Detailed information for compound 1212894

Basic information

Technical information
  • TDR Targets ID: 1212894
  • Name: N,N-dimethyl-4-(morpholine-4-carbonyl)benzene sulfonamide
  • MW: 298.358 | Formula: C13H18N2O4S
  • H donors: 0 H acceptors: 3 LogP: 0.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(S(=O)(=O)c1ccc(cc1)C(=O)N1CCOCC1)C
  • InChi: 1S/C13H18N2O4S/c1-14(2)20(17,18)12-5-3-11(4-6-12)13(16)15-7-9-19-10-8-15/h3-6H,7-10H2,1-2H3
  • InChiKey: BODPUUHEIFCXBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-dimethyl-4-(morpholino-oxomethyl)benzenesulfonamide
  • N,N-dimethyl-4-morpholin-4-ylcarbonyl-benzenesulfonamide
  • SMR000135964
  • ZINC00307418
  • MLS000530986
  • T5284026
  • N,N-dimethyl-4-(4-morpholinylcarbonyl)benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.9867 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.1067 0.1107
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0808 1
Onchocerca volvulus 0.0043 0.1314 0.0713
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.1077 0.7421
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1314 0.1303
Schistosoma mansoni importin beta-1 0.0028 0.0785 0.0785
Leishmania major DNA polymerase kappa, putative 0.0012 0.023 0.0221
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0785 0.0773
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0161 0.0221
Schistosoma mansoni importin-beta 2 0.0005 0.0012 0.0012
Schistosoma mansoni ap endonuclease 0.0019 0.0469 0.0469
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.3444 0.6575
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.1067 0.7358
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0533 0.3675
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0161 0.1874
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Echinococcus multilocularis bloom syndrome protein 0.0023 0.063 0.0618
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.4581 0.4636
Onchocerca volvulus 0.0043 0.1314 0.0713
Entamoeba histolytica hypothetical protein 0.0023 0.0604 0.0633
Loa Loa (eye worm) hypothetical protein 0.0029 0.0824 0.0813
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0462 0.0462
Giardia lamblia DNA damage repair protein 0.0012 0.023 0.0073
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0469 0.0479
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.1115 0.0918
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.3444 0.3609
Leishmania major DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0604 0.0621
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.1314 0.0957
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.1314 0.2218
Mycobacterium tuberculosis Conserved protein 0.0043 0.1314 0.0957
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1314 0.1125
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.1067 0.1056
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.1115 0.1119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0824 0.0824
Entamoeba histolytica Ran family GTPase 0.0021 0.0533 0.0559
Plasmodium vivax SET domain protein, putative 0.0029 0.0824 0.6235
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0161 0.0149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.9544 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.9544 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.1067 0.1713
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.2911 0.2902
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0824 0.0824
Echinococcus granulosus dna polymerase kappa 0.0038 0.1115 0.1104
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0808 0.6111
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0808 0.0835
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0808 0.0835
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0808 0.5569
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.9544 1
Echinococcus multilocularis geminin 0.0168 0.5571 0.5566
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 1 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.1314 0.0957
Mycobacterium leprae conserved hypothetical protein 0.0043 0.1314 0.1034
Trichomonas vaginalis set domain proteins, putative 0.0231 0.7703 0.8069
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0469 0.0489
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1067 0.0869
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0808 0.5569
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Loa Loa (eye worm) hypothetical protein 0.0028 0.0785 0.0773
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0808 0.0847
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.1115 0.1809
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1314 0.1303
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.1314 0.0957
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.1067 0.1107
Loa Loa (eye worm) hypothetical protein 0.0043 0.1314 0.1303
Brugia malayi beta-lactamase family protein 0.0043 0.1314 0.1933
Schistosoma mansoni hypothetical protein 0.0298 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0808 0.0835
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1314 0.1366
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1314 0.1366
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.9544 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.9544 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0533 0.0773
Loa Loa (eye worm) hypothetical protein 0.0043 0.1314 0.1303
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.2911 0.4304
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.3444 0.3609
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.023 0.1674
Mycobacterium tuberculosis Conserved protein 0.0043 0.1314 0.0957
Schistosoma mansoni DNA helicase recq1 0.001 0.0161 0.0161
Loa Loa (eye worm) beta-lactamase 0.0043 0.1314 0.1303
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.3444 0.3482
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1314 1
Brugia malayi phosphofructokinase 0.0106 0.3444 0.5095
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1314 0.1125
Leishmania major hypothetical protein, conserved 0.0043 0.1314 0.1321
Brugia malayi Pre-SET motif family protein 0.0203 0.6748 1
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.3444 0.3444
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0161 0.0221
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0258 0.0271
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.1115 0.1809
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0808 0.5
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0469 0.0328
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0533 0.6546
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.063 0.0917
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0469 0.0464
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.1961 0.1977
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.1115 0.1119
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.9867 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0785 0.5408
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0938 0.0531
Loa Loa (eye worm) inositol-1 0.0036 0.1067 0.1056
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.023 0.0221
Loa Loa (eye worm) hypothetical protein 0.0118 0.3847 0.384
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.023 0.2739
Loa Loa (eye worm) hypothetical protein 0.0043 0.1314 0.1303
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.4576 0.4651
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0808 0.5569
Trypanosoma brucei unspecified product 0.0038 0.1115 0.1119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.9544 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.1243 0.1051
Loa Loa (eye worm) hypothetical protein 0.001 0.0161 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2911 0.2911
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.1115 0.1168
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.3444 0.3436
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0808 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0469 0.0457
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.1115 0.1115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2911 0.2911
Onchocerca volvulus 0.0043 0.1314 0.0713
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.9544 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.1961 0.1796
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.1115 0.0731
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0808 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.1115 0.0918
Echinococcus multilocularis dna polymerase kappa 0.0038 0.1115 0.1104
Schistosoma mansoni ran 0.0021 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0043 0.1314 0.1303
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.1115 0.1119
Brugia malayi RNA, U transporter 1 0.0079 0.2541 0.3754
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.1314 0.0957
Echinococcus granulosus geminin 0.0168 0.5571 0.5566
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.3444 0.3368
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.1243 0.1051
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.3444 0.36
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0533 0.0314
Schistosoma mansoni hypothetical protein 0.0168 0.5571 0.5571
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0533 0.0314
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0824 0.568
Echinococcus granulosus importin subunit beta 1 0.0028 0.0785 0.0773
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1314 0.1933
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.1314 0.0957
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0012 0.0085
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.1314 0.0957
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.1243 0.1249
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.063 0.0648
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.3444 0.3436
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1067 0.1071
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0824 0.0813
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0808 0.0689
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1314 0.1366
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.023 0.0221
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.063 0.0648
Leishmania major GTP-binding protein, putative 0.0021 0.0533 0.0529
Trypanosoma brucei unspecified product 0.0026 0.0717 0.0715
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.9544 1
Brugia malayi 6-phosphofructokinase 0.0106 0.3444 0.5095
Brugia malayi beta-lactamase 0.0043 0.1314 0.1933
Brugia malayi Importin beta-1 subunit 0.0028 0.0785 0.1147
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1314 0.1303
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.023 0.0221
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.1115 0.1115
Echinococcus multilocularis dna polymerase eta 0.0062 0.1961 0.1951
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.1115 0.0918
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.4576 0.8891
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0258 0.0258
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.3444 0.3609
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.1067 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0258 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0717 0.0715
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0161 0.1113
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.1115 0.1157
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.1961 0.2893
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.1067 0.1118
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.9544 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0824 0.1205
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0258 0.0029
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0469 0.0457
Schistosoma mansoni DNA polymerase eta 0.0062 0.1961 0.1961
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.1552 0.1371
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1314 0.1366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2911 0.2911
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.4581 0.4636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2911 0.2902
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.3444 0.3444
Schistosoma mansoni DNA helicase recq5 0.001 0.0161 0.0161
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0469 0.0492
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0533 0.6544
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.023 0.0221
Plasmodium vivax importin-beta 2, putative 0.0028 0.0785 0.5932
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.3444 0.3482
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0808 0.0847
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0161 0.0149
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.3444 0.3436
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1067 0.1071
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0808 0.0835
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.023 0.0221
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.1314 0.0957
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.5118 0.5264
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0258 0.025
Brugia malayi 6-phosphofructokinase 0.0106 0.3444 0.5095
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0808 0.0835
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0604 0.0388
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.1115 0.1104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1314 0.1314
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0469 0.3509
Onchocerca volvulus 0.0231 0.7703 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0161 0.0149
Mycobacterium ulcerans lipase LipD 0.0043 0.1314 0.2218
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.1067 0.1107
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0717 0.0715
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.1115 0.1637
Brugia malayi polk-prov protein 0.0012 0.023 0.0324
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0533 0.0521
Loa Loa (eye worm) hypothetical protein 0.0043 0.1314 0.1303
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0717 0.0715
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0469 0.0479
Echinococcus multilocularis snurportin 1 0.0298 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0788 0.0776
Giardia lamblia DINP protein human, muc B family 0.0038 0.1115 0.1016
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.023 0.1587
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.3444 0.3335
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.023 0.0221
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.3444 0.36
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0469 0.0248
Toxoplasma gondii exonuclease III APE 0.0019 0.0469 0.3234
Plasmodium falciparum importin beta, putative 0.0028 0.0785 0.9707
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0824 0.0813
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.1115 0.0918
Mycobacterium leprae Probable lipase LipE 0.0043 0.1314 0.1034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0824 0.0813
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0161 0.1113
Loa Loa (eye worm) hypothetical protein 0.0043 0.1314 0.1303
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0808 0.0835
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.1115 0.1104
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.023 0.023
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0604 0.0621
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.9301 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.1243 0.1051
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0785 0.0784
Schistosoma mansoni hypothetical protein 0.0168 0.5571 0.5571
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2911 0.2902
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Trichomonas vaginalis ran, putative 0.0021 0.0533 0.0546
Toxoplasma gondii hypothetical protein 0.0047 0.1451 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0469 0.5741
Brugia malayi beta-lactamase family protein 0.0043 0.1314 0.1933
Schistosoma mansoni inositol monophosphatase 0.0036 0.1067 0.1067
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0469 0.0464
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.1314 0.2218
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0533 0.0521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2911 0.2902
Brugia malayi Inositol-1 0.0036 0.1067 0.1567
Mycobacterium ulcerans hypothetical protein 0.0043 0.1314 0.2218
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.1115 0.1104
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.1314 0.0957
Schistosoma mansoni ran 0.0021 0.0533 0.0533
Loa Loa (eye worm) phosphofructokinase 0.0106 0.3444 0.3436
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0808 0.6111
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0469 0.0248
Loa Loa (eye worm) hypothetical protein 0.0012 0.023 0.0218
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.9544 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.1961 0.1951
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Schistosoma mansoni inositol monophosphatase 0.0036 0.1067 0.1067
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.9544 1
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0012 0.0085
Leishmania major DNA polymerase eta, putative 0.0062 0.1961 0.1977
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.1067 0.1056
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0161 0.0149
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.6748 0.6744
Echinococcus granulosus dna polymerase eta 0.0062 0.1961 0.1951
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.1077 0.0878
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.4576 1
Schistosoma mansoni ap endonuclease 0.0019 0.0469 0.0469
Mycobacterium ulcerans beta-lactamase 0.0043 0.1314 0.2218
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.1115 0.0731
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.3444 0.3609
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0785 0.0784
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0469 0.0492
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.3444 0.6888
Echinococcus granulosus bloom syndrome protein 0.0023 0.063 0.0618
Leishmania major DNA damage repair protein, putative 0.0012 0.023 0.0221
Trypanosoma brucei unspecified product 0.0026 0.0717 0.0715
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1067 0.0869
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0469 0.0678
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.3444 0.36
Leishmania major importin beta-1 subunit, putative 0.0023 0.0604 0.0601
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.023 0.1587
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0469 0.0457
Entamoeba histolytica HEAT repeat domain containing protein 0.0005 0.0012 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1314 0.1314
Leishmania major DNA polymerase eta, putative 0.0037 0.1077 0.108
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.4581 0.4515
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.9544 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0824 0.0824
Mycobacterium ulcerans hypothetical protein 0.0155 0.5118 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0161 0.0149
Loa Loa (eye worm) RecQ helicase 0.0023 0.063 0.0618
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.9867 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1314 0.1366
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2911 0.2902
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.1314 0.1321
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.9867 1
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.1115 0.1119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0824 0.0824
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0533 0.0529
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0533 0.0521
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0604 0.0621
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0533 0.4001
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0533 0.0396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0365 0.2517
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1115 0.1119
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.3444 0.36
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0372 0.2759
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.1115 0.1157
Toxoplasma gondii ABC1 family protein 0.0043 0.1314 0.9059
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.3444 0.3436
Trichomonas vaginalis esterase, putative 0.0043 0.1314 0.1366
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.023 0.0221
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0808 0.0835

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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