Detailed information for compound 1212538

Basic information

Technical information
  • TDR Targets ID: 1212538
  • Name: (8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroperox y-5-propan-2-ylhept-6-en-2-yl]-10,13-dimethyl -2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclo penta[a]phenanthrene-3,6-dione
  • MW: 456.657 | Formula: C29H44O4
  • H donors: 1 H acceptors: 3 LogP: 6.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OOC(C(C)C)(CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC(=O)C2=CC(=O)CC[C@]12C)C)C=C
  • InChi: 1S/C29H44O4/c1-7-29(33-32,18(2)3)15-10-19(4)22-8-9-23-21-17-26(31)25-16-20(30)11-13-28(25,6)24(21)12-14-27(22,23)5/h7,16,18-19,21-24,32H,1,8-15,17H2,2-6H3/t19-,21+,22-,23+,24+,27-,28-,29?/m1/s1
  • InChiKey: PGUZRCYRDRXYDE-VRXDQMMBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (8S,9S,10R,13R,14S,17R)-17-[(1R)-4-hydroperoxy-4-isopropyl-1-methyl-hex-5-enyl]-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,6-dione
  • (8S,9S,10R,13R,14S,17R)-17-[(1R)-4-hydroperoxy-4-isopropyl-1-methylhex-5-enyl]-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,6-dione
  • (8S,9S,10R,13R,14S,17R)-17-[(1R)-4-hydroperoxy-4-isopropyl-1-methyl-hex-5-enyl]-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,6-quinone
  • (8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroperoxy-5-propan-2-yl-hept-6-en-2-yl]-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,6-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0049 0.0052 0.0595
Schistosoma mansoni ap endonuclease 0.002 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0041 0.0041
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0072 0.0069
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0039 0.0229
Leishmania major C-8 sterol isomerase-like protein 0.0377 0.057 1
Echinococcus multilocularis neuropeptide receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Onchocerca volvulus 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0003
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0006 0.0003
Echinococcus multilocularis dna polymerase kappa 0.002 0.0005 0.0002
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.0081 0.0714
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0014 0.0142
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0009 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0041 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0005 0.0044
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0059 0.0066 0.0064
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0006 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0012 0.017
Brugia malayi RE15519p 0.002 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0006 0.0003
Echinococcus multilocularis somatostatin receptor 0.002 0.0006 0.0003
Trichomonas vaginalis DNA topoisomerase II, putative 0.0144 0.0202 0.1182
Brugia malayi hypothetical protein 0.0037 0.0032 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0003 0.001
Plasmodium vivax DNA gyrase subunit B, putative 0.0084 0.0107 0.1255
Echinococcus multilocularis neuroligin 0.1071 0.1668 0.1666
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0012 0.0058
Loa Loa (eye worm) acetylcholinesterase 1 0.6338 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0039
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.0391 0.2338
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0037
Plasmodium falciparum flap endonuclease 1 0.0027 0.0016 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0006 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0005 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.0923 0.5519
Toxoplasma gondii DNA topoisomerase 2, putative 0.0144 0.0202 0.7214
Onchocerca volvulus 0.002 0.0006 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0006 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0006 0.0003
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0081 0.0481
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1071 0.1668 0.1666
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0006 0.0006
Trichomonas vaginalis esterase, putative 0.0041 0.0039 0.0205
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0009 0.0009
Schistosoma mansoni microtubule-associated protein tau 0.1416 0.2214 0.2212
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0006 0.0003
Onchocerca volvulus 0.0099 0.013 0.0752
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Brugia malayi nuclear receptor NHR-88 0.002 0.0006 0.0006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0006 0.0003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0041 0.0038
Leishmania major ubiquitin-activating enzyme-like protein 0.0032 0.0025 0.0398
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0049 0.0052 0.0049
Trypanosoma brucei unspecified product 0.002 0.0005 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.0923 0.5519
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0015 0.0012
Trypanosoma brucei C-8 sterol isomerase, putative 0.0377 0.057 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0041 0.0041
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0016 0.0236
Echinococcus granulosus serotonin receptor 0.002 0.0006 0.0003
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0031 0.0502
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0039
Trypanosoma cruzi hypothetical protein 0.0068 0.0081 0.1388
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.0923 0.5519
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0012 0.017
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0007
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0084 0.0107 0.0634
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0005 0.0005
Schistosoma mansoni opsin-like receptor 0.002 0.0006 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0006 0.0003
Brugia malayi hypothetical protein 0.0026 0.0014 0.0014
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0192 0.0278 0.4861
Echinococcus granulosus g-protein coupled receptor 0.002 0.0006 0.0003
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0144 0.0202 0.0202
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0127 0.0732
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0041 0.0041
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0006 0.0003
Plasmodium falciparum DNA gyrase subunit A 0.0031 0.0023 0.0245
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0032 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Schistosoma mansoni myosin xvIII 0.002 0.0006 0.0003
Brugia malayi Nuclear hormone receptor E75 0.002 0.0006 0.0006
Giardia lamblia Kinase, PLK 0.0097 0.0127 0.1139
Loa Loa (eye worm) carboxylesterase 0.1071 0.1668 0.1666
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0094 0.1608
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0006 0.0003
Plasmodium vivax ubiquitin activating enzyme, putative 0.0049 0.0052 0.0595
Onchocerca volvulus 0.1071 0.1668 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0039
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0041 0.0213
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.002 0.0017
Plasmodium vivax topoisomerase I, putative 0.0192 0.0278 0.3327
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0006 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0012 0.0068
Brugia malayi G protein-coupled receptor 0.002 0.0006 0.0006
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0041 0.0038
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0003 0.001
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0041 0.0039
Echinococcus granulosus acetylcholinesterase 0.6338 1 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0084 0.0107 0.2215
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.031 0.0464 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0031 0.0023 0.039
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0006 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0039 0.0039
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0006 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0012 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0041 0.0041
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0031 0.0029
Leishmania major hypothetical protein, conserved 0.0026 0.0014 0.0206
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0037
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0039 0.0229
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Trichomonas vaginalis spcc417.12 protein, putative 0.1071 0.1668 1
Brugia malayi steroid hormone receptor 0.0042 0.0041 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus multilocularis g protein coupled receptor 0.002 0.0006 0.0003
Schistosoma mansoni coup transcription factor 0.0042 0.0041 0.0038
Echinococcus granulosus neuropeptide receptor A26 0.0491 0.075 0.0748
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0006 0.0003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0006 0.0003
Onchocerca volvulus 0.1071 0.1668 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.0923 0.8582
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0041 0.0041
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0009 0.0007
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0012
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0006 0.0003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0006 0.0003
Mycobacterium ulcerans lipase LipD 0.0041 0.0039 0.022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0039 0.0037
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0006 0.0003
Schistosoma mansoni amine GPCR 0.002 0.0006 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0094 0.1608
Brugia malayi ThiF family protein 0.0049 0.0052 0.0052
Schistosoma mansoni neuropeptide receptor 0.002 0.0006 0.0003
Schistosoma mansoni neuropeptide receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0006 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0012 0.0068
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0009 0.0009
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0005 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0039 0.0205
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0006 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0014 0.0206
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus granulosus neuropeptide receptor 0.002 0.0006 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0041 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.0923 0.5519
Brugia malayi Cytochrome P450 family protein 0.0018 0.0003 0.0003
Schistosoma mansoni single-minded 0.005 0.0053 0.005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0039 0.0037
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0014 0.0142
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0003
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1071 0.1668 0.1666
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0192 0.0278 0.4861
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0088 0.0112 0.0643
Schistosoma mansoni neuropeptide receptor 0.002 0.0006 0.0003
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0006 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0006 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0039 0.0643
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0012 0.0209
Loa Loa (eye worm) hypothetical protein 0.6338 1 1
Treponema pallidum fructose-bisphosphate aldolase 0.06 0.0923 1
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0041 0.0213
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0007
Schistosoma mansoni neuropeptide receptor 0.002 0.0006 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0003 0.001
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0041 0.0038
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Schistosoma mansoni DNA polymerase eta 0.002 0.0005 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0057 0.0054
Brugia malayi nuclear hormone receptor 0.002 0.0006 0.0006
Schistosoma mansoni amine GPCR 0.002 0.0006 0.0003
Echinococcus multilocularis allatostatin A receptor 0.002 0.0006 0.0003
Schistosoma mansoni hypothetical protein 0.0037 0.0032 0.0029
Brugia malayi Melatonin receptor type 1A 0.002 0.0006 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0127 0.0732
Loa Loa (eye worm) hypothetical protein 0.0053 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0031 0.0029
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0088 0.0112 0.1935
Loa Loa (eye worm) DNA topoisomerase I 0.0192 0.0278 0.0276
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0006 0.0003
Brugia malayi Dopamine receptor protein 2 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0377 0.057 0.0568
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0039 0.0643
Echinococcus granulosus lamin dm0 0.0054 0.0059 0.0057
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0005 0.0044
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0094 0.0548
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0009 0.0007
Schistosoma mansoni glutaminase 0.0277 0.0412 0.041
Plasmodium falciparum topoisomerase I 0.0192 0.0278 0.3327
Onchocerca volvulus 0.002 0.0006 0.0003
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Schistosoma mansoni inositol monophosphatase 0.0076 0.0094 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0127 0.0124
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0006 0.0003
Echinococcus granulosus family S9 non peptidase ue S09 family 0.1071 0.1668 0.1666
Echinococcus multilocularis neuropeptide receptor A26 0.0491 0.075 0.0748
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0057 0.0054
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0016 0.0236
Entamoeba histolytica hypothetical protein 0.0037 0.0032 0.0254
Echinococcus multilocularis geminin 0.0173 0.0248 0.0246
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0014 0.0424
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0006 0.0003
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0003 0.001
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0127 0.0124
Echinococcus multilocularis microtubule associated protein 2 0.1416 0.2214 0.2212
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0006 0.0003
Mycobacterium tuberculosis Carboxylesterase LipT 0.1071 0.1668 1
Brugia malayi Carboxylesterase family protein 0.6338 1 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0005 0.0002
Plasmodium falciparum telomerase reverse transcriptase 0.0542 0.0832 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0006 0.0003
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0127 0.2188
Schistosoma mansoni biogenic amine receptor 0.002 0.0006 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0022 0.002
Onchocerca volvulus 0.0031 0.0022 0.01
Brugia malayi Carboxylesterase family protein 0.1071 0.1668 0.1668
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0136 0.0189 0.3291
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0006 0.0003
Echinococcus multilocularis serotonin receptor 0.002 0.0006 0.0003
Echinococcus multilocularis acetylcholinesterase 0.6338 1 1
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0033 0.003
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0006 0.0003
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0006 0.0003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0006 0.0003
Giardia lamblia DNA topoisomerase II 0.0136 0.019 0.1727
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0492 0.0753 0.0751
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0006 0.0003
Leishmania major DNA topoisomerase ii 0.0136 0.0189 0.3291
Entamoeba histolytica hypothetical protein 0.0037 0.0032 0.0254
Schistosoma mansoni histamine h1 receptor 0.002 0.0006 0.0003
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0006 0.0003
Brugia malayi tailless protein 0.002 0.0006 0.0006
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0006 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0006 0.0003
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0293 0.0437 0.2618
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0006 0.0003
Mycobacterium leprae Probable lipase LipE 0.0041 0.0039 0.0791
Loa Loa (eye worm) hypothetical protein 0.0485 0.0742 0.074
Onchocerca volvulus 0.0054 0.0059 0.0323
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.0923 0.5519
Brugia malayi hypothetical protein 0.0485 0.0742 0.0742
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0006 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0006 0.0003
Schistosoma mansoni hypothetical protein 0.0173 0.0248 0.0246
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0005 0.0029
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0094 0.1936
Onchocerca volvulus 0.0041 0.0039 0.0202
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0005 0.0041
Mycobacterium ulcerans cell division protein FtsZ 0.031 0.0464 0.277
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0039 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0041 0.0041
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0022 0.002
Loa Loa (eye worm) hypothetical protein 0.6338 1 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0097 0.0128 0.0735
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0022 0.002
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0006 0.0003
Plasmodium vivax SET domain protein, putative 0.0031 0.0022 0.0237
Schistosoma mansoni survival motor neuron protein 0.0099 0.013 0.0128
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0003 0.0009
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.0041 0.0039 0.0229
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0127 0.1139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0057 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0012 0.0058
Echinococcus granulosus g protein coupled receptor 0.002 0.0006 0.0003
Mycobacterium ulcerans hypothetical protein 0.0024 0.0012 0.0058
Echinococcus multilocularis fmrfamide receptor 0.002 0.0006 0.0003
Toxoplasma gondii DNA topoisomerase I, putative 0.0192 0.0278 1
Brugia malayi Carboxylesterase family protein 0.1071 0.1668 0.1668
Toxoplasma gondii ThiF family protein 0.0032 0.0025 0.0819
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0127 0.0732
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0094 0.0831
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0005 0.0005
Echinococcus multilocularis lamin dm0 0.0054 0.0059 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0022 0.002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0022 0.071
Echinococcus multilocularis BC026374 protein (S09 family) 0.1071 0.1668 0.1666
Brugia malayi TAR-binding protein 0.0062 0.0072 0.0072
Loa Loa (eye worm) beta-lactamase 0.0041 0.0039 0.0037
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0097 0.0128 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Trypanosoma brucei DNA topoisomerase ii 0.0162 0.0229 0.3998
Mycobacterium ulcerans hypothetical protein 0.0041 0.0039 0.022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.0923 0.5519
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0041 0.0041
Onchocerca volvulus 0.002 0.0006 0.0003
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0198 0.0287 0.2637
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0033 0.018
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0081 0.0459
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0003 0.001
Brugia malayi ORL1-like opioid receptor 0.002 0.0006 0.0006
Toxoplasma gondii exonuclease III APE 0.002 0.0005 0.0085
Onchocerca volvulus 0.002 0.0006 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.1071 0.1668 0.1666
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0032 0.0029
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0032 0.0025 0.0023
Schistosoma mansoni nuclear receptor 0.002 0.0006 0.0003
Schistosoma mansoni DNA topoisomerase type I 0.0192 0.0278 0.0276
Onchocerca volvulus 0.002 0.0006 0.0003
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0006 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.0311 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0055 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0039 0.0205
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0081 0.1704
Onchocerca volvulus 0.0024 0.0012 0.0041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0041 0.0038
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.6338 1 1
Toxoplasma gondii RNA-directed DNA polymerase 0.0088 0.0112 0.3981
Schistosoma mansoni DNA topoisomerase type I 0.0192 0.0278 0.0276
Loa Loa (eye worm) Ulp1 protease 0.0068 0.0081 0.0079
Brugia malayi cytochrome P450 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0039
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0006 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0057 0.0054
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0045 0.0045 0.0042
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0006 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0127 0.0732
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0055 0.0052
Chlamydia trachomatis DNA gyrase subunit B 0.0066 0.0079 0.7322
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0153 0.0216 0.0213
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0084 0.0107 0.3772
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0006 0.0003
Trypanosoma cruzi DNA topoisomerase II, putative 0.0136 0.0189 0.3291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0057 0.0054
Loa Loa (eye worm) hypothetical protein 0.1071 0.1668 0.1666
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0144 0.0202 0.0199
Schistosoma mansoni amine GPCR 0.002 0.0006 0.0003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0005 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0059 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0039 0.0643
Echinococcus granulosus carboxylesterase 5A 0.6338 1 1
Chlamydia trachomatis DNA gyrase subunit B 0.0084 0.0107 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0003 0.001
Treponema pallidum cell division protein FtsZ 0.031 0.0464 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0006 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0039 0.0229
Entamoeba histolytica hypothetical protein 0.0037 0.0032 0.0254
Onchocerca volvulus 0.0054 0.0059 0.0323
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0041 0.0038
Plasmodium vivax DNA gyrase subunit A, putative 0.0031 0.0023 0.0245
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Onchocerca volvulus 0.002 0.0006 0.0003
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0216 0.0213
Loa Loa (eye worm) glutaminase 2 0.0277 0.0412 0.041
Echinococcus granulosus microtubule associated protein 2 0.1416 0.2214 0.2212
Schistosoma mansoni hypothetical protein 0.0035 0.0029 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0003 0.001
Brugia malayi nuclear receptor RXR 0.0022 0.0009 0.0009
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0094 0.0091
Brugia malayi neuropeptide F receptor 0.002 0.0006 0.0006
Plasmodium falciparum DNA gyrase subunit B 0.0084 0.0107 0.1255
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0029 0.0029
Schistosoma mansoni tsg101-related 0.0059 0.0068 0.0065
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Loa Loa (eye worm) carboxylesterase 0.1071 0.1668 0.1666
Leishmania major DNA topoisomerase IB, large subunit 0.0192 0.0278 0.4861
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0006 0.0003
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0006 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0003 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0041 0.0038
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0003
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0005 0.0002
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Echinococcus multilocularis dna polymerase eta 0.002 0.0005 0.0002
Echinococcus granulosus para nitrobenzyl esterase 0.1071 0.1668 0.1666
Mycobacterium ulcerans DNA gyrase subunit B 0.0084 0.0107 0.0625
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0039 0.0229
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Schistosoma mansoni opsin-like receptor 0.002 0.0006 0.0003
Plasmodium vivax telomerase reverse transcriptase, putative 0.0542 0.0832 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0097 0.0128 0.0126
Schistosoma mansoni flap endonuclease-1 0.0024 0.0012 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0041 0.0038
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0006 0.0003
Onchocerca volvulus 0.002 0.0006 0.0003
Echinococcus granulosus survival motor neuron protein 1 0.0485 0.0742 0.0739
Brugia malayi hypothetical protein 0.0022 0.0009 0.0009
Loa Loa (eye worm) TOPoisomerase family member 0.0144 0.0202 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0003 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0039 0.0037
Onchocerca volvulus 0.0041 0.0039 0.0202
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0006 0.0003
Echinococcus multilocularis sentrin specific protease 8 0.0068 0.0081 0.0079
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.005 0.0425
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0377 0.057 1
Brugia malayi putative neuropeptide receptor 0.002 0.0006 0.0006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0006 0.0003
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0094 0.0534
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0006 0.0003
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0006 0.0003
Brugia malayi RNA binding protein 0.0062 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0003
Brugia malayi GnHR receptor homolog 0.002 0.0006 0.0006
Echinococcus multilocularis survival motor neuron protein 1 0.0485 0.0742 0.0739
Schistosoma mansoni neuroligin 3 (S09 family) 0.1071 0.1668 0.1666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0006 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0041 0.0041
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.0923 0.8582
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0006 0.0004
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0293 0.0437 0.2611
Loa Loa (eye worm) hypothetical protein 0.0059 0.0066 0.0064
Entamoeba histolytica hypothetical protein 0.0037 0.0032 0.0254
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0014 0.0206
Schistosoma mansoni amine GPCR 0.002 0.0006 0.0003
Brugia malayi DNA topoisomerase I 0.0192 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Onchocerca volvulus 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0039
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0041 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.0041 0.0039 0.0643
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0053 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0016 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0041 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.0923 0.5519
Echinococcus granulosus neuropeptide s receptor 0.0491 0.075 0.0748
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0041 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0377 0.057 0.057
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0144 0.0202 0.0199
Leishmania major telomerase reverse transcriptase, putative 0.0088 0.0112 0.1935
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0005 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0003 0.001
Brugia malayi Flap endonuclease-1 0.0027 0.0016 0.0016
Schistosoma mansoni inositol monophosphatase 0.0076 0.0094 0.0091
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0037
Brugia malayi Dopamine receptor protein 1 0.002 0.0006 0.0006
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0031 0.0023 0.0733
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0293 0.0437 0.9427
Brugia malayi PAS domain containing protein 0.005 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Entamoeba histolytica DNA topoisomerase II, putative 0.0144 0.0202 0.1838
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.001 0.0128
Brugia malayi larval opioid receptor 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0094 0.0534
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0006 0.0003
Echinococcus granulosus neuroligin 0.1071 0.1668 0.1666
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0041 0.0041
Brugia malayi hypothetical protein 0.1071 0.1668 0.1668
Trypanosoma brucei telomerase reverse transcriptase 0.0088 0.0112 0.1935
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0039 0.0037
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0006 0.0006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0041 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.0012
Onchocerca volvulus 0.0242 0.0357 0.2116
Schistosoma mansoni biogenic amine receptor 0.002 0.0006 0.0003
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0006 0.0003
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0006 0.0003
Trypanosoma brucei polo-like protein kinase 0.0097 0.0127 0.2188
Onchocerca volvulus 0.002 0.0006 0.0003
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0127 0.2188
Schistosoma mansoni adenoreceptor 0.002 0.0006 0.0003
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.1071 0.1668 0.1666
Onchocerca volvulus 0.002 0.0006 0.0003
Schistosoma mansoni amine GPCR 0.002 0.0006 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0054 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0125 0.0172 0.017
Trichomonas vaginalis hypothetical protein 0.0035 0.0029 0.0143
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0005 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0003 0.001
Echinococcus multilocularis lamin 0.0054 0.0059 0.0057
Giardia lamblia DNA repair protein RAD52 0.0696 0.1075 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0006 0.0003
Echinococcus granulosus geminin 0.0173 0.0248 0.0246
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.002
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0016 0.0067
Echinococcus multilocularis carboxylesterase 5A 0.6338 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Giardia lamblia Telomerase catalytic subunit 0.0088 0.0112 0.1004
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0136 0.0189 0.3291
Schistosoma mansoni gliotactin 0.1071 0.1668 0.1666
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0005 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0039 0.0205
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0094 0.1608
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0049 0.0052 0.0049
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0012 0.0068
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.1071 0.1668 0.1666
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0005 0.0044
Echinococcus granulosus dna polymerase kappa 0.002 0.0005 0.0002
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0005 0.0044
Brugia malayi AKH receptor 0.002 0.0006 0.0006
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0053 0.005
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0012 0.0209
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0059 0.0057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0005 0.0041
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0005 0.0002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0012 0.0058
Echinococcus granulosus intermediate filament protein 0.0054 0.0059 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Schistosoma mansoni tsg101-related 0.0048 0.005 0.0048
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0006 0.0003
Brugia malayi glutaminase DH11.1 0.0277 0.0412 0.0412
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0081 0.0459
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0006 0.0006
Onchocerca volvulus 0.002 0.0006 0.0003
Brugia malayi hypoxia-induced factor 1 0.0155 0.0219 0.0219
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0037 0.0033 0.0659
Leishmania major mitochondrial DNA topoisomerase II 0.0162 0.0229 0.3998
Brugia malayi conserved hypotetical protein 0.002 0.0006 0.0006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0041 0.0038
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0081 0.0459
Brugia malayi ecdysteroid receptor 0.0042 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0006 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0005 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0041 0.0039
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Schistosoma mansoni lamin 0.0054 0.0059 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0006 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0012 0.0058
Trypanosoma cruzi DNA topoisomerase II, putative 0.0136 0.0189 0.3291
Echinococcus multilocularis neuropeptide receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) DR-78 0.002 0.0006 0.0003
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0006 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0041 0.0039
Schistosoma mansoni zinc finger protein 0.002 0.0006 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0005 0.0002
Schistosoma mansoni DNA topoisomerase type I 0.0192 0.0278 0.0276
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0006 0.0003
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0006 0.0003
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.0086 0.0084
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0006 0.0003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0006 0.0003
Brugia malayi Carboxylesterase family protein 0.1071 0.1668 0.1668
Brugia malayi hypothetical protein 0.0071 0.0086 0.0086
Echinococcus granulosus DNA topoisomerase 1 0.0192 0.0278 0.0276
Giardia lamblia DINP protein human, muc B family 0.002 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0037
Brugia malayi G-protein coupled receptor 0.002 0.0006 0.0006
Echinococcus multilocularis conserved hypothetical protein 0.0706 0.1091 0.1088
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0094 0.0534
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0006 0.0003
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0021 0.0006 0.0363
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0005 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0041 0.0038
Brugia malayi ThiF family protein 0.0032 0.0025 0.0025
Brugia malayi ecdysone receptor 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0006 0.0003
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0006 0.0003
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.0081 0.0081
Schistosoma mansoni kinase 0.0049 0.0052 0.0049
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0006 0.0003
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0097 0.0128 0.0735
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0012 0.0068
Echinococcus multilocularis muscleblind protein 0.0153 0.0216 0.0213
Chlamydia trachomatis DNA gyrase subunit A 0.0031 0.0023 0.195
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0084 0.0107 0.1108
Brugia malayi neuropeptide F receptor 0.002 0.0006 0.0006
Brugia malayi beta-lactamase 0.0041 0.0039 0.0039
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0006 0.0003
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus granulosus tar DNA binding protein 0.0062 0.0072 0.0069
Schistosoma mansoni DNA topoisomerase II 0.0144 0.0202 0.0199
Schistosoma mansoni intermediate filament proteins 0.0054 0.0059 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0094 0.0091
Schistosoma mansoni nuclear hormone receptor 0.002 0.0006 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0041 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0041 0.0041
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.1071 0.1668 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.002 0.0018
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.0086 0.0084
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0005 0.0015
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0041 0.0038
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0025 0.0398
Loa Loa (eye worm) hypothetical protein 0.1071 0.1668 0.1666
Echinococcus multilocularis g protein coupled receptor 0.002 0.0006 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0006 0.0003
Echinococcus granulosus allatostatin A receptor 0.002 0.0006 0.0003
Toxoplasma gondii hypothetical protein 0.0049 0.0052 0.1787
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Trichomonas vaginalis set domain proteins, putative 0.0242 0.0357 0.2118
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0031 0.0023 0.0131
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0031 0.0502
Onchocerca volvulus 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0051 0.0055 0.0052
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0009 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0006 0.0003
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1623 0.2541 0.2539
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0037
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.0219 0.0217
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Brugia malayi intermediate filament protein 0.0054 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Brugia malayi sulfakinin receptor protein 0.002 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1071 0.1668 0.1666
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.1071 0.1668 0.1666
Brugia malayi Inositol-1 0.0076 0.0094 0.0094
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0041 0.0038
Loa Loa (eye worm) glutaminase 0.0277 0.0412 0.041
Brugia malayi follicle stimulating hormone receptor 0.0492 0.0753 0.0753
Loa Loa (eye worm) hypothetical protein 0.0071 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0068 0.0081 0.0079
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0006 0.0006
Echinococcus granulosus orexin receptor type 2 0.002 0.0006 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.005 0.0268
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0127 0.2188
Toxoplasma gondii ABC1 family protein 0.0041 0.0039 0.1324
Brugia malayi Cell division protein ftsZ 0.0153 0.0216 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0003 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0006 0.0003
Brugia malayi Probable DNA topoisomerase II 0.0144 0.0202 0.0202
Plasmodium vivax DNA topoisomerase II, putative 0.0144 0.0202 0.24
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0041 0.0041
Mycobacterium tuberculosis Cell division protein FtsZ 0.031 0.0464 0.2777
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0039
Loa Loa (eye worm) carboxylesterase 0.6338 1 1
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0041 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0006 0.0003
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0032 0.0025 0.0398
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0016 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0072 0.0069
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0039 0.0791
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0003 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0041 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0007
Schistosoma mansoni opsin-like receptor 0.002 0.0006 0.0003
Brugia malayi nuclear hormone receptor 0.0042 0.0041 0.0041
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0006 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0041 0.0038
Mycobacterium ulcerans glutaminase 0.0277 0.0412 0.2461
Onchocerca volvulus 0.002 0.0006 0.0003
Brugia malayi Muscleblind-like protein 0.0153 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0006 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0022 0.002
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0016 0.0236
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0012 0.0058
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0003 0.001
Echinococcus granulosus hypothetical protein 0.0726 0.1123 0.112
Brugia malayi beta-lactamase family protein 0.0041 0.0039 0.0039
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0003 0.001
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0039 0.0229
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0006 0.0004
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0006 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0041 0.0038
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0006 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0039 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0005 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0041 0.0038
Brugia malayi Dopamine receptor 0.002 0.0006 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0003 0.001
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0088 0.0112 0.1935
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0094 0.3307
Schistosoma mansoni nuclear hormone receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0153 0.0216 0.0213
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0039 0.0229
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0094 0.1608
Echinococcus granulosus g protein coupled receptor 0.002 0.0006 0.0003
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0039 0.0229
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0006 0.0003
Echinococcus multilocularis para nitrobenzyl esterase 0.1071 0.1668 0.1666
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0005 0.0029
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0006 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0127 0.0732
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0006 0.0003
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0144 0.0202 0.0202
Schistosoma mansoni tsg101-related 0.0059 0.0068 0.0065
Brugia malayi Nuclear hormone receptor E75 0.002 0.0006 0.0006
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0005 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0006 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0006 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0193 0.0278 0.0276
Mycobacterium leprae cell division protein FtsZ 0.031 0.0464 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0057 0.0054
Onchocerca volvulus 0.0041 0.0039 0.0202
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0005 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0031 0.0502
Onchocerca volvulus 0.002 0.0006 0.0003
Echinococcus granulosus lamin 0.0054 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0168 0.024 0.0237
Echinococcus multilocularis DNA topoisomerase 1 0.0192 0.0278 0.0276
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0009 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0006 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.1071 0.1668 0.1666
Loa Loa (eye worm) hypothetical protein 0.0049 0.0052 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0006 0.0003
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0198 0.0287 0.2637
Echinococcus granulosus sentrin specific protease 8 0.0068 0.0081 0.0079
Schistosoma mansoni acetylcholinesterase 0.1071 0.1668 0.1666
Schistosoma mansoni BC026374 protein (S09 family) 0.1071 0.1668 0.1666
Schistosoma mansoni hypothetical protein 0.0173 0.0248 0.0246
Schistosoma mansoni lamin 0.0054 0.0059 0.0057
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0041 0.0038
Echinococcus multilocularis neuropeptide s receptor 0.0491 0.075 0.0748
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0041 0.0038
Echinococcus granulosus single minded 2 0.0037 0.0033 0.003
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Brugia malayi Cytochrome P450 family protein 0.0036 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0006 0.0003
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0003 0.001
Brugia malayi hypothetical protein 0.0168 0.024 0.024
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0127 0.0127
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0006 0.0003
Giardia lamblia Fructose-bisphosphate aldolase 0.06 0.0923 0.8582
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0041 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0006 0.0003
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0127 0.0729
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0127 0.0124
Brugia malayi hypothetical protein 0.0125 0.0172 0.0172
Echinococcus granulosus fmrfamide receptor 0.002 0.0006 0.0003
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0016 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.005 0.0268
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0006 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0127 0.0732
Brugia malayi Cytochrome P450 family protein 0.0036 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0003
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0016 0.0486
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0012 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus granulosus somatostatin receptor 0.002 0.0006 0.0003
Echinococcus multilocularis fmrfamide receptor 0.002 0.0006 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0055 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.0923 0.5519
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0032 0.0029
Schistosoma mansoni biogenic amine receptor 0.002 0.0006 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0072 0.0072
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0003 0.001
Brugia malayi Serotonin receptor 0.002 0.0006 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0014 0.0142
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.013 0.013
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0049 0.0052 0.0049
Onchocerca volvulus 0.0037 0.0033 0.0162
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) inositol-1 0.0076 0.0094 0.0091
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0006 0.0003
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0006 0.0004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0057 0.0054
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0006 0.0003
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0162 0.0229 0.3998
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.001 0.0128
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0006 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0012 0.017
Leishmania major DNA polymerase eta, putative 0.002 0.0005 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0022 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0003 0.001
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0006 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0127 0.0732
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1071 0.1668 1
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0033 0.0033
Mycobacterium ulcerans beta-lactamase 0.0041 0.0039 0.022
Loa Loa (eye worm) ThiF family protein 0.0032 0.0025 0.0023
Brugia malayi beta-lactamase family protein 0.0041 0.0039 0.0039
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0006 0.0004
Onchocerca volvulus 0.0042 0.0041 0.0213
Brugia malayi hypothetical protein 0.0022 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0072 0.0069
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0006 0.0003
Schistosoma mansoni ap endonuclease 0.002 0.0005 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0006 0.0004
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1071 0.1668 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0005 0.0041
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0162 0.0229 0.3998
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0031 0.0029
Brugia malayi Pre-SET motif family protein 0.0213 0.0311 0.0311
Leishmania major cytochrome p450-like protein 0.0036 0.0031 0.0502
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Chlamydia trachomatis DNA gyrase subunit A 0.0031 0.0023 0.195
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0041 0.0038
Brugia malayi nuclear receptor NHR-67 0.002 0.0006 0.0006
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0031 0.0023 0.0195
Leishmania major hypothetical protein, conserved 0.0023 0.001 0.0128
Onchocerca volvulus 0.1071 0.1668 1
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0016 0.0013
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0032 0.0025 0.0273
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0039 0.0205
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0012 0.0068
Brugia malayi Cytochrome P450 family protein 0.0018 0.0003 0.0003
Brugia malayi Carboxylesterase family protein 0.1071 0.1668 0.1668
Mycobacterium ulcerans DNA gyrase subunit A 0.0031 0.0023 0.0122
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0039 0.022
Brugia malayi nuclear receptor RXR 0.002 0.0006 0.0006
Onchocerca volvulus Huntingtin homolog 0.0125 0.0172 0.1002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0007
Brugia malayi hypothetical protein 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus flap endonuclease 1 0.0027 0.0016 0.0013
Trichomonas vaginalis Sentrin-specific protease, putative 0.0068 0.0081 0.0459
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0006 0.0003
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Brugia malayi G-protein coupled receptor 0.002 0.0006 0.0006
Plasmodium falciparum DNA topoisomerase 2 0.0144 0.0202 0.24
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0006 0.0003
Echinococcus multilocularis g protein coupled receptor 0.002 0.0006 0.0003
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0003
Onchocerca volvulus 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0097 0.0128 0.0126
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0006 0.0003
Onchocerca volvulus 0.002 0.0006 0.0003
Echinococcus granulosus sex peptide receptor 0.002 0.0006 0.0003
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0006 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0041 0.0038
Mycobacterium ulcerans carboxylesterase, LipT 0.1071 0.1668 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0005 0.0041
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0041 0.0038
Echinococcus multilocularis sex peptide receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0015 0.0012
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0014 0.0206
Loa Loa (eye worm) hypothetical protein 0.0125 0.0172 0.017
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0006 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0003 0.001
Echinococcus multilocularis musashi 0.0054 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0037
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0696 0.1075 1
Echinococcus granulosus acetylcholinesterase 0.6338 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0006 0.0003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0006 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0006 0.0003
Loa Loa (eye worm) RNA binding protein 0.0062 0.0072 0.007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0005 0.0014
Brugia malayi Pre-SET motif family protein 0.0031 0.0022 0.0022
Mycobacterium tuberculosis Conserved protein 0.0041 0.0039 0.0229
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0011
Brugia malayi nuclear receptor NHR-88 0.0042 0.0041 0.0041
Echinococcus multilocularis acetylcholinesterase 0.6338 1 1
Echinococcus multilocularis orexin receptor type 2 0.002 0.0006 0.0003
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0006 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0013
Brugia malayi Serotonin receptor 0.002 0.0006 0.0006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0039 0.022
Loa Loa (eye worm) hypothetical protein 0.1071 0.1668 0.1666
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0027
Leishmania major DNA polymerase kappa, putative 0.002 0.0005 0.0044
Echinococcus granulosus BC026374 protein S09 family 0.1071 0.1668 0.1666
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0005 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0057 0.0054
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0005 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0072 0.0069
Schistosoma mansoni nuclear receptor 0.002 0.0006 0.0003
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0032 0.0025 0.0023
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0041 0.0041
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0006 0.0003
Onchocerca volvulus Huntingtin homolog 0.0125 0.0172 0.1002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0006 0.0003
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0032 0.0025 0.0273
Echinococcus granulosus g protein coupled receptor 0.002 0.0006 0.0003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0031 0.0171
Schistosoma mansoni hypothetical protein 0.0099 0.013 0.0128
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0127 0.0124
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0006 0.0003
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0005 0.0002
Echinococcus granulosus dna polymerase eta 0.002 0.0005 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.002 0.002
Brugia malayi Cell division protein ftsZ 0.0149 0.0209 0.0209
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0041 0.0038
Echinococcus multilocularis serotonin receptor 0.002 0.0006 0.0003
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0018 0.0272
Trichomonas vaginalis glutaminase, putative 0.0277 0.0412 0.245
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0006 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0039 0.0441
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0022 0.002
Mycobacterium tuberculosis Conserved protein 0.0041 0.0039 0.0229
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0004
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0072 0.0069
Echinococcus granulosus neuropeptide receptor 0.002 0.0006 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0041 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0072 0.0069
Onchocerca volvulus 0.1071 0.1668 1
Echinococcus granulosus muscleblind protein 0.0153 0.0216 0.0213
Onchocerca volvulus 0.1071 0.1668 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.8 ug ml-1 Cytotoxicity against mouse P388 cells ChEMBL. 17618015
ED50 (functional) = 0.8 ug ml-1 Cytotoxicity against mouse P388 cells after 6 days ChEMBL. 10075746
ED50 (functional) = 1.4 ug ml-1 Cytotoxicity against human HT29 cells ChEMBL. 17618015
ED50 (functional) = 1.4 ug ml-1 Cytotoxicity against human HT-29 cells after 3 days by MTT assay ChEMBL. 10075746
ED50 (functional) = 2.5 ug ml-1 Cytotoxicity against human A549 cells ChEMBL. 17618015
ED50 (functional) = 2.5 ug ml-1 Cytotoxicity against human A549 cells after 3 days by MTT assay ChEMBL. 10075746
ED50 (functional) = 4 ug ml-1 Cytotoxicity against human KB cells ChEMBL. 17618015
ED50 (functional) = 4 ug ml-1 Cytotoxicity against human KB cells after 6 days by MTT assay ChEMBL. 10075746

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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