Detailed information for compound 1209043

Basic information

Technical information
  • TDR Targets ID: 1209043
  • Name: N-phenyl-N'-[4-(2-piperidin-1-ylethoxy)phenyl ]benzenecarboximidamide
  • MW: 399.528 | Formula: C26H29N3O
  • H donors: 1 H acceptors: 0 LogP: 5.45 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN(CC1)CCOc1ccc(cc1)N/C(=N\c1ccccc1)/c1ccccc1
  • InChi: 1S/C26H29N3O/c1-4-10-22(11-5-1)26(27-23-12-6-2-7-13-23)28-24-14-16-25(17-15-24)30-21-20-29-18-8-3-9-19-29/h1-2,4-7,10-17H,3,8-9,18-21H2,(H,27,28)
  • InChiKey: DYALBHGUHWDYTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-phenyl-N'-[4-[2-(1-piperidyl)ethoxy]phenyl]benzamidine
  • N-phenyl-N'-[4-(2-piperidinoethoxy)phenyl]benzamidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni zinc finger protein 0.002 0.0657 0.259
Loa Loa (eye worm) hypothetical protein 0.0039 0.1464 0.1464
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2537 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2537 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0376 0.0376
Echinococcus multilocularis calcium activated potassium channel 0.005 0.1921 0.2416
Loa Loa (eye worm) RNA binding protein 0.0065 0.2537 0.2537
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.105 1
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.2537 0.1811
Loa Loa (eye worm) hypothetical protein 0.0152 0.6231 0.6231
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.238 0.3223
Schistosoma mansoni hypothetical protein 0.0016 0.0473 0.1866
Echinococcus multilocularis muscleblind protein 0.0152 0.6231 1
Brugia malayi RNA binding protein 0.0065 0.2537 0.1811
Trichomonas vaginalis set domain proteins, putative 0.0232 0.9608 0.5
Plasmodium vivax SET domain protein, putative 0.0029 0.105 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2537 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.105 0.4141
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.0033 0.1214 0.1214
Brugia malayi Muscleblind-like protein 0.0152 0.6231 0.5865
Leishmania major hypothetical protein, conserved 0.0016 0.0473 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.1359 0.1427
Echinococcus granulosus calcium activated potassium channel variant 0.0046 0.1774 0.2157
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2537 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.2537 0.3498
Loa Loa (eye worm) hypothetical protein 0.0072 0.2853 0.2853
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.105 0.4141
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0549 0.2163
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0784 0.0415
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.1783 0.2172
Echinococcus multilocularis muscleblind protein 1 0.0152 0.6231 1
Onchocerca volvulus 0.0232 0.9608 1
Trypanosoma cruzi ISWI complex protein 0.0016 0.0473 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0549 0.2163
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0575 0.0575
Echinococcus multilocularis calcium activated potassium channel variant 0.0046 0.1774 0.2157
Echinococcus multilocularis potassium large conductance calcium activated 0.005 0.1921 0.2416
Brugia malayi Bromodomain containing protein 0.0076 0.3037 0.236
Loa Loa (eye worm) hypothetical protein 0.0047 0.1783 0.1783
Loa Loa (eye worm) TAR-binding protein 0.0065 0.2537 0.2537
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.842 0.842
Brugia malayi TAR-binding protein 0.0065 0.2537 0.1811
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2537 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0784 0.3092
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.1005 0.0803
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0033 0.1214 0.036
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.238 0.3223
Brugia malayi Bromodomain containing protein 0.0039 0.1461 0.0631
Schistosoma mansoni calcium-activated potassium channel 0.005 0.1921 0.7575
Echinococcus granulosus muscleblind protein 0.0152 0.6231 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.1214 0.1214
Schistosoma mansoni zinc finger protein 0.0016 0.0473 0.1866
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0784 0.0415
Schistosoma mansoni hypothetical protein 0.0021 0.0702 0.2769
Loa Loa (eye worm) hypothetical protein 0.0043 0.1648 0.1648
Trypanosoma brucei ISWI complex protein 0.0016 0.0473 1
Echinococcus multilocularis zinc finger protein 0.002 0.0657 0.0191
Trypanosoma cruzi ISWI complex protein 0.0016 0.0473 1
Echinococcus granulosus zinc finger protein 0.002 0.0657 0.0191
Schistosoma mansoni bromodomain containing protein 0.0064 0.2534 0.9989
Schistosoma mansoni calcium-activated potassium channel 0.0046 0.1774 0.6994
Echinococcus granulosus calcium activated potassium channel 0.005 0.1921 0.2416
Brugia malayi Pre-SET motif family protein 0.0204 0.842 0.8266
Loa Loa (eye worm) hypothetical protein 0.0041 0.1566 0.1566
Loa Loa (eye worm) hypothetical protein 0.0152 0.6231 0.6231
Plasmodium falciparum potassium channel 0.0013 0.0376 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.1359 0.1427
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0046 0.1774 0.1774
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.1783 0.7028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.1783 0.7028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.105 0.0883
Brugia malayi Pre-SET motif family protein 0.0029 0.105 0.018
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.2537 0.2537
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.1783 0.2172
Echinococcus granulosus potassium large conductance calcium activated 0.005 0.1921 0.2416
Echinococcus multilocularis tar DNA binding protein 0.0065 0.2537 0.3498
Schistosoma mansoni calcium-activated potassium channel 0.0013 0.0376 0.1482
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0702 0.0702

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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