Detailed information for compound 1211331

Basic information

Technical information
  • TDR Targets ID: 1211331
  • Name: N-[2-(3,4-diethoxyphenyl)ethyl]-1-[2-(3,4-dim ethoxyphenyl)ethyl]-5-oxopyrrolidine-3-carbox amide
  • MW: 484.585 | Formula: C27H36N2O6
  • H donors: 1 H acceptors: 2 LogP: 3.24 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(CCNC(=O)C2CC(=O)N(C2)CCc2ccc(c(c2)OC)OC)ccc1OCC
  • InChi: 1S/C27H36N2O6/c1-5-34-23-10-8-19(16-25(23)35-6-2)11-13-28-27(31)21-17-26(30)29(18-21)14-12-20-7-9-22(32-3)24(15-20)33-4/h7-10,15-16,21H,5-6,11-14,17-18H2,1-4H3,(H,28,31)
  • InChiKey: YSOIWIZUXWJQNP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[2-(3,4-diethoxyphenyl)ethyl]-1-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxo-pyrrolidine-3-carboxamide
  • N-[2-(3,4-diethoxyphenyl)ethyl]-1-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxo-3-pyrrolidinecarboxamide
  • N-[2-(3,4-diethoxyphenyl)ethyl]-1-[2-(3,4-dimethoxyphenyl)ethyl]-5-keto-pyrrolidine-3-carboxamide
  • K786-8600
  • NCGC00140154-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Macaaca fascicularis T-complex protein 1 subunit beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium knowlesi T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Giardia lamblia TCP-1 chaperonin subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Theileria parva T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K09494 T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Neospora caninum TCP-1/cpn60 family chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum GroEL-like chaperone (ATpase); T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis TCP-1/cpn60 chaperonin-related protein Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania infantum T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium falciparum T-complex protein 1 subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis chaperonin-60kD, ch60, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium yoelii putative T-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium berghei T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis T-complex protein beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium vivax T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei gambiense T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania braziliensis T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Toxoplasma gondii t-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania donovani T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica T-complex protein 1 beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Echinococcus granulosus T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.5 %
Trypanosoma cruzi T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Cryptosporidium hominis CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 536 aa 28.4 %
Leishmania infantum chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi T-complex protein 1, eta subunit T-complex protein 1 subunit beta   535 aa 534 aa 33.1 %
Drosophila melanogaster CG8351 gene product from transcript CG8351-RA T-complex protein 1 subunit beta   535 aa 527 aa 32.3 %
Plasmodium knowlesi T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.7 %
Leishmania braziliensis chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 542 aa 26.2 %
Leishmania mexicana T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.6 %
Giardia lamblia TCP-1 chaperonin subunit gamma T-complex protein 1 subunit beta   535 aa 561 aa 29.8 %
Trypanosoma brucei T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.4 %
Trypanosoma brucei gambiense T-complex protein 1, theta subunit, putative,CCT-theta, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Plasmodium yoelii T-complex protein 1 T-complex protein 1 subunit beta   535 aa 534 aa 26.2 %
Neospora caninum hypothetical protein T-complex protein 1 subunit beta   535 aa 531 aa 29.0 %
Echinococcus multilocularis chaperonin containing TCP1, subunit 5 (epsilon) T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Schistosoma mansoni chaperonin containing t-complex protein 1 epsilon subunit tcpe T-complex protein 1 subunit beta   535 aa 505 aa 33.9 %
Echinococcus granulosus T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 34.0 %
Theileria parva T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 522 aa 32.4 %
Trypanosoma cruzi chaperonin/T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 30.9 %
Schistosoma japonicum ko:K09496 T-complex protein 1 subunit delta, putative T-complex protein 1 subunit beta   535 aa 533 aa 32.1 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Brugia malayi T-complex protein 1, zeta subunit T-complex protein 1 subunit beta   535 aa 517 aa 27.7 %
Leishmania donovani chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Cryptosporidium parvum conserved probable chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.7 %
Plasmodium yoelii chaperonin, 60 kDa T-complex protein 1 subunit beta   535 aa 530 aa 34.9 %
Giardia lamblia TCP-1 chaperonin subunit zeta T-complex protein 1 subunit beta   535 aa 516 aa 24.8 %
Babesia bovis HSP60 fold T-complex protein 1, putative T-complex protein 1 subunit beta   535 aa 497 aa 28.0 %
Schistosoma mansoni chaperonin containing t-complex protein 1 theta subunit tcpq T-complex protein 1 subunit beta   535 aa 515 aa 27.2 %
Schistosoma mansoni chaperonin containing t-complex protein 1 delta subunit tcpd T-complex protein 1 subunit beta   535 aa 530 aa 32.8 %
Loa Loa (eye worm) CCT-5 protein T-complex protein 1 subunit beta   535 aa 521 aa 31.3 %
Leishmania braziliensis T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Leishmania braziliensis T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Leishmania major T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 28.8 %
Plasmodium yoelii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 523 aa 30.0 %
Babesia bovis TCP-1/cpn60 chaperonin family protein T-complex protein 1 subunit beta   535 aa 538 aa 30.5 %
Leishmania mexicana chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 538 aa 26.8 %
Leishmania infantum chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, gamma subunit, tcpg, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Leishmania mexicana chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.3 %
Plasmodium vivax T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Onchocerca volvulus Integrator complex subunit 3 homolog T-complex protein 1 subunit beta   535 aa 534 aa 35.8 %
Plasmodium vivax heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 540 aa 21.9 %
Theileria parva chaperonin 60 kDa, putative T-complex protein 1 subunit beta   535 aa 544 aa 26.1 %
Plasmodium vivax T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Leishmania braziliensis chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Plasmodium yoelii T-complex protein 1 epsilon subunit T-complex protein 1 subunit beta   535 aa 508 aa 32.9 %
Plasmodium berghei T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 539 aa 34.1 %
Schistosoma mansoni chaperonin containing t-complex protein 1 zeta subunit tcpz T-complex protein 1 subunit beta   535 aa 544 aa 26.3 %
Plasmodium falciparum T-complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 522 aa 29.9 %
Entamoeba histolytica chaperonin containing TCP-1 delta subunit, putative T-complex protein 1 subunit beta   535 aa 531 aa 30.7 %
Trypanosoma cruzi chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 528 aa 33.0 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 579 aa 23.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii T-complex protein 1, epsilon subunit (TCP-1-epsilon), putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Giardia lamblia TCP-1 chaperonin subunit alpha T-complex protein 1 subunit beta   535 aa 528 aa 32.6 %
Brugia malayi T-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 534 aa 35.6 %
Trypanosoma cruzi T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 29.7 %
Cryptosporidium parvum TCP-1/cpn60 chaperonin family, T-complex protein subunit 7 (eta) T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Trypanosoma brucei t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.6 %
Cryptosporidium hominis T-complex protein 1 T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Dictyostelium discoideum chaperonin containing TCP1 epsilon subunit T-complex protein 1 subunit beta   535 aa 520 aa 34.4 %
Trypanosoma brucei gambiense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Giardia lamblia TCP-1 chaperonin subunit eta T-complex protein 1 subunit beta   535 aa 543 aa 32.0 %
Leishmania infantum T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Schistosoma mansoni chaperonin containing t-complex protein 1 gamma subunit tcpg T-complex protein 1 subunit beta   535 aa 552 aa 29.7 %
Toxoplasma gondii TCP-1 chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 26.9 %
Dictyostelium discoideum chaperonin containing TCP1 alpha subunit T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Giardia lamblia TCP-1 chaperonin subunit epsilon T-complex protein 1 subunit beta   535 aa 535 aa 31.6 %
Babesia bovis T-complex protein 1 zeta subunit T-complex protein 1 subunit beta   535 aa 532 aa 26.7 %
Toxoplasma gondii T complex chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.0 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 561 aa 27.1 %
Echinococcus multilocularis T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Plasmodium vivax T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.3 %
Drosophila melanogaster T-complex Chaperonin 5 T-complex protein 1 subunit beta   535 aa 506 aa 34.6 %
Echinococcus multilocularis t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, epsilon subunit, tcpe, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Plasmodium yoelii putative chaperonin T-complex protein 1 subunit beta   535 aa 497 aa 22.7 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Schistosoma mansoni T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-complex protein 1 subunit beta   535 aa 552 aa 33.5 %
Leishmania donovani T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Trypanosoma brucei T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Entamoeba histolytica T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 31.6 %
Cryptosporidium parvum T complex chaperonin T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Trichomonas vaginalis chaperonin-60kD, ch60, putative T-complex protein 1 subunit beta   535 aa 538 aa 33.6 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 533 aa 33.8 %
Entamoeba histolytica hypothetical protein T-complex protein 1 subunit beta   535 aa 516 aa 22.5 %
Leishmania infantum T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Entamoeba histolytica chaperonin-containing TCP-1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 550 aa 23.5 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 533 aa 28.3 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Echinococcus granulosus chaperonin containing TCP1 subunit 5 epsilon T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Leishmania major chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.3 %
Cryptosporidium hominis CCTepsilon subunit T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Trypanosoma brucei T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Leishmania donovani chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.5 %
Echinococcus granulosus T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 517 aa 27.1 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, beta subunit, tcpb, putative T-complex protein 1 subunit beta   535 aa 541 aa 35.5 %
Theileria parva T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 580 aa 33.3 %
Echinococcus multilocularis T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 27.1 %
Neospora caninum GL18351, related T-complex protein 1 subunit beta   535 aa 530 aa 26.2 %
Leishmania braziliensis chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Echinococcus granulosus t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Plasmodium knowlesi T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.1 %
Plasmodium knowlesi T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 526 aa 31.0 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 550 aa 32.0 %
Plasmodium berghei T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 526 aa 25.7 %
Trypanosoma brucei gambiense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 547 aa 32.7 %
Leishmania major T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.3 %
Cryptosporidium hominis t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Plasmodium berghei T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Trypanosoma congolense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.4 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.4 %
Toxoplasma gondii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 531 aa 29.2 %
Plasmodium knowlesi T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 544 aa 23.5 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Babesia bovis t-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Leishmania mexicana T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.2 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 604 aa 22.9 %
Leishmania infantum chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.7 %
Brugia malayi T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 502 aa 26.3 %
Trypanosoma brucei gambiense T-complex protein 1, eta subunit, putative,t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.4 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 528 aa 20.8 %
Cryptosporidium parvum putative t-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 545 aa 28.3 %
Plasmodium vivax T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 539 aa 22.4 %
Echinococcus multilocularis T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Leishmania major T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.8 %
Leishmania donovani chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Schistosoma japonicum ko:K09499 T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Plasmodium falciparum T-complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 23.1 %
Leishmania mexicana chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.6 %
Schistosoma japonicum ko:K09498 T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 552 aa 25.7 %
Trypanosoma congolense T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 28.6 %
Leishmania braziliensis T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 29.1 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 561 aa 23.0 %
Echinococcus granulosus T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Leishmania major chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.1 %
Theileria parva T-complex protein 1, alpha subunit , putative T-complex protein 1 subunit beta   535 aa 527 aa 34.9 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Dictyostelium discoideum chaperonin containing TCP1 zeta subunit T-complex protein 1 subunit beta   535 aa 523 aa 26.6 %
Schistosoma japonicum ko:K09497 T-complex protein 1 subunit epsilon, putative T-complex protein 1 subunit beta   535 aa 505 aa 33.5 %
Plasmodium berghei T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 523 aa 30.2 %
Leishmania infantum T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.4 %
Plasmodium knowlesi T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 33.7 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Trypanosoma congolense t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Plasmodium falciparum T-complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 539 aa 23.4 %
Plasmodium vivax T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Dictyostelium discoideum chaperonin containing TCP1 eta subunit T-complex protein 1 subunit beta   535 aa 528 aa 33.5 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 33.5 %
Trypanosoma cruzi T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 29.5 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 550 aa 32.9 %
Trypanosoma congolense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 525 aa 34.1 %
Toxoplasma gondii T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.8 %
Giardia lamblia TCP-1 chaperonin subunit theta T-complex protein 1 subunit beta   535 aa 563 aa 25.2 %
Leishmania major T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.5 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 549 aa 35.7 %
Cryptosporidium parvum t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Trypanosoma brucei T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Babesia bovis T-complex protein 1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 32.6 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 29.8 %
Leishmania donovani T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Schistosoma japonicum ko:K09493 T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 585 aa 31.5 %
Leishmania donovani T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.8 %
Trypanosoma brucei T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Trypanosoma brucei gambiense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Trypanosoma brucei T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Entamoeba histolytica T-complex protein 1 theta subunit, putative T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Leishmania infantum T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 545 aa 29.7 %
Trypanosoma brucei gambiense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Cryptosporidium parvum putative T complex chaperonin T-complex protein 1 subunit beta   535 aa 546 aa 25.1 %
Theileria parva T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 27.1 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Leishmania braziliensis T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Entamoeba histolytica chaperonin containing TCP-1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 508 aa 32.7 %
Entamoeba histolytica T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 29.9 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 575 aa 23.1 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.2 %
Plasmodium falciparum T-complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 546 aa 34.4 %
Trypanosoma cruzi chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 547 aa 26.0 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 546 aa 33.7 %
Babesia bovis heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 530 aa 22.3 %
Leishmania donovani T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Neospora caninum Thermosome subunit, related T-complex protein 1 subunit beta   535 aa 527 aa 31.3 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Dictyostelium discoideum chaperonin containing TCP1 theta subunit T-complex protein 1 subunit beta   535 aa 501 aa 27.1 %
Toxoplasma gondii T-complex protein 1 eta subunit T-complex protein 1 subunit beta   535 aa 546 aa 33.9 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Plasmodium falciparum T-complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 542 aa 34.9 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 542 aa 27.7 %
Trypanosoma congolense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 521 aa 29.6 %
Mycobacterium tuberculosis 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (a T-complex protein 1 subunit beta   535 aa 565 aa 23.5 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Cryptosporidium hominis chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.9 %
Schistosoma mansoni chaperonin containing t-complex protein 1 eta subunit tcph T-complex protein 1 subunit beta   535 aa 536 aa 32.8 %
Trypanosoma congolense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 32.2 %
Leishmania mexicana T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 35.1 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 549 aa 20.6 %
Toxoplasma gondii T-complex protein 1 delta subunit T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Trichomonas vaginalis rubisco subunit binding-protein alpha subunit, ruba, putative T-complex protein 1 subunit beta   535 aa 580 aa 23.3 %
Brugia malayi T-complex protein 1, epsilon subunit T-complex protein 1 subunit beta   535 aa 513 aa 31.4 %
Leishmania major chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Plasmodium berghei T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 537 aa 23.5 %
Loa Loa (eye worm) T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 514 aa 26.5 %
Brugia malayi T-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 529 aa 28.4 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0076 0.0392 0.0511
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Echinococcus granulosus synaptic glycoprotein sc2 0.0844 0.5869 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0076 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Loa Loa (eye worm) hypothetical protein 0.016 0.0994 0.098
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0029 0.0062 0.0106
Brugia malayi nuclear receptor NHR-67 0.0076 0.0392 0.0392
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0399 0.0384
Echinococcus granulosus ectonucleotide 0.0029 0.0059 0.01
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0844 0.5869 0.5869
Echinococcus granulosus FTZ F1 alpha 0.016 0.0994 0.1694
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0029 0.0062 0.0062
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.016 0.0994 0.1694
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1424 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.016 0.0994 0.098
Trichomonas vaginalis chaperonin, putative 0.0029 0.0062 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.016 0.0994 0.098
Brugia malayi hypothetical protein 0.0076 0.0392 0.0392
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.016 0.0994 0.1694
Loa Loa (eye worm) RNA binding protein 0.0076 0.0399 0.0384
Brugia malayi MH2 domain containing protein 0.0144 0.0881 0.0881
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.016 0.0994 0.1694
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0081
Brugia malayi RNA binding protein 0.0076 0.0399 0.0399
Brugia malayi Steroid receptor seven-up type 2 0.016 0.0994 0.0994
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-14 0.016 0.0994 0.0994
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0248 0.0422
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0085 0.0456 0.0441
Toxoplasma gondii t-complex protein beta subunit 0.0029 0.0062 0.0062
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.016 0.0994 0.1555
Schistosoma mansoni RAR-like nuclear receptor 0.016 0.0994 0.1694
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1424 1 1
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1424 1 1
Schistosoma mansoni ap endonuclease 0.0023 0.0016 0.0027
Schistosoma mansoni coup transcription factor 0.016 0.0994 0.1694
Brugia malayi ecdysteroid receptor 0.016 0.0994 0.0994
Brugia malayi Nuclear hormone receptor E75 0.0076 0.0392 0.0392
Schistosoma mansoni Tr4/Tr2 (homologue) 0.016 0.0994 0.1694
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.0097 0.0165
Loa Loa (eye worm) nuclear hormone receptor 0.0076 0.0392 0.0377
Loa Loa (eye worm) hypothetical protein 0.016 0.0994 0.098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.016 0.0994 0.098
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0844 0.5869 0.5863
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0844 0.5869 0.5869
Brugia malayi Nuclear hormone receptor family member nhr-40 0.016 0.0994 0.0994
Brugia malayi ecdysone receptor 0.0076 0.0392 0.0392
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.016 0.0994 0.1694
Onchocerca volvulus Protein ultraspiracle homolog 0.016 0.0994 0.1555
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0399 0.068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0111 0.0189
Brugia malayi nuclear hormone receptor family member nhr-6 0.0076 0.0392 0.0392
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.016 0.0994 0.1694
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0076 0.0392 0.0377
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0399 0.068
Loa Loa (eye worm) hypothetical protein 0.016 0.0994 0.098
Brugia malayi hypothetical protein 0.0085 0.0456 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-31 0.016 0.0994 0.0994
Loa Loa (eye worm) nuclear receptor NHR-67 0.0076 0.0392 0.0377
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.0392 0.0668
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.0392 0.0668
Loa Loa (eye worm) hypothetical protein 0.016 0.0994 0.098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0111 0.0189
Brugia malayi photoreceptor-specific nuclear receptor 0.016 0.0994 0.0994
Plasmodium falciparum T-complex protein 1 subunit beta 0.0029 0.0062 0.0079
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0881 0.0867
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0147 0.0147
Schistosoma mansoni retinoid-x-receptor (RXR) 0.016 0.0994 0.1694
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.016 0.0994 0.098
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.0456 0.0456
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0844 0.5869 1
Brugia malayi TAR-binding protein 0.0076 0.0399 0.0399
Echinococcus granulosus nuclear receptor 2DBD gamma 0.016 0.0994 0.1694
Brugia malayi nuclear hormone receptor 0.0076 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0095
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.0392 0.0668
Echinococcus multilocularis ectonucleotide 0.0029 0.0059 0.01
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.016 0.0994 0.1694
Entamoeba histolytica hypothetical protein 0.0844 0.5869 0.5863
Brugia malayi nuclear receptor RXR 0.0085 0.0456 0.0456
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0016 0.0016
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0844 0.5869 1
Giardia lamblia TCP-1 chaperonin subunit beta 0.0029 0.0062 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0111 0.0189
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0844 0.5869 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.016 0.0994 0.098
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0076 0.0392 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-19 0.016 0.0994 0.0994
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Brugia malayi conserved hypotetical protein 0.0076 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0029 0.0059 0.0043
Schistosoma mansoni retinoic acid receptor RXR 0.016 0.0994 0.1694
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.016 0.0994 0.098
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0111 0.0111
Schistosoma mansoni nuclear receptor 0.0076 0.0392 0.0668
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0399 0.068
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0844 0.5869 0.5863
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0399 0.068
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0029 0.0062 0.0106
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.016 0.0994 0.1694
Plasmodium vivax SET domain protein, putative 0.0036 0.0111 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0399 0.068
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0147 0.0132
Loa Loa (eye worm) hypothetical protein 0.016 0.0994 0.098
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0111 0.0189
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0016 0.0027
Echinococcus granulosus ecdysone induced protein 78C 0.016 0.0994 0.1694
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1424 1 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1424 1 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0994 0.098
Schistosoma mansoni thyroid hormone receptor 0.016 0.0994 0.1694
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.1424 1 1
Schistosoma mansoni nuclear receptor 0.0076 0.0392 0.0668
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0085 0.0456 0.0778
Toxoplasma gondii exonuclease III APE 0.0023 0.0016 0.0016
Echinococcus granulosus nuclear receptor nhr 48 0.0076 0.0392 0.0668
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.0456 0.0456
Loa Loa (eye worm) steroid hormone receptor 0.016 0.0994 0.098
Brugia malayi Nuclear hormone receptor family member nhr-41 0.016 0.0994 0.0994
Echinococcus granulosus retinoic acid receptor rxr beta a 0.016 0.0994 0.1694
Brugia malayi nuclear hormone receptor 0.016 0.0994 0.0994
Trichomonas vaginalis conserved hypothetical protein 0.0844 0.5869 0.5863
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.0097 0.0165
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0062 0.0062
Mycobacterium ulcerans hypothetical protein 0.1424 1 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.0097 0.0165
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0081
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Loa Loa (eye worm) hypothetical protein 0.0085 0.0456 0.0441
Echinococcus granulosus tar DNA binding protein 0.0076 0.0399 0.068
Echinococcus multilocularis synaptic glycoprotein sc2 0.0844 0.5869 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0248 0.0422
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.016 0.0994 0.0994
Loa Loa (eye worm) hypothetical protein 0.0085 0.0456 0.0441
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0029 0.0059 0.01
Brugia malayi Nuclear hormone receptor family member nhr-3 0.016 0.0994 0.0994
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0111 0.0189
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.1424 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.016 0.0994 0.0994
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0248 0.0422
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Loa Loa (eye worm) hypothetical protein 0.016 0.0994 0.098
Loa Loa (eye worm) hypothetical protein 0.006 0.0283 0.0268
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.016 0.0994 0.1694
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0085 0.0456 0.0778
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Echinococcus multilocularis ecdysone induced protein 78C 0.016 0.0994 0.1694
Brugia malayi hypothetical protein 0.0076 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.0041 0.0147 0.0251
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0076 0.0392 0.0668
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0029 0.0062 0.0047
Schistosoma mansoni thyroid hormone receptor 0.016 0.0994 0.1694
Brugia malayi Nuclear hormone receptor-like 1 0.016 0.0994 0.0994
Giardia lamblia Synaptic glycoprotein SC2 0.0844 0.5869 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0085 0.0456 0.0441
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Brugia malayi orphan nuclear receptor NR2E1 0.0076 0.0392 0.0392
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0085 0.0456 0.0778
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0844 0.5869 0.5863
Onchocerca volvulus 0.0286 0.1892 0.311
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0062 0.0062
Brugia malayi nuclear receptor NHR-88 0.016 0.0994 0.0994
Brugia malayi Nuclear hormone receptor family member nhr-19 0.016 0.0994 0.0994
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0076 0.0392 0.0668
Onchocerca volvulus 0.0844 0.5869 1
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0844 0.5869 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0399 0.0399
Brugia malayi steroid hormone receptor 0.016 0.0994 0.0994
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0392 0.0668
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.0392 0.0511
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0392 0.0668
Echinococcus granulosus nuclear receptor 2DBD gamma 0.016 0.0994 0.1694
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Loa Loa (eye worm) hypothetical protein 0.0085 0.0456 0.0441
Entamoeba histolytica steroid 5-alpha reductase, putative 0.1424 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.016 0.0994 0.0994
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0248 0.0248
Schistosoma mansoni steroid hormone receptor ad4bp 0.016 0.0994 0.1694
Brugia malayi Pre-SET motif family protein 0.0251 0.1645 0.1645
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1892 0.1879
Brugia malayi Nuclear hormone receptor E75 0.0076 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.016 0.0994 0.098
Brugia malayi Synaptic glycoprotein SC2 0.0844 0.5869 0.5869
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.0392 0.0511
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0062 0.0106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0111 0.0189
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0283 0.0268
Brugia malayi tailless protein 0.0076 0.0392 0.0392
Brugia malayi nuclear hormone receptor family member odr-7 0.0076 0.0392 0.0392
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.0097 0.0165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0392 0.0668
Schistosoma mansoni ap endonuclease 0.0023 0.0016 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0283 0.0283
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.016 0.0994 0.1694
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0016 0.0016
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0097 0.0165
Plasmodium vivax polyprenol reductase, putative 0.0844 0.5869 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.016 0.0994 0.098
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0844 0.5869 0.5863
Leishmania major T-complex protein 1, beta subunit, putative 0.0029 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Echinococcus multilocularis FTZ F1 alpha 0.016 0.0994 0.1694
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0016 0.5
Schistosoma mansoni zinc finger protein 0.0076 0.0392 0.0668
Onchocerca volvulus 0.016 0.0994 0.1555
Echinococcus multilocularis nuclear receptor nhr 48 0.0076 0.0392 0.0668
Loa Loa (eye worm) DR-78 0.0076 0.0392 0.0377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0248 0.0422
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0844 0.5869 1
Trichomonas vaginalis conserved hypothetical protein 0.0844 0.5869 0.5863
Onchocerca volvulus Bile acid receptor homolog 0.016 0.0994 0.1555
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0062 0.0106
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0399 0.0384
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0283 0.0283
Echinococcus granulosus thyroid hormone receptor alpha 0.0076 0.0392 0.0668
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0074 0.0379 0.0364
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.0392 0.0668
Brugia malayi Pre-SET motif family protein 0.0036 0.0111 0.0111
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0034 0.0097 0.0097
Brugia malayi hypothetical protein 0.0085 0.0456 0.0456
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0016 0.5
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0844 0.5869 0.5863
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0248 0.0422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0248 0.0422
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0016 0.0027
Brugia malayi Thrombospondin type 1 domain containing protein 0.0074 0.0379 0.0379
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0844 0.5869 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0029 0.0059 0.01
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0029 0.0062 0.0062
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.016 0.0994 0.1694
Onchocerca volvulus 0.0036 0.0111 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.016 0.0994 0.0994
Schistosoma mansoni nuclear hormone receptor 0.016 0.0994 0.1694
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0881 0.0867
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.016 0.0994 0.1694
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.016 0.0994 0.0994
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0111 0.0189
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0101 0.0173
Loa Loa (eye worm) T-complex protein 1 0.0029 0.0062 0.0047
Loa Loa (eye worm) hypothetical protein 0.0844 0.5869 0.5863
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0392 0.0668
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0076 0.0392 0.0668
Plasmodium falciparum polyprenol reductase, putative 0.0844 0.5869 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1424 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.016 0.0994 0.1694
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Loa Loa (eye worm) hypothetical protein 0.0085 0.0456 0.0441
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0085 0.0456 0.0778
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.016 0.0994 0.1694
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0248 0.0422
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0029 0.0062 0.0047
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0076 0.0392 0.0668
Schistosoma mansoni nuclear receptor nhr-48 0.0076 0.0392 0.0668
Onchocerca volvulus 0.0074 0.0379 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-1 0.016 0.0994 0.0994
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0062 0.0106
Loa Loa (eye worm) hypothetical protein 0.0844 0.5869 0.5863
Brugia malayi nuclear receptor RXR 0.0076 0.0392 0.0392
Onchocerca volvulus 0.0076 0.0392 0.0511
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0844 0.5869 0.5869
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0844 0.5869 0.5869
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0844 0.5869 0.5863
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0399 0.068
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0016 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.016 0.0994 0.1694
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0248 0.0232
Brugia malayi nuclear receptor NHR-88 0.0076 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.0074 0.0379 0.0645
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.016 0.0994 0.1694
Loa Loa (eye worm) hypothetical protein 0.0076 0.0392 0.0377
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1645 0.1632
Loa Loa (eye worm) hypothetical protein 0.1424 1 1
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0029 0.0062 0.0079

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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