Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0249 | 0.8748 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0142 | 0.4023 | 0.4477 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 0.059 | 0.0871 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.2317 | 0.2649 |
Brugia malayi | jmjC domain containing protein | 0.0064 | 0.059 | 0.0675 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0064 | 0.059 | 0.0465 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4023 | 0.5936 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4023 | 0.5936 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0064 | 0.059 | 0.0465 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0142 | 0.4023 | 0.4598 |
Loa Loa (eye worm) | TAR-binding protein | 0.0142 | 0.4023 | 0.4477 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0875 | 0.0797 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0142 | 0.4023 | 0.4477 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.2317 | 0.2649 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4023 | 0.5936 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0193 | 0.0285 |
Brugia malayi | RNA binding protein | 0.0142 | 0.4023 | 0.4598 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.059 | 0.0465 |
Echinococcus multilocularis | tar DNA binding protein | 0.0142 | 0.4023 | 0.4477 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0875 | 0.1291 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0875 | 0.1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.58 | 0.6555 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6776 | 0.7696 |
Echinococcus granulosus | geminin | 0.0205 | 0.6776 | 0.7696 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6776 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0249 | 0.8748 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0064 | 0.059 | 0.0871 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0193 | 0.022 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0249 | 0.8748 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6776 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0064 | 0.059 | 0.0675 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4023 | 0.5936 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 0.059 | 0.0871 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.2317 | 0.2483 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.8748 | 1 |
Brugia malayi | hypothetical protein | 0.0182 | 0.58 | 0.663 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0193 | 0.0285 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0064 | 0.059 | 0.0465 |
Onchocerca volvulus | 0.0182 | 0.58 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0193 | 0.0285 |
Loa Loa (eye worm) | RNA binding protein | 0.0142 | 0.4023 | 0.4477 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0064 | 0.059 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2317 | 0.2483 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4023 | 0.5936 |
Brugia malayi | TAR-binding protein | 0.0142 | 0.4023 | 0.4598 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.