Detailed information for compound 1208482

Basic information

Technical information
  • TDR Targets ID: 1208482
  • Name: [2-oxo-2-(3-oxo-2,4-dihydroquinoxalin-1-yl)et hyl] 2-chloropyridine-3-carboxylate
  • MW: 345.737 | Formula: C16H12ClN3O4
  • H donors: 1 H acceptors: 4 LogP: 1.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2ccccc2N(C1)C(=O)COC(=O)c1cccnc1Cl
  • InChi: 1S/C16H12ClN3O4/c17-15-10(4-3-7-18-15)16(23)24-9-14(22)20-8-13(21)19-11-5-1-2-6-12(11)20/h1-7H,8-9H2,(H,19,21)
  • InChiKey: ZEZTTXFHRRWUKE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-chloro-3-pyridinecarboxylic acid [2-oxo-2-(3-oxo-2,4-dihydroquinoxalin-1-yl)ethyl] ester
  • 2-chloronicotinic acid [2-keto-2-(3-keto-2,4-dihydroquinoxalin-1-yl)ethyl] ester
  • ZINC03416435
  • T5337063
  • MLS000771822
  • SMR000344222

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0266 0.5759
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0812 0.1183
Schistosoma mansoni hypothetical protein 0.0036 0.0288 0.0288
Plasmodium vivax importin-beta 2, putative 0.0035 0.0266 0.5759
Schistosoma mansoni hypothetical protein 0.0372 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0041 0.0433 0.0433
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0812 0.0812
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.1349 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0461 1
Schistosoma mansoni ap endonuclease 0.0042 0.0461 0.0461
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0266 0.0266
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0288 0.0288
Brugia malayi Importin beta-1 subunit 0.0035 0.0266 0.0387
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0288
Brugia malayi RNA binding protein 0.0142 0.3376 0.4919
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.251 0.3657
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0122 0.2796 0.2796
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0433 0.0433
Echinococcus granulosus transcription factor btf3 0.004 0.043 0.043
Brugia malayi beta-lactamase family protein 0.0041 0.0433 0.063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0433 0.0433
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.1349 1
Leishmania major hypothetical protein, conserved 0.0041 0.0433 0.3208
Loa Loa (eye worm) hypothetical protein 0.0045 0.0569 0.0569
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.0047 0.0631 0.0631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0812 0.0812
Echinococcus multilocularis GPCR, family 2 0.0036 0.0288 0.0288
Entamoeba histolytica hypothetical protein 0.0122 0.2796 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0433 0.0433
Echinococcus granulosus geminin 0.0186 0.4638 0.4638
Brugia malayi RNA, U transporter 1 0.0099 0.2121 0.309
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0122 0.2796 0.2796
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0142 0.3376 0.3376
Loa Loa (eye worm) hypothetical protein 0.0263 0.6863 0.6863
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0433 0.9379
Schistosoma mansoni hypothetical protein 0.0122 0.2796 0.2796
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.043 0.1537
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0288 0.0288
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.0433 0.0433
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0461 0.1649
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0461 1
Loa Loa (eye worm) ICD-1 protein 0.004 0.043 0.043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0812 0.0812
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.6863 0.6863
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0461 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.139 0.139
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.1482 0.2159
Echinococcus multilocularis geminin 0.0186 0.4638 0.4638
Schistosoma mansoni transcription factor btf3 0.004 0.043 0.043
Schistosoma mansoni survival motor neuron protein 0.0054 0.081 0.081
Echinococcus granulosus GPCR family 2 0.0036 0.0288 0.0288
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0461 0.0461
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.6754 1
Loa Loa (eye worm) RNA binding protein 0.0142 0.3376 0.3376
Schistosoma mansoni hypothetical protein 0.0036 0.0288 0.0288
Schistosoma mansoni tar DNA-binding protein 0.0142 0.3376 0.3376
Echinococcus multilocularis tar DNA binding protein 0.0142 0.3376 0.3376
Brugia malayi TAR-binding protein 0.0142 0.3376 0.4919
Brugia malayi hypothetical protein 0.0122 0.2796 0.4074
Echinococcus multilocularis snurportin 1 0.0372 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0433 0.9379
Loa Loa (eye worm) hypothetical protein 0.0041 0.0433 0.0433
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0415 0.0415
Brugia malayi beta-lactamase 0.0041 0.0433 0.063
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0075 0.1634
Brugia malayi Ets-domain containing protein 0.0086 0.1751 0.2551
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0433 0.0433
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0433 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0433 0.9379
Loa Loa (eye worm) TAR-binding protein 0.0142 0.3376 0.3376
Loa Loa (eye worm) hypothetical protein 0.0041 0.0433 0.0433
Loa Loa (eye worm) beta-lactamase 0.0041 0.0433 0.0433
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.251 0.251
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0075 0.1634
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0433 0.9379
Schistosoma mansoni transcription factor LCR-F1 0.0122 0.2796 0.2796
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0288 0.042
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.1349 0.1349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0812 0.0812
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.1349 0.1449
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0433 0.9379
Echinococcus multilocularis transcription factor btf3 0.004 0.043 0.043
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0433 0.9379
Toxoplasma gondii NAC domain-containing protein 0.004 0.043 0.3186
Plasmodium falciparum importin beta, putative 0.0035 0.0266 0.5759
Loa Loa (eye worm) hypothetical protein 0.0041 0.0433 0.0433
Trichomonas vaginalis esterase, putative 0.0041 0.0433 0.9379
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0266 0.197
Entamoeba histolytica hypothetical protein 0.0122 0.2796 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0433 0.063
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0075 0.1634
Schistosoma mansoni ap endonuclease 0.0042 0.0461 0.0461
Schistosoma mansoni tar DNA-binding protein 0.0142 0.3376 0.3376
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0075 0.1634
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0461 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0812 0.0812
Entamoeba histolytica hypothetical protein 0.0028 0.0075 0.0269
Schistosoma mansoni ets-related 0.0262 0.6823 0.6823
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0812 0.0812
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.0113 0.251 0.251
Schistosoma mansoni hypothetical protein 0.0054 0.081 0.081
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0433 0.9379
Schistosoma mansoni hypothetical protein 0.0186 0.4638 0.4638
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0288 0.0288
Mycobacterium leprae Probable lipase LipE 0.0041 0.0433 0.5
Brugia malayi Bromodomain containing protein 0.0043 0.0491 0.0715
Schistosoma mansoni tar DNA-binding protein 0.0142 0.3376 0.3376
Toxoplasma gondii ABC1 family protein 0.0041 0.0433 0.3208
Brugia malayi beta-lactamase family protein 0.0041 0.0433 0.063
Schistosoma mansoni gabp alpha 0.0086 0.1751 0.1751
Schistosoma mansoni hypothetical protein 0.0077 0.1482 0.1482
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0415 0.0415
Schistosoma mansoni tar DNA-binding protein 0.0142 0.3376 0.3376
Echinococcus granulosus tar DNA binding protein 0.0142 0.3376 0.3376
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0288 0.0288
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0461 0.5
Onchocerca volvulus 0.0054 0.081 1
Brugia malayi RNA recognition motif domain containing protein 0.0142 0.3376 0.4919
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0288 0.042
Schistosoma mansoni hypothetical protein 0.0186 0.4638 0.4638
Brugia malayi PHD-finger family protein 0.0028 0.0061 0.0088
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0461 0.5
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.043 0.9316
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.1179 0.1179
Trichomonas vaginalis conserved hypothetical protein 0.004 0.043 0.9316
Echinococcus granulosus GA binding protein alpha chain 0.0086 0.1751 0.1751
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.043 0.9316
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.043 0.9316
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0461 0.0312
Brugia malayi Bromodomain containing protein 0.0083 0.1671 0.2435
Schistosoma mansoni hypothetical protein 0.0036 0.0288 0.0288
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.1349 1
Brugia malayi hypothetical protein 0.0263 0.6863 1
Schistosoma mansoni tar DNA-binding protein 0.0142 0.3376 0.3376
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.1349 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1482 0.1482
Schistosoma mansoni importin beta-1 0.0035 0.0266 0.0266
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.1349 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.043 0.9316
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0461 1
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0461 1
Toxoplasma gondii exonuclease III APE 0.0042 0.0461 0.342
Entamoeba histolytica hypothetical protein 0.0122 0.2796 1
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0433 0.9379
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.251 0.3657
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.043 0.9316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0812 0.0812
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.1349 0.1349
Echinococcus granulosus importin subunit beta 1 0.0035 0.0266 0.0266
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0041 0.0433 0.0433
Schistosoma mansoni hypothetical protein 0.0036 0.0288 0.0288
Brugia malayi beta-NAC-like protein 0.004 0.043 0.0626
Leishmania major basic transcription factor 3a, putative 0.004 0.043 0.3186
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0461 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0812 0.0812
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0266 0.5759
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0433 0.9379
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0461 1
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.043 0.9316
Leishmania major importin beta-1 subunit, putative 0.0028 0.0075 0.0559
Loa Loa (eye worm) hypothetical protein 0.0079 0.1534 0.1534
Loa Loa (eye worm) fli-1 protein 0.0262 0.6823 0.6823
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0461 0.0672
Entamoeba histolytica hypothetical protein 0.0122 0.2796 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0433 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.004 0.043 0.9316
Entamoeba histolytica hypothetical protein 0.004 0.043 0.1537
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.6863 0.6863
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0086 0.1751 0.1751
Brugia malayi Fli-1 protein 0.0262 0.6823 0.9942
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0461 0.0461
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0461 0.342
Schistosoma mansoni bromodomain containing protein 0.007 0.1294 0.1294
Brugia malayi Ets-domain containing protein 0.0086 0.1751 0.2551
Loa Loa (eye worm) hypothetical protein 0.0043 0.0493 0.0493
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.081 0.1181
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0461 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.1179 0.1179
Echinococcus multilocularis GA binding protein alpha chain 0.0086 0.1751 0.1751

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8356 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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