Detailed information for compound 1208036

Basic information

Technical information
  • TDR Targets ID: 1208036
  • Name: but-2-enedioic acid; 1-phenethyl-3,4-dihydrop yrrolo[1,2-a]pyrazine
  • MW: 340.373 | Formula: C19H20N2O4
  • H donors: 2 H acceptors: 4 LogP: 1.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)CCC1=NCCn2c1ccc2.OC(=O)/C=C/C(=O)O
  • InChi: 1S/C15H16N2.C4H4O4/c1-2-5-13(6-3-1)8-9-14-15-7-4-11-17(15)12-10-16-14;5-3(6)1-2-4(7)8/h1-7,11H,8-10,12H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
  • InChiKey: SBKCQHWUUXCELP-WLHGVMLRSA-N  

Network

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Synonyms

  • MLS000038103
  • SMR000057792

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0055 0.0231 0.1904
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0229 0.0557
Leishmania major protein kinase A regulatory subunit, putative 0.0032 0.0089 0.0694
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0024 0.0041 0.0285
Giardia lamblia Multidrug resistance-associated protein 1 0.0024 0.0041 0.023
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0077 0.0365 0.3578
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0055 0.0231 0.6086
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0026 0.0132
Entamoeba histolytica hypothetical protein 0.0073 0.0341 0.9019
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0024 0.0041 0.0285
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0231 0.0322
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0064 0.0282 0.0471
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0158 0.0859 0.2087
Loa Loa (eye worm) ctsf protein 0.0055 0.0232 0.0365
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0008 0.0011
Onchocerca volvulus Huntingtin homolog 0.0096 0.0478 0.0701
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Mycobacterium tuberculosis Hypothetical protein 0.0189 0.1053 0.1854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0144 0.0847
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0133 0.109
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0495 0.0689
Loa Loa (eye worm) hypothetical protein 0.0032 0.0089 0.014
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Loa Loa (eye worm) multidrug resistance protein 3 0.0077 0.0365 0.0574
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0089 0.0145
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0039 0.0133 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0232 0.1378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0064 0.0282 0.0471
Giardia lamblia Multidrug resistance-associated protein 1 0.0023 0.0036 0.018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0136 0.1121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Trypanosoma cruzi acyl transferase-like protein, putative 0.004 0.0137 0.1123
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0041 0.01
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Echinococcus granulosus cGMP dependent protein kinase 0.0032 0.0089 0.0216
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0282 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Schistosoma mansoni smad1 5 8 and 0.0021 0.0024 0.0059
Echinococcus granulosus muscleblind protein 0.0295 0.17 0.4129
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0108 0.017
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.009 0.0218
Echinococcus granulosus multidrug resistance protein 1 0.0054 0.0222 0.054
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0039 0.0133 0.0164
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0087 0.0124
Entamoeba histolytica hypothetical protein 0.0073 0.0341 0.9019
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0142 0.0223
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0076 0.036 0.0873
Mycobacterium tuberculosis Conserved protein 0.0032 0.0089 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0068 0.0386
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0064 0.0282 0.0488
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0032 0.0089 0.0694
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0048 0.0188 0.1535
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0232 0.0232
Toxoplasma gondii quinone oxidoreductase, putative 0.0039 0.0133 0.0315
Echinococcus granulosus cathepsin l1 0.0055 0.0232 0.0564
Schistosoma mansoni lamin 0.0044 0.0164 0.0399
Schistosoma mansoni inositol monophosphatase 0.004 0.0136 0.0331
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0024 0.0041 0.0313
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0236 0.1337 0.1958
Trypanosoma cruzi cysteine peptidase, putative 0.0211 0.1183 1
Brugia malayi Cytochrome P450 family protein 0.0032 0.0087 0.0122
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0668 0.3979 0.7048
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0032 0.0089 0.0216
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0357 0.2081 0.3679
Brugia malayi Calcitonin receptor-like protein seb-1 0.0128 0.0677 0.0942
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0089 0.0216
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0008
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.004 0.0137 0.0137
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.009 0.0698
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0158 0.0859 0.2087
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0254 0.1449 0.2558
Toxoplasma gondii type I fatty acid synthase, putative 0.0448 0.2632 0.6608
Toxoplasma gondii ABC transporter, putative 0.0024 0.0041 0.0084
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0039 0.0133 0.0205
Schistosoma mansoni multidrug resistance protein 0.0077 0.0365 0.0886
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0032 0.0237
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0185
Brugia malayi Cathepsin L-like precursor 0.0037 0.012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0209
Loa Loa (eye worm) hypothetical protein 0.004 0.0142 0.0223
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0136 0.0136
Trypanosoma cruzi cAMP response protein 1, putative 0.0032 0.0089 0.072
Leishmania major oxidoreductase-like protein 0.0039 0.0133 0.1065
Loa Loa (eye worm) hypothetical protein 0.0077 0.0365 0.0574
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0344
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0024 0.0041 0.0313
Brugia malayi Phosphopantetheine attachment site family protein 0.0064 0.0282 0.0393
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0064 0.0282 0.2359
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0039 0.0133 0.0205
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0008 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0526
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0032 0.0089 0.0089
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Brugia malayi AMP-binding enzyme family protein 0.0587 0.3488 0.4854
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0168 0.0409
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0026 0.0026
Leishmania major regulatory subunit of protein kinase a-like protein 0.0032 0.0089 0.0694
Echinococcus multilocularis dna polymerase eta 0.0022 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0236 0.1337 0.2103
Mycobacterium leprae Polyketide synthase Pks13 0.094 0.5643 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0229 0.0557
Echinococcus granulosus tumor protein p63 0.029 0.1668 0.4052
Loa Loa (eye worm) hypothetical protein 0.0046 0.0173 0.0272
Mycobacterium ulcerans hypothetical protein 0.0032 0.0089 0.0128
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0282 0.0431
Loa Loa (eye worm) hypothetical protein 0.0055 0.0232 0.0365
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0668 0.3979 0.7048
Echinococcus granulosus NADH dehydrogenase 0.0064 0.0282 0.0686
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0133 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.0076
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0026 0.0584
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Echinococcus multilocularis lamin dm0 0.0044 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0482 0.2841 0.447
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0024 0.0041 0.0059
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0032 0.0089 0.0205
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0158 0.0859 0.7254
Schistosoma mansoni acyl carrier protein 0.0064 0.0282 0.0686
Leishmania major hypothetical protein, conserved 0.0032 0.0089 0.0694
Entamoeba histolytica hypothetical protein 0.0024 0.0041 0.0987
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0039 0.0133 0.109
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0032 0.0089 0.0205
Echinococcus multilocularis GPCR, family 2 0.004 0.0142 0.0142
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0026 0.0036
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0629 0.374 0.6624
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Plasmodium vivax vivapain-1 0.0028 0.0068 0.0793
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0185
Entamoeba histolytica P-glycoprotein-2, putative 0.0077 0.0365 0.9655
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0158 0.0859 0.2144
Echinococcus granulosus TGF beta signal transducer SmadC 0.0021 0.0024 0.0059
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.004 0.0137 0.019
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.004 0.0137 0.1417
Onchocerca volvulus 0.0055 0.0232 0.034
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.069 0.4118 0.4118
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0064 0.0282 0.0488
Plasmodium vivax ABC transporter B family member 7, putative 0.0024 0.0041 0.0479
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0035 0.0105 0.0255
Onchocerca volvulus 0.0398 0.2331 0.3414
Plasmodium falciparum multidrug resistance protein 2 0.0024 0.0041 0.0479
Schistosoma mansoni smdr1 0.0024 0.0041 0.01
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.004 0.0137 0.159
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0032 0.0089 0.0216
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0032 0.0089 0.072
Onchocerca volvulus 0.0055 0.0232 0.034
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0089 0.0216
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0232 0.1933
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Loa Loa (eye worm) ABC transporter 0.0024 0.0041 0.0065
Leishmania major cathepsin L-like protease 0.0211 0.1183 1
Giardia lamblia DINP protein human, muc B family 0.0022 0.0026 0.0085
Onchocerca volvulus 0.0044 0.0164 0.024
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0024 0.0041 0.0285
Plasmodium vivax unspecified product 0.0028 0.0068 0.0793
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0173 0.042
Loa Loa (eye worm) runx1 0.005 0.02 0.0314
Plasmodium vivax hypothetical protein, conserved 0.009 0.0445 0.518
Loa Loa (eye worm) cysteine protease 0.0055 0.0232 0.0365
Schistosoma mansoni ap endonuclease 0.002 0.0017 0.0042
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0089 0.0513
Echinococcus granulosus cathepsin L 0.0028 0.0068 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Loa Loa (eye worm) hypothetical protein 0.0128 0.0677 0.1065
Trypanosoma brucei oxidoreductase, putative 0.0039 0.0133 0.1065
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.009 0.0125
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0017 0.0079
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0416 0.2437 0.4302
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0009
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0293 0.1688 0.1688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0133 0.0185
Schistosoma mansoni hypothetical protein 0.0064 0.0282 0.0686
Loa Loa (eye worm) MH1 domain-containing protein 0.0021 0.0024 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0041 0.0987
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0096 0.0484 0.0845
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0192 0.1071 0.9051
Brugia malayi hypothetical protein 0.0398 0.2331 0.3244
Trypanosoma cruzi target of rapamycin kinase 3 0.0048 0.0188 0.1558
Trichomonas vaginalis ABC transporter, putative 0.0077 0.0365 0.2178
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0346
Loa Loa (eye worm) hypothetical protein 0.0086 0.0423 0.0665
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0032 0.0089 0.0216
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0341 0.0828
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0039 0.0133 0.0164
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.009 0.0725
Schistosoma mansoni hypothetical protein 0.0573 0.34 0.8256
Echinococcus granulosus cysteine protease 0.0028 0.0068 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0144 0.0847
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0416 0.2437 0.4278
Onchocerca volvulus 0.1094 0.6589 0.965
Echinococcus multilocularis cysteine protease 0.0055 0.0232 0.0232
Mycobacterium ulcerans hypothetical protein 0.0032 0.0089 0.0128
Trichomonas vaginalis abcb9, putative 0.0077 0.0365 0.2178
Entamoeba histolytica P-glycoprotein-2 0.0077 0.0365 0.9655
Echinococcus multilocularis cpg binding protein 0.003 0.0076 0.0076
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0032 0.0089 0.0216
Mycobacterium ulcerans hypothetical protein 0.0064 0.0282 0.0471
Onchocerca volvulus 0.0587 0.3488 0.5108
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0032 0.0089 0.0216
Mycobacterium ulcerans hypothetical protein 0.0032 0.0089 0.0128
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0054 0.0222 0.1319
Mycobacterium leprae Probable polyketide synthase Pks1 0.0668 0.3979 0.703
Leishmania major DNA polymerase eta, putative 0.0022 0.0026 0.0157
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0039 0.0133 0.3441
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0032 0.0089 0.0513
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Entamoeba histolytica hypothetical protein 0.0073 0.0341 0.9019
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0064 0.0282 0.2337
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0024 0.0041 0.0285
Mycobacterium ulcerans oxidoreductase FadB5 0.0039 0.0133 0.0205
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0232 0.0323
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Loa Loa (eye worm) hypothetical protein 0.0043 0.0159 0.025
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0027 0.0061 0.045
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0032 0.0089 0.0694
Leishmania major hypothetical protein, conserved 0.0032 0.0089 0.0694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0068 0.0386
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0232 0.6105
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0068 0.0541
Brugia malayi MH2 domain containing protein 0.0313 0.1808 0.2516
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0229 0.0377
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.004 0.0137 0.0332
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0032 0.0089 0.1037
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0041 0.01
Echinococcus multilocularis cathepsin L 0.0028 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0398 0.2331 0.3668
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0142 0.0344
Trypanosoma cruzi protein kinase A regulatory subunit 0.0032 0.0089 0.072
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0154 0.0834 0.1466
Echinococcus multilocularis NADH dehydrogenase 0.0064 0.0282 0.0282
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0032 0.0089 0.0124
Loa Loa (eye worm) MH2 domain-containing protein 0.0021 0.0024 0.0038
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0158 0.0859 0.1497
Brugia malayi AMP-binding enzyme family protein 0.0193 0.1076 0.1498
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0142 0.0142
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0128 0.0677 0.0942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0068 0.0515
Schistosoma mansoni inositol monophosphatase 0.004 0.0136 0.0331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0068 0.0515
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0185
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0524 0.3099 0.5459
Schistosoma mansoni alcohol dehydrogenase 0.0039 0.0133 0.0322
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0068 0.0095
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0041 0.0987
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Echinococcus granulosus multidrug resistance protein 1 0.0054 0.0222 0.054
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0158 0.0859 0.7246
Plasmodium vivax vivapain-3 0.0028 0.0068 0.0793
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0055 0.0231 0.0231
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0032 0.0089 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0068 0.0541
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0004 0.0006
Toxoplasma gondii ABC transporter family protein 0.0024 0.0041 0.0084
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0064 0.0282 0.0488
Brugia malayi ABC transporter 0.0024 0.0041 0.0057
Echinococcus granulosus intermediate filament protein 0.0044 0.0164 0.0399
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.009 0.0141
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0041 0.0987
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0024 0.0041 0.0285
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0077 0.0365 0.3038
Brugia malayi Methyltransferase-like protein 4 0.0189 0.1053 0.1465
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0282 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0231 0.1373
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0275 0.1575 0.3825
Onchocerca volvulus 0.0032 0.0089 0.0131
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0017 0.0202
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0032 0.0089 0.1037
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0055 0.0231 0.1904
Brugia malayi hypothetical protein 0.0482 0.2841 0.3954
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0068 0.0165
Brugia malayi multidrug resistance protein 3 0.0077 0.0365 0.0508
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0105 0.0146
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0033 0.0094 0.0154
Brugia malayi Cathepsin L-like precursor 0.0018 0.0006 0.0008
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0039 0.0133 0.0776
Mycobacterium ulcerans regulatory protein 0.0032 0.0089 0.0128
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0068 0.171
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Loa Loa (eye worm) hypothetical protein 0.0086 0.0423 0.0665
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0008 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.0779
Mycobacterium tuberculosis Polyketide synthase Pks13 0.094 0.5643 1
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0024 0.0041 0.0285
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0039 0.0133 0.0776
Echinococcus granulosus cathepsin l cysteine peptidase 0.0055 0.0232 0.0564
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0064 0.0282 0.0471
Plasmodium falciparum cysteine proteinase falcipain 3 0.0055 0.0232 0.2702
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0026 0.0063
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0231 0.0364
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0041 0.0042
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Echinococcus granulosus lamin dm0 0.0044 0.0164 0.0399
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0024 0.0041 0.0479
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0133 0.0185
Mycobacterium ulcerans polyketide synthase 0.0668 0.3979 0.7043
Mycobacterium ulcerans thioesterase TesA 0.0524 0.3099 0.5478
Onchocerca volvulus 0.0055 0.0232 0.034
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.069 0.4118 1
Trypanosoma cruzi cysteine peptidase, putative 0.0211 0.1183 1
Echinococcus multilocularis musashi 0.0044 0.0164 0.0164
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.0365 0.0886
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.009 0.0698
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0046 0.0173 0.0173
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0158 0.0859 0.0859
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0024 0.0041 0.0084
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0041 0.0223
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0055 0.0231 0.1927
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0629 0.374 0.6604
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0068 0.0165
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0017 0.0202
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0136 0.0212
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0232 0.0232
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0008 0.0088
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Schistosoma mansoni cathepsin s 0.0018 0.0006 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0313 0.1808 0.2844
Brugia malayi Cytochrome P450 family protein 0.0032 0.0087 0.0122
Schistosoma mansoni [ACP] S-malonyltransferase 0.004 0.0137 0.0332
Schistosoma mansoni cpg binding protein 0.003 0.0076 0.0185
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0039 0.0133 0.3441
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0111 0.0125
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0064 0.0282 0.0471
Echinococcus multilocularis muscleblind protein 1 0.0295 0.17 0.17
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0046 0.0173 0.0272
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0158 0.0859 0.7254
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Brugia malayi latrophilin 2 splice variant baaae 0.0087 0.0429 0.0597
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0089 0.0513
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0041 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0102 0.0593
Onchocerca volvulus Cathepsin F homolog 0.0055 0.0232 0.034
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0032 0.0089 0.072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0065
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0189
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0039 0.0133 0.0205
Plasmodium vivax ABC transporter B family member 4, putative 0.0024 0.0041 0.0479
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0525
Echinococcus granulosus multidrug resistance protein 1 0.0077 0.0365 0.0886
Echinococcus granulosus hyperpolarization activated cyclic 0.069 0.4118 1
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0216 0.1216 0.2145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0168 0.0409
Schistosoma mansoni methyltransferase-related 0.0189 0.1053 0.2556
Trypanosoma cruzi oxidoreductase, putative 0.0039 0.0133 0.109
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0514 0.3039 0.538
Giardia lamblia MRP-like ABC transporter 0.0024 0.0041 0.023
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0629 0.374 0.6604
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0041 0.0987
Schistosoma mansoni multidrug resistance protein 0.0023 0.0036 0.0087
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.009 0.0698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0669
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0017 0.0023
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0039 0.0133 0.0222
Toxoplasma gondii type I fatty acid synthase 0.0096 0.0484 0.1199
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0039 0.0133 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.0779
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0232 0.0232
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0032 0.0089 0.0205
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0158 0.0859 0.7246
Leishmania major cytochrome p450-like protein 0.0032 0.0087 0.0678
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0035 0.0105 0.0854
Mycobacterium leprae Probable oxidireductase 0.0039 0.0133 0.0164
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0158 0.0859 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0008
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0039 0.0133 0.3441
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0378 0.348
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.004 0.0137 0.159
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0168 0.0168
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0629 0.374 0.6624
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.069 0.4118 1
Brugia malayi MH1 domain containing protein 0.0021 0.0024 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0128 0.0677 0.1065
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0087 0.0678
Mycobacterium ulcerans Type I modular polyketide synthase 0.0629 0.374 0.6618
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Trypanosoma cruzi multidrug resistance protein E, putative 0.0024 0.0041 0.0313
Mycobacterium tuberculosis Probable thioesterase TesA 0.0524 0.3099 0.5486
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Schistosoma mansoni lamin 0.0044 0.0164 0.0399
Echinococcus granulosus hyperpolarization activated cyclic 0.069 0.4118 1
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0133 0.109
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0087 0.0137
Entamoeba histolytica cysteine protease, putative 0.0055 0.0232 0.6105
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0168 0.0234
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0026 0.0157
Schistosoma mansoni cpg binding protein 0.003 0.0076 0.0185
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0041 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0017 0.0111
Mycobacterium tuberculosis Possible dehydrogenase 0.0039 0.0133 0.0222
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0055 0.0231 0.6086
Loa Loa (eye worm) hypothetical protein 0.0028 0.0067 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.078
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0032 0.0089 0.0205
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0026 0.0036
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0077 0.0365 0.0899
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0064 0.0282 0.0488
Schistosoma mansoni multidrug resistance protein 0.0077 0.0365 0.0886
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.004 0.0137 0.0616
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.0422 0.1042
Echinococcus multilocularis multidrug resistance associated protein 1 0.0024 0.0041 0.0041
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.0422 0.2522
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0067 0.0534
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0064 0.0282 0.0444
Entamoeba histolytica hypothetical protein 0.0035 0.0105 0.2698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0036 0.0192
Brugia malayi Inositol-1 0.004 0.0136 0.019
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0039 0.0133 0.0205
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0209
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.012 0.0292
Echinococcus granulosus multidrug resistance associated protein 7 0.0024 0.0041 0.01
Schistosoma mansoni zinc binding dehydrogenase 0.0039 0.0133 0.0322
Plasmodium falciparum ABC transporter B family member 4, putative 0.0024 0.0041 0.0479
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0035 0.0105 0.0828
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0096 0.0484 0.0845
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0024 0.0041 0.0059
Entamoeba histolytica P-glyco protein 6, putative 0.0077 0.0365 0.9655
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0193 0.1076 0.1897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.078
Schistosoma mansoni hypothetical protein 0.0032 0.0089 0.0216
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0668 0.3979 0.7043
Loa Loa (eye worm) acetyltransferase 0.0293 0.1688 0.2656
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0232 0.1378
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0017 0.0111
Echinococcus multilocularis survival motor neuron protein 1 0.0482 0.2841 0.2841
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0185
Trypanosoma brucei Flagellar Member 6 0.0032 0.0089 0.0694
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0087 0.0137
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0023 0.0036 0.018
Brugia malayi Intermediate filament tail domain containing protein 0.0044 0.0164 0.0228
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0229 0.0557
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0133 0.109
Mycobacterium ulcerans oxidoreductase 0.0039 0.0133 0.0205
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0318 0.1838 0.4608
Echinococcus multilocularis AMP dependent ligase 0.0064 0.0282 0.0282
Schistosoma mansoni [ACP] S-malonyltransferase 0.004 0.0137 0.0332
Trypanosoma cruzi cAMP binding protein, putative 0.0032 0.0089 0.072
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0136 0.1096
Echinococcus multilocularis 0.0024 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0402 0.2353 0.5714
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0026 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0146 0.0857
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0232 0.034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Giardia lamblia Methyltransferase like 2 0.0189 0.1053 1
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0041 0.0057
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0024 0.0041 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0027
Trypanosoma cruzi oxidoreductase, putative 0.0039 0.0133 0.109
Loa Loa (eye worm) hypothetical protein 0.0096 0.0478 0.0753
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Entamoeba histolytica P-glycoprotein 5, putative 0.0023 0.0036 0.0849
Echinococcus multilocularis muscleblind protein 0.0295 0.17 0.17
Leishmania major zinc-binding dehydrogenase-like protein 0.0039 0.0133 0.1065
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0032 0.0089 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0526
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0032 0.0089 0.0089
Mycobacterium ulcerans quinone oxidoreductase 0.0039 0.0133 0.0205
Schistosoma mansoni hypothetical protein 0.0087 0.0429 0.1042
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.0422 0.2522
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0039 0.0133 0.0133
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0136 0.0798
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0024 0.0041 0.0042
Onchocerca volvulus 0.0055 0.0232 0.034
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.0089 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0168 0.0168
Mycobacterium ulcerans quinone oxidoreductase 0.0039 0.0133 0.0205
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0041 0.0041
Onchocerca volvulus 0.0055 0.0232 0.034
Echinococcus granulosus cathepsin l1 0.0037 0.012 0.0292
Loa Loa (eye worm) hypothetical protein 0.1056 0.6356 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0173 0.042
Loa Loa (eye worm) hypothetical protein 0.0096 0.0478 0.0753
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0068 0.171
Trypanosoma cruzi cruzipain precursor, putative 0.0211 0.1183 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0229 0.1887
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0024 0.0041 0.0285
Toxoplasma gondii cathepsin CPL 0.0055 0.0232 0.0565
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0344
Mycobacterium tuberculosis Conserved protein 0.0189 0.1053 0.1854
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0259 0.063
Echinococcus granulosus geminin 0.0573 0.34 0.8256
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0142 0.0197
Plasmodium falciparum acyl carrier protein 0.0064 0.0282 0.3286
Brugia malayi multidrug resistance related protein 1 0.0024 0.0041 0.0057
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0036 0.0192
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0506 0.2989 0.5282
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.0422 0.4905
Toxoplasma gondii exonuclease III APE 0.002 0.0017 0.0024
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0039 0.0133 0.109
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.0422 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0229 0.0558
Echinococcus multilocularis lamin 0.0044 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0096 0.0484 0.0761
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0189
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0506 0.2989 0.5282
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0032 0.0089 0.072
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0026 0.0016
Plasmodium vivax ABC transporter B family member 3, putative 0.0024 0.0041 0.0479
Echinococcus granulosus serine protein kinase ATM 0.0035 0.0105 0.0255
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.4036 0.9802
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.1053 0.6337
Leishmania major protein kinase, putative 0.0032 0.0089 0.0694
Brugia malayi acetyltransferase, GNAT family protein 0.0293 0.1688 0.235
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0378 0.4394
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0021 0.0024 0.0059
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0017 0.0042
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0096 0.0484 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Toxoplasma gondii acyl transferase domain-containing protein 0.004 0.0137 0.0325
Treponema pallidum catabolite gene activator 0.0032 0.0089 0.271
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0018
Giardia lamblia GTOR 0.0055 0.0231 0.2068
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0024 0.0041 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Brugia malayi hypothetical protein 0.0096 0.0478 0.0666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Mycobacterium ulcerans Type I modular polyketide synthase 0.0629 0.374 0.6618
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0087 0.0704
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0197 0.1102 0.1894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0168 0.0409
Echinococcus multilocularis mothers against decapentaplegic 5 0.0021 0.0024 0.0024
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0039 0.0133 0.0205
Loa Loa (eye worm) hypothetical protein 0.0295 0.17 0.2675
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0017 0.0017
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0024 0.0041 0.0057
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0004 0.0004
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.0089 0.0216
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0041 0.0041
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0046 0.0173 0.042
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0036 0.0192
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.004 0.0137 0.0212
Echinococcus granulosus multidrug resistance associated protein 1 0.0024 0.0041 0.01
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0026 0.0063
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0024 0.0041 0.0283
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0136 0.1096
Treponema pallidum cyclic nucleotide binding protein 0.0032 0.0089 0.271
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.009 0.0698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0041 0.0987
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0089 0.0145
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0036 0.0192
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0064 0.0282 0.3148
Schistosoma mansoni hypothetical protein 0.0573 0.34 0.8256
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0007
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0064 0.0282 0.0282
Leishmania major p-glycoprotein 0.0077 0.0365 0.3038
Leishmania major quinone oxidoreductase, putative 0.0039 0.0133 0.1065
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0068 0.0541
Echinococcus multilocularis geminin 0.0573 0.34 0.34
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0032 0.0089 0.0216
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0158 0.0859 1
Leishmania major hypothetical protein, conserved 0.0025 0.0045 0.0319
Toxoplasma gondii FATC domain-containing protein 0.0035 0.0105 0.0245
Brugia malayi Egg laying defective protein 4 0.0032 0.0089 0.0124
Schistosoma mansoni Smad4 0.0021 0.0024 0.0059
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0039 0.0133 0.0222
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0068 0.0541
Plasmodium vivax unspecified product 0.0018 0.0006 0.0066
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0024 0.0041 0.0042
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.0089 0.0089
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0046 0.0173 0.0272
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.012 0.0167
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0136 0.1121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0231 0.1373
Treponema pallidum cyclic nucleotide binding protein 0.0032 0.0089 0.271
Echinococcus multilocularis cysteine protease 0.0055 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0401 0.2349 0.5705
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0046 0.0173 0.024
Brugia malayi ABC transporter transmembrane region family protein 0.0023 0.0036 0.005
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Leishmania major p-glycoprotein e 0.0024 0.0041 0.0285
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0346
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0017 0.0017
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0044 0.0164 0.0258
Brugia malayi ABC transporter family protein 0.0024 0.0041 0.0057
Brugia malayi P-glycoprotein-like protein 0.0024 0.0041 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0232 0.0232
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0032 0.0089 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Onchocerca volvulus 0.0039 0.0133 0.0194
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0096 0.0484 0.0845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Schistosoma mansoni cpg binding protein 0.0028 0.0066 0.0161
Loa Loa (eye worm) acyl carrier protein 0.0064 0.0282 0.0444
Onchocerca volvulus Fatty acid synthase homolog 0.1133 0.6828 1
Entamoeba histolytica P-glycoprotein-5 0.0077 0.0365 0.9655
Plasmodium falciparum multidrug resistance-associated protein 2 0.0024 0.0041 0.0479
Trypanosoma brucei acyl transferase-like protein 0.004 0.0137 0.1098
Trypanosoma cruzi cysteine peptidase, putative 0.0211 0.1183 1
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0039 0.0133 0.0222
Trypanosoma brucei protein kinase A regulatory subunit 0.0032 0.0089 0.0694
Leishmania major protein kinase, putative 0.0032 0.0089 0.0694
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.0173 0.024
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0609 0.3622 0.6415
Schistosoma mansoni cellular tumor antigen P53 0.0042 0.0154 0.0373
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0039 0.0133 0.0205
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0587 0.3488 0.6176
Mycobacterium ulcerans short-chain dehydrogenase 0.0039 0.0133 0.0205
Schistosoma mansoni smad 0.0021 0.0024 0.0059
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0232 0.0564
Onchocerca volvulus 0.0064 0.0282 0.0413
Trypanosoma cruzi acyl transferase-like protein 0.004 0.0137 0.1123
Giardia lamblia Multidrug resistance-associated protein 1 0.0024 0.0041 0.023
Loa Loa (eye worm) acyl carrier protein 0.0289 0.1663 0.2616
Mycobacterium ulcerans hypothetical protein 0.0032 0.0089 0.0128
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0026 0.0033
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0008 0.0088
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0046 0.0173 0.0272
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0046 0.0173 0.042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0136 0.0798
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0026 0.0157
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0158 0.0859 1
Schistosoma mansoni eyes absent homolog 0.0086 0.0423 0.1027
Onchocerca volvulus 0.0032 0.0089 0.0131
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0168 0.0265
Echinococcus multilocularis hyperpolarization activated cyclic 0.069 0.4118 0.4118
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.009 0.0725
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0089 0.0089
Entamoeba histolytica P-glycoprotein 5, putative 0.0077 0.0365 0.9655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.012 0.0701
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0032 0.0089 0.0145
Entamoeba histolytica acyl-CoA synthetase, putative 0.0064 0.0282 0.7449
Schistosoma mansoni smad1 5 8 and 0.0021 0.0024 0.0059
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0021 0.0024 0.0059
Leishmania major acyl carrier protein, putative 0.0064 0.0282 0.2337
Mycobacterium ulcerans thioesterase 0.0524 0.3099 0.5478
Onchocerca volvulus 0.0028 0.0066 0.0097
Leishmania major pentamidine resistance protein 1 0.0024 0.0041 0.0285
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0064 0.0282 0.0488
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.012 0.3108
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0506 0.2989 0.5262
Loa Loa (eye worm) hypothetical protein 0.0037 0.012 0.0189
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0133 0.109
Plasmodium vivax acyl carrier protein, putative 0.0064 0.0282 0.3286
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0039 0.0133 0.0222
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Brugia malayi hypothetical protein 0.0024 0.0041 0.0057
Echinococcus granulosus cpg binding protein 0.003 0.0076 0.0185
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0064 0.0282 0.0471
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0173 0.042
Echinococcus multilocularis multidrug resistance protein 1 0.0077 0.0365 0.0365
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0629 0.374 0.6618
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0017 0.0083
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0215
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0068 0.0095
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0142 0.0344
Toxoplasma gondii type I fatty acid synthase, putative 0.0668 0.3979 1
Plasmodium falciparum ABC transporter B family member 6, putative 0.0024 0.0041 0.0479
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0041 0.0041
Brugia malayi MH2 domain containing protein 0.0021 0.0024 0.0034
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.009 0.0218
Mycobacterium ulcerans transmembrane transport protein 0.0032 0.0089 0.0128
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Onchocerca volvulus 0.0042 0.0154 0.0225
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0282 0.0488
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0039 0.0133 0.0164
Mycobacterium ulcerans oxidoreductase 0.0039 0.0133 0.0205
Schistosoma mansoni [ACP] S-malonyltransferase 0.004 0.0137 0.0332
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Schistosoma mansoni ap endonuclease 0.002 0.0017 0.0042
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.0365 0.0886
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0032 0.0089 0.0089
Mycobacterium ulcerans acyl carrier protein 0.0064 0.0282 0.0471
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Leishmania major cathepsin L-like protease 0.0211 0.1183 1
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Brugia malayi CXXC zinc finger family protein 0.0028 0.0066 0.0092
Loa Loa (eye worm) ABC transporter 0.0024 0.0041 0.0065
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0209
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0032 0.0089 0.0694
Leishmania major nuclear receptor binding factor-like protein 0.0039 0.0133 0.1065
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0039 0.0133 0.1371
Leishmania major d-xylulose reductase, putative 0.0039 0.0133 0.1065
Echinococcus multilocularis serine protein kinase ATM 0.0035 0.0105 0.0105
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0096 0.0484 0.0845
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Brugia malayi Muscleblind-like protein 0.0295 0.17 0.2366
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0344
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.0365 0.0886
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0087 0.0137
Mycobacterium ulcerans quinone reductase Qor 0.0039 0.0133 0.0205
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0039 0.0133 0.0205
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.0089 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0089 0.0216
Onchocerca volvulus 0.0039 0.0133 0.0194
Echinococcus granulosus cathepsin L cysteine proteinase 0.0055 0.0232 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.0779
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.0365 0.2178
Mycobacterium tuberculosis Possible dehydrogenase 0.0039 0.0133 0.0222
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.003
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0089 0.0089
Schistosoma mansoni DNA polymerase eta 0.0022 0.0026 0.0063
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0089 0.0513
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.0089 0.0089
Plasmodium falciparum ABC transporter B family member 3, putative 0.0024 0.0041 0.0479
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0049 0.0191 0.0464
Leishmania major phosphatidylinositol kinase related protein, putative 0.0023 0.0032 0.0209
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0158 0.0859 0.1196
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0026 0.0157
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0173 0.0173
Onchocerca volvulus 0.0098 0.0495 0.0725
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0064 0.0282 0.0471
Trypanosoma brucei unspecified product 0.0022 0.0026 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0068 0.171
Echinococcus granulosus smad 0.0021 0.0024 0.0059
Entamoeba histolytica multidrug resistance protein, putative 0.0024 0.0041 0.0987
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0032 0.0089 0.0205
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.4036 0.4036
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0032 0.0089 0.014
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0004 0.001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0017 0.0027
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Mycobacterium ulcerans dehydrogenase 0.0039 0.0133 0.0205
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0045 0.0319
Brugia malayi Latrophilin receptor protein 2 0.004 0.0142 0.0197
Trypanosoma brucei oxidoreductase, putative 0.0039 0.0133 0.1065
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Brugia malayi hypothetical protein 0.0073 0.0341 0.0475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.012 0.0701
Leishmania major ABC-thiol transporter 0.0024 0.0041 0.0285
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0089 0.0513
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0068 0.171
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0609 0.3622 0.6415
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0668 0.3979 0.703
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0024 0.0041 0.01
Schistosoma mansoni smad1 5 8 and 0.0021 0.0024 0.0059
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0039 0.0133 0.0205
Loa Loa (eye worm) hypothetical protein 0.0087 0.0429 0.0675
Leishmania major zinc binding dehydrogenase-like protein 0.0039 0.0133 0.1065
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.002 0.0019 0.0093
Echinococcus granulosus AMP dependent ligase 0.0064 0.0282 0.0686
Plasmodium falciparum ABC transporter B family member 5, putative 0.0024 0.0041 0.0479
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0158 0.0859 0.1352
Brugia malayi cathepsin L-like precursor 0.0037 0.012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0352 0.2049 0.3224
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0064 0.0282 0.0413
Trichomonas vaginalis abcb9, putative 0.0077 0.0365 0.2178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Echinococcus granulosus acyl carrier protein mitochondrial 0.0064 0.0282 0.0686
Trichomonas vaginalis ABC transporter, putative 0.0077 0.0365 0.2178
Chlamydia trachomatis acyl carrier protein 0.0064 0.0282 0.2508
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.0173 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0055 0.0232 0.2702
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0282 0.0488
Echinococcus granulosus GPCR family 2 0.004 0.0142 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0055 0.0232 0.2702
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0006 0.0009
Echinococcus granulosus patatin phospholipase domain containing protein 0.0032 0.0089 0.0216
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0378 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0232 0.0365
Leishmania major hypothetical protein, conserved 0.0189 0.1053 0.889
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0229 0.0229
Plasmodium falciparum multidrug resistance-associated protein 1 0.0024 0.0041 0.0479
Trypanosoma brucei p-glycoprotein 0.0024 0.0041 0.0285
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0039 0.0133 0.0209
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Mycobacterium ulcerans fatty acid synthase Fas 0.0197 0.1102 0.1928
Schistosoma mansoni smdr2 0.0077 0.0365 0.0886
Loa Loa (eye worm) fatty acid synthase 0.062 0.3689 0.5804
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0038
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0068 0.0793
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0344
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0087 0.0704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Entamoeba histolytica P-glycoprotein-2, putative 0.0023 0.0036 0.0849
Mycobacterium ulcerans Type I modular polyketide synthase 0.0629 0.374 0.6618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Schistosoma mansoni multidrug resistance protein 0.0024 0.0041 0.01
Entamoeba histolytica P-glycoprotein-1 0.0077 0.0365 0.9655
Toxoplasma gondii acyl carrier protein ACP 0.0064 0.0282 0.0692
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.009 0.0445 0.518
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0024 0.0041 0.0285
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0039 0.0133 0.0205
Plasmodium falciparum ABC transporter B family member 7, putative 0.0024 0.0041 0.0479
Loa Loa (eye worm) AGC/PKG protein kinase 0.0032 0.0089 0.014
Leishmania major DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Onchocerca volvulus 0.0037 0.012 0.0176
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.0422 0.1024
Schistosoma mansoni multidrug resistance protein 0.0077 0.0365 0.0886
Echinococcus multilocularis hyperpolarization activated cyclic 0.069 0.4118 0.4118
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0668 0.3979 0.703
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0077 0.0365 0.0899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Brugia malayi intermediate filament protein 0.0044 0.0164 0.0228
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0017 0.0024
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0055 0.0231 0.0562
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0021 0.0024 0.0024
Leishmania major cysteine peptidase A (CPA) 0.0055 0.0232 0.1911
Schistosoma mansoni survival motor neuron protein 0.0098 0.0495 0.1202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Mycobacterium ulcerans polyketide synthase 0.0629 0.374 0.6618
Mycobacterium ulcerans polyketide synthase Pks9 0.0416 0.2437 0.4302
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0168 0.0409
Echinococcus granulosus ATP binding cassette sub family B 0.0023 0.0036 0.0087
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0136 0.3539
Giardia lamblia ABC transporter, putative 0.0024 0.0041 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0089 0.072
Mycobacterium tuberculosis Probable oxidoreductase 0.0039 0.0133 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Loa Loa (eye worm) hypothetical protein 0.0295 0.17 0.2675
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0229 0.0377
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0055 0.0231 0.1904
Brugia malayi Cytochrome P450 family protein 0.0035 0.0108 0.015
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0039 0.0133 0.0222
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0173 0.042
Echinococcus granulosus lamin 0.0044 0.0164 0.0399
Echinococcus granulosus multidrug resistance protein 1 0.0077 0.0365 0.0886
Loa Loa (eye worm) inositol-1 0.004 0.0136 0.0215
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0232 0.6105
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0024 0.0041 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0188 0.1109
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0041
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0032 0.0089 0.0216
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0046 0.0173 0.0173
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0032 0.0089 0.0513
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0068 0.0165
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0064 0.0282 0.0488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Leishmania major hypothetical protein, unknown function 0.0032 0.0089 0.0694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0006 0.0008
Echinococcus multilocularis ATP binding cassette sub family B 0.0076 0.036 0.036
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0034 0.0104 0.0253
Entamoeba histolytica acyl-CoA synthetase, putative 0.0064 0.0282 0.7449
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0232 0.034
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0032 0.0089 0.0216
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0197 0.1102 0.1942
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0057
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0525
Plasmodium vivax multidrug resistance protein 2, putative 0.0024 0.0041 0.0479
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0045 0.0525
Loa Loa (eye worm) fibroinase 0.0055 0.0232 0.0365
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0024 0.0039 0.0061
Echinococcus multilocularis tumor protein p63 0.029 0.1668 0.1668
Schistosoma mansoni lozenge 0.005 0.02 0.0485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0136 0.1414
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0068 0.171
Brugia malayi cytoplasmic intermediate filament protein 0.0024 0.0039 0.0054
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0039 0.0133 0.0222
Plasmodium vivax ABC transporter B family member 6, putative 0.0024 0.0041 0.0479
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0209
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0026 0.0016
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0098 0.0495 0.1202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Loa Loa (eye worm) ABC transporter 0.0024 0.0041 0.0065
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0026 0.0157
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0452 0.2657 0.4702
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0055 0.0232 0.0365
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Loa Loa (eye worm) hypothetical protein 0.0077 0.0365 0.0574
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0039 0.0133 0.0205
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0629 0.374 0.5206
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0008 0.0008
Trichomonas vaginalis taga, putative 0.0077 0.0365 0.2178
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0024 0.0041 0.0285
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0024 0.0041 0.0313
Loa Loa (eye worm) hypothetical protein 0.0044 0.0164 0.0258
Loa Loa (eye worm) Smad1 0.0021 0.0024 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Echinococcus granulosus Ion_trans_N domain containing protein 0.0402 0.2353 0.5714
Loa Loa (eye worm) hypothetical protein 0.0076 0.036 0.0566
Trichomonas vaginalis abcb9, putative 0.0077 0.0365 0.2178
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0077 0.0365 0.0634
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0008 0.0008
Echinococcus multilocularis expressed conserved protein 0.0032 0.0089 0.0089
Mycobacterium ulcerans polyketide synthase Pks13 0.094 0.5643 1
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0032 0.0089 0.0145
Loa Loa (eye worm) hypothetical protein 0.0042 0.0154 0.0242
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.094 0.5643 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0017 0.0349
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0024 0.0041 0.0313
Schistosoma mansoni hypothetical protein 0.0073 0.0341 0.0828
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0055 0.0231 0.1904
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0046 0.0173 0.042
Plasmodium vivax multidrug resistance protein 1, putative 0.0077 0.0365 0.4244
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0341 0.0828
Onchocerca volvulus 0.0044 0.0164 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0231 0.1373
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0136 0.0798
Trypanosoma brucei cAMP response protein 1, putative 0.0032 0.0089 0.0694
Echinococcus granulosus histone acetyltransferase KAT2B 0.0285 0.1638 0.3978
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0006 0.0012
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0077 0.0365 0.2178
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0668 0.3979 0.7048
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0039 0.0133 0.0776
Echinococcus multilocularis Protein lozenge 0.005 0.02 0.02
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0017 0.0083
Brugia malayi ABC transporter family protein 0.0024 0.0041 0.0057
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0008 0.0012
Leishmania major cyclic nucleotide-binding protein-like protein 0.0032 0.0089 0.0694
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0232 0.0564
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0071
Leishmania major oxidoreductase, putative 0.0039 0.0133 0.1065
Brugia malayi ABC transporter 0.0023 0.0036 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0526
Onchocerca volvulus 0.0055 0.0232 0.034
Onchocerca volvulus Huntingtin homolog 0.0096 0.0478 0.0701
Trypanosoma cruzi major cysteine proteinase, putative 0.0166 0.0907 0.7659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0105 0.0609
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0024 0.0041 0.0285
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0032 0.0089 0.0089
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0401 0.2349 0.5705
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0136 0.0331
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0039 0.0133 0.0315
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0229 0.0394
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0032 0.0089 0.1037
Brugia malayi Cyclic-nucleotide gated cation channel 0.0046 0.0173 0.024
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0026 0.0185
Echinococcus multilocularis multidrug resistance protein 1 0.0077 0.0365 0.0365
Echinococcus multilocularis multidrug resistance protein 1 0.0054 0.0222 0.0222
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0045 0.0094
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1192 0.7185 1
Echinococcus multilocularis smad 0.0021 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0398 0.2331 0.3668
Leishmania major hypothetical protein, conserved 0.004 0.0137 0.1098
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0032 0.0089 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.0365 0.0365
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0136 0.0324
Entamoeba histolytica hypothetical protein 0.0073 0.0341 0.9019
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0041 0.0987
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0089 0.0216
Echinococcus granulosus dna polymerase kappa 0.0022 0.0026 0.0063
Echinococcus granulosus multidrug resistance protein 1 0.0077 0.0365 0.0886
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0066 0.0104
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0026 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0064 0.0282 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0516
Echinococcus granulosus dna polymerase eta 0.0022 0.0026 0.0063
Echinococcus granulosus mothers against decapentaplegic 5 0.0021 0.0024 0.0059
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0158 0.0859 0.1497
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0049 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0089 0.0513
Mycobacterium ulcerans acyl carrier protein 0.0064 0.0282 0.0471
Brugia malayi N-terminal motif family protein 0.0236 0.1337 0.1861
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0587 0.3488 0.5487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.009 0.009
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0039 0.0133 0.1065
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0365 0.2178
Onchocerca volvulus Putative alcohol dehydrogenase 0.0039 0.0133 0.0194
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0068 0.0165
Trypanosoma cruzi cAMP response protein 1 0.0032 0.0089 0.072
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0032 0.0089 0.0124
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0142 0.0142
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0024 0.0041 0.0283
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0026 0.0033
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.0365 0.0886
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0055 0.0231 0.1927
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0408 0.2389 0.5996
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0041 0.0084
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0039 0.0133 0.1065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.078
Leishmania major cathepsin L-like protease 0.0211 0.1183 1
Brugia malayi hypothetical protein 0.0086 0.0423 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0077 0.0365 0.0574
Schistosoma mansoni lipoxygenase 0.0049 0.0191 0.0464
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0008 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0065
Plasmodium falciparum cGMP-dependent protein kinase 0.0032 0.0089 0.1037
Echinococcus granulosus survival motor neuron protein 1 0.0482 0.2841 0.6899
Trichomonas vaginalis ABC transporter, putative 0.0077 0.0365 0.2178
Leishmania major cathepsin L-like protease 0.0055 0.0232 0.1911
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0065
Echinococcus granulosus Smad4 0.0021 0.0024 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0229 0.0377
Loa Loa (eye worm) hypothetical protein 0.0046 0.0173 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0133 0.078
Brugia malayi hypothetical protein 0.0025 0.0045 0.0063
Brugia malayi Alcohol dehydrogenase class III 0.0039 0.0133 0.0185
Treponema pallidum acyl carrier protein 0.0064 0.0282 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0484 0.0761
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0009
Trypanosoma brucei multidrug resistance protein E 0.0024 0.0041 0.0285
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0023 0.0036 0.0087
Onchocerca volvulus 0.0055 0.0232 0.034
Mycobacterium ulcerans transcriptional regulatory protein 0.0032 0.0089 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.1183 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0293 0.1688 0.41
Brugia malayi MH1 domain containing protein 0.0021 0.0024 0.0034
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0064 0.0282 0.0431
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0039 0.0133 0.0222
Echinococcus multilocularis hypothetical protein 0.0402 0.2353 0.2353
Loa Loa (eye worm) intermediate filament protein 0.0044 0.0164 0.0258
Entamoeba histolytica ABC transporter, putative 0.0024 0.0041 0.0987
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0157
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Trichomonas vaginalis ABC transporter, putative 0.0077 0.0365 0.2178
Treponema pallidum catabolite gene activator (Crp) 0.0032 0.0089 0.271
Toxoplasma gondii target of rapamycin (TOR), putative 0.0046 0.0177 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0173 0.0173
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0046 0.0173 0.042
Entamoeba histolytica P-glycoprotein-2 0.0077 0.0365 0.9655
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0032 0.0089 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0232 0.1378
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0041 0.0042
Plasmodium vivax vivapain-2 0.0055 0.0232 0.2702
Onchocerca volvulus 0.0077 0.0365 0.0534
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0288 0.1659 1
Brugia malayi ABC transporter family protein 0.0024 0.0041 0.0057
Echinococcus multilocularis multidrug resistance associated protein 7 0.0024 0.0041 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0064 0.0282 0.0431
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0064 0.0282 0.0393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0232 0.1378
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0048 0.0188 0.1535
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0111 0.0183
Loa Loa (eye worm) transcription factor SMAD2 0.0313 0.1808 0.2844
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0068 0.171
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0173 0.1018
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0077 0.0365 0.2178
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0158 0.0859 1
Brugia malayi Cathepsin L-like precursor 0.0055 0.0232 0.0323
Entamoeba histolytica cysteine protease, putative 0.0028 0.0068 0.171
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0006 0.0012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0341 0.0341
Brugia malayi isocitrate dehydrogenase 0.0019 0.0008 0.0011
Trypanosoma cruzi oxidoreductase, putative 0.0039 0.0133 0.109
Plasmodium vivax vivapain-2 0.0055 0.0232 0.2702
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0055 0.0231 0.0562
Giardia lamblia Hypothetical protein 0.0023 0.0036 0.018
Echinococcus granulosus microtubule associated protein 2 0.0677 0.4036 0.9802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0068 0.0541
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0026 0.0063
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0032 0.0089 0.0216
Plasmodium falciparum multidrug resistance protein 1 0.0077 0.0365 0.4244
Brugia malayi Smad1 0.0021 0.0024 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0177 0.1043
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.2349 0.2349
Brugia malayi ABC transporter family protein 0.0077 0.0365 0.0508
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0173 0.042
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0004 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0168 0.0409
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.069 0.4118 1
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0039 0.0133 0.0222
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0021 0.0024 0.0024
Echinococcus granulosus voltage gated potassium channel 0.0046 0.0173 0.042
Trypanosoma cruzi Flagellar Member 6 0.0032 0.0089 0.072
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0026 0.0157
Brugia malayi MH2 domain containing protein 0.0021 0.0024 0.0034
Trypanosoma brucei cAMP binding protein, putative 0.0032 0.0089 0.0694
Plasmodium vivax ABC transporter B family member 5, putative 0.0024 0.0041 0.0479
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0668 0.3979 0.7043
Leishmania major hypothetical protein, conserved 0.0032 0.0089 0.0694
Brugia malayi Cathepsin L-like precursor 0.0037 0.012 0.0167
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0365 0.2178
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0032 0.0089 0.0216
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0006 0.0008
Schistosoma mansoni intermediate filament proteins 0.0044 0.0164 0.0399
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0264 0.0647
Echinococcus multilocularis Smad4 0.0021 0.0024 0.0024
Mycobacterium ulcerans polyketide synthase MbtC 0.0158 0.0859 0.1497
Mycobacterium ulcerans polyketide synthase MbtD 0.0193 0.1076 0.1883
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0629 0.374 0.6624
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0017 0.0079
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0026 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0089 0.0216

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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