Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.918 | 0.918 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0.0002 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2244 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0.0002 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0015 | 0.0002 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0.0002 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2244 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.0002 | 0.0002 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.918 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1205 | 0.1205 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1205 | 0.5371 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0008 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0015 | 0.0002 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0.0002 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.918 | 0.918 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2244 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0008 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0008 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1205 | 0.5371 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0015 | 0.0002 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0015 | 0.0002 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2244 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0224 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.