 0.0197 0.204
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0288 0.1049
Brugia malayi latrophilin 2 splice variant baaae 0.0378 0.0944 0.1067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0136 0.0136
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0316 0.0781 0.1048
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0128 0.0476
Loa Loa (eye worm) fli-1 protein 0.0221 0.053 0.0596
Brugia malayi MH2 domain containing protein 0.0492 0.1246 0.1412
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0045 0.0064 0.0064
Plasmodium falciparum phd finger protein, putative 0.0028 0.002 0.0047
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0026 0.0022
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0095 0.0197 0.0707
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Echinococcus multilocularis glutamate synthase 0.0095 0.0197 0.0215
Trypanosoma brucei hypothetical protein, conserved 0.0467 0.1181 0.4388
Trichomonas vaginalis bromodomain-containing protein, putative 0.0024 0.0007 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0089 0.0328
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.2624 0.6887 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0089 0.0806
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.002 0.0014
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0095 0.0197 0.0707
Schistosoma mansoni disulfide oxidoreductase 0.0095 0.0197 0.0218
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0175 0.0407 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0299 0.0299
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.043 0.0486
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0034 0.003
Plasmodium falciparum zinc finger protein, putative 0.0024 0.0008 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.013 0.0288 0.032
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0095 0.0197 0.0216
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0057 0.007
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0033 0.0037

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.125892541 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (binding) = 0.265 uM PUBCHEM_BIOASSAY: MLPCN Dyrk1A - CLK1 Selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-05_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] ChEMBL. No reference
AC50 (functional) = 0.398107171 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 0.1259 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Firefly Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 2309 (Probe Summary for Inhibitors and Stabilizers of Firefly Luciferase)] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-FP Assay). (Class of assay: confirmatory) [Related pubchem assays: 1771, 1770 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.