Detailed information for compound 1210065

Basic information

Technical information
  • TDR Targets ID: 1210065
  • Name: [2-[(2,4-dimethoxyphenyl)amino]-2-oxoethyl] 2 -(4-phenylphenyl)acetate
  • MW: 405.443 | Formula: C24H23NO5
  • H donors: 1 H acceptors: 2 LogP: 4.18 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1NC(=O)COC(=O)Cc1ccc(cc1)c1ccccc1
  • InChi: 1S/C24H23NO5/c1-28-20-12-13-21(22(15-20)29-2)25-23(26)16-30-24(27)14-17-8-10-19(11-9-17)18-6-4-3-5-7-18/h3-13,15H,14,16H2,1-2H3,(H,25,26)
  • InChiKey: NKWYFYDBUNXYDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[(2,4-dimethoxyphenyl)amino]-2-oxo-ethyl] 2-(4-phenylphenyl)acetate
  • 2-(4-phenylphenyl)acetic acid [2-[(2,4-dimethoxyphenyl)amino]-2-oxoethyl] ester
  • 2-(4-phenylphenyl)acetic acid [2-[(2,4-dimethoxyphenyl)amino]-2-keto-ethyl] ester
  • [2-[(2,4-dimethoxyphenyl)amino]-2-oxo-ethyl] 2-(4-phenylphenyl)ethanoate
  • ZINC03297813
  • MLS000392207
  • SMR000261158
  • T0515-4406

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0032 0.0137 0.1565
Entamoeba histolytica hypothetical protein 0.0035 0.0171 0.5064
Mycobacterium ulcerans beta-lactamase 0.0041 0.0242 0.1141
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0032 0.0137 0.4704
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0189 0.2066 0.1997
Onchocerca volvulus 0.0041 0.0242 0.0919
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.064 0.3019
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0242 0.0815
Schistosoma mansoni hypothetical protein 0.0138 0.1436 0.135
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0032 0.0137 0.0645
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.064 0.2158
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0001 0.0005
Brugia malayi beta-lactamase family protein 0.0041 0.0242 0.0873
Echinococcus granulosus GPCR family 2 0.0064 0.0523 0.0441
Mycobacterium ulcerans Type I modular polyketide synthase 0.0129 0.133 0.6279
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0129 0.133 0.6278
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0089 0.032
Schistosoma mansoni jumonji domain containing protein 0.015 0.1587 0.1502
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0523 0.0441
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.064 0.0545
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0597 0.0503
Loa Loa (eye worm) hypothetical protein 0.0202 0.2223 0.9154
Toxoplasma gondii ABC1 family protein 0.0041 0.0242 0.1417
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0043 0.0966
Mycobacterium tuberculosis Conserved protein 0.0039 0.0217 0.0731
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0141 0.0696
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.01 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.01 0.0411
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0523 0.2155
Mycobacterium ulcerans hypothetical protein 0.0041 0.0242 0.1141
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.064 0.0545
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0141 0.4915
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0367
Loa Loa (eye worm) acyl carrier protein 0.006 0.0469 0.1933
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.064 0.3019
Trichomonas vaginalis esterase, putative 0.0041 0.0242 0.0104
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0032 0.0137 0.0037
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0141 0.0041
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0141 0.0507
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.2223 0.9154
Brugia malayi hypothetical protein 0.0035 0.0171 0.0615
Mycobacterium leprae Polyketide synthase Pks13 0.0193 0.2119 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.025 1
Onchocerca volvulus 0.0234 0.2614 0.9981
Brugia malayi hypothetical protein 0.0165 0.1764 0.6396
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0242 0.0143
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0125 0.1281 0.4324
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0242 0.1141
Mycobacterium tuberculosis Conserved protein 0.0041 0.0242 0.0815
Loa Loa (eye worm) hypothetical protein 0.0219 0.2428 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0242 0.0873
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1407 0.132
Onchocerca volvulus 0.0041 0.0242 0.0919
Echinococcus multilocularis peregrin 0.0058 0.0448 0.0351
Schistosoma mansoni hypothetical protein 0.0352 0.4072 0.4012
Loa Loa (eye worm) fatty acid synthase 0.0128 0.1309 0.5391
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0171 0.0085
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.064 0.0558
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0104 0.1019 0.4809
Loa Loa (eye worm) hypothetical protein 0.0099 0.0956 0.3936
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0089 0.0421
Mycobacterium ulcerans polyketide synthase MbtC 0.0032 0.0137 0.0645
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0242 1
Brugia malayi Bromodomain containing protein 0.0058 0.0448 0.162
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0141 0.0475
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.064 0.0545
Entamoeba histolytica hypothetical protein 0.0035 0.0171 0.5064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0523 0.2155
Loa Loa (eye worm) hypothetical protein 0.0138 0.1436 0.5914
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0137 0.1429 0.6745
Onchocerca volvulus 0.0029 0.0089 0.0337
Mycobacterium ulcerans thioesterase TesA 0.0108 0.1065 0.5025
Mycobacterium tuberculosis Probable thioesterase TesA 0.0108 0.1065 0.3592
Mycobacterium ulcerans thioesterase 0.0108 0.1065 0.5025
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0129 0.133 0.4489
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0089 0.0769
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0523 0.0441
Brugia malayi Pre-SET motif family protein 0.0029 0.01 0.0358
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0597 0.246
Echinococcus multilocularis GPCR, family 2 0.0064 0.0523 0.0428
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0001 0.0005
Onchocerca volvulus 0.0165 0.1764 0.6734
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0242 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0242 0.0815
Loa Loa (eye worm) hypothetical protein 0.0041 0.0242 0.0995
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0242 0.0815
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0089 0.0416
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.1022 0.4209
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.9744 0.9742
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0242 0.1141
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0523 0.1895
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0242 0.0815
Mycobacterium ulcerans Type I modular polyketide synthase 0.0129 0.133 0.6279
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0242 0.0815
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0106 0.104 0.3509
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0032 0.0137 0.305
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0129 0.133 0.4489
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0137 0.1429 0.6745
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0032 0.0137 0.0645
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.1022 0.3704
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0104 0.1019 0.4807
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0141 0.0055
Echinococcus multilocularis geminin 0.0352 0.4072 0.4012
Leishmania major hypothetical protein, conserved 0.0039 0.0217 0.2908
Loa Loa (eye worm) hypothetical protein 0.0165 0.1764 0.7264
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0067 0.0556 0.3664
Echinococcus granulosus tar DNA binding protein 0.0136 0.1407 0.1332
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0089 0.0421
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0032 0.0137 0.0562
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0041 0.0237 0.08
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1189 0.4898
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0448 0.0364
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0032 0.0137 0.0037
Brugia malayi beta-lactamase 0.0041 0.0242 0.0873
Plasmodium vivax SET domain protein, putative 0.0029 0.01 0.2229
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0242 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0129 0.133 0.6278
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0032 0.0137 0.5
Giardia lamblia PHD finger protein 15 0.0058 0.0448 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0137 0.1429 0.6747
Entamoeba histolytica hypothetical protein 0.0035 0.0171 0.5064
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.1436 0.5207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1022 0.0932
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0178
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0086 0.079 0.3731
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1022 0.0944
Loa Loa (eye worm) hypothetical protein 0.0058 0.0448 0.1844
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0032 0.0137 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0242 0.0104
Echinococcus multilocularis tar DNA binding protein 0.0136 0.1407 0.132
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0089 0.0421
Echinococcus granulosus geminin 0.0352 0.4072 0.402
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0193 0.2119 0.7149
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0242 0.0143
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0089 0.0416
Mycobacterium ulcerans fatty acid synthase Fas 0.0041 0.0237 0.1119
Schistosoma mansoni hypothetical protein 0.0058 0.0448 0.0351
Brugia malayi TAR-binding protein 0.0136 0.1407 0.5101
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0141 0.3144
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0448 0.1844
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0523 0.0428
Toxoplasma gondii type I fatty acid synthase, putative 0.0092 0.0871 0.5911
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0242 0.0157
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2269 0.9344
Brugia malayi beta-lactamase family protein 0.0041 0.0242 0.0873
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0242 0.0995
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0367
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0104 0.1019 0.4809
Loa Loa (eye worm) hypothetical protein 0.0041 0.0242 0.0995
Mycobacterium ulcerans hypothetical protein 0.0029 0.0089 0.0421
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0189 0.2066 0.1986
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1407 0.132
Brugia malayi Methyltransferase-like protein 4 0.0039 0.0217 0.0782
Loa Loa (eye worm) hypothetical protein 0.0041 0.0242 0.0995
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.064 0.3019
Loa Loa (eye worm) TAR-binding protein 0.0136 0.1407 0.5794
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0032 0.0137 0.0492
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0141 0.058
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0108 0.1065 0.5023
Onchocerca volvulus Alhambra homolog 0.0058 0.0448 0.1706
Loa Loa (eye worm) hypothetical protein 0.0041 0.0242 0.0995
Onchocerca volvulus 0.0129 0.1329 0.5073
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0245 0.2757 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0125 0.1281 0.4324
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0041 0.0237 0.1115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1022 0.0944
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0129 0.1329 0.5473
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0089 0.0421
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0141 0.0696
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0086 0.079 0.3728
Brugia malayi hypothetical protein 0.0025 0.0043 0.0153
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0141 0.4915
Brugia malayi PHD-finger family protein 0.0058 0.0448 0.162
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.064 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0242 0.0104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0141 0.0041
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0523 0.0428
Schistosoma mansoni hypothetical protein 0.0064 0.0523 0.0428
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0129 0.133 0.4823
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0242 0.5397
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0137 0.1429 0.6747
Onchocerca volvulus 0.0041 0.0242 0.0919
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0044 0.0284 0.096
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0171 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0089 0.032
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0597 0.0503
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0141 0.3144
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.1407 0.5794
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.064 0.4258
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0001 0.0004
Brugia malayi jmjC domain containing protein 0.007 0.0597 0.2163
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0137 0.1429 0.4823
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0141 0.4915
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0242 0.1136
Brugia malayi jmjC domain containing protein 0.0189 0.2066 0.749
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0726 0.0633
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0141 0.0041
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0001 0.0004
Plasmodium falciparum phd finger protein, putative 0.0058 0.0448 1
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1407 0.132
Schistosoma mansoni methyltransferase-related 0.0039 0.0217 0.0118
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0032 0.0137 0.0666
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1022 0.0932
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0032 0.0137 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0089 0.0769
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0032 0.0137 0.4704
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0241 0.087
Mycobacterium tuberculosis Conserved protein 0.0041 0.0242 0.0815
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0242 0.0143
Toxoplasma gondii type I fatty acid synthase, putative 0.0139 0.1444 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0242 0.0995
Onchocerca volvulus 0.0234 0.2619 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0242 0.0104
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0137 0.1429 0.4823
Mycobacterium ulcerans lipase LipD 0.0041 0.0242 0.1141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.2223 0.8061
Schistosoma mansoni hypothetical protein 0.0352 0.4072 0.4012
Mycobacterium tuberculosis Hypothetical protein 0.0039 0.0217 0.0731
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0001 0.0005
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0032 0.0137 0.4704
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0129 0.133 0.4489
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0448 0.2888
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0523 0.1895
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0137 0.1429 0.4823
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0089 0.0301
Loa Loa (eye worm) hypothetical protein 0.0041 0.0242 0.0995
Brugia malayi Pre-SET motif family protein 0.0206 0.2269 0.8228
Onchocerca volvulus 0.0029 0.01 0.0377
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1407 0.132
Echinococcus granulosus jumonji domain containing protein 0.008 0.0726 0.0645
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0129 0.133 0.6279
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0043 0.0966
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0141 0.4915
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0052 0.0381 0.1286
Mycobacterium ulcerans polyketide synthase 0.0137 0.1429 0.6747
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0171 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0129 0.1329 0.4818
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.1205 0.4962
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0093 0.0881 0.2974
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0141 0.1635
Brugia malayi isocitrate dehydrogenase 0.0033 0.0141 0.0507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0089 0.0301
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0367
Brugia malayi RNA binding protein 0.0136 0.1407 0.5101
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2619 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0448 0.0351
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0448 0.2888
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.2964 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1022 0.0932
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0242 0.0104
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0089 0.0769
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0001 0.0005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0242 0.0815
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0242 0.0815
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0089 0.0421
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0448 0.0351
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0084 0.077 0.5193
Mycobacterium ulcerans polyketide synthase MbtD 0.004 0.0227 0.1069
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0597 0.0503
Mycobacterium ulcerans polyketide synthase Pks9 0.0086 0.079 0.3731
Schistosoma mansoni hypothetical protein 0.0035 0.0171 0.0072
Schistosoma mansoni hypothetical protein 0.0064 0.0523 0.0428
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0032 0.0126 0.0425
Loa Loa (eye worm) hypothetical protein 0.0073 0.0629 0.2592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1022 0.0932
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0089 0.032
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0089 0.0421
Brugia malayi MH2 domain containing protein 0.0118 0.1189 0.4311
Schistosoma mansoni hypothetical protein 0.0064 0.0523 0.0428
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0242 0.0815
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.1407 0.5101
Schistosoma mansoni tar DNA-binding protein 0.0136 0.1407 0.132
Entamoeba histolytica hypothetical protein 0.0035 0.0171 0.5064
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0129 0.1329 0.4485
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1022 0.0932
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0242 0.0104
Loa Loa (eye worm) beta-lactamase 0.0041 0.0242 0.0995
Echinococcus granulosus peregrin 0.0058 0.0448 0.0364
Leishmania major hypothetical protein, conserved 0.0041 0.0242 0.3326
Mycobacterium ulcerans polyketide synthase 0.0129 0.133 0.6279
Loa Loa (eye worm) RNA binding protein 0.0136 0.1407 0.5794
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.2223 0.8061
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0141 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1189 0.4898
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0001 0.0004
Mycobacterium ulcerans polyketide synthase Pks13 0.0193 0.2119 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0141 0.0041
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0141 0.0041
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0032 0.0137 0.305
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0089 0.0421
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0448 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0001 0.0005
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.004 0.0227 0.0764
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0074 0.0643 0.2168
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.01 0.0404
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0597 0.0515
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0193 0.2119 0.7149
Schistosoma mansoni hypothetical protein 0.0064 0.0523 0.0428
Onchocerca volvulus Fatty acid synthase homolog 0.0233 0.261 0.9964
Mycobacterium leprae Probable lipase LipE 0.0041 0.0242 0.1136
Mycobacterium ulcerans Type I modular polyketide synthase 0.0129 0.133 0.6279
Mycobacterium leprae Probable polyketide synthase Pks1 0.0137 0.1429 0.6745
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0001 0.0004
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0043 0.0966

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.