Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.2805 | 0.2805 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.053 | 0.053 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.3701 | 0.3701 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.2805 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.053 | 0.053 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.2805 | 0.2805 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.3701 | 0.3701 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.2805 | 0.2805 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.2805 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.3701 | 0.3701 |
Echinococcus granulosus | lamin | 0.0027 | 0.3701 | 0.3701 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.3701 | 0.3701 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.2805 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.2805 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.2805 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.2805 | 0.2805 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0953 | 0.0953 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.3701 | 0.3701 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.2805 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.3701 | 0.3701 |
Onchocerca volvulus | 0.0027 | 0.3701 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0953 | 0.0953 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0638 | 0.0638 |
Echinococcus multilocularis | musashi | 0.0027 | 0.3701 | 0.3701 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.3701 | 0.3701 |
Echinococcus multilocularis | lamin | 0.0027 | 0.3701 | 0.3701 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.2805 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.2805 | 0.2805 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2805 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.2805 | 0.2805 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2805 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.3701 | 0.3701 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.2805 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.2805 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.3701 | 1 | |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.3701 | 0.3701 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2805 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.3701 | 0.3701 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2805 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2805 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0638 | 0.0638 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2805 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3701 | 0.3701 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1337 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.