Detailed information for compound 1209735

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1624.9 | Formula: C69H121N31O15
  • H donors: 27 H acceptors: 15 LogP: -10.52 Rotable bonds: 72
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)O)CCCNC(=N)N)CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](O)C)N)CCC(=O)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N
  • InChi: 1S/C69H121N31O15/c1-37(101)53(73)64(115)100-33-13-23-50(100)63(114)98-48(24-25-51(72)102)61(112)96-47(22-12-32-88-69(82)83)60(111)99-49(34-38-35-89-40-15-3-2-14-39(38)40)62(113)97-46(21-11-31-87-68(80)81)59(110)95-45(20-10-30-86-67(78)79)58(109)94-44(19-9-29-85-66(76)77)57(108)93-43(17-5-7-27-71)56(107)92-42(16-4-6-26-70)55(106)91-41(18-8-28-84-65(74)75)54(105)90-36-52(103)104/h2-3,14-15,35,37,41-50,53,89,101H,4-13,16-34,36,70-71,73H2,1H3,(H2,72,102)(H,90,105)(H,91,106)(H,92,107)(H,93,108)(H,94,109)(H,95,110)(H,96,112)(H,97,113)(H,98,114)(H,99,111)(H,103,104)(H4,74,75,84)(H4,76,77,85)(H4,78,79,86)(H4,80,81,87)(H4,82,83,88)/t37-,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,53+/m1/s1
  • InChiKey: XNOJGQVLZXEKDB-JYCYLZJCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens furin (paired basic amino acid cleaving enzyme) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Proprotein convertase subtilisin/kexin type 6 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Endoprotease bli-4 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Giardia lamblia High cysteine membrane protein Group 2 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) endoprotease bli-4 Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi endoprotease bli-4 precursor Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Furin-like protease 1, isoforms 1/1-X/2 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus furin Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi celfurPC protein Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Brugia malayi Protein kinase domain containing protein 0.0005 0.0002 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Echinococcus multilocularis growth factor receptor bound protein 2 0.0007 0.0063 0.0061
Onchocerca volvulus 0.005 0.1082 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0007 0.0063 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.007 0.0078
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0007 0.0063 0.0107
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0008 0.007 0.5
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0091 0.0089
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0037 0.0764 0.0762
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Echinococcus multilocularis NCK adaptor protein 0.0007 0.0063 0.0061
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0008 0.007 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0008 0.0087 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Echinococcus granulosus neuroendocrine convertase 2 0.0111 0.2531 0.2529
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0008 0.007 0.0068
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0591 0.0589
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1391 1
Brugia malayi neuroendocrine convertase 1 precursor 0.0111 0.2531 0.4411
Loa Loa (eye worm) endoprotease bli-4 0.0177 0.4092 0.7134
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0764 0.0762
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0034 0.0703 0.2724
Schistosoma mansoni site-1 peptidase (S08 family) 0.0008 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Blk 0.0033 0.0679 0.0677
Loa Loa (eye worm) proprotein convertase 2 0.0042 0.0883 0.1537
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1391 0.1391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0883 0.3475
Echinococcus granulosus Smad4 0.0008 0.0091 0.0089
Echinococcus granulosus tyrosine protein kinase Blk 0.0033 0.0679 0.0677
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0091 0.0091
Schistosoma mansoni Smad4 0.0008 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0037 0.0764 0.0762
Loa Loa (eye worm) hypothetical protein 0.0069 0.1538 0.268
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Brugia malayi SRC-1 0.0037 0.0764 0.1329
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0008 0.0087 0.0085
Schistosoma mansoni hypothetical protein 0.005 0.1082 0.1082
Giardia lamblia High cysteine membrane protein Group 2 0.0066 0.1452 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0764 0.0762
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0067 0.0065
Brugia malayi Tyrosine-protein kinase abl-1 0.0008 0.0087 0.015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.2444 1
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0008 0.007 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0037 0.0764 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.007 0.0078
Echinococcus multilocularis tyrosine protein kinase Srms 0.0033 0.0679 0.0677
Brugia malayi MH1 domain containing protein 0.0008 0.0091 0.0157
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0063 0.0107
Brugia malayi Protein kinase domain containing protein 0.0005 0.0002 0.0001
Brugia malayi Protein kinase domain containing protein 0.0005 0.0002 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0764 0.0762
Brugia malayi MH1 domain containing protein 0.0008 0.0091 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Schistosoma mansoni tyrosine kinase 0.0005 0.0002 0.0002
Schistosoma mansoni tyrosine kinase 0.0008 0.0087 0.0087
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.2841 0.4953
Brugia malayi Smad1 0.0008 0.0091 0.0157
Echinococcus granulosus membrane bound transcription factor site 1 0.0008 0.007 0.0068
Loa Loa (eye worm) histone methyltransferase 0.0009 0.011 0.0189
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0063 0.0107
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0007 0.0063 0.0063
Trichomonas vaginalis hypothetical protein 0.0034 0.0703 0.2724
Brugia malayi endoprotease bli-4 precursor 0.0177 0.4092 0.7134
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1082 0.1885
Plasmodium vivax subtilisin-like serine protease, putative 0.0008 0.007 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1235 0.8819
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1391 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.007 0.0119
Schistosoma mansoni nck2/grb4 0.0007 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0654 0.0652
Echinococcus multilocularis neuroendocrine convertase 2 0.0111 0.2531 0.2529
Loa Loa (eye worm) subtilase 0.0008 0.007 0.0119
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0037 0.0764 0.0762
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Brugia malayi MH2 domain containing protein 0.0008 0.0091 0.0157
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Schistosoma mansoni cpg binding protein 0.003 0.06 0.06
Schistosoma mansoni furin-1 (S08 family) 0.0077 0.1718 0.1718
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0067 0.0065
Brugia malayi CXXC zinc finger family protein 0.003 0.06 0.1044
Plasmodium falciparum subtilisin-like protease 2 0.0008 0.007 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.2444 1
Loa Loa (eye worm) TK protein kinase 0.003 0.0591 0.1029
Loa Loa (eye worm) TK/ABL protein kinase 0.0005 0.0002 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0037 0.0764 0.0762
Echinococcus multilocularis Smad4 0.0008 0.0091 0.0089
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0108 0.2444 0.2442
Echinococcus granulosus cpg binding protein 0.0032 0.0641 0.0639
Onchocerca volvulus 0.003 0.06 0.5535
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1391 0.1389
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0091 0.0089
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0008 0.007 0.007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.011 0.0108
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0091 0.0089
Brugia malayi Protein kinase domain containing protein 0.0005 0.0002 0.0001
Brugia malayi SH2 domain containing protein 0.0005 0.0002 0.0001
Echinococcus granulosus tyrosine protein kinase Src64B 0.0037 0.0764 0.0762
Echinococcus multilocularis membrane bound transcription factor site 1 0.0008 0.007 0.0068
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0177 0.4092 0.4092
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.007 0.0078
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0008 0.007 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0091 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0091 0.0157
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0008 0.007 0.5
Schistosoma mansoni adapter molecule crk 0.0007 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0426 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0883 0.3475
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.5735 0.5734
Schistosoma mansoni growth factor receptor-bound protein 0.0007 0.0063 0.0063
Schistosoma mansoni growth factor receptor-bound protein 0.0007 0.0063 0.0063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0067 0.0067
Brugia malayi hypothetical protein 0.0246 0.5735 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0883 0.3475
Schistosoma mansoni smad 0.0008 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.007 0.0078
Plasmodium falciparum subtilisin-like protease 3 0.0008 0.007 0.5
Trypanosoma brucei subtilisin peptidase 0.0008 0.007 0.5
Brugia malayi protein-tyrosine kinase 0.0033 0.0679 0.1181
Loa Loa (eye worm) TK protein kinase 0.0033 0.0679 0.1181
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1391 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0091 0.0091
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0008 0.007 0.5
Schistosoma mansoni site-1 peptidase (S08 family) 0.0008 0.007 0.007
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0764 0.0762
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0033 0.0679 0.0677
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0591 0.0589
Plasmodium vivax subtilisin-like protease 1 0.0008 0.007 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.0703 0.0703
Echinococcus multilocularis tyrosine protein kinase Abl 0.0008 0.0087 0.0085
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0008 0.007 0.007
Schistosoma mansoni cpg binding protein 0.0032 0.0641 0.0641
Schistosoma mansoni tyrosine kinase 0.0037 0.0764 0.0764
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0007 0.0063 0.0107
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0764 0.0762
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0037 0.0764 0.0762
Echinococcus granulosus Furin 1 0.0042 0.0883 0.0881
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1391 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.4092 0.7134
Schistosoma mansoni tyrosine kinase 0.0005 0.0002 0.0002
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0042 0.0883 0.0883
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1391 0.1389
Brugia malayi Sex muscle abnormal protein 5 0.0007 0.0063 0.0107
Brugia malayi Protein kinase domain containing protein 0.0005 0.0002 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1391 0.1391
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0008 0.0087 0.0085
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.5735 0.5734
Brugia malayi celfurPC protein 0.0143 0.3279 0.5716
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0764 0.0762
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0091 0.0089
Brugia malayi MH2 domain containing protein 0.0008 0.0091 0.0157
Schistosoma mansoni tyrosine kinase 0.0008 0.0087 0.0087
Echinococcus granulosus tyrosine kinase 0.0033 0.0679 0.0677
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1391 1
Echinococcus granulosus smad 0.0008 0.0091 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0008 0.007 0.5
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0034 0.0703 0.2724
Loa Loa (eye worm) hypothetical protein 0.0246 0.5735 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0067 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0067 0.0065
Onchocerca volvulus 0.0008 0.007 0.0627
Loa Loa (eye worm) Smad1 0.0008 0.0091 0.0157
Echinococcus multilocularis smad 0.0008 0.0091 0.0089
Echinococcus multilocularis cpg binding protein 0.0032 0.0641 0.0639
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.011 0.0108
Schistosoma mansoni tyrosine kinase 0.0037 0.0764 0.0764
Plasmodium vivax subtilisin-like protease 2, putative 0.0008 0.007 0.5
Brugia malayi hypothetical protein 0.0005 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Schistosoma mansoni smad1 5 8 and 0.0008 0.0091 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Entamoeba histolytica protein kinase, putative 0.003 0.0591 1
Brugia malayi SH2 domain containing protein 0.0005 0.0002 0.0001
Trypanosoma cruzi subtilisin peptidase 0.0008 0.007 0.5
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0008 0.007 0.0119
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.06 0.1044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Brugia malayi proprotein convertase 2 0.0111 0.2531 0.4411
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0107 0.0184
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0008 0.0087 0.0087
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0764 0.0762
Loa Loa (eye worm) SRC-1 0.0037 0.0764 0.1329
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Brugia malayi MH2 domain containing protein 0.0124 0.2841 0.4953
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0654 0.0652
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0883 0.3475
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Echinococcus granulosus furin 0.0177 0.4092 0.409
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Schistosoma mansoni survival motor neuron protein 0.005 0.1082 0.1082
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0008 0.007 0.0068
Mycobacterium leprae Possible secreted protease 0.0008 0.007 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0033 0.0679 0.0677
Echinococcus multilocularis Furin 1 0.0042 0.0883 0.0881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.2841 0.4953
Schistosoma mansoni smad1 5 8 and 0.0008 0.0091 0.0091
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0005 0.0002 0.0001
Brugia malayi Subtilase family protein 0.0008 0.007 0.0119
Echinococcus granulosus c src tyrosine kinase 0.0008 0.0087 0.0085
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Loa Loa (eye worm) hypothetical protein 0.0007 0.0063 0.0107
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0034 0.0703 0.2724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0883 0.3475
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1396 0.1396
Echinococcus multilocularis 0.0143 0.3279 0.3278
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0037 0.0764 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Plasmodium falciparum subtilisin-like protease 1 0.0008 0.007 0.5
Echinococcus granulosus NCK adaptor protein 0.0007 0.0063 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.007 0.0078
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1391 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0037 0.0764 0.0762
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0764 0.0762
Schistosoma mansoni cpg binding protein 0.0032 0.0641 0.0641
Echinococcus multilocularis dnaJ subfamily B 0.0426 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0703 0.2724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0008 0.007 0.0078
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0108 0.2444 0.2442
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0883 0.3475

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 0.1 uM Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage ChEMBL. 17537721

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.