Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3039 | 0.3039 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0375 | 0.0375 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.3537 | 0.6116 |
Schistosoma mansoni | lamin | 0.0033 | 0.3537 | 0.6116 |
Schistosoma mansoni | lamin | 0.0033 | 0.3537 | 0.6116 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3039 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.3537 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.3537 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0375 | 0.0375 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3039 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3039 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3039 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.3537 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.3039 | 0.5 |
Brugia malayi | hypothetical protein | 0.002 | 0.0516 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5545 | 0.5545 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.3537 | 0.3537 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0375 | 0.0375 |
Echinococcus granulosus | lamin | 0.0033 | 0.3537 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5545 | 0.5545 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3537 | 0.3537 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5545 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0375 | 0.0375 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.3537 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.3039 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.3537 | 0.3537 |
Echinococcus multilocularis | musashi | 0.0033 | 0.3537 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.3537 | 0.3537 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3039 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.3537 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.3039 | 0.3039 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.3537 | 0.5 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3039 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0447 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.