Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0345 | 0.2574 |
Onchocerca volvulus | 0.0033 | 0.1339 | 1 | |
Echinococcus multilocularis | musashi | 0.0033 | 0.1339 | 0.1339 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0192 | 0.1432 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.9197 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0345 | 0.2574 |
Schistosoma mansoni | lamin | 0.0033 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1339 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.9197 | 0.9197 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1339 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.9197 | 0.9197 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1339 | 0.1456 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0192 | 0.1432 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1339 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1339 | 0.1339 |
Onchocerca volvulus | 0.0033 | 0.1339 | 1 | |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0231 | 0.0251 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1339 | 0.1339 |
Schistosoma mansoni | lamin | 0.0033 | 0.1339 | 0.1339 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1339 | 0.1456 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0231 | 0.1725 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.1339 | 0.1456 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1339 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1339 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.13 | 0.9707 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2818 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.