Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.2862 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1612 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1156 | 0.3185 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.4499 | 0.4499 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.4499 | 0.4499 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.4499 | 0.4499 |
Brugia malayi | N-terminal motif family protein | 0.0158 | 0.6882 | 0.6882 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.4499 | 0.4499 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2156 | 0.6979 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.1156 | 0.3298 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2952 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.1156 | 0.3298 |
Brugia malayi | MH2 domain containing protein | 0.0015 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.2862 | 0.2862 |
Loa Loa (eye worm) | Smad1 | 0.0015 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0015 | 0.0316 | 0.0316 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.2862 | 0.2862 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2862 | 0.9658 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1612 | 0.5 |
Brugia malayi | RNA binding protein | 0.0071 | 0.2862 | 0.2862 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1156 | 0.1156 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1612 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0225 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2156 | 0.7227 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.2862 | 0.2862 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.1156 | 0.3298 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1612 | 0.4916 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.6882 | 0.6882 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0225 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.1156 | 0.3298 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.1156 | 0.3298 |
Brugia malayi | MH1 domain containing protein | 0.0015 | 0.0316 | 0.0316 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1612 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.1156 | 0.3298 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2952 | 0.2952 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2156 | 0.2156 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2862 | 0.9658 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.2862 | 0.2862 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1612 | 0.4916 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.1156 | 0.1156 |
Brugia malayi | MH2 domain containing protein | 0.0015 | 0.0316 | 0.0316 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2156 | 0.2156 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.2952 | 0.2952 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2156 | 0.7227 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0158 | 0.6882 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.1156 | 0.1156 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2862 | 0.9658 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2156 | 0.7227 |
Brugia malayi | Smad1 | 0.0015 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.2862 | 0.2862 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1612 | 0.509 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1156 | 0.3185 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1156 | 0.3185 |
Brugia malayi | MH1 domain containing protein | 0.0015 | 0.0316 | 0.0316 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2156 | 0.7227 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1612 | 0.1612 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2862 | 0.9658 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0015 | 0.0316 | 0.0316 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2156 | 0.6979 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.2862 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2156 | 0.6979 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1156 | 0.3185 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1612 | 0.509 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.1156 | 0.1156 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2862 | 0.9658 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2909 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 1.5849 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.