TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 301.344 | Formula: C13H7N3O2S2
H donors: 1 H acceptors: 4 LogP: 2.38 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cccnc1SC1=N[S+](=O)(c2c1cccc2)[O-]
InChi: 1S/C13H7N3O2S2/c14-8-9-4-3-7-15-12(9)19-13-10-5-1-2-6-11(10)20(17,18)16-13/h1-7H
InChiKey: HNFFGLRPZDNLJO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Leishmania mexicana	pyruvate kinase, putative	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium knowlesi	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Theileria parva	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium falciparum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Neospora caninum	Pyruvate kinase (EC 2.7.1.40), related	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma congolense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Babesia bovis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	Pyruvate kinase, muscle isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania donovani	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei	pyruvate kinase 1	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium berghei	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase-PB	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium vivax	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium parvum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Giardia lamblia	Pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium leprae	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	Pyruvate kinase isozyme R, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium yoelii	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium hominis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	Pyruvate kinase, M2 isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Entamoeba histolytica	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium ulcerans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	ko:K00873 pyruvate kinase [EC2.7.1.40], putative	Get druggable targets OG5_126685	All targets in OG5_126685
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Toxoplasma gondii	pyruvate kinase PyK1	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Chlamydia trachomatis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyruvate kinase	pyruvate kinase, putative	498 aa	515 aa	27.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0129	0.1698	0.3137
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0201	0.2834	0.5424
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0291	0.019
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Trypanosoma cruzi	DNA damage repair protein, putative	0.004	0.0291	0.019
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0226	0.3232	0.3161
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0112	0.1431	0.1341
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0103	0.0143
Leishmania major	DNA damage repair protein, putative	0.004	0.0291	0.019
Brugia malayi	jmjC domain containing protein	0.0078	0.09	0.1247
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0226	0.3232	1
Giardia lamblia	PHD finger protein 15	0.0065	0.0684	0.3639
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0141	0.0038
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0398	0.0693
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Trypanosoma cruzi	trypanothione reductase, putative	0.0088	0.105	0.0957
Brugia malayi	polk-prov protein	0.004	0.0291	0.0404
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0296	0.041
Leishmania major	DNA polymerase eta, putative	0.0154	0.2088	0.2006
Echinococcus granulosus	thioredoxin glutathione reductase	0.0089	0.1069	0.1859
Echinococcus granulosus	pyruvate kinase	0.004	0.0296	0.0514
Trypanosoma brucei	DNA polymerase kappa, putative	0.0089	0.1065	0.0972
Mycobacterium ulcerans	DNA polymerase IV	0.0129	0.1698	0.3137
Trypanosoma brucei	DNA damage repair protein, putative	0.004	0.0291	0.019
Treponema pallidum	NADH oxidase	0.003	0.0141	0.5
Loa Loa (eye worm)	RNA binding protein	0.0134	0.1781	0.247
Brugia malayi	F/Y-rich N-terminus family protein	0.0024	0.0033	0.0046
Trichomonas vaginalis	DNA polymerase eta, putative	0.0129	0.1698	0.1957
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0141	0.5
Toxoplasma gondii	NADPH-glutathione reductase	0.003	0.0141	0.0188
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0309	0.4553	0.4496
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.003	0.0141	0.0038
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.0742	0.129
Mycobacterium tuberculosis	Probable oxidoreductase	0.0223	0.3188	0.6138
Echinococcus granulosus	lysine specific demethylase 5A	0.0078	0.09	0.1564
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.0038
Giardia lamblia	Pyruvate kinase	0.004	0.0296	0.1206
Brugia malayi	TAR-binding protein	0.0134	0.1781	0.247
Echinococcus multilocularis	dna polymerase kappa	0.0129	0.1698	0.2954
Loa Loa (eye worm)	hypothetical protein	0.017	0.2354	0.3265
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0103	0.0983
Toxoplasma gondii	pyruvate kinase PyK1	0.004	0.0296	0.0969
Onchocerca volvulus		0.0543	0.8255	1
Brugia malayi	glutaminase DH11.1	0.0283	0.4141	0.5743
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.0742	0.129
Onchocerca volvulus	Pyruvate kinase homolog	0.004	0.0296	0.0358
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0223	0.3188	1
Mycobacterium ulcerans	hypothetical protein	0.0344	0.5106	1
Trichomonas vaginalis	pyruvate kinase, putative	0.004	0.0296	0.0236
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0092	0.1112	0.102
Plasmodium falciparum	thioredoxin reductase	0.0088	0.105	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0154	0.2088	1
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0161	0.0281
Plasmodium vivax	SET domain protein, putative	0.0068	0.0742	0.7061
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.003	0.0141	0.0245
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0037	0.024	0.0138
Trichomonas vaginalis	rotamase, putative	0.0038	0.0254	0.0185
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0226	0.3232	0.4482
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0398	0.0693
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0398	0.0552
Leishmania major	pyruvate kinase	0.004	0.0296	0.0194
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0129	0.1703	0.2961
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0398	0.0693
Trypanosoma cruzi	DNA polymerase eta, putative	0.0242	0.3495	0.3427
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0129	0.1698	0.1957
Plasmodium falciparum	DNA repair protein REV1, putative	0.004	0.0291	0.2774
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0291	0.019
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0201	0.2834	0.8775
Loa Loa (eye worm)	thioredoxin reductase	0.0088	0.105	0.1457
Loa Loa (eye worm)	pyruvate kinase-PB	0.0028	0.0103	0.0143
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0092	0.1112	0.102
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.003	0.0141	0.1339
Echinococcus multilocularis	tar DNA binding protein	0.0134	0.1781	0.3097
Mycobacterium tuberculosis	Probable dehydrogenase	0.0201	0.2834	0.5424
Brugia malayi	hypothetical protein	0.017	0.2354	0.3265
Brugia malayi	PHD-finger family protein	0.0065	0.0684	0.0948
Trypanosoma brucei	unspecified product	0.0089	0.1065	0.0972
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.004	0.0291	0.0948
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Loa Loa (eye worm)	hypothetical protein	0.004	0.0296	0.041
Trypanosoma brucei	DNA polymerase IV, putative	0.0129	0.1698	0.1612
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0141	0.0038
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0129	0.1698	0.5099
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0254	0.0185
Trichomonas vaginalis	pyruvate kinase, putative	0.004	0.0296	0.0236
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0022	0.0013	0.0017
Trypanosoma brucei	DNA polymerase IV, putative	0.0129	0.1698	0.1612
Echinococcus granulosus	geminin	0.0385	0.575	1
Toxoplasma gondii	thioredoxin reductase	0.0088	0.105	0.4771
Echinococcus multilocularis	lysine specific demethylase 5A	0.0078	0.09	0.1564
Loa Loa (eye worm)	glutathione reductase	0.0088	0.105	0.1457
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0398	0.0693
Trichomonas vaginalis	mercuric reductase, putative	0.003	0.0141	0.0046
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0103	0.0983
Onchocerca volvulus	Alhambra homolog	0.0065	0.0684	0.0828
Plasmodium falciparum	thioredoxin reductase	0.003	0.0141	0.1339
Trypanosoma brucei	chrX additional, unordered contigs	0.004	0.0291	0.019
Trypanosoma cruzi	DNA damage repair protein, putative	0.004	0.0291	0.019
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0129	0.1698	0.2355
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.1781	0.3097
Brugia malayi	Muscleblind-like protein	0.0153	0.2075	0.2877
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0223	0.3188	0.6138
Trypanosoma brucei	DNA damage repair protein, putative	0.004	0.0291	0.019
Echinococcus multilocularis	geminin	0.0385	0.575	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0212	0.3017	0.5247
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.003	0.0141	0.0038
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.003	0.0141	0.1339
Echinococcus multilocularis	pyruvate kinase	0.004	0.0296	0.0514
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0344	0.5106	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0089	0.1069	0.1859
Loa Loa (eye worm)	glutaminase 2	0.0283	0.4141	0.5743
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0141	0.0038
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0141	0.5
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.003	0.0141	0.1339
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0226	0.3232	0.4482
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0134	0.1781	0.247
Trypanosoma cruzi	pyruvate kinase 2, putative	0.004	0.0296	0.0194
Leishmania major	DNA polymerase eta, putative	0.0242	0.3495	0.3427
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0296	0.041
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0103	0.018
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0078	0.09	0.1564
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0141	0.0038
Schistosoma mansoni	rotamase	0.0038	0.0254	0.0442
Brugia malayi	Pyruvate kinase, M2 isozyme	0.004	0.0296	0.041
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0212	0.3017	0.5247
Echinococcus multilocularis	muscleblind protein	0.0153	0.2075	0.3608
Loa Loa (eye worm)	PHD-finger family protein	0.0065	0.0684	0.0948
Plasmodium falciparum	glutathione reductase	0.0088	0.105	1
Chlamydia trachomatis	pyruvate kinase	0.004	0.0296	1
Brugia malayi	Flap endonuclease-1	0.0028	0.0103	0.0143
Loa Loa (eye worm)	TAR-binding protein	0.0134	0.1781	0.247
Schistosoma mansoni	DNA polymerase IV / kappa	0.004	0.0291	0.0507
Schistosoma mansoni	glutaminase	0.0283	0.4141	0.7202
Brugia malayi	ImpB/MucB/SamB family protein	0.0129	0.1698	0.2355
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.004	0.0296	0.0312
Schistosoma mansoni	jumonji domain containing protein	0.0169	0.2327	0.4046
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0654	1	1
Plasmodium vivax	DNA repair protein REV1, putative	0.004	0.0291	0.2774
Trypanosoma brucei	DNA polymerase kappa, putative	0.0089	0.1065	0.0972
Trypanosoma cruzi	trypanothione reductase, putative	0.003	0.0141	0.0038
Trypanosoma brucei	pyruvate kinase 1	0.004	0.0296	0.0194
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0024	0.0033	0.0058
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0065	0.0684	0.1189
Echinococcus granulosus	jumonji domain containing protein	0.009	0.1085	0.1888
Plasmodium falciparum	glutathione reductase	0.003	0.0141	0.1339
Loa Loa (eye worm)	glutaminase	0.0283	0.4141	0.5743
Plasmodium falciparum	pyruvate kinase	0.004	0.0296	0.2815
Giardia lamblia	DNA damage repair protein	0.004	0.0291	0.118
Echinococcus multilocularis	pyruvate kinase	0.004	0.0296	0.0514
Mycobacterium ulcerans	DNA polymerase IV	0.0129	0.1698	0.3137
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0038	0.0254	0.0353
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0654	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.0038
Mycobacterium ulcerans	glutaminase	0.0283	0.4141	0.8058
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0398	0.0693
Leishmania major	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0129	0.1698	0.3137
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0226	0.3232	0.3161
Echinococcus multilocularis	jumonji domain containing protein	0.009	0.1085	0.1888
Giardia lamblia	NADH oxidase lateral transfer candidate	0.003	0.0141	0.0234
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0291	0.019
Loa Loa (eye worm)	hypothetical protein	0.004	0.0291	0.0404
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0068	0.0742	0.3216
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0103	0.018
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0038	0.0254	0.0353
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.003	0.0141	0.1339
Echinococcus granulosus	muscleblind protein	0.0153	0.2075	0.3608
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.1781	0.3097
Trypanosoma brucei	unspecified product	0.0089	0.1065	0.0972
Echinococcus granulosus	PHD finger protein rhinoceros	0.0065	0.0684	0.1189
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0037	0.024	0.0138
Echinococcus granulosus	dna polymerase eta	0.0242	0.3495	0.6078
Brugia malayi	Bromodomain containing protein	0.0065	0.0684	0.0948
Schistosoma mansoni	flap endonuclease-1	0.0025	0.0061	0.0105
Schistosoma mansoni	pyruvate kinase	0.004	0.0296	0.0514
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.0038
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0226	0.3232	0.562
Toxoplasma gondii	PHD-finger domain-containing protein	0.0065	0.0684	0.2925
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0129	0.1698	0.1612
Trichomonas vaginalis	glutathione reductase, putative	0.003	0.0141	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0742	0.1028
Toxoplasma gondii	PHD-finger domain-containing protein	0.0065	0.0684	0.2925
Plasmodium vivax	hypothetical protein, conserved	0.0065	0.0684	0.651
Schistosoma mansoni	hypothetical protein	0.0065	0.0684	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0684	0.0948
Loa Loa (eye worm)	jmjC domain-containing protein	0.0134	0.1776	0.2462
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.0742	0.129
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0654	1	1
Schistosoma mansoni	lipoxygenase	0.009	0.1087	0.1891
Echinococcus multilocularis	peregrin	0.0065	0.0684	0.1189
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0129	0.1703	0.2961
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.1781	0.3097
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.003	0.0141	0.0038
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0226	0.3232	0.562
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0226	0.3232	0.3161
Toxoplasma gondii	hypothetical protein	0.0105	0.1326	0.6161
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Leishmania major	DNA polymerase kappa, putative	0.004	0.0291	0.019
Brugia malayi	Pyruvate kinase, muscle isozyme	0.004	0.0296	0.041
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0103	0.0002
Schistosoma mansoni	DNA polymerase eta	0.0242	0.3495	0.6078
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0092	0.1112	0.102
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0129	0.1698	0.2954
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.0038
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0092	0.1112	0.102
Echinococcus granulosus	tar DNA binding protein	0.0134	0.1781	0.3097
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.003	0.0141	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0153	0.2075	0.2877
Echinococcus multilocularis	transcription factor Dp 1	0.0131	0.1727	0.3003
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.003	0.0141	0.0245
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0129	0.1698	0.2954
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Schistosoma mansoni	lipoxygenase	0.0129	0.1703	0.2961
Plasmodium vivax	glutathione reductase, putative	0.0088	0.105	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0068	0.0742	0.129
Toxoplasma gondii	peptidylprolyl isomerase	0.0037	0.024	0.069
Echinococcus granulosus	histone lysine methyltransferase setb	0.0068	0.0742	0.129
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.1781	0.3097
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0398	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0242	0.3495	0.4847
Schistosoma mansoni	hypothetical protein	0.0385	0.575	1
Leishmania major	pyruvate kinase	0.004	0.0296	0.0194
Loa Loa (eye worm)	jmjC domain-containing protein	0.0078	0.09	0.1247
Trypanosoma brucei	DNA polymerase eta, putative	0.0242	0.3495	0.3427
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.1781	0.3097
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0477	0.7211	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0291	0.019
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0088	0.105	0.1832
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0398	0.0693
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0201	0.2834	0.5424
Mycobacterium ulcerans	pyruvate kinase	0.004	0.0296	0.0312
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0309	0.4553	0.4496
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0398	0.0552
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0022	0.0013	0.0017
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.0038
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0129	0.1698	0.2954
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0226	0.3232	0.3161
Plasmodium vivax	pyruvate kinase, putative	0.004	0.0296	0.2815
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0226	0.3232	0.562
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0291	0.019
Brugia malayi	Thioredoxin reductase	0.0088	0.105	0.1457
Mycobacterium ulcerans	hypothetical protein	0.004	0.0291	0.0304
Echinococcus multilocularis	expressed protein	0.0038	0.0254	0.0442
Plasmodium vivax	thioredoxin reductase, putative	0.0088	0.105	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Giardia lamblia	DINP protein human, muc B family	0.0129	0.1698	1
Trypanosoma brucei	trypanothione reductase	0.0088	0.105	0.0957
Brugia malayi	RNA recognition motif domain containing protein	0.0134	0.1781	0.247
Echinococcus granulosus	peregrin	0.0065	0.0684	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0153	0.2075	0.2877
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0066	0.0702	0.122
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.003	0.0141	0.0195
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0068	0.0742	0.129
Echinococcus granulosus	expressed protein	0.0038	0.0254	0.0442
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.003	0.0141	0.0188
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0201	0.2834	0.5424
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1416	0.1964
Brugia malayi	ImpB/MucB/SamB family protein	0.0242	0.3495	0.4847
Trichomonas vaginalis	rotamase, putative	0.0037	0.024	0.0168
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0129	0.1698	0.2954
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0037	0.024	0.0138
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0223	0.3188	0.6138
Echinococcus multilocularis	muscleblind protein 1	0.0153	0.2075	0.3608
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0037	0.024	0.0138
Trypanosoma brucei	DNA polymerase IV, putative	0.0129	0.1698	0.1612
Onchocerca volvulus	Pyruvate kinase homolog	0.004	0.0296	0.0358
Trichomonas vaginalis	set domain proteins, putative	0.0543	0.8255	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.004	0.0296	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0143
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0078	0.09	0.1564
Echinococcus granulosus	transcription factor Dp 1	0.0131	0.1727	0.3003
Schistosoma mansoni	pyruvate kinase	0.004	0.0296	0.0514
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0065	0.0684	0.1189
Brugia malayi	RNA binding protein	0.0134	0.1781	0.247
Schistosoma mansoni	hypothetical protein	0.0385	0.575	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0154	0.2088	0.2006
Trypanosoma brucei	pyruvate kinase 1, putative	0.004	0.0296	0.0194
Echinococcus multilocularis	dna polymerase eta	0.0242	0.3495	0.6078
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.0038
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0068	0.0742	0.129
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0037	0.024	0.0439
Brugia malayi	jmjC domain containing protein	0.0212	0.3017	0.4184
Trypanosoma brucei	DNA polymerase kappa, putative	0.0129	0.1698	0.1612
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0296	0.041
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.004	0.0291	0.0948
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0201	0.2834	0.5424
Plasmodium falciparum	phd finger protein, putative	0.0065	0.0684	0.651
Trypanosoma brucei	unspecified product	0.0129	0.1698	0.1612
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0309	0.4553	0.4496
Trypanosoma brucei	DNA polymerase kappa, putative	0.0089	0.1065	0.0972
Brugia malayi	glutathione reductase	0.0088	0.105	0.1457
Echinococcus granulosus	pyruvate kinase	0.004	0.0296	0.0514
Echinococcus granulosus	dna polymerase kappa	0.0129	0.1698	0.2954
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.0038
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0291	0.019
Brugia malayi	Pre-SET motif family protein	0.0068	0.0742	0.1028
Trichomonas vaginalis	glutaminase, putative	0.0283	0.4141	0.4954
Brugia malayi	Pre-SET motif family protein	0.0477	0.7211	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.0038
Onchocerca volvulus		0.017	0.2354	0.2852
Mycobacterium tuberculosis	Probable reductase	0.0201	0.2834	0.5424
Leishmania major	trypanothione reductase	0.0088	0.105	0.0957
Onchocerca volvulus		0.0068	0.0742	0.0898
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.003	0.0141	0.0245
Onchocerca volvulus	Pyruvate kinase homolog	0.004	0.0296	0.0358

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	16.3433 uM	PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK): for Probe SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1379, AID1721, AID2266]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1354229

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1210104