Detailed information for compound 1211392

Basic information

Technical information
  • TDR Targets ID: 1211392
  • Name: MLS000877508
  • MW: 383.272 | Formula: C17H20Cl2N4O2
  • H donors: 1 H acceptors: 2 LogP: 1.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)C1CC2C(N1C)c1n(C2)c2c(n1)cc(c(c2)Cl)Cl
  • InChi: 1S/C17H20Cl2N4O2/c1-22-14(17(24)20-3-4-25-2)5-9-8-23-13-7-11(19)10(18)6-12(13)21-16(23)15(9)22/h6-7,9,14-15H,3-5,8H2,1-2H3,(H,20,24)
  • InChiKey: JYYMTFLJOYYNFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000463800

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0045 0.0087
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0205 0.2364 0.4553
Onchocerca volvulus 0.0011 0.0045 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0837 0.1388
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.045 0.5276 1
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0008 0.0014 0.002
Trypanosoma brucei unspecified product 0.0142 0.1605 0.4354
Schistosoma mansoni DNA polymerase IV / kappa 0.0064 0.0678 0.131
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0474 0.0461
Schistosoma mansoni ap endonuclease 0.004 0.0392 0.0757
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0694 0.3455
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0216 0.0355
Mycobacterium ulcerans DNA polymerase IV 0.0205 0.2364 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0392 0.1033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0147 0.1673 0.3152
Trypanosoma brucei DNA damage repair protein, putative 0.0064 0.0678 0.1816
Echinococcus multilocularis 0.0014 0.008 0.0066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0837 0.1563
Brugia malayi ImpB/MucB/SamB family protein 0.0205 0.2364 0.4465
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0392 0.1606
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0694 0.1341
Echinococcus granulosus geminin 0.0366 0.4278 0.8263
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0694 0.1341
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0045 0.0087
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0045 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0045 0.0059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.1673 0.3214
Loa Loa (eye worm) hypothetical protein 0.0315 0.3668 0.6944
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0045 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0837 0.1388
Trypanosoma brucei PAB1-binding protein , putative 0.0104 0.1157 0.3128
Trichomonas vaginalis DNA polymerase eta, putative 0.0205 0.2364 0.3927
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0045 0.0087
Toxoplasma gondii ABC1 family protein 0.0077 0.0837 0.418
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0837 0.1563
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0014 0.008 0.0334
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0008 0.0014 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0045 0.0059
Schistosoma mansoni ran 0.0023 0.0189 0.0364
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.008 0.0129
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0059
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0014 0.002
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.008 0.0129
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0039 0.0024
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0392 0.0717
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0837 0.2251
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.1157 0.3128
Echinococcus granulosus importin subunit beta 1 0.0031 0.0285 0.0525
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0045 0.006
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0285 0.0271
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0474 0.0891
Mycobacterium ulcerans hypothetical protein 0.0064 0.0678 0.2131
Schistosoma mansoni ran 0.0023 0.0189 0.0364
Schistosoma mansoni terminal deoxycytidyl transferase 0.0205 0.2364 0.4568
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0993 0.1919
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0285 0.1377
Plasmodium falciparum importin beta, putative 0.0031 0.0285 0.2371
Loa Loa (eye worm) hypothetical protein 0.0077 0.0837 0.1563
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0837 0.1426
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0045 0.0087
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0008 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0077 0.0837 0.1563
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0392 0.0647
Trichomonas vaginalis esterase, putative 0.0077 0.0837 0.1388
Trypanosoma brucei chrX additional, unordered contigs 0.0064 0.0678 0.1816
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.008 0.0576
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0014 0.0028
Brugia malayi hypothetical protein 0.0067 0.0718 0.1338
Schistosoma mansoni DNA polymerase eta 0.0315 0.3668 0.7089
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0837 0.7197
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0837 1
Plasmodium vivax ataxin-2 like protein, putative 0.0104 0.1157 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0189 0.1525
Entamoeba histolytica Ran family GTPase 0.0023 0.0189 0.0741
Trypanosoma cruzi DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0837 0.1388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.1673 0.3233
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0678 0.1816
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0205 0.2364 0.3927
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0837 0.1426
Loa Loa (eye worm) hypothetical protein 0.0077 0.0837 0.1563
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0045 0.0059
Mycobacterium ulcerans hypothetical protein 0.0077 0.0837 0.2874
Echinococcus multilocularis dna polymerase kappa 0.0205 0.2364 0.2353
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0678 0.1816
Schistosoma mansoni hypothetical protein 0.0013 0.0078 0.0151
Brugia malayi steroid hormone receptor 0.0011 0.0045 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0694 0.1341
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0045 0.0087
Entamoeba histolytica hypothetical protein 0.0025 0.0221 0.088
Schistosoma mansoni hypothetical protein 0.0366 0.4278 0.8268
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0045 0.0059
Schistosoma mansoni hypothetical protein 0.0008 0.0014 0.0028
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0189 0.0174
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0288 0.052
Schistosoma mansoni cpg binding protein 0.0031 0.0288 0.0556
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0392 0.1033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.1673 0.3233
Schistosoma mansoni cpg binding protein 0.0033 0.0309 0.0597
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0045 0.0059
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.383 0.7253
Mycobacterium ulcerans beta-lactamase 0.0077 0.0837 0.2874
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0837 0.1388
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0392 0.0654
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0678 0.1816
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0216 0.0355
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0045 0.0059
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0045 0.0087
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0221 0.0566
Brugia malayi hypothetical protein 0.0104 0.1157 0.2172
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Trichomonas vaginalis dullard protein, putative 0.0014 0.008 0.0129
Brugia malayi Pre-SET motif family protein 0.045 0.5276 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0678 0.1261
Mycobacterium ulcerans lipase LipD 0.0077 0.0837 0.2874
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0064 0.0678 0.3372
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0392 0.0378
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0694 0.1317
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0837 0.1594
Leishmania major DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Toxoplasma gondii exonuclease III APE 0.004 0.0392 0.1918
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0061 0.0089
Leishmania major GTP-binding protein, putative 0.0023 0.0189 0.0477
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0045 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0694 0.1341
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0646 0.3212
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.008 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0059
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0189 0.0331
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0837 0.2874
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0993 0.186
Schistosoma mansoni ap endonuclease 0.004 0.0392 0.0757
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0837 0.1426
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0493 0.5783 1
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0837 0.1426
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0014 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0678 0.1816
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0045 0.0031
Loa Loa (eye worm) hypothetical protein 0.0077 0.0837 0.1563
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0045 0.0059
Echinococcus granulosus FTZ F1 alpha 0.0414 0.4852 0.9376
Echinococcus granulosus snurportin 1 0.0329 0.383 0.7395
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.008 0.0125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0045 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.1157 0.3128
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0045 0.0059
Trypanosoma cruzi DNA polymerase eta, putative 0.0173 0.1982 0.5385
Leishmania major hypothetical protein, conserved 0.0077 0.0837 0.2251
Schistosoma mansoni nocturnin 0.0008 0.0014 0.0028
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0392 0.0796
Schistosoma mansoni hypothetical protein 0.0366 0.4278 0.8268
Echinococcus granulosus dna polymerase eta 0.0315 0.3668 0.7081
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0014 0.002
Plasmodium vivax SET domain protein, putative 0.0065 0.0694 0.5949
Schistosoma mansoni cpg binding protein 0.0033 0.0309 0.0597
Brugia malayi CXXC zinc finger family protein 0.0031 0.0288 0.052
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0392 0.1033
Brugia malayi Importin beta-1 subunit 0.0031 0.0285 0.0515
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0837 0.2251
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0216 0.0552
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0837 0.1426
Echinococcus granulosus cpg binding protein 0.0033 0.0309 0.0571
Onchocerca volvulus 0.0077 0.0837 0.1371
Brugia malayi ecdysteroid receptor 0.0011 0.0045 0.0059
Onchocerca volvulus 0.0512 0.6015 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0993 0.098
Loa Loa (eye worm) beta-lactamase 0.0077 0.0837 0.1563
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.008 0.0127
Trypanosoma cruzi DNA polymerase eta, putative 0.0315 0.3668 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0678 0.1816
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0045 0.006
Brugia malayi nuclear receptor NHR-88 0.0011 0.0045 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.1673 0.3233
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0392 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.1673 0.3214
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0064 0.0678 0.3372
Trypanosoma cruzi DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0059
Trypanosoma brucei DNA polymerase eta, putative 0.0315 0.3668 1
Trypanosoma brucei unspecified product 0.0142 0.1605 0.4354
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0392 0.3302
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0045 0.0087
Schistosoma mansoni hypothetical protein 0.0442 0.5174 1
Schistosoma mansoni synaptojanin 0.0008 0.0014 0.0028
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0694 0.0681
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0008 0.0014 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0045 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.018
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0189 0.0331
Onchocerca volvulus 0.0077 0.0837 0.1371
Leishmania major DNA polymerase kappa, putative 0.0064 0.0678 0.1816
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0061 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0205 0.2364 0.6431
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0216 0.0355
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.008 0.018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0837 0.1617
Schistosoma mansoni hypothetical protein 0.0047 0.0474 0.0916
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0014 0.008 0.028
Brugia malayi polk-prov protein 0.0064 0.0678 0.1261
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0837 0.1617
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0173 0.1982 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0039 0.0047
Plasmodium vivax importin-beta 2, putative 0.0031 0.0285 0.2371
Schistosoma mansoni cript-related 0.0008 0.0014 0.0028
Mycobacterium tuberculosis Conserved protein 0.0077 0.0837 0.1426
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.006 0.0086
Onchocerca volvulus 0.009 0.0993 0.1631
Trypanosoma cruzi DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.1673 0.1661
Toxoplasma gondii LsmAD domain-containing protein 0.0104 0.1157 0.5808
Brugia malayi Pre-SET motif family protein 0.0065 0.0694 0.1292
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0014 0.008 0.0576
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0039 0.0075
Echinococcus multilocularis snurportin 1 0.0329 0.383 0.3821
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.008 0.0155
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0837 0.2874
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Onchocerca volvulus 0.0065 0.0694 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0045 0.0059
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.008 0.0129
Onchocerca volvulus 0.0031 0.0288 0.0456
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0189 0.0338
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.0125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0045 0.0031
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0189 0.0477
Loa Loa (eye worm) hypothetical protein 0.0065 0.0694 0.1292
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0045 0.0059
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.5174 0.5167
Trichomonas vaginalis ran, putative 0.0023 0.0189 0.0309
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0285 0.0742
Mycobacterium tuberculosis Conserved protein 0.0077 0.0837 0.1426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0045 0.0059
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.008 0.0155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0045 0.006
Giardia lamblia DINP protein human, muc B family 0.0205 0.2364 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0837 0.1388
Echinococcus multilocularis cpg binding protein 0.0033 0.0309 0.0295
Loa Loa (eye worm) hypothetical protein 0.009 0.0993 0.186
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0837 0.2251
Trypanosoma brucei unspecified product 0.0205 0.2364 0.6431
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0045 0.0031
Schistosoma mansoni hypothetical protein 0.0329 0.383 0.7403
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0205 0.2364 0.4568
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0221 0.5478
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.008 0.0129
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.1157 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0064 0.0678 0.1816
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0045 0.0087
Trichomonas vaginalis Phospholipase C precursor, putative 0.0008 0.0014 0.002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0205 0.2364 0.4073
Leishmania major DNA damage repair protein, putative 0.0064 0.0678 0.1816
Brugia malayi nuclear hormone receptor 0.0011 0.0045 0.0059
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.008 0.0576
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0045 0.0031
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0189 0.1525
Leishmania major DNA polymerase eta, putative 0.0173 0.1982 0.5385
Mycobacterium tuberculosis Conserved protein 0.0077 0.0837 0.1426
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0205 0.2364 0.4465
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0045 0.0059
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0285 0.0742
Echinococcus granulosus dnaJ subfamily B 0.0442 0.5174 1
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0993 0.1897
Entamoeba histolytica hypothetical protein 0.0025 0.0216 0.0858
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0014 0.008 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.1605 0.4354
Schistosoma mansoni coup transcription factor 0.0011 0.0045 0.0087
Leishmania major hypothetical protein, conserved 0.0104 0.1157 0.3128
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.1605 0.4354
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0658 0.1247
Leishmania major DNA polymerase eta, putative 0.0315 0.3668 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0059
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0837 0.1426
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0045 0.0031
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0392 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0189 0.0477
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0045 0.0087
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.008 0.0127
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0045 0.0051
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0205 0.2364 0.2353
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0039 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0045 0.0059
Brugia malayi RNA, U transporter 1 0.0088 0.0961 0.1799
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.1673 0.1661
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0147 0.1673 0.3152
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0045 0.0059
Echinococcus multilocularis geminin 0.0366 0.4278 0.427
Trypanosoma brucei DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0837 0.0824
Schistosoma mansoni importin beta-1 0.0031 0.0285 0.0551
Loa Loa (eye worm) hypothetical protein 0.0077 0.0837 0.1563
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0008 0.0014 0.002
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0045 0.0059
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0221 0.1809
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0045 0.0059
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0045 0.0051
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0221 0.0358
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0014 0.002
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0189 0.0741
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0039 0.0047
Plasmodium vivax DNA repair protein REV1, putative 0.0064 0.0678 0.5805
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0045 0.0059
Leishmania major importin beta-1 subunit, putative 0.0025 0.0216 0.0552
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0045 0.0031
Echinococcus granulosus dna polymerase kappa 0.0205 0.2364 0.4553
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0045 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0205 0.2364 0.4073
Schistosoma mansoni synaptojanin 0.0008 0.0014 0.0028
Brugia malayi beta-lactamase family protein 0.0077 0.0837 0.1563
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.1605 0.4354
Trypanosoma brucei DNA damage repair protein, putative 0.0064 0.0678 0.1816
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0045 0.0087
Mycobacterium leprae Probable lipase LipE 0.0077 0.0837 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0045 0.0031
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0221 0.1051
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0045 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0045 0.0059
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0205 0.2364 0.6431
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0837 0.1426
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0221 0.0566
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0045 0.0051
Trichomonas vaginalis dullard protein, putative 0.0014 0.008 0.0129
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0014 0.008 0.028
Trichomonas vaginalis set domain proteins, putative 0.0512 0.6015 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0045 0.0031
Brugia malayi beta-lactamase 0.0077 0.0837 0.1563
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0189 0.0477
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0392 0.0647
Brugia malayi beta-lactamase family protein 0.0077 0.0837 0.1563
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0045 0.006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0392 0.3302
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0045 0.0087
Brugia malayi ImpB/MucB/SamB family protein 0.0315 0.3668 0.6944
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0059
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0061 0.0091
Loa Loa (eye worm) hypothetical protein 0.0013 0.0078 0.0121
Entamoeba histolytica deoxycytidyl transferase, putative 0.0205 0.2364 1
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0678 0.1816
Loa Loa (eye worm) hypothetical protein 0.0104 0.1157 0.2172
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0014 0.0028
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0221 0.1809
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0392 0.0717
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0392 0.0731
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0045 0.0059
Loa Loa (eye worm) hypothetical protein 0.0077 0.0837 0.1563
Trypanosoma brucei DNA polymerase IV, putative 0.0205 0.2364 0.6431
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0694 0.0681
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0392 0.1606
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0045 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0205 0.2364 0.6431
Trypanosoma cruzi DNA damage repair protein, putative 0.0064 0.0678 0.1816
Loa Loa (eye worm) hypothetical protein 0.0031 0.0285 0.0515
Trypanosoma brucei DNA polymerase IV, putative 0.0205 0.2364 0.6431
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0221 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0045 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0045 0.0059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0045 0.006
Onchocerca volvulus 0.0077 0.0837 0.1371
Echinococcus multilocularis dna polymerase eta 0.0315 0.3668 0.3659
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0221 0.1051
Giardia lamblia DNA damage repair protein 0.0064 0.0678 0.2824
Plasmodium falciparum DNA repair protein REV1, putative 0.0064 0.0678 0.5805
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0189 0.0885
Mycobacterium ulcerans DNA polymerase IV 0.0205 0.2364 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0392 0.1033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.073 0.141
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.1157 1
Trichomonas vaginalis dullard protein, putative 0.0014 0.008 0.0129

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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