Detailed information for compound 1208036

Basic information

Technical information
  • TDR Targets ID: 1208036
  • Name: but-2-enedioic acid; 1-phenethyl-3,4-dihydrop yrrolo[1,2-a]pyrazine
  • MW: 340.373 | Formula: C19H20N2O4
  • H donors: 2 H acceptors: 4 LogP: 1.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)CCC1=NCCn2c1ccc2.OC(=O)/C=C/C(=O)O
  • InChi: 1S/C15H16N2.C4H4O4/c1-2-5-13(6-3-1)8-9-14-15-7-4-11-17(15)12-10-16-14;5-3(6)1-2-4(7)8/h1-7,11H,8-10,12H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
  • InChiKey: SBKCQHWUUXCELP-WLHGVMLRSA-N  

Network

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Synonyms

  • MLS000038103
  • SMR000057792

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Polyketide synthase Pks13 0.094 0.5643 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0055 0.0231 0.0231
Mycobacterium tuberculosis Probable oxidoreductase 0.0039 0.0133 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0089 0.0216
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0034 0.0104 0.0253
Entamoeba histolytica hypothetical protein 0.0073 0.0341 0.9019
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0068 0.0095
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0232 0.6105
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0006 0.0012
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0006 0.0008
Plasmodium vivax vivapain-3 0.0028 0.0068 0.0793
Mycobacterium ulcerans quinone oxidoreductase 0.0039 0.0133 0.0205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0282 0.0488
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0039 0.0133 0.0222
Loa Loa (eye worm) acyl carrier protein 0.0289 0.1663 0.2616
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0039 0.0133 0.3441
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0168 0.0168
Chlamydia trachomatis acyl carrier protein 0.0064 0.0282 0.2508
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0408 0.2389 0.5996
Toxoplasma gondii type I fatty acid synthase, putative 0.0668 0.3979 1
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0024 0.0041 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0048 0.0188 0.1535
Echinococcus granulosus multidrug resistance protein 1 0.0077 0.0365 0.0886
Mycobacterium tuberculosis Conserved protein 0.0032 0.0089 0.0145
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0041 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0039 0.0133 0.0205
Echinococcus granulosus cysteine protease 0.0028 0.0068 0.0165
Plasmodium vivax multidrug resistance protein 2, putative 0.0024 0.0041 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.078
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0089 0.0216
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0046 0.0173 0.042
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0039 0.0133 0.0164
Trypanosoma cruzi acyl transferase-like protein 0.004 0.0137 0.1123
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.0089 0.0216
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0054 0.0222 0.1319
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.0089 0.0086
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0318 0.1838 0.4608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0102 0.0593
Mycobacterium ulcerans oxidoreductase FadB5 0.0039 0.0133 0.0205
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0077 0.0365 0.2178
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0024 0.0041 0.0313
Toxoplasma gondii ABC transporter family protein 0.0024 0.0041 0.0084
Echinococcus multilocularis GPCR, family 2 0.004 0.0142 0.0142
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0041 0.0223
Giardia lamblia Multidrug resistance-associated protein 1 0.0024 0.0041 0.023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0285 0.1638 0.3978
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0158 0.0859 1
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0068 0.0541
Schistosoma mansoni hypothetical protein 0.0032 0.0089 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Echinococcus multilocularis AMP dependent ligase 0.0064 0.0282 0.0282
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0068 0.0165
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0064 0.0282 0.0488
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0231 0.0364
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0032 0.0089 0.0216
Brugia malayi MH2 domain containing protein 0.0021 0.0024 0.0034
Plasmodium falciparum cGMP-dependent protein kinase 0.0032 0.0089 0.1037
Plasmodium falciparum multidrug resistance-associated protein 1 0.0024 0.0041 0.0479
Plasmodium falciparum ABC transporter B family member 5, putative 0.0024 0.0041 0.0479
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0049 0.0191 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0024 0.0041 0.0285
Loa Loa (eye worm) hypothetical protein 0.0096 0.0484 0.0761
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0232 0.1933
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0158 0.0859 0.1497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0105 0.0609
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0027
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0173 0.1018
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.0365 0.0886
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0136 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0032 0.0089 0.0694
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0158 0.0859 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.0365 0.0886
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0024 0.0041 0.0057
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0055 0.0231 0.1904
Entamoeba histolytica multidrug resistance protein, putative 0.0024 0.0041 0.0987
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0024 0.0041 0.01
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0065
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0045 0.0525
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0032 0.0089 0.0089
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0066 0.0104
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0087 0.0678
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0232 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Loa Loa (eye worm) hypothetical protein 0.0032 0.0089 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Schistosoma mansoni lamin 0.0044 0.0164 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0231 0.1373
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0341 0.0341
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0004 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0313 0.1808 0.2844
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0668 0.3979 0.7048
Plasmodium falciparum acyl carrier protein 0.0064 0.0282 0.3286
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0024 0.0041 0.0479
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0076 0.036 0.0873
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0068 0.0541
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0185
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0229 0.0558
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0024 0.0041 0.0285
Toxoplasma gondii ABC transporter, putative 0.0024 0.0041 0.0084
Brugia malayi Phosphopantetheine attachment site family protein 0.0064 0.0282 0.0393
Mycobacterium tuberculosis Hypothetical protein 0.0189 0.1053 0.1854
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0057
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0039 0.0133 0.0205
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0039 0.0133 0.0205
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0344
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0416 0.2437 0.4302
Loa Loa (eye worm) MH2 domain-containing protein 0.0021 0.0024 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Plasmodium vivax vivapain-2 0.0055 0.0232 0.2702
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0017 0.0042
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Loa Loa (eye worm) fatty acid synthase 0.062 0.3689 0.5804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0282 0.0393
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0282 0.0431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0024 0.0041 0.01
Leishmania major oxidoreductase, putative 0.0039 0.0133 0.1065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.069 0.4118 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.003
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0096 0.0484 0.0845
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0032 0.0089 0.0145
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.0173 0.0173
Leishmania major phosphatidylinositol kinase related protein, putative 0.0023 0.0032 0.0209
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0032 0.0089 0.0216
Onchocerca volvulus 0.0037 0.012 0.0176
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0017 0.0079
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0026 0.0584
Loa Loa (eye worm) acyl carrier protein 0.0064 0.0282 0.0444
Giardia lamblia Multidrug resistance-associated protein 1 0.0023 0.0036 0.018
Trichomonas vaginalis abcb9, putative 0.0077 0.0365 0.2178
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0046 0.0173 0.0272
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0133 0.109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0168 0.0409
Onchocerca volvulus 0.0042 0.0154 0.0225
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0024 0.0041 0.0283
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0133 0.0185
Schistosoma mansoni smdr2 0.0077 0.0365 0.0886
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0039 0.0133 0.3441
Schistosoma mansoni inositol monophosphatase 0.004 0.0136 0.0331
Echinococcus multilocularis serine protein kinase ATM 0.0035 0.0105 0.0105
Loa Loa (eye worm) acetyltransferase 0.0293 0.1688 0.2656
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0133 0.109
Mycobacterium ulcerans polyketide synthase Pks13 0.094 0.5643 1
Echinococcus multilocularis tumor protein p63 0.029 0.1668 0.1668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Entamoeba histolytica hypothetical protein 0.0073 0.0341 0.9019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0064 0.0282 0.7449
Brugia malayi ABC transporter family protein 0.0024 0.0041 0.0057
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0026 0.0026
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0668 0.3979 0.7043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Loa Loa (eye worm) hypothetical protein 0.0086 0.0423 0.0665
Echinococcus multilocularis cathepsin L 0.0028 0.0068 0.0068
Plasmodium falciparum ABC transporter B family member 4, putative 0.0024 0.0041 0.0479
Echinococcus multilocularis smad 0.0021 0.0024 0.0024
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0136 0.0212
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0026 0.0157
Brugia malayi hypothetical protein 0.0024 0.0041 0.0057
Echinococcus granulosus tumor protein p63 0.029 0.1668 0.4052
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0629 0.374 0.6624
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0017 0.0083
Echinococcus granulosus cGMP dependent protein kinase 0.0032 0.0089 0.0216
Echinococcus granulosus cathepsin L 0.0028 0.0068 0.0165
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0506 0.2989 0.5262
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0046 0.0173 0.0272
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.004 0.0137 0.0137
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0236 0.1337 0.1958
Loa Loa (eye worm) hypothetical protein 0.0096 0.0478 0.0753
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0032 0.0089 0.1037
Echinococcus granulosus dna polymerase kappa 0.0022 0.0026 0.0063
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0006 0.0012
Echinococcus granulosus hyperpolarization activated cyclic 0.069 0.4118 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0232 0.1378
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.009 0.0141
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0173 0.0173
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0039 0.0133 0.0322
Echinococcus multilocularis Protein lozenge 0.005 0.02 0.02
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0039 0.0133 0.0164
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0032 0.0089 0.0205
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0136 0.0798
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0068 0.0386
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0035 0.0105 0.0828
Loa Loa (eye worm) inositol-1 0.004 0.0136 0.0215
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0039 0.0133 0.0222
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0039 0.0133 0.0776
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.1053 0.6337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0032 0.0089 0.0216
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0142 0.0142
Onchocerca volvulus 0.0055 0.0232 0.034
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0018
Echinococcus granulosus cathepsin L cysteine proteinase 0.0055 0.0232 0.0564
Brugia malayi isocitrate dehydrogenase 0.0019 0.0008 0.0011
Mycobacterium ulcerans oxidoreductase 0.0039 0.0133 0.0205
Leishmania major pentamidine resistance protein 1 0.0024 0.0041 0.0285
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.004 0.0137 0.0212
Brugia malayi Alcohol dehydrogenase class III 0.0039 0.0133 0.0185
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0024 0.0041 0.0285
Treponema pallidum catabolite gene activator (Crp) 0.0032 0.0089 0.271
Loa Loa (eye worm) hypothetical protein 0.0128 0.0677 0.1065
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0068 0.0165
Plasmodium vivax ABC transporter B family member 3, putative 0.0024 0.0041 0.0479
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0026 0.0157
Brugia malayi ABC transporter family protein 0.0077 0.0365 0.0508
Brugia malayi ABC transporter family protein 0.0024 0.0041 0.0057
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0032 0.0089 0.0216
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0055 0.0232 0.0365
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0064 0.0282 0.0471
Trichomonas vaginalis abcb9, putative 0.0077 0.0365 0.2178
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.0089 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0026 0.0063
Schistosoma mansoni intermediate filament proteins 0.0044 0.0164 0.0399
Brugia malayi multidrug resistance protein 3 0.0077 0.0365 0.0508
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.004 0.0137 0.1417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0024 0.0041 0.0285
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0032 0.0089 0.1037
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.009 0.0698
Brugia malayi P-glycoprotein-like protein 0.0024 0.0041 0.0057
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0032 0.0089 0.0205
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0024 0.0039 0.0061
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.2349 0.2349
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0026 0.0063
Loa Loa (eye worm) multidrug resistance protein 3 0.0077 0.0365 0.0574
Brugia malayi MH1 domain containing protein 0.0021 0.0024 0.0034
Brugia malayi Cathepsin L-like precursor 0.0037 0.012 0.0167
Brugia malayi Intermediate filament tail domain containing protein 0.0044 0.0164 0.0228
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0039 0.0133 0.1065
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0026 0.0157
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0032 0.0089 0.0089
Echinococcus multilocularis multidrug resistance associated protein 7 0.0024 0.0041 0.0041
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0077 0.0365 0.2178
Schistosoma mansoni hypothetical protein 0.0087 0.0429 0.1042
Brugia malayi MH1 domain containing protein 0.0021 0.0024 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0232 0.034
Brugia malayi Egg laying defective protein 4 0.0032 0.0089 0.0124
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0024 0.0041 0.0313
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.009 0.0725
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0089 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Echinococcus granulosus smad 0.0021 0.0024 0.0059
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0193 0.1076 0.1897
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0142 0.0223
Loa Loa (eye worm) hypothetical protein 0.0087 0.0429 0.0675
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0068 0.171
Echinococcus granulosus GPCR family 2 0.004 0.0142 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0526
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0004 0.001
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.0422 0.4905
Loa Loa (eye worm) ABC transporter 0.0024 0.0041 0.0065
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0024 0.0041 0.0042
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0609 0.3622 0.6415
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0142 0.0344
Loa Loa (eye worm) hypothetical protein 0.0398 0.2331 0.3668
Echinococcus multilocularis expressed conserved protein 0.0032 0.0089 0.0089
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0039 0.0133 0.1371
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0017 0.0079
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.0365 0.0886
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.009 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0346
Trypanosoma brucei oxidoreductase, putative 0.0039 0.0133 0.1065
Brugia malayi Cathepsin L-like precursor 0.0018 0.0006 0.0008
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0039 0.0133 0.0164
Echinococcus multilocularis survival motor neuron protein 1 0.0482 0.2841 0.2841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Schistosoma mansoni survival motor neuron protein 0.0098 0.0495 0.1202
Leishmania major d-xylulose reductase, putative 0.0039 0.0133 0.1065
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0055 0.0231 0.1904
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.009 0.0698
Mycobacterium leprae Polyketide synthase Pks13 0.094 0.5643 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Onchocerca volvulus 0.0098 0.0495 0.0725
Loa Loa (eye worm) ABC transporter 0.0024 0.0041 0.0065
Onchocerca volvulus 0.0064 0.0282 0.0413
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0039 0.0133 0.0222
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0046 0.0173 0.0272
Mycobacterium ulcerans short-chain dehydrogenase 0.0039 0.0133 0.0205
Mycobacterium ulcerans polyketide synthase MbtC 0.0158 0.0859 0.1497
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0032 0.0089 0.0205
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0046 0.0173 0.042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0044 0.0164 0.0258
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0111 0.0183
Brugia malayi hypothetical protein 0.0073 0.0341 0.0475
Leishmania major acyl carrier protein, putative 0.0064 0.0282 0.2337
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.009 0.0725
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0587 0.3488 0.6176
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0041
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Mycobacterium ulcerans transmembrane transport protein 0.0032 0.0089 0.0128
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0067 0.0534
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0057
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0017 0.0202
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0032 0.0089 0.072
Onchocerca volvulus 0.0039 0.0133 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0041 0.0041
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0049 0.0191 0.0464
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0041 0.0987
Onchocerca volvulus 0.1094 0.6589 0.965
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0108 0.017
Echinococcus granulosus lamin 0.0044 0.0164 0.0399
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0275 0.1575 0.3825
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0064 0.0282 0.0488
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0006 0.0009
Mycobacterium ulcerans polyketide synthase 0.0629 0.374 0.6618
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0136 0.1414
Schistosoma mansoni alcohol dehydrogenase 0.0039 0.0133 0.0322
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0036 0.0192
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0039 0.0133 0.0209
Toxoplasma gondii target of rapamycin (TOR), putative 0.0046 0.0177 0.0426
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0032 0.0089 0.072
Brugia malayi latrophilin 2 splice variant baaae 0.0087 0.0429 0.0597
Schistosoma mansoni multidrug resistance protein 0.0023 0.0036 0.0087
Trypanosoma brucei protein kinase A regulatory subunit 0.0032 0.0089 0.0694
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0017 0.0202
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0089 0.0089
Plasmodium vivax acyl carrier protein, putative 0.0064 0.0282 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0032 0.0089 0.0205
Leishmania major zinc-binding dehydrogenase-like protein 0.0039 0.0133 0.1065
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0041 0.0042
Onchocerca volvulus 0.0587 0.3488 0.5108
Brugia malayi intermediate filament protein 0.0044 0.0164 0.0228
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0189
Mycobacterium tuberculosis Possible dehydrogenase 0.0039 0.0133 0.0222
Echinococcus multilocularis muscleblind protein 1 0.0295 0.17 0.17
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0024 0.0041 0.0042
Trypanosoma brucei Flagellar Member 6 0.0032 0.0089 0.0694
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0032 0.0089 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Schistosoma mansoni multidrug resistance protein 0.0077 0.0365 0.0886
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0136 0.1121
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0021 0.0024 0.0059
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0064 0.0282 0.0444
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.0089 0.0216
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0033 0.0094 0.0154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0229 0.0377
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0229 0.1887
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Leishmania major hypothetical protein, conserved 0.0032 0.0089 0.0694
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0168 0.0234
Trypanosoma cruzi cAMP binding protein, putative 0.0032 0.0089 0.072
Leishmania major zinc binding dehydrogenase-like protein 0.0039 0.0133 0.1065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0229 0.0377
Loa Loa (eye worm) MH1 domain-containing protein 0.0021 0.0024 0.0038
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0096 0.0484 0.0845
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0136 0.0798
Leishmania major cyclic nucleotide-binding protein-like protein 0.0032 0.0089 0.0694
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0209
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Trypanosoma cruzi protein kinase A regulatory subunit 0.0032 0.0089 0.072
Loa Loa (eye worm) runx1 0.005 0.02 0.0314
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0039 0.0133 0.0205
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0087 0.0704
Leishmania major DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Schistosoma mansoni ap endonuclease 0.002 0.0017 0.0042
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0032 0.0089 0.0513
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0032 0.0089 0.014
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0041 0.0987
Echinococcus multilocularis multidrug resistance protein 1 0.0077 0.0365 0.0365
Entamoeba histolytica P-glycoprotein-5 0.0077 0.0365 0.9655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.012 0.0701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Loa Loa (eye worm) ABC transporter 0.0024 0.0041 0.0065
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Brugia malayi Cytochrome P450 family protein 0.0032 0.0087 0.0122
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0068 0.0541
Onchocerca volvulus 0.0044 0.0164 0.024
Echinococcus granulosus multidrug resistance associated protein 1 0.0024 0.0041 0.01
Mycobacterium ulcerans polyketide synthase Pks9 0.0416 0.2437 0.4302
Brugia malayi ABC transporter family protein 0.0024 0.0041 0.0057
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0008 0.0012
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0039 0.0133 0.0205
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0089 0.0145
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.004 0.0137 0.159
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0017 0.0111
Schistosoma mansoni multidrug resistance protein 0.0077 0.0365 0.0886
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0144 0.0847
Echinococcus granulosus geminin 0.0573 0.34 0.8256
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0017 0.0111
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0229 0.0557
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Entamoeba histolytica P-glycoprotein-2, putative 0.0023 0.0036 0.0849
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0173 0.042
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.009 0.0445 0.518
Loa Loa (eye worm) hypothetical protein 0.0295 0.17 0.2675
Leishmania major DNA polymerase eta, putative 0.0022 0.0026 0.0157
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0026 0.0185
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0089 0.0513
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0032 0.0089 0.1037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0068 0.0386
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0259 0.063
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0668 0.3979 0.7043
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0032 0.0089 0.0205
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0232 0.0232
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0064 0.0282 0.2359
Onchocerca volvulus 0.0055 0.0232 0.034
Schistosoma mansoni acyl carrier protein 0.0064 0.0282 0.0686
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0173 0.042
Schistosoma mansoni lozenge 0.005 0.02 0.0485
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0629 0.374 0.6624
Echinococcus granulosus survival motor neuron protein 1 0.0482 0.2841 0.6899
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0024 0.0041 0.0313
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0158 0.0859 0.1352
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.004 0.0137 0.019
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0045 0.0094
Brugia malayi multidrug resistance related protein 1 0.0024 0.0041 0.0057
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.069 0.4118 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0128 0.0677 0.0942
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0158 0.0859 0.0859
Echinococcus granulosus cathepsin l cysteine peptidase 0.0055 0.0232 0.0564
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0077 0.0365 0.0899
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0055 0.0232 0.2702
Schistosoma mansoni [ACP] S-malonyltransferase 0.004 0.0137 0.0332
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Plasmodium vivax ABC transporter B family member 5, putative 0.0024 0.0041 0.0479
Loa Loa (eye worm) hypothetical protein 0.0055 0.0232 0.0365
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0416 0.2437 0.4278
Trichomonas vaginalis ABC transporter, putative 0.0077 0.0365 0.2178
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Plasmodium vivax ABC transporter B family member 6, putative 0.0024 0.0041 0.0479
Trypanosoma cruzi major cysteine proteinase, putative 0.0166 0.0907 0.7659
Echinococcus granulosus intermediate filament protein 0.0044 0.0164 0.0399
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0064 0.0282 0.0431
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.009 0.0218
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0232 0.0365
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0142 0.0197
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0089 0.0513
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0039 0.0133 0.0222
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0525
Plasmodium vivax ABC transporter B family member 4, putative 0.0024 0.0041 0.0479
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0136 0.0331
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0087 0.0124
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0036 0.0192
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0026 0.0033
Entamoeba histolytica P-glycoprotein 5, putative 0.0077 0.0365 0.9655
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0158 0.0859 0.1196
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0158 0.0859 0.2144
Schistosoma mansoni hypothetical protein 0.0064 0.0282 0.0686
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0232 0.0564
Trichomonas vaginalis ABC transporter, putative 0.0077 0.0365 0.2178
Mycobacterium ulcerans hypothetical protein 0.0032 0.0089 0.0128
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0008 0.0088
Brugia malayi N-terminal motif family protein 0.0236 0.1337 0.1861
Loa Loa (eye worm) hypothetical protein 0.0046 0.0173 0.0272
Schistosoma mansoni ap endonuclease 0.002 0.0017 0.0042
Brugia malayi Latrophilin receptor protein 2 0.004 0.0142 0.0197
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0024 0.0041 0.0059
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0158 0.0859 0.2087
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0629 0.374 0.6604
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0077 0.0365 0.0634
Leishmania major hypothetical protein, conserved 0.0025 0.0045 0.0319
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.004 0.0137 0.0616
Leishmania major hypothetical protein, conserved 0.0032 0.0089 0.0694
Brugia malayi cathepsin L-like precursor 0.0037 0.012 0.0167
Giardia lamblia GTOR 0.0055 0.0231 0.2068
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.0189 0.1053 0.889
Mycobacterium ulcerans polyketide synthase MbtD 0.0193 0.1076 0.1883
Giardia lamblia DINP protein human, muc B family 0.0022 0.0026 0.0085
Echinococcus multilocularis ATP binding cassette sub family B 0.0076 0.036 0.036
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0229 0.0394
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0293 0.1688 0.1688
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0231 0.0322
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0064 0.0282 0.3148
Toxoplasma gondii FATC domain-containing protein 0.0035 0.0105 0.0245
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0041 0.0041
Loa Loa (eye worm) intermediate filament protein 0.0044 0.0164 0.0258
Echinococcus multilocularis hyperpolarization activated cyclic 0.069 0.4118 0.4118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0024 0.0041 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0146 0.0857
Mycobacterium tuberculosis Possible dehydrogenase 0.0039 0.0133 0.0222
Treponema pallidum acyl carrier protein 0.0064 0.0282 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0026 0.0033
Brugia malayi MH2 domain containing protein 0.0021 0.0024 0.0034
Echinococcus multilocularis cysteine protease 0.0055 0.0232 0.0232
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0039 0.0133 0.109
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0158 0.0859 0.1497
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Leishmania major hypothetical protein, conserved 0.004 0.0137 0.1098
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Brugia malayi Cytochrome P450 family protein 0.0035 0.0108 0.015
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0039 0.0133 0.0222
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0024 0.0041 0.0285
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.4036 0.4036
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0068 0.0165
Loa Loa (eye worm) hypothetical protein 0.0096 0.0478 0.0753
Schistosoma mansoni inositol monophosphatase 0.004 0.0136 0.0331
Mycobacterium ulcerans dehydrogenase 0.0039 0.0133 0.0205
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0089 0.0216
Trypanosoma cruzi acyl transferase-like protein, putative 0.004 0.0137 0.1123
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0039 0.0133 0.0222
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0452 0.2657 0.4702
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0587 0.3488 0.5487
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0039 0.0133 0.3441
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0232 0.0232
Toxoplasma gondii acyl carrier protein ACP 0.0064 0.0282 0.0692
Mycobacterium tuberculosis Probable thioesterase TesA 0.0524 0.3099 0.5486
Echinococcus granulosus cpg binding protein 0.003 0.0076 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Loa Loa (eye worm) hypothetical protein 0.0398 0.2331 0.3668
Schistosoma mansoni [ACP] S-malonyltransferase 0.004 0.0137 0.0332
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0629 0.374 0.6618
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0064 0.0282 0.0413
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0017 0.0083
Trypanosoma cruzi multidrug resistance protein E, putative 0.0024 0.0041 0.0313
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.0422 0.2522
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Brugia malayi AMP-binding enzyme family protein 0.0193 0.1076 0.1498
Trypanosoma cruzi cAMP response protein 1, putative 0.0032 0.0089 0.072
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0064 0.0282 0.0393
Entamoeba histolytica hypothetical protein 0.0073 0.0341 0.9019
Leishmania major p-glycoprotein 0.0077 0.0365 0.3038
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0026 0.0016
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.009 0.0218
Schistosoma mansoni hypothetical protein 0.0402 0.2353 0.5714
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0087 0.0704
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0032 0.0089 0.0124
Trypanosoma brucei acyl transferase-like protein 0.004 0.0137 0.1098
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0111 0.0125
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Echinococcus granulosus ATP binding cassette sub family B 0.0023 0.0036 0.0087
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.004 0.0137 0.159
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0077 0.0365 0.0574
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0142 0.0344
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0038
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0506 0.2989 0.5282
Plasmodium vivax multidrug resistance protein 1, putative 0.0077 0.0365 0.4244
Schistosoma mansoni smdr1 0.0024 0.0041 0.01
Echinococcus granulosus serine protein kinase ATM 0.0035 0.0105 0.0255
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0064 0.0282 0.0471
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0231 0.1373
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0086 0.0423 0.0665
Schistosoma mansoni lamin 0.0044 0.0164 0.0399
Echinococcus granulosus NADH dehydrogenase 0.0064 0.0282 0.0686
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0039 0.0133 0.0776
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.0365 0.0886
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0341 0.0828
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0032 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0076
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0197 0.1102 0.1894
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0136 0.3539
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0068 0.171
Echinococcus multilocularis multidrug resistance protein 1 0.0054 0.0222 0.0222
Schistosoma mansoni lipoxygenase 0.0049 0.0191 0.0464
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0173 0.0173
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0232 0.0232
Onchocerca volvulus 0.0055 0.0232 0.034
Echinococcus multilocularis cpg binding protein 0.003 0.0076 0.0076
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1192 0.7185 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0068 0.0515
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.069 0.4118 0.4118
Schistosoma mansoni smad1 5 8 and 0.0021 0.0024 0.0059
Loa Loa (eye worm) cysteine protease 0.0055 0.0232 0.0365
Mycobacterium tuberculosis Conserved protein 0.0189 0.1053 0.1854
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0036 0.0192
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0039 0.0133 0.0205
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0039 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0482 0.2841 0.447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0526
Leishmania major hypothetical protein, conserved 0.0032 0.0089 0.0694
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0378 0.4394
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0506 0.2989 0.5282
Mycobacterium ulcerans Type I modular polyketide synthase 0.0629 0.374 0.6618
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0024 0.0041 0.0285
Trypanosoma cruzi oxidoreductase, putative 0.0039 0.0133 0.109
Entamoeba histolytica hypothetical protein 0.0024 0.0041 0.0987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.078
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0136 0.1121
Mycobacterium ulcerans Type I modular polyketide synthase 0.0629 0.374 0.6618
Loa Loa (eye worm) hypothetical protein 0.0295 0.17 0.2675
Trichomonas vaginalis abcb9, putative 0.0077 0.0365 0.2178
Brugia malayi hypothetical protein 0.0096 0.0478 0.0666
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.012 0.3108
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0032 0.0089 0.0216
Loa Loa (eye worm) hypothetical protein 0.0077 0.0365 0.0574
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0039 0.0133 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0023 0.0036 0.018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0168 0.0409
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0525
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0158 0.0859 0.7246
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Giardia lamblia Multidrug resistance-associated protein 1 0.0024 0.0041 0.023
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0039 0.0133 0.0205
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0045 0.0319
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0039 0.0133 0.1065
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0055 0.0231 0.6086
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0089 0.0089
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0133 0.109
Onchocerca volvulus 0.0077 0.0365 0.0534
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0006 0.0008
Echinococcus multilocularis geminin 0.0573 0.34 0.34
Onchocerca volvulus Huntingtin homolog 0.0096 0.0478 0.0701
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0293 0.1688 0.41
Echinococcus granulosus Ion_trans_N domain containing protein 0.0402 0.2353 0.5714
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0026 0.0132
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0185
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0133 0.109
Mycobacterium ulcerans hypothetical protein 0.0032 0.0089 0.0128
Plasmodium vivax ABC transporter B family member 7, putative 0.0024 0.0041 0.0479
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0023 0.0036 0.0087
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0039 0.0133 0.0222
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0024 0.0041 0.0313
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0032 0.0089 0.0145
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Entamoeba histolytica hypothetical protein 0.0073 0.0341 0.9019
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0035 0.0105 0.0854
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0068 0.0165
Echinococcus granulosus microtubule associated protein 2 0.0677 0.4036 0.9802
Echinococcus multilocularis NADH dehydrogenase 0.0064 0.0282 0.0282
Onchocerca volvulus 0.0028 0.0066 0.0097
Loa Loa (eye worm) Smad1 0.0021 0.0024 0.0038
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Mycobacterium ulcerans hypothetical protein 0.0032 0.0089 0.0128
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0282 0.0488
Mycobacterium ulcerans acyl carrier protein 0.0064 0.0282 0.0471
Trypanosoma brucei oxidoreductase, putative 0.0039 0.0133 0.1065
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0008 0.0018
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.0422 0.1042
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0024 0.0041 0.0285
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0021 0.0024 0.0024
Brugia malayi hypothetical protein 0.0086 0.0423 0.0588
Entamoeba histolytica hypothetical protein 0.0035 0.0105 0.2698
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0068 0.0541
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.012 0.0701
Mycobacterium ulcerans transcriptional regulatory protein 0.0032 0.0089 0.0128
Echinococcus granulosus AMP dependent ligase 0.0064 0.0282 0.0686
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0021 0.0024 0.0024
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0032 0.0089 0.0216
Treponema pallidum cyclic nucleotide binding protein 0.0032 0.0089 0.271
Leishmania major oxidoreductase-like protein 0.0039 0.0133 0.1065
Echinococcus multilocularis Smad4 0.0021 0.0024 0.0024
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0077 0.0365 0.3578
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0017 0.0017
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0046 0.0173 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.0779
Schistosoma mansoni cpg binding protein 0.0028 0.0066 0.0161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0032 0.0089 0.0216
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0158 0.0859 0.2087
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0609 0.3622 0.6415
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0065
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0039 0.0133 0.0315
Mycobacterium ulcerans oxidoreductase 0.0039 0.0133 0.0205
Echinococcus multilocularis hypothetical protein 0.0402 0.2353 0.2353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Schistosoma mansoni smad 0.0021 0.0024 0.0059
Mycobacterium ulcerans polyketide synthase 0.0668 0.3979 0.7043
Toxoplasma gondii cathepsin CPL 0.0055 0.0232 0.0565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.078
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0077 0.0365 0.0899
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0027 0.0061 0.045
Schistosoma mansoni hypothetical protein 0.0573 0.34 0.8256
Onchocerca volvulus 0.0032 0.0089 0.0131
Echinococcus granulosus dna polymerase eta 0.0022 0.0026 0.0063
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0142 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0004 0.001
Entamoeba histolytica P-glycoprotein-2 0.0077 0.0365 0.9655
Treponema pallidum cyclic nucleotide binding protein 0.0032 0.0089 0.271
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0232 0.034
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0189
Leishmania major protein kinase, putative 0.0032 0.0089 0.0694
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0344
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0173 0.042
Brugia malayi ABC transporter 0.0024 0.0041 0.0057
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0041 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.0779
Onchocerca volvulus 0.0044 0.0164 0.024
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0209
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0344
Giardia lamblia Methyltransferase like 2 0.0189 0.1053 1
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0158 0.0859 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.0422 0.2522
Mycobacterium ulcerans Type I modular polyketide synthase 0.0629 0.374 0.6618
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0035 0.0105 0.0255
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.012 0.0167
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0136 0.1096
Trypanosoma brucei multidrug resistance protein E 0.0024 0.0041 0.0285
Trichomonas vaginalis taga, putative 0.0077 0.0365 0.2178
Plasmodium falciparum ABC transporter B family member 3, putative 0.0024 0.0041 0.0479
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0154 0.0834 0.1466
Mycobacterium leprae Probable polyketide synthase Pks1 0.0668 0.3979 0.703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Plasmodium vivax vivapain-1 0.0028 0.0068 0.0793
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0524 0.3099 0.5459
Leishmania major nuclear receptor binding factor-like protein 0.0039 0.0133 0.1065
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Brugia malayi acetyltransferase, GNAT family protein 0.0293 0.1688 0.235
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.004 0.0137 0.0332
Brugia malayi Methyltransferase-like protein 4 0.0189 0.1053 0.1465
Brugia malayi Muscleblind-like protein 0.0295 0.17 0.2366
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0032 0.0089 0.0205
Loa Loa (eye worm) hypothetical protein 0.0077 0.0365 0.0574
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0064 0.0282 0.0282
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0032 0.0089 0.0694
Schistosoma mansoni eyes absent homolog 0.0086 0.0423 0.1027
Onchocerca volvulus 0.0055 0.0232 0.034
Trypanosoma cruzi cysteine peptidase, putative 0.0211 0.1183 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0023 0.0036 0.0849
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0041 0.0042
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0514 0.3039 0.538
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0024 0.0041 0.0479
Schistosoma mansoni Smad4 0.0021 0.0024 0.0059
Plasmodium falciparum multidrug resistance-associated protein 2 0.0024 0.0041 0.0479
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0158 0.0859 0.7254
Loa Loa (eye worm) hypothetical protein 0.0046 0.0173 0.0272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0105 0.0146
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0357 0.2081 0.3679
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0055 0.0231 0.1904
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0064 0.0282 0.0488
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0232 0.0323
Leishmania major protein kinase, putative 0.0032 0.0089 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0048 0.0188 0.1535
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.094 0.5643 1
Entamoeba histolytica ABC transporter, putative 0.0024 0.0041 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Toxoplasma gondii exonuclease III APE 0.002 0.0017 0.0024
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0039 0.0133 0.0222
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.0422 0.1024
Leishmania major cysteine peptidase A (CPA) 0.0055 0.0232 0.1911
Schistosoma mansoni hypothetical protein 0.0098 0.0495 0.1202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0168 0.0409
Onchocerca volvulus Fatty acid synthase homolog 0.1133 0.6828 1
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Schistosoma mansoni hypothetical protein 0.0073 0.0341 0.0828
Echinococcus multilocularis multidrug resistance associated protein 1 0.0024 0.0041 0.0041
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Trichomonas vaginalis ABC transporter, putative 0.0077 0.0365 0.2178
Echinococcus multilocularis dna polymerase eta 0.0022 0.0026 0.0026
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0026 0.0036
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0158 0.0859 0.7246
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0168 0.0265
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0024 0.0041 0.0285
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0068 0.0793
Plasmodium falciparum ABC transporter B family member 7, putative 0.0024 0.0041 0.0479
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0024 0.0041 0.0065
Brugia malayi MH2 domain containing protein 0.0313 0.1808 0.2516
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0068 0.171
Echinococcus granulosus Smad4 0.0021 0.0024 0.0059
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0024 0.0041 0.0285
Echinococcus granulosus multidrug resistance protein 1 0.0077 0.0365 0.0886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Toxoplasma gondii quinone oxidoreductase, putative 0.0039 0.0133 0.0315
Leishmania major quinone oxidoreductase, putative 0.0039 0.0133 0.1065
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0041 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Schistosoma mansoni cathepsin s 0.0018 0.0006 0.0014
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0032 0.0089 0.0216
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0032 0.0089 0.0145
Schistosoma mansoni DNA polymerase eta 0.0022 0.0026 0.0063
Echinococcus multilocularis lamin dm0 0.0044 0.0164 0.0164
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0668 0.3979 0.7048
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.4036 0.9802
Echinococcus granulosus muscleblind protein 0.0295 0.17 0.4129
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0039 0.0133 0.109
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.009 0.0698
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0282 0.0471
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0071
Toxoplasma gondii acyl transferase domain-containing protein 0.004 0.0137 0.0325
Echinococcus granulosus acyl carrier protein mitochondrial 0.0064 0.0282 0.0686
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0055 0.0231 0.1927
Leishmania major cathepsin L-like protease 0.0211 0.1183 1
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0026 0.0157
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0087 0.0137
Trypanosoma cruzi cruzipain precursor, putative 0.0211 0.1183 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0232 0.1378
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0495 0.0689
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0024 0.0041 0.0084
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0068 0.0541
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0026 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0346
Trypanosoma brucei cAMP response protein 1, putative 0.0032 0.0089 0.0694
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0096 0.0484 0.0845
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Echinococcus granulosus multidrug resistance protein 1 0.0054 0.0222 0.054
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0032 0.0089 0.0216
Plasmodium vivax vivapain-2 0.0055 0.0232 0.2702
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0168 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0089 0.0513
Mycobacterium ulcerans quinone reductase Qor 0.0039 0.0133 0.0205
Leishmania major cytochrome p450-like protein 0.0032 0.0087 0.0678
Mycobacterium ulcerans thioesterase TesA 0.0524 0.3099 0.5478
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0068 0.171
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Entamoeba histolytica P-glycoprotein-2 0.0077 0.0365 0.9655
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0089 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.0779
Schistosoma mansoni zinc binding dehydrogenase 0.0039 0.0133 0.0322
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0008 0.0028
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0192 0.1071 0.9051
Leishmania major ABC-thiol transporter 0.0024 0.0041 0.0285
Leishmania major hypothetical protein, unknown function 0.0032 0.0089 0.0694
Entamoeba histolytica P-glycoprotein-1 0.0077 0.0365 0.9655
Echinococcus multilocularis multidrug resistance protein 1 0.0077 0.0365 0.0365
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0064 0.0282 0.0471
Echinococcus multilocularis cysteine protease 0.0055 0.0232 0.0232
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0046 0.0173 0.042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0154 0.0242
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0046 0.0173 0.024
Mycobacterium ulcerans acyl carrier protein 0.0064 0.0282 0.0471
Entamoeba histolytica acyl-CoA synthetase, putative 0.0064 0.0282 0.7449
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.002 0.0019 0.0093
Plasmodium falciparum cysteine proteinase falcipain 3 0.0055 0.0232 0.2702
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.0089 0.0089
Brugia malayi Smad1 0.0021 0.0024 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0231 0.1373
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0041 0.0041
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0032 0.0237
Brugia malayi ABC transporter 0.0023 0.0036 0.005
Echinococcus granulosus multidrug resistance protein 1 0.0077 0.0365 0.0886
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0629 0.374 0.5206
Trypanosoma cruzi cysteine peptidase, putative 0.0211 0.1183 1
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0068 0.171
Loa Loa (eye worm) hypothetical protein 0.0352 0.2049 0.3224
Giardia lamblia Hypothetical protein 0.0023 0.0036 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0087 0.0137
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0055 0.0231 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.078
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0229 0.0229
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0026 0.0016
Plasmodium falciparum ABC transporter B family member 6, putative 0.0024 0.0041 0.0479
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Mycobacterium ulcerans thioesterase 0.0524 0.3099 0.5478
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0017 0.0024
Echinococcus multilocularis muscleblind protein 0.0295 0.17 0.17
Loa Loa (eye worm) hypothetical protein 0.0043 0.0159 0.025
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0133 0.0185
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0096 0.0484 0.079
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.012 0.0292
Loa Loa (eye worm) hypothetical protein 0.004 0.0142 0.0223
Brugia malayi AMP-binding enzyme family protein 0.0587 0.3488 0.4854
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Echinococcus granulosus voltage gated potassium channel 0.0046 0.0173 0.042
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0096 0.0484 0.0845
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0017 0.0349
Leishmania major cathepsin L-like protease 0.0211 0.1183 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0068 0.171
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0026 0.0132
Trypanosoma brucei p-glycoprotein 0.0024 0.0041 0.0285
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.003
Onchocerca volvulus Cathepsin F homolog 0.0055 0.0232 0.034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.009 0.0125
Entamoeba histolytica cysteine protease, putative 0.0055 0.0232 0.6105
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0232 0.0564
Plasmodium vivax unspecified product 0.0028 0.0068 0.0793
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0046 0.0173 0.0173
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0158 0.0859 1
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0064 0.0282 0.0471
Schistosoma mansoni smad1 5 8 and 0.0021 0.0024 0.0059
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0039 0.0133 0.0776
Echinococcus granulosus cathepsin l1 0.0037 0.012 0.0292
Trypanosoma brucei cAMP binding protein, putative 0.0032 0.0089 0.0694
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0264 0.0647
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0629 0.374 0.6604
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0039 0.0133 0.0205
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0089 0.0513
Echinococcus granulosus lamin dm0 0.0044 0.0164 0.0399
Echinococcus multilocularis mothers against decapentaplegic 5 0.0021 0.0024 0.0024
Brugia malayi ABC transporter transmembrane region family protein 0.0023 0.0036 0.005
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0064 0.0282 0.0488
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Mycobacterium leprae Probable oxidireductase 0.0039 0.0133 0.0164
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0215
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0089 0.0145
Brugia malayi Inositol-1 0.004 0.0136 0.019
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0136 0.0324
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0087 0.0137
Trypanosoma cruzi Flagellar Member 6 0.0032 0.0089 0.072
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0055 0.0231 0.1904
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Mycobacterium leprae conserved hypothetical protein 0.0064 0.0282 0.0431
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0041 0.0987
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0064 0.0282 0.0471
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0017 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0089 0.072
Schistosoma mansoni methyltransferase-related 0.0189 0.1053 0.2556
Echinococcus granulosus patatin phospholipase domain containing protein 0.0032 0.0089 0.0216
Onchocerca volvulus Putative alcohol dehydrogenase 0.0039 0.0133 0.0194
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0136 0.1096
Loa Loa (eye worm) hypothetical protein 0.0028 0.0067 0.0106
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0024 0.0041 0.0285
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0032 0.0089 0.0216
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0209
Brugia malayi cytoplasmic intermediate filament protein 0.0024 0.0039 0.0054
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0008 0.0011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0089 0.0513
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0026 0.0063
Trypanosoma brucei unspecified product 0.0022 0.0026 0.0157
Plasmodium vivax unspecified product 0.0018 0.0006 0.0066
Plasmodium vivax hypothetical protein, conserved 0.009 0.0445 0.518
Leishmania major cathepsin L-like protease 0.0211 0.1183 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.036 0.0566
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0229 0.0377
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0344
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0668 0.3979 0.703
Giardia lamblia ABC transporter, putative 0.0024 0.0041 0.023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0017 0.0017
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0008
Echinococcus granulosus cathepsin l1 0.0055 0.0232 0.0564
Mycobacterium ulcerans fatty acid synthase Fas 0.0197 0.1102 0.1928
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0026 0.0157
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0229 0.0557
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Onchocerca volvulus 0.0055 0.0232 0.034
Toxoplasma gondii type I fatty acid synthase, putative 0.0448 0.2632 0.6608
Trypanosoma cruzi target of rapamycin kinase 3 0.0048 0.0188 0.1558
Loa Loa (eye worm) fibroinase 0.0055 0.0232 0.0365
Schistosoma mansoni hypothetical protein 0.0573 0.34 0.8256
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0055 0.0231 0.1927
Entamoeba histolytica P-glyco protein 6, putative 0.0077 0.0365 0.9655
Loa Loa (eye worm) hypothetical protein 0.1056 0.6356 1
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0341 0.0828
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0128 0.0677 0.1065
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0041 0.0987
Onchocerca volvulus 0.0055 0.0232 0.034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0026 0.0026
Echinococcus granulosus mothers against decapentaplegic 5 0.0021 0.0024 0.0059
Treponema pallidum catabolite gene activator 0.0032 0.0089 0.271
Mycobacterium ulcerans regulatory protein 0.0032 0.0089 0.0128
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.0422 0.1042
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0008 0.0028
Onchocerca volvulus 0.0398 0.2331 0.3414
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0064 0.0282 0.0488
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0065
Schistosoma mansoni multidrug resistance protein 0.0077 0.0365 0.0886
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0254 0.1449 0.2558
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0009
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0173 0.042
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0055 0.0231 0.6086
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0032 0.0089 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0144 0.0847
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0032 0.0089 0.0124
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0229 0.0557
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.069 0.4118 1
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0039 0.0133 0.0222
Trypanosoma cruzi oxidoreductase, putative 0.0039 0.0133 0.109
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0378 1
Onchocerca volvulus Huntingtin homolog 0.0096 0.0478 0.0701
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0064 0.0282 0.0471
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0032 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0401 0.2349 0.5705
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0064 0.0282 0.0488
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0158 0.0859 0.7254
Echinococcus multilocularis musashi 0.0044 0.0164 0.0164
Brugia malayi Cathepsin L-like precursor 0.0037 0.012 0.0167
Mycobacterium ulcerans hypothetical protein 0.0064 0.0282 0.0471
Schistosoma mansoni [ACP] S-malonyltransferase 0.004 0.0137 0.0332
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0288 0.1659 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Plasmodium falciparum multidrug resistance protein 1 0.0077 0.0365 0.4244
Brugia malayi CXXC zinc finger family protein 0.0028 0.0066 0.0092
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.009 0.0698
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0064 0.0282 0.2337
Echinococcus multilocularis 0.0024 0.0041 0.0041
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0378 0.348
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0055 0.0232 0.2702
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0064 0.0282 0.0488
Echinococcus granulosus dnaJ subfamily B 0.0401 0.2349 0.5705
Mycobacterium ulcerans quinone oxidoreductase 0.0039 0.0133 0.0205
Trypanosoma cruzi cAMP response protein 1 0.0032 0.0089 0.072
Toxoplasma gondii type I fatty acid synthase 0.0096 0.0484 0.1199
Loa Loa (eye worm) hypothetical protein 0.0044 0.0164 0.0258
Brugia malayi Cyclic-nucleotide gated cation channel 0.0046 0.0173 0.024
Loa Loa (eye worm) ctsf protein 0.0055 0.0232 0.0365
Echinococcus granulosus TGF beta signal transducer SmadC 0.0021 0.0024 0.0059
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Brugia malayi hypothetical protein 0.0398 0.2331 0.3244
Loa Loa (eye worm) AGC/PKG protein kinase 0.0032 0.0089 0.014
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0032 0.0089 0.0216
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0041 0.0987
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0036 0.0192
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0017 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0168 0.0409
Loa Loa (eye worm) hypothetical protein 0.0096 0.0484 0.0761
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0668 0.3979 0.7048
Schistosoma mansoni cpg binding protein 0.003 0.0076 0.0185
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0032 0.0089 0.0216
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0185
Giardia lamblia MRP-like ABC transporter 0.0024 0.0041 0.023
Loa Loa (eye worm) MH2 domain-containing protein 0.0313 0.1808 0.2844
Plasmodium falciparum multidrug resistance protein 2 0.0024 0.0041 0.0479
Echinococcus multilocularis hyperpolarization activated cyclic 0.069 0.4118 0.4118
Schistosoma mansoni cpg binding protein 0.003 0.0076 0.0185
Loa Loa (eye worm) hypothetical protein 0.0236 0.1337 0.2103
Schistosoma mansoni smad1 5 8 and 0.0021 0.0024 0.0059
Brugia malayi Calcitonin receptor-like protein seb-1 0.0128 0.0677 0.0942
Brugia malayi hypothetical protein 0.0482 0.2841 0.3954
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0041 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0026 0.0041
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Onchocerca volvulus 0.0055 0.0232 0.034
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Onchocerca volvulus 0.0032 0.0089 0.0131
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0004 0.0006
Schistosoma mansoni cellular tumor antigen P53 0.0042 0.0154 0.0373
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0024 0.0041 0.0285
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0008 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0068 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Trichomonas vaginalis ABC transporter, putative 0.0077 0.0365 0.2178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0077 0.0365 0.3038
Leishmania major p-glycoprotein e 0.0024 0.0041 0.0285
Brugia malayi Cytochrome P450 family protein 0.0032 0.0087 0.0122
Onchocerca volvulus 0.0039 0.0133 0.0194
Mycobacterium ulcerans hypothetical protein 0.0032 0.0089 0.0128
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0068 0.0095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0168 0.0168
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0136 0.0798
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0055 0.0231 0.0562
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0232 0.6105
Brugia malayi hypothetical protein 0.0025 0.0045 0.0063
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0021 0.0024 0.0059
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0668 0.3979 0.703
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0133 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Echinococcus multilocularis lamin 0.0044 0.0164 0.0164
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0039 0.0133 0.0205
Echinococcus granulosus hyperpolarization activated cyclic 0.069 0.4118 1
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0032 0.0089 0.072
Entamoeba histolytica P-glycoprotein-2, putative 0.0077 0.0365 0.9655
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0216 0.1216 0.2145
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0197 0.1102 0.1942
Leishmania major protein kinase A regulatory subunit, putative 0.0032 0.0089 0.0694
Trypanosoma cruzi cysteine peptidase, putative 0.0211 0.1183 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0041 0.0987
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0032 0.0089 0.0513
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.0173 0.024
Echinococcus granulosus multidrug resistance protein 1 0.0054 0.0222 0.054
Trypanosoma cruzi oxidoreductase, putative 0.0039 0.0133 0.109
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0173 0.042
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0629 0.374 0.6624
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0041 0.01
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0008 0.0008
Leishmania major regulatory subunit of protein kinase a-like protein 0.0032 0.0089 0.0694

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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