Detailed information for compound 1211605

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 567.842 | Formula: C36H57NO4
  • H donors: 2 H acceptors: 4 LogP: 8.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C(=O)O)NC(=O)[C@@]12CCC(C[C@H]2C2=CC[C@H]3[C@@]([C@@]2(CC1)C)(C)CC[C@@H]1[C@]3(C)CCC(=O)C1(C)C)(C)C)C
  • InChi: 1S/C36H57NO4/c1-22(2)20-25(29(39)40)37-30(41)36-18-16-31(3,4)21-24(36)23-10-11-27-33(7)14-13-28(38)32(5,6)26(33)12-15-35(27,9)34(23,8)17-19-36/h10,22,24-27H,11-21H2,1-9H3,(H,37,41)(H,39,40)/t24-,25-,26-,27+,33-,34+,35+,36-/m0/s1
  • InChiKey: TZBLPCCOFGTPTL-GDCLZHJBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0157 0.1467 0.1524
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0124 0.0128
Plasmodium falciparum glutathione reductase 0.0056 0.0386 0.7756
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0369
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0124 0.0243
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0124 0.0128
Brugia malayi glutaminase DH11.1 0.0307 0.3058 0.602
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0124 0.0128
Schistosoma mansoni intermediate filament proteins 0.0053 0.0353 0.0367
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0066 0.0498 0.6
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0064 0.0067
Entamoeba histolytica protein kinase domain containing protein 0.0097 0.083 1
Brugia malayi beta-lactamase 0.0042 0.0239 0.0471
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0127 0.1144 0.4342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0124 0.0138
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0278 0.2749 0.5362
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0066 0.0498 0.6
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0138
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0086 0.1033
Mycobacterium tuberculosis Conserved protein 0.0042 0.0239 0.0909
Echinococcus multilocularis dual specificity protein kinase clk2 0.0066 0.0498 0.0498
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0239 0.0249
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0127 0.1144 0.4342
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0239 0.0909
Leishmania major protein kinase, putative 0.0066 0.0498 0.6
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0124 0.0128
Schistosoma mansoni hypothetical protein 0.0157 0.1467 0.1524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0124 0.0138
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0157 0.1467 0.1524
Brugia malayi hypothetical protein 0.0027 0.0086 0.0169
Echinococcus granulosus dual specificity 0.0097 0.083 0.0862
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0497 0.508 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0239 0.0909
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0239 0.0783
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0239 0.0909
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0097 0.083 1
Onchocerca volvulus 0.0257 0.2528 1
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0239 0.0909
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.083 0.0862
Brugia malayi TAR-binding protein 0.0278 0.2749 0.5412
Schistosoma mansoni tar DNA-binding protein 0.0278 0.2749 0.2855
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0124 0.0243
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0498 0.0517
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0497 0.508 1
Brugia malayi steroid hormone receptor 0.0031 0.0124 0.0243
Echinococcus multilocularis 0.0065 0.0487 0.0487
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0127 0.1144 0.4342
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0124 0.0124
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0097 0.083 1
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0239 0.0909
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0086 0.1721
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0124 0.0243
Echinococcus multilocularis GPCR, family 2 0.0157 0.1467 0.1467
Toxoplasma gondii ABC1 family protein 0.0042 0.0239 0.4807
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0086 0.1033
Loa Loa (eye worm) glutaminase 2 0.0307 0.3058 0.5977
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0254 0.2492 0.2588
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0239 0.2884
Brugia malayi Protein kinase domain containing protein 0.0066 0.0498 0.0981
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0 0.5
Brugia malayi Pre-SET motif family protein 0.0226 0.2196 0.4324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0254 0.2492 0.2588
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0386 0.4654
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0124 0.0128
Loa Loa (eye worm) hypothetical protein 0.0497 0.508 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0124 0.0243
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0124 0.0124
Mycobacterium ulcerans beta-lactamase 0.0042 0.0239 0.0783
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0124 0.0138
Treponema pallidum NADH oxidase 0.0019 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0124 0.0243
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0124 0.0243
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0369
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0141 0.1294 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0254 0.2492 0.4851
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0239 0.4807
Echinococcus multilocularis dual specificity 0.0097 0.083 0.083
Echinococcus granulosus lamin dm0 0.0053 0.0353 0.0367
Leishmania major hypothetical protein, conserved 0.0042 0.0239 0.2884
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0124 0.0128
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0138
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0124 0.0138
Brugia malayi nuclear receptor NHR-88 0.0031 0.0124 0.0243
Brugia malayi Latrophilin receptor protein 2 0.0157 0.1467 0.2888
Loa Loa (eye worm) glutaminase 0.0307 0.3058 0.5977
Plasmodium vivax glutathione reductase, putative 0.0056 0.0386 0.7756
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0124 0.0128
Plasmodium falciparum thioredoxin reductase 0.0056 0.0386 0.7756
Trichomonas vaginalis set domain proteins, putative 0.0257 0.2528 0.8268
Mycobacterium tuberculosis Probable dehydrogenase 0.0127 0.1144 0.4342
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0066 0.0498 0.6
Echinococcus granulosus GPCR family 2 0.0157 0.1467 0.1524
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0127 0.1144 0.4342
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0124 0.0138
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0239 0.0783
Echinococcus granulosus tar DNA binding protein 0.0278 0.2749 0.2855
Entamoeba histolytica protein kinase, putative 0.0097 0.083 1
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0353 0.0595
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.014 0.0145
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.083 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0124 0.0243
Entamoeba histolytica hypothetical protein 0.0097 0.083 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0124 0.0128
Loa Loa (eye worm) hypothetical protein 0.0032 0.014 0.017
Mycobacterium tuberculosis Probable oxidoreductase 0.0141 0.1294 0.4914
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0086 0.1721
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0239 0.0369
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0066 0.0498 0.6
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0066 0.0498 0.6
Loa Loa (eye worm) TAR-binding protein 0.0278 0.2749 0.5362
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0239 0.0909
Schistosoma mansoni coup transcription factor 0.0031 0.0124 0.0128
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0239 0.0471
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0239 0.0249
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0124 0.0128
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0157 0.1467 0.1467
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0124 0.0128
Loa Loa (eye worm) glutathione reductase 0.0056 0.0386 0.0661
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0124 0.0124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0239 0.0249
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0254 0.2492 0.4905
Brugia malayi beta-lactamase family protein 0.0042 0.0239 0.0471
Schistosoma mansoni tar DNA-binding protein 0.0278 0.2749 0.2855
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0063
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0064 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0254 0.2492 0.2492
Plasmodium vivax serine/threonine kinase-1, putative 0.0066 0.0498 1
Mycobacterium ulcerans hypothetical protein 0.0042 0.0239 0.0783
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0124 0.0128
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0138
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0239 0.0783
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0124 0.0128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.014 0.2802
Onchocerca volvulus 0.0053 0.0353 0.0954
Loa Loa (eye worm) RNA binding protein 0.0278 0.2749 0.5362
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0124 0.0124
Brugia malayi Thioredoxin reductase 0.0056 0.0386 0.0761
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0124 0.0138
Schistosoma mansoni hypothetical protein 0.0926 0.9627 1
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0094 0.0185
Echinococcus multilocularis lamin 0.0053 0.0353 0.0353
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0124 0.0128
Loa Loa (eye worm) hypothetical protein 0.0157 0.1467 0.2812
Leishmania major hypothetical protein, conserved 0.0027 0.0086 0.1033
Mycobacterium ulcerans lipase LipD 0.0042 0.0239 0.0783
Plasmodium vivax SET domain protein, putative 0.0032 0.014 0.2802
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0124 0.0243
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0086 0.1721
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0124 0.0243
Loa Loa (eye worm) hypothetical protein 0.0096 0.082 0.1523
Echinococcus granulosus intermediate filament protein 0.0053 0.0353 0.0367
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0157 0.1467 0.2888
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0254 0.2492 0.2588
Echinococcus granulosus hypothetical protein 0.0065 0.0487 0.0506
Echinococcus granulosus lamin 0.0053 0.0353 0.0367
Schistosoma mansoni tar DNA-binding protein 0.0278 0.2749 0.2855
Loa Loa (eye worm) latrophilin receptor protein 2 0.0157 0.1467 0.2812
Schistosoma mansoni lamin 0.0053 0.0353 0.0367
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.014 0.014
Schistosoma mansoni hypothetical protein 0.034 0.3408 0.354
Trichomonas vaginalis esterase, putative 0.0042 0.0239 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0254 0.2492 0.2588
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0369
Mycobacterium tuberculosis Probable reductase 0.0127 0.1144 0.4342
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0157 0.1467 0.1524
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0086 0.1033
Onchocerca volvulus 0.0042 0.0239 0.0482
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0127 0.1144 0.8573
Brugia malayi Pre-SET motif family protein 0.0032 0.014 0.0275
Echinococcus granulosus geminin 0.0926 0.9627 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0239 0.2884
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0097 0.083 0.1544
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0239 0.2884
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.014 0.0145
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0239 0.0783
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0124 0.0128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0254 0.2492 0.2492
Loa Loa (eye worm) hypothetical protein 0.0053 0.0353 0.0595
Schistosoma mansoni tar DNA-binding protein 0.0278 0.2749 0.2855
Schistosoma mansoni lamin 0.0053 0.0353 0.0367
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.083 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0239 0.0249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0254 0.2492 0.2588
Echinococcus multilocularis musashi 0.0053 0.0353 0.0353
Schistosoma mansoni hypothetical protein 0.0157 0.1467 0.1524
Echinococcus multilocularis tar DNA binding protein 0.0278 0.2749 0.2749
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0138
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0124 0.0243
Brugia malayi RNA binding protein 0.0278 0.2749 0.5412
Echinococcus granulosus dual specificity protein kinase clk2 0.0066 0.0498 0.0517
Loa Loa (eye worm) hypothetical protein 0.0052 0.0343 0.0574
Entamoeba histolytica protein kinase, putative 0.0097 0.083 1
Onchocerca volvulus 0.0032 0.014 0.0066
Trypanosoma brucei trypanothione reductase 0.0056 0.0386 0.4654
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0369
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0138
Onchocerca volvulus 0.0042 0.0239 0.0482
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0386 0.7756
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0353 0.0595
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0386 0.0661
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0239 0.0249
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.2196 0.4263
Schistosoma mansoni hypothetical protein 0.0042 0.0239 0.0249
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0124 0.0243
Giardia lamblia Kinase, CMGC CLK 0.0066 0.0498 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0124 0.0243
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0124 0.0243
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0124 0.0128
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0124 0.0128
Plasmodium falciparum protein serine/threonine kinase-1 0.0066 0.0498 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0239 0.0783
Brugia malayi beta-lactamase family protein 0.0042 0.0239 0.0471
Brugia malayi ecdysteroid receptor 0.0031 0.0124 0.0243
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0124 0.0138
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0066 0.0498 0.6
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0369
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.2634 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.014 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0124 0.0243
Onchocerca volvulus 0.0042 0.0239 0.0482
Brugia malayi Calcitonin receptor-like protein seb-1 0.0497 0.508 1
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0239 0.0909
Brugia malayi glutathione reductase 0.0056 0.0386 0.0761
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0124 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0124 0.0128
Loa Loa (eye worm) hypothetical protein 0.0096 0.082 0.1523
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0124 0.0124
Schistosoma mansoni hypothetical protein 0.0157 0.1467 0.1524
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0094 0.0079
Toxoplasma gondii thioredoxin reductase 0.0056 0.0386 0.7756
Brugia malayi hypothetical protein 0.0042 0.0239 0.0471
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0239 0.0239
Onchocerca volvulus 0.0053 0.0353 0.0954
Loa Loa (eye worm) hypothetical protein 0.034 0.3408 0.6673
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0124 0.0124
Brugia malayi nuclear hormone receptor 0.0031 0.0124 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0124 0.0243
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0127 0.0132
Brugia malayi Protein kinase domain containing protein 0.0097 0.083 0.1634
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0239 0.0239
Schistosoma mansoni glutaminase 0.0307 0.3058 0.3176
Loa Loa (eye worm) beta-lactamase 0.0042 0.0239 0.0369
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0141 0.1294 0.4914
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0086 0.1721
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0239 0.0783
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0124 0.0128
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0386 0.0401
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0386 0.1467
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0066 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0487 0.0862
Schistosoma mansoni hypothetical protein 0.0926 0.9627 1
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0239 0.0909
Brugia malayi RNA recognition motif domain containing protein 0.0278 0.2749 0.5412
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0138
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0124 0.0128
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0124 0.0128
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0239 0.0783
Echinococcus multilocularis lamin dm0 0.0053 0.0353 0.0353
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0124 0.0243
Leishmania major protein kinase, putative 0.0066 0.0498 0.6
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0369
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0124 0.0124
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0124 0.0124
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0124 0.0128
Mycobacterium ulcerans glutaminase 0.0307 0.3058 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.014 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0278 0.2749 0.2855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0124 0.0138
Brugia malayi latrophilin 2 splice variant baaae 0.034 0.3408 0.6708
Trichomonas vaginalis glutaminase, putative 0.0307 0.3058 1
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0498 0.0517
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0141 0.1294 0.4914
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0353 0.0695
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0157 0.1467 0.1467
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0386 0.0386
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0066 0.0498 0.0883
Mycobacterium tuberculosis Conserved protein 0.0042 0.0239 0.0909
Brugia malayi intermediate filament protein 0.0053 0.0353 0.0695
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0498 0.1629
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.014 0.0145
Echinococcus multilocularis geminin 0.0926 0.9627 0.9627
Leishmania major trypanothione reductase 0.0056 0.0386 0.4654

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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