Detailed information for compound 1214394

Basic information

Technical information
  • TDR Targets ID: 1214394
  • Name: (3E)-3-[(5-bromofuran-2-yl)methylidene]-5-met hylfuran-2-one
  • MW: 255.065 | Formula: C10H7BrO3
  • H donors: 0 H acceptors: 1 LogP: 2.84 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1=C/C(=C\c2ccc(o2)Br)/C(=O)O1
  • InChi: 1S/C10H7BrO3/c1-6-4-7(10(12)13-6)5-8-2-3-9(11)14-8/h2-5H,1H3/b7-5+
  • InChiKey: MDNPWZAMXKTAQO-FNORWQNLSA-N  


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Synonyms

  • 3-[(5-bromofuran-2-yl)methylidene]-5-methylfuran-2-one
  • (3E)-3-[(5-bromo-2-furyl)methylene]-5-methyl-furan-2-one
  • 3-[(5-bromo-2-furyl)methylene]-5-methyl-furan-2-one
  • 3-[(5-bromo-2-furyl)methylene]-5-methyl-2-furanone
  • (3E)-3-[(5-bromo-2-furyl)methylene]-5-methyl-2-furanone
  • 3-[(5-bromofuran-2-yl)methylidene]-5-methyl-furan-2-one
  • (3E)-3-[(5-bromofuran-2-yl)methylidene]-5-methyl-furan-2-one
  • STOCK2S-04545
  • ZINC04712216
  • 3-[1-(5-Bromo-furan-2-yl)-meth-(E)-ylidene]-5-methyl-3H-furan-2-one
  • MLS000589482
  • SMR000212886
  • ZINC00348516

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens Wolf-Hirschhorn syndrome candidate 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens DNA (cytosine-5-)-methyltransferase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni SET domain protein Get druggable targets OG5_130029 All targets in OG5_130029
Cryptosporidium parvum protein with 4 PHD domains plus a SET domain and associated cysteine cluster at the C-terminus Get druggable targets OG5_130029 All targets in OG5_130029
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_130029 All targets in OG5_130029
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum expressed protein Get druggable targets OG5_130029 All targets in OG5_130029
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Histone-lysine N-methyltransferase NSD3, putative Get druggable targets OG5_130029 All targets in OG5_130029
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative Get druggable targets OG5_130029 All targets in OG5_130029
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1161 0.1717
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1161 0.1717
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.3664 0.8753
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.156 0.2311
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1904 0.2823
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.156 0.2311
Brugia malayi Phosphoglycerate kinase 0.0075 0.1161 0.1161
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.156 0.2311
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0024 0.0168 0.0258
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0267 0.0429
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1328 0.2182
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.3664 0.8753
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1161 0.1717
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.3664 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.071 0.1046
Loa Loa (eye worm) hypothetical protein 0.0535 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.1096 0.162
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0818 0.1251
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0713 0.105
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.1675 0.4433
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.1534 0.1534
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0713 0.105
Brugia malayi polk-prov protein 0.0052 0.071 0.071
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0818 0.0818
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0684 0.1681
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0597 0.1122
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1904 0.4374
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0971 0.1486
Brugia malayi Disco-interacting protein 2 homolog 0.0047 0.0604 0.0604
Loa Loa (eye worm) RecQ helicase 0.0029 0.0267 0.0123
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.6726 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.156 0.2565
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0696 0.1025
Loa Loa (eye worm) glutaminase 2 0.033 0.6061 0.6002
Schistosoma mansoni glutaminase 0.033 0.6061 0.9275
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.3664 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0604 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.156 0.2311
Onchocerca volvulus 0.0058 0.0818 0.0818
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0818 0.1671
Brugia malayi Phosphoglycerate kinase 0.0206 0.3664 0.3664
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.0246 0.0456
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0092 0.0126
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0818 0.1251
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0943 0.0808
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.1243 0.1902
Echinococcus multilocularis dna polymerase eta 0.0095 0.1534 0.3454
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.1534 0.2273
Schistosoma mansoni cpg binding protein 0.004 0.0488 0.0747
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0146 0.0207
Echinococcus granulosus disco interacting protein 2 0.0047 0.0604 0.114
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.3664 0.5442
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.3664 0.5442
Leishmania major DNA polymerase kappa, putative 0.0072 0.1096 0.162
Echinococcus granulosus chromobox protein 1 0.0084 0.1328 0.2941
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.1243 0.1243
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0146 0.023
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.3664 0.604
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0146 0.0207
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1243 0.1839
Loa Loa (eye worm) hypothetical protein 0.0535 1 1
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0597 0.1122
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0146 0.0146
Toxoplasma gondii exonuclease III APE 0.0023 0.0146 0.018
Loa Loa (eye worm) MBCTL1 0.0066 0.0971 0.0837
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0072 0.1096 0.2699
Leishmania major DNA polymerase eta, putative 0.0051 0.0684 0.1007
Echinococcus multilocularis chromobox protein 1 0.0084 0.1328 0.2941
Loa Loa (eye worm) hypothetical protein 0.0052 0.071 0.0572
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.3664 0.5
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.1243 0.2729
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0684 0.1007
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0092 0.0126
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.3664 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0686 0.1121
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0092 0.0126
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0267 0.0267
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.156 0.2311
Trypanosoma brucei polo-like protein kinase 0.0114 0.1904 0.2823
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0072 0.1096 0.162
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0796 0.1303
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.015 0.0229
Brugia malayi Heterochromatin protein 1 0.0084 0.1328 0.1328
Onchocerca volvulus 0.004 0.0488 0.0488
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.1243 0.1839
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.303 0.4499
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0092 0.0126
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1904 0.2823
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0352 0.0569
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.3664 0.5607
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0818 0.1251
Loa Loa (eye worm) glutaminase 0.033 0.6061 0.6002
Echinococcus multilocularis dna polymerase kappa 0.0096 0.156 0.3518
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0696 0.1025
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.004 0.0471 0.0807
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1904 0.3133
Toxoplasma gondii hypothetical protein 0.0059 0.0841 0.2119
Schistosoma mansoni ap endonuclease 0.0023 0.0146 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.156 0.2311
Schistosoma mansoni kinase 0.0058 0.0825 0.1262
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0943 0.1981
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1904 0.3133
Echinococcus multilocularis cpg binding protein 0.004 0.0488 0.085
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.6726 1
Treponema pallidum phosphoglycerate kinase 0.0206 0.3664 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1904 0.1784
Echinococcus granulosus dna polymerase eta 0.0095 0.1534 0.3454
Echinococcus granulosus cpg binding protein 0.004 0.0488 0.085
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0818 0.1671
Loa Loa (eye worm) runx1 0.0067 0.1 0.0867
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.1407 0.2083
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0686 0.1121
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.4165 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0146 0.0152
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0943 0.2263
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0796 0.1303
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1904 0.3133
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0092 0.0126
Brugia malayi mbt repeat family protein 0.0058 0.0818 0.0818
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.156 0.2311
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0971 0.2052
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.071 0.1046
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0146 0.0167
Echinococcus multilocularis disco interacting protein 2 0.0047 0.0604 0.114
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.156 0.2311
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1328 0.2182
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0943 0.0943
Echinococcus granulosus bloom syndrome protein 0.0029 0.0267 0.0301
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.3664 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1534 0.1409
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.3664 0.5442
Loa Loa (eye worm) hypothetical protein 0.0066 0.0971 0.0837
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0146 0.023
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.156 0.246
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0024 0.0168 0.0229
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.6726 1
Schistosoma mansoni cpg binding protein 0.004 0.0488 0.0747
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1904 0.4374
Mycobacterium ulcerans hypothetical protein 0.0192 0.3405 0.5551
Leishmania major DNA damage repair protein, putative 0.002 0.0092 0.0126
Schistosoma mansoni DNA polymerase eta 0.0095 0.1534 0.2348
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.156 0.2565
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0092 0.0126
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0092 0.0141
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1904 0.1904
Giardia lamblia Phosphoglycerate kinase 0.0206 0.3664 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1161 0.1717
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0971 0.2052
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1161 0.1717
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0092 0.0126
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1904 0.2823
Loa Loa (eye worm) hypothetical protein 0.0037 0.0421 0.0278
Loa Loa (eye worm) CXXC zinc finger family protein 0.004 0.0488 0.0347
Loa Loa (eye worm) hypothetical protein 0.0058 0.0818 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0617 0.1007
Trichomonas vaginalis glutaminase, putative 0.033 0.6061 1
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.3664 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.6726 1
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.3664 0.5607
Toxoplasma gondii hypothetical protein 0.0102 0.1675 0.4449
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0146 0.0207
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0818 0.0681
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1904 0.2914
Schistosoma mansoni chromobox protein 0.0084 0.1328 0.2033
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0818 0.1671
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.4165 1
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.3664 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1904 0.3133
Onchocerca volvulus 0.0037 0.0421 0.0421
Schistosoma mansoni ap endonuclease 0.0023 0.0146 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.156 0.2311
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0943 0.1981
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0024 0.0168 0.0213
Schistosoma mansoni chromobox protein 0.0084 0.1328 0.2033
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.3664 0.604
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0617 0.1007
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.3664 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0617 0.0477
Brugia malayi chromobox protein homolog 3 0.0047 0.0617 0.0617
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0092 0.0126
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0092 0.0126
Brugia malayi mbt repeat family protein 0.0058 0.0818 0.0818
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0092 0.0016
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.3664 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0696 0.1025
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0818 0.1671
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.02 0.03
Loa Loa (eye worm) hypothetical protein 0.0206 0.3664 0.3569
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0024 0.0168 0.0055
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.1161 0.1717
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.1243 0.338
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1243 0.1839
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0024 0.0168 0.044
Loa Loa (eye worm) hypothetical protein 0.0146 0.2517 0.2406
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0024 0.0168 0.0239
Trypanosoma brucei unspecified product 0.0088 0.1407 0.2083
Echinococcus granulosus dna polymerase kappa 0.0096 0.156 0.3518
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.156 0.2311
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1904 0.5187
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.004 0.0471 0.0807
Giardia lamblia DINP protein human, muc B family 0.0072 0.1096 0.281
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0146 0.038
Echinococcus multilocularis Protein lozenge 0.0067 0.1 0.2125
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0943 0.2557
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1243 0.1839
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0617 0.0617
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0024 0.0168 0.0241
Schistosoma mansoni SET domain protein 0.004 0.0471 0.0721
Echinococcus granulosus DNA methyltransferase 2, putative 0.0024 0.0168 0.0055
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0943 0.1442
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0092 0.0028
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.3664 0.5984
Toxoplasma gondii DNA methyltransferase 2, putative 0.0024 0.0168 0.0241
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.156 0.246
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.3664 0.5442
Schistosoma mansoni lozenge 0.0067 0.1 0.1531
Onchocerca volvulus 0.0047 0.0604 0.0604
Mycobacterium ulcerans glutaminase 0.033 0.6061 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.1328 0.2941
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.1243 0.1113
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.3664 0.5442
Brugia malayi CXXC zinc finger family protein 0.004 0.0488 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.156 0.2311
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0267 0.0301
Onchocerca volvulus 0.0535 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1904 0.1904
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.156 0.2311
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.3664 0.5442
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0146 0.0152
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0971 0.0971
Trypanosoma brucei unspecified product 0.0044 0.056 0.0822
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0696 0.1025
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1904 0.3133
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.303 0.4499
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.156 0.2311
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0146 0.0091
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.1243 0.2729
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0352 0.0569
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1328 0.1199
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0971 0.2052
Echinococcus granulosus chromobox protein 1 0.0084 0.1328 0.2941
Schistosoma mansoni cpg binding protein 0.004 0.0488 0.0747
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.1161 0.1717
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0713 0.105
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1904 0.3133
Giardia lamblia Kinase, PLK 0.0114 0.1904 0.5073
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.156 0.2311
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.1161 0.1717
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.303 0.4499
Brugia malayi glutaminase DH11.1 0.033 0.6061 0.6061
Leishmania major DNA polymerase kappa, putative 0.002 0.0092 0.0126
Leishmania major modification methylase-like protein 0.0024 0.0168 0.0239
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0146 0.0207
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0267 0.0429
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1904 0.3133
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.3405 0.9266
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.156 0.2311
Leishmania major DNA polymerase eta, putative 0.0095 0.1534 0.2273
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0047 0.0604 0.0925
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0971 0.2052
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0686 0.0686
Trypanosoma brucei unspecified product 0.0044 0.056 0.0822
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0912 0.1346
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0943 0.1442
Schistosoma mansoni hypothetical protein 0.0355 0.6535 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.1534 0.2273

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 4.71 uM PubChem BioAssay. Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 4.99 uM PUBCHEM_BIOASSAY: Dose response confirmation of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 3.6588 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.691 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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