Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 1 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 1 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0012 | 1 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 1 | 0.5 |
Onchocerca volvulus | 0.0012 | 1 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 1 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 1 | 0.5 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 1 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 0.7943 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.