Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.5833 | 0.5833 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 1 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.5833 | 0.5 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.5833 | 0.5833 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5833 | 0.5833 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.8382 | 0.5 |
Echinococcus granulosus | lamin | 0.0029 | 0.5833 | 0.5833 |
Onchocerca volvulus | 0.0029 | 0.5833 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.5833 | 0.5833 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.8382 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.5833 | 0.5568 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.5833 | 0.5833 |
Echinococcus multilocularis | musashi | 0.0029 | 0.5833 | 0.5833 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.5833 | 0.5833 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.5627 | 0.5627 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0599 | 0.0599 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.5833 | 0.5568 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0029 | 0.5833 | 0.5833 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 1 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.