TDR Targets

Basic information

Technical information

TDR Targets ID: 1209961
Name: ZINC02619540
MW: 361.889 | Formula: C18H20ClN3OS
H donors: 1 H acceptors: 2 LogP: 4.8 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cc2c(s1)n(nc2C)Cc1ccccc1Cl)NC(C)(C)C
InChi: 1S/C18H20ClN3OS/c1-11-13-9-15(16(23)20-18(2,3)4)24-17(13)22(21-11)10-12-7-5-6-8-14(12)19/h5-9H,10H2,1-4H3,(H,20,23)
InChiKey: GLUWQMOOSFQALM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000566111
SMR000153215
T5259009

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0082	0.0298
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0525	0.0713
Mycobacterium ulcerans	hypothetical protein	0.0161	0.1368	1
Plasmodium vivax	vivapain-2	0.0054	0.0333	0.4753
Leishmania major	acetyl-CoA synthetase, putative	0.0036	0.0164	0.0593
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0059	0.0382	0.0382
Trichomonas vaginalis	set domain proteins, putative	0.0484	0.4482	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.1668	0.3605
Trichomonas vaginalis	antibiotic synthetase, putative	0.0036	0.0164	0.0185
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0333	0.057
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0025	0.0025
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0036	0.0164	0.0768
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0043	0.023	0.0834
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0305	0.2762	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0164	0.0418
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0061	0.0404	0.0404
Echinococcus granulosus	geminin	0.0205	0.1789	0.1789
Mycobacterium ulcerans	acyl-CoA synthetase	0.0123	0.1	0.6951
Onchocerca volvulus		0.0036	0.0162	0.0307
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0321	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0025	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0333	0.0851
Trypanosoma cruzi	cysteine peptidase, putative	0.0204	0.1786	0.6469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0036	0.0164	0.0768
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0391	0.1886
Schistosoma mansoni	tar DNA-binding protein	0.0397	0.3649	0.4958
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0123	0.1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0025	0.0065
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0653	0.3062
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0082	0.0611	0.0611
Schistosoma mansoni	acetyl-CoA synthetase	0.0036	0.0164	0.0223
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0025	0.0025
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0333	0.0851
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0164	0.0418
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0043	0.023	0.0834
Brugia malayi	nuclear hormone receptor	0.0022	0.0025	0.0065
Loa Loa (eye worm)	acetyltransferase	0.0142	0.1188	0.3034
Echinococcus granulosus	cathepsin L cysteine protease	0.0028	0.0082	0.0082
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0333	0.057
Echinococcus granulosus	histone lysine methyltransferase setb	0.0061	0.0404	0.0404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0162	0.0181
Echinococcus granulosus	tumor protein p63	0.0716	0.6721	0.6721
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0025	0.0065
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0025	0.0035
Echinococcus granulosus	tar DNA binding protein	0.0397	0.3649	0.3649
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0036	0.0164	0.4053
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0257	0.0257
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0025	0.0025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0082	0.0611	0.156
Leishmania major	cathepsin L-like protease	0.0204	0.1786	0.6469
Mycobacterium ulcerans	lipase LipD	0.0038	0.0178	0.0122
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0404	0.0549
Onchocerca volvulus		0.0036	0.0164	0.031
Loa Loa (eye worm)	fibroinase	0.0054	0.0333	0.0851
Brugia malayi	MH2 domain containing protein	0.0135	0.1121	0.2863
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0178	0.0122
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0082	0.021
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0333	0.057
Trichomonas vaginalis	glucosylceramidase, putative	0.0293	0.2639	0.5811
Schistosoma mansoni	hypothetical protein	0.0082	0.0611	0.083
Leishmania major	cathepsin L-like protease	0.0054	0.0333	0.1207
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0261	0.2329	0.5947
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0162	0.022
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0333	0.1207
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0025	0.0035
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0333	0.069
Echinococcus multilocularis	GPCR, family 2	0.0082	0.0611	0.0611
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0025	0.0025
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0145	0.121	0.4382
Mycobacterium ulcerans	acyl-CoA synthetase	0.0123	0.1	0.6951
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0178	0.0178
Schistosoma mansoni	hypothetical protein	0.0082	0.0611	0.083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0162	0.0181
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.1668	0.3605
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0391	0.0391
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0178	0.0218
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0061	0.0404	0.0404
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0025	0.0065
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0025	0.0025
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.022	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0404	0.1032
Loa Loa (eye worm)	oxidoreductase	0.0036	0.0164	0.0418
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0025	0.0065
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0333	0.0851
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0028	0.0082	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0178	0.0456
Onchocerca volvulus		0.0038	0.0178	0.0343
Leishmania major	cathepsin L-like protease	0.0204	0.1786	0.6469
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0025	0.0065
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0036	0.0164	0.0593
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0178	0.0218
Trichomonas vaginalis	glucosylceramidase, putative	0.0293	0.2639	0.5811
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0092	0.0701	0.3288
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0036	0.0164	0.4053
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.0333	0.4753
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0025	0.0035
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0257	0.0349
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0123	0.1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0202	0.1768	0.3831
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0162	0.0869
Echinococcus multilocularis	geminin	0.0205	0.1789	0.1789
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0161	0.1368	0.6415
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.0333	0.4753
Schistosoma mansoni	microtubule-associated protein tau	0.0782	0.736	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0164	0.0418
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.1188	0.1188
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0186	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0025	0.0025
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0082	0.0112
Plasmodium vivax	SET domain protein, putative	0.0061	0.0404	0.5764
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0391	0.1833
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0178	0.0456
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0391	0.0391
Plasmodium vivax	vivapain-1	0.0028	0.0082	0.1176
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.0333	0.0333
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0404	0.0549
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0164	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0201	0.1755	0.4482
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0391	0.9672
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0404	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0701	0.179
Echinococcus multilocularis	neuropeptide receptor A26	0.1056	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0178	0.0218
Echinococcus multilocularis	cathepsin L	0.0028	0.0082	0.0082
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0025	0.0065
Loa Loa (eye worm)	MH2 domain-containing protein	0.0135	0.1121	0.2863
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0025	0.0065
Onchocerca volvulus		0.0036	0.0164	0.031
Schistosoma mansoni	hypothetical protein	0.0178	0.1534	0.2084
Brugia malayi	cathepsin L-like precursor	0.0036	0.0162	0.0414
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.022	0.5432
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0092	0.0701	0.5
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0293	0.2639	0.674
Trichomonas vaginalis	glucosylceramidase, putative	0.0293	0.2639	0.5811
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0025	0.0025
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.0333	0.1207
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Brugia malayi	AMP-binding enzyme family protein	0.0123	0.1	0.2555
Trichomonas vaginalis	esterase, putative	0.0038	0.0178	0.0218
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0305	0.2762	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0036	0.0164	0.0418
Schistosoma mansoni	cellular tumor antigen P53	0.0105	0.0827	0.1123
Plasmodium vivax	acyl-CoA synthetase, putative	0.0092	0.0701	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.022	0.5432
Plasmodium falciparum	acyl-CoA synthetase	0.0092	0.0701	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0161	0.1365	0.4942
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0257	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1534	0.3916
Leishmania major	cathepsin L-like protease	0.0204	0.1786	0.6469
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0025	0.0035
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0025	0.0065
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0178	0.0176
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0025	0.0035
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.115	0.115
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0123	0.1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0123	0.1	0.3623
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0178	0.0837
Toxoplasma gondii	hypothetical protein	0.0049	0.0291	0.7204
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0025	0.0065
Onchocerca volvulus		0.0061	0.0404	0.085
Echinococcus granulosus	GPCR family 2	0.0082	0.0611	0.0611
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.1668	0.3605
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.0333	0.069
Entamoeba histolytica	hypothetical protein	0.0074	0.0525	0.4819
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0025	0.0065
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0425	0.3916	1
Leishmania major	mitochondrial DNA polymerase beta	0.0305	0.2762	1
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0025	0.0025
Loa Loa (eye worm)	RNA binding protein	0.0397	0.3649	0.9318
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0525	0.0525
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0333	0.2731
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0025	0.0065
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0082	0.0298
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0611	0.156
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.0333	0.0851
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.1668	0.3605
Echinococcus multilocularis	microtubule associated protein 2	0.0782	0.736	0.736
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0333	0.069
Trypanosoma cruzi	cysteine peptidase, putative	0.0204	0.1786	0.6469
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0178	0.0837
Brugia malayi	RNA binding protein	0.0397	0.3649	0.9318
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0031	0.0115	0.0542
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0178	0.0837
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0333	0.2731
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0082	0.0611	0.0611
Leishmania major	cathepsin L-like protease	0.0054	0.0333	0.1207
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0025	0.0065
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0178	0.0646
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0333	0.2731
Leishmania major	4-coumarate:coa ligase-like protein	0.0123	0.1	0.3623
Toxoplasma gondii	ABC1 family protein	0.0038	0.0178	0.4417
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0701	0.179
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0025	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0178	0.0456
Echinococcus multilocularis	tar DNA binding protein	0.0397	0.3649	0.3649
Onchocerca volvulus		0.0038	0.0178	0.0343
Leishmania major	cathepsin L-like protease	0.0054	0.0333	0.1207
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0123	0.1	0.6951
Echinococcus multilocularis	neuropeptide s receptor	0.1056	1	1
Onchocerca volvulus		0.0054	0.0333	0.069
Toxoplasma gondii	cathepsin CPL	0.0054	0.0333	0.8246
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0333	0.0851
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0178	0.2546
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0036	0.0164	0.0418
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0082	0.0112
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0178	0.0122
Brugia malayi	ecdysteroid receptor	0.0022	0.0025	0.0065
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0082	0.0112
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0025	0.0025
Echinococcus granulosus	cathepsin l1	0.0036	0.0162	0.0162
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.0333	0.0333
Brugia malayi	TAR-binding protein	0.0397	0.3649	0.9318
Brugia malayi	AMP-binding enzyme family protein	0.0123	0.1	0.2555
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0123	0.1	0.6951
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0025	0.0035
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0025	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0701	0.179
Trichomonas vaginalis	glucosylceramidase, putative	0.0293	0.2639	0.5811
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0036	0.0164	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0178	0.0456
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0333	0.057
Onchocerca volvulus		0.0054	0.0333	0.069
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0025	0.0065
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0025	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0178	0.0456
Brugia malayi	Pre-SET motif family protein	0.0061	0.0404	0.1032
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0123	0.1	1
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0333	0.0851
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0025	0.0065
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0164	0.0418
Brugia malayi	beta-lactamase family protein	0.0038	0.0178	0.0456
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.1668	0.3605
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0036	0.0164	0.0768
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0653	0.3062
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0391	0.1886
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0025	0.0065
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0305	0.2762	1
Echinococcus multilocularis	cysteine protease	0.0054	0.0333	0.0333
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0333	0.0851
Toxoplasma gondii	propionate-CoA ligase	0.0036	0.0164	0.4053
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0025	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0025	0.0065
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0178	0.0837
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0257	0.0655
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0391	0.0531
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0025	0.0025
Trichomonas vaginalis	glucosylceramidase, putative	0.0293	0.2639	0.5811
Mycobacterium ulcerans	acyl-CoA synthetase	0.0123	0.1	0.6951
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0653	0.3062
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0025	0.0025
Onchocerca volvulus		0.0054	0.0333	0.069
Schistosoma mansoni	tar DNA-binding protein	0.0397	0.3649	0.4958
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0178	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1	0.2555
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0397	0.3649	0.9318
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0025	0.0065
Brugia malayi	steroid hormone receptor	0.0022	0.0025	0.0065
Entamoeba histolytica	acyl-coA synthetase, putative	0.0123	0.1	1
Trypanosoma cruzi	cysteine protease, putative	0.0028	0.0082	0.0298
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0178	0.0646
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0186	0.2652
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2329	0.5947
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0025	0.0065
Leishmania major	hypothetical protein, conserved	0.0038	0.0178	0.0646
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.1668	0.3605
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0333	0.057
Leishmania major	acetyl-CoA synthetase, putative	0.0036	0.0164	0.0593
Schistosoma mansoni	tar DNA-binding protein	0.0397	0.3649	0.4958
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.0082	0.0298
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0162	0.0414
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0164	0.0768
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0178	0.0178
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0178	0.0837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.0333	0.4753
Echinococcus granulosus	cysteine protease	0.0028	0.0082	0.0082
Schistosoma mansoni	hypothetical protein	0.0074	0.0525	0.0713
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.023	0.0834
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0082	0.0298
Trichomonas vaginalis	glucosylceramidase, putative	0.0202	0.1768	0.3831
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0036	0.0164	0.0886
Trypanosoma cruzi	cysteine peptidase, putative	0.0204	0.1786	0.6469
Echinococcus granulosus	cathepsin L	0.0028	0.0082	0.0082
Onchocerca volvulus		0.0054	0.0333	0.069
Schistosoma mansoni	hypothetical protein	0.0082	0.0611	0.083
Echinococcus multilocularis	cysteine protease	0.0054	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0178	0.0456
Brugia malayi	latrophilin 2 splice variant baaae	0.0178	0.1534	0.3916
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0162	0.0414
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.0333	0.0453
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0036	0.0164	0.0593
Schistosoma mansoni	tar DNA-binding protein	0.0397	0.3649	0.4958
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0025	0.0035
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0025	0.0025
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0025	0.0065
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0036	0.0164	0.0768
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0025	0.0065
Trichomonas vaginalis	antibiotic synthetase, putative	0.0036	0.0164	0.0185
Plasmodium vivax	vivapain-3	0.0028	0.0082	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0025	0.0065
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.0333	0.0333
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.1188	0.3034
Echinococcus granulosus	neuropeptide receptor A26	0.1056	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.0333	0.057
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0025	0.0025
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0092	0.0701	0.4463
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0025	0.0025
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0187	0.1615	0.585
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0178	0.0122
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0025	0.0035
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0391	0.0531
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0025	0.0065
Schistosoma mansoni	hypothetical protein	0.0082	0.0611	0.083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Brugia malayi	AMP-binding enzyme family protein	0.0123	0.1	0.2555
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0178	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0827	0.2111
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0036	0.0162	0.0414
Mycobacterium ulcerans	hypothetical protein	0.0123	0.1	0.6951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.022	0.0312
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0025	0.0035
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0036	0.0164	0.0593
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0145	0.121	0.4382
Onchocerca volvulus		0.0123	0.1	0.2188
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0025	0.0025
Leishmania major	cathepsin L-like protease	0.0054	0.0333	0.1207
Onchocerca volvulus		0.0054	0.0333	0.069
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0025	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0025	0.0065
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0178	0.0837
Echinococcus multilocularis	tumor protein p63	0.0716	0.6721	0.6721
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0162	0.0414
Loa Loa (eye worm)	transcription factor SMAD2	0.0135	0.1121	0.2863
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0178	0.0646
Entamoeba histolytica	hypothetical protein	0.0074	0.0525	0.4819
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0525	0.0525
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0178	0.0176
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.0333	0.0333
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0082	0.0611	0.0611
Schistosoma mansoni	coup transcription factor	0.0022	0.0025	0.0035
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0025	0.0035
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0178	0.0837
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0391	0.1886
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0178	0.0456
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0333	0.0851
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0036	0.0164	0.0164
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.1668	0.3605
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0123	0.1	0.6951
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0164	0.0768
Onchocerca volvulus		0.0036	0.0164	0.031
Loa Loa (eye worm)	cysteine protease	0.0054	0.0333	0.0851
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0201	0.1755	0.4482
Schistosoma mansoni	hypothetical protein	0.0205	0.1789	0.2431
Schistosoma mansoni	hypothetical protein	0.0205	0.1789	0.2431
Onchocerca volvulus		0.0484	0.4482	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0257	0.0349
Plasmodium vivax	unspecified product	0.0028	0.0082	0.1176
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.023	0.0834
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.022	0.3131
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0061	0.0404	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.022	0.022
Brugia malayi	RNA recognition motif domain containing protein	0.0397	0.3649	0.9318
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0028	0.0082	0.0298
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0261	0.2329	0.5947
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0333	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0178	0.0456
Entamoeba histolytica	hypothetical protein	0.0074	0.0525	0.4819
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.1702	0.3681
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0036	0.0164	0.0593
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0025	0.0025
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0123	0.1	0.4693
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0036	0.0164	0.0768
Brugia malayi	beta-lactamase family protein	0.0038	0.0178	0.0456
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0333	0.057
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0025	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0162	0.0414
Brugia malayi	hypothetical protein	0.0074	0.0525	0.134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.2132	1
Brugia malayi	Pre-SET motif family protein	0.0425	0.3916	1
Schistosoma mansoni	tar DNA-binding protein	0.0397	0.3649	0.4958
Echinococcus granulosus	microtubule associated protein 2	0.0782	0.736	0.736
Onchocerca volvulus		0.0054	0.0333	0.069
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0025	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0701	0.179
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0082	0.0611	0.156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0257	0.0349
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0025	0.0065
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0061	0.0404	0.0549
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0257	0.0257
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0257	0.0257
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.0333	0.0453
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0036	0.0164	0.2336
Trichomonas vaginalis	glucosylceramidase, putative	0.0293	0.2639	0.5811
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0036	0.0164	0.0768
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.0333	0.0333
Loa Loa (eye worm)	ctsf protein	0.0054	0.0333	0.0851
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0178	0.0218
Leishmania major	4-coumarate:coa ligase-like protein	0.0123	0.1	0.3623
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0333	0.057
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0036	0.0164	0.0593
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0025	0.0025
Onchocerca volvulus		0.0054	0.0333	0.069
Loa Loa (eye worm)	TAR-binding protein	0.0397	0.3649	0.9318
Plasmodium vivax	vivapain-2	0.0054	0.0333	0.4753
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0036	0.0164	0.0593
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0082	0.0298
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0145	0.121	0.4382
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.0333	0.057
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0082	0.0611	0.0611
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0164	0.0418
Brugia malayi	beta-lactamase	0.0038	0.0178	0.0456
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0178	0.0837
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0082	0.021
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0036	0.0164	0.2336
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0123	0.1	0.4693
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Trypanosoma cruzi	cruzipain precursor, putative	0.0204	0.1786	0.6469
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1	0.2555
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0036	0.0164	0.0593
Onchocerca volvulus		0.0036	0.0164	0.031
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.0333	0.0851
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0293	0.2639	0.674
Onchocerca volvulus		0.0105	0.0827	0.1798
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0178	0.0837
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0178	0.0243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0391	0.1415
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0261	0.2329	0.5947
Entamoeba histolytica	hypothetical protein	0.0074	0.0525	0.4819
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0025	0.0065
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0257	0.0655
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0186	0.1127
Echinococcus granulosus	cathepsin l1	0.0054	0.0333	0.0333
Brugia malayi	Latrophilin receptor protein 2	0.0082	0.0611	0.156
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1	0.2555
Onchocerca volvulus		0.0038	0.0178	0.0343
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0333	0.057
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0036	0.0164	0.0418
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0036	0.0164	0.0768
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0333	0.057
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.1786	0.6469
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0701	0.179
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0162	0.0414
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0025	0.0035
Leishmania major	cathepsin L-like protease	0.0054	0.0333	0.1207
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0653	0.3062
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0025	0.0065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0333	0.057
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0123	0.1	0.6951
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0178	0.0218
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0164	0.0768
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.1188	0.1614
Onchocerca volvulus	Glucosylceramidase homolog	0.0192	0.1668	0.3686
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0178	0.0837
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0178	0.0456
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0025	0.0065
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0036	0.0164	0.0164
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0164	0.0768

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.3078 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	75.6863 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1323829

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1209961