Detailed information for compound 1209595

Basic information

Technical information
  • TDR Targets ID: 1209595
  • Name: 1-(2-methoxyphenyl)-3-methylimidazolidine-2,4 ,5-trione
  • MW: 234.208 | Formula: C11H10N2O4
  • H donors: 0 H acceptors: 3 LogP: 1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1C(=O)N(C(=O)C1=O)C
  • InChi: 1S/C11H10N2O4/c1-12-9(14)10(15)13(11(12)16)7-5-3-4-6-8(7)17-2/h3-6H,1-2H3
  • InChiKey: UEYHKLLNODNNSX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-methoxyphenyl)-3-methyl-imidazolidine-2,4,5-trione
  • AE-848/36203043
  • 1-(2-methoxyphenyl)-3-methyl-2,4,5-imidazolidinetrione
  • MLS001180405
  • SMR000476032
  • ZINC03159879

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.00000000020295 0.00000000045326
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Echinococcus multilocularis chromobox protein 1 0.0069 0.2894 0.693
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Trypanosoma cruzi hypothetical protein, conserved 0.0211 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0882 0.2111
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0882 0.2137
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0071 0.0171
Trypanosoma cruzi hypothetical protein, conserved 0.0211 1 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.00000000020295 0.00000000045326
Schistosoma mansoni hypothetical protein 0.0011 0.00000000020295 0.00000000049196
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.006 0.2459 0.5491
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.065 0.0584
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.4125 0.759
Brugia malayi Bromodomain containing protein 0.0029 0.0882 0.2111
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0093 0.4065 0.9734
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.4478 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.00000000020295 0.00000000049196
Loa Loa (eye worm) hypothetical protein 0.0029 0.0882 0.1622
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1756 0.3922
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0093 0.4065 0.9734
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.4176 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.065 0.0584
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.4125 0.9878
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.4125 0.4084
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.00000000020295 0.00000000048596
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.006 0.2459 0.5295
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.4125 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Echinococcus granulosus bloom syndrome protein 0.0024 0.0626 0.1499
Loa Loa (eye worm) hypothetical protein 0.0011 0.00000000020295 0.00000000037338
Schistosoma mansoni hypothetical protein 0.0029 0.0882 0.2137
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0626 0.1398
Echinococcus multilocularis peregrin 0.0029 0.0882 0.2111
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1756 0.3922
Trypanosoma brucei hypothetical protein, conserved 0.0211 1 1
Onchocerca volvulus Alhambra homolog 0.0029 0.0882 0.2137
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.00000000020295 0.00000000049196
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.4125 0.9878
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.065 0.0584
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.1186 0.2841
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0031 0.0968 0.0904
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.023 0.0514
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.4125 0.9878
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.1186 0.2876
Loa Loa (eye worm) hypothetical protein 0.005 0.1916 0.3525
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0101 0.4478 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Brugia malayi chromobox protein homolog 3 0.0039 0.1373 0.3289
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0626 0.1499
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.1373 0.3329
Plasmodium falciparum phd finger protein, putative 0.0029 0.0882 0.1969
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.4125 1
Echinococcus multilocularis Chromo domain 0.0011 0.00000000020295 0.00000000048596
Echinococcus granulosus chromobox protein 1 0.0069 0.2894 0.693
Echinococcus granulosus jumonji domain containing protein 0.004 0.1449 0.3469
Echinococcus granulosus chromobox protein 1 0.0069 0.2894 0.693
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0882 0.1622
Brugia malayi jmjC domain containing protein 0.0095 0.4176 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.024 0.0536
Plasmodium vivax hypothetical protein, conserved 0.0011 0.00000000020295 0.00000000045326
Schistosoma mansoni chromobox protein 0.0069 0.2894 0.7015
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0101 0.4478 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0375 0.0909
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0882 0.1969
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Brugia malayi jmjC domain containing protein 0.0035 0.1186 0.2841
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Schistosoma mansoni kinase 0.0048 0.1818 0.4407
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0093 0.4065 0.7479
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0882 0.2111
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0101 0.4478 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 0.9854
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0093 0.4065 0.4023
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.00000000020295 0.00000000048596
Echinococcus granulosus peregrin 0.0029 0.0882 0.2111
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0093 0.4065 0.4023
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0626 0.1398
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0882 0.1969
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.065 0.1453
Entamoeba histolytica hypothetical protein 0.0011 0.00000000020295 0.00000000049196
Echinococcus granulosus Chromo domain 0.0011 0.00000000020295 0.00000000048596
Brugia malayi glucose-6-phosphate dehydrogenase 0.0093 0.4065 0.9734
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0071 0.0158
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0626 0.1499
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0032 0.104 1
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.2894 0.5325
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Loa Loa (eye worm) hypothetical protein 0.003 0.0954 0.1756
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Loa Loa (eye worm) RecQ helicase 0.0024 0.0626 0.1152
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.1521 0.3686
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.4125 1
Brugia malayi CHD4 protein 0.0011 0.00000000020295 0.00000000048596
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.1373 0.3067
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.4125 0.4084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0882 0.1969
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0101 0.4478 1
Trichomonas vaginalis chromobox protein, putative 0.0069 0.2894 0.6464
Loa Loa (eye worm) hypothetical protein 0.0039 0.1373 0.2527
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 0.4023
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.00000000020295 0.00000000048596
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Giardia lamblia Kinase, PLK 0.0094 0.4125 0.902
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.1186 0.2183
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.1186 0.2841
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.1186 0.2876
Loa Loa (eye worm) hypothetical protein 0.012 0.5435 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0101 0.4478 1
Schistosoma mansoni chromobox protein 0.0069 0.2894 0.7015
Schistosoma mansoni jumonji domain containing protein 0.0075 0.3202 0.7761
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.1373 0.3067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0101 0.4478 1
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0807 0.1802
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000049196
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.2424 0.4459
Trichomonas vaginalis chromobox protein, putative 0.0042 0.1521 0.3396
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.00000000020295 0.00000000048596
Trypanosoma brucei polo-like protein kinase 0.0094 0.4125 0.4084
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.065 0.1557
Trichomonas vaginalis chromobox protein, putative 0.0042 0.1521 0.3396
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0807 0.1802
Trichomonas vaginalis chromobox protein, putative 0.0069 0.2894 0.6464
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000049196
Onchocerca volvulus 0.003 0.0954 0.2313
Brugia malayi Heterochromatin protein 1 0.0069 0.2894 0.693
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 0.5
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.00000000020295 0.00000000048596
Echinococcus multilocularis jumonji domain containing protein 0.004 0.1449 0.3469
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.003 0.0924 0.0859
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.00000000020295 0.00000000048596
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.4125 0.4084
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.065 0.1557
Brugia malayi PHD-finger family protein 0.0029 0.0882 0.2111
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.4176 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.00000000020295 0.00000000037338
Echinococcus multilocularis chromobox protein 1 0.0069 0.2894 0.693
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0481 0.1075
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000049196

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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