Detailed information for compound 1214627

Basic information

Technical information
  • TDR Targets ID: 1214627
  • Name: ASN 06387868
  • MW: 512.985 | Formula: C26H29ClN4O5
  • H donors: 2 H acceptors: 4 LogP: 1.91 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)CN1C(=O)C2C3(C1C(=O)NC(C)(C)C)C=CC(C2C(=O)Nc1noc(c1)C)(O3)C
  • InChi: 1S/C26H29ClN4O5/c1-14-12-17(30-35-14)28-21(32)18-19-23(34)31(13-15-6-8-16(27)9-7-15)20(22(33)29-24(2,3)4)26(19)11-10-25(18,5)36-26/h6-12,18-20H,13H2,1-5H3,(H,29,33)(H,28,30,32)
  • InChiKey: VLTALBNDTZYDIK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-Chloro-benzyl)-7-methyl-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0*1,5*]dec-8-ene-2,6-dicarboxylic acid 2-tert-butylamide 6-[(5-methyl-isoxazol-3-yl)-amide]
  • MLS000527961
  • SMR000120535

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0027 0.0257 0.0356
Toxoplasma gondii ABC1 family protein 0.0037 0.0394 0.219
Leishmania major RNA-editing complex protein MP100, putative 0.0027 0.0257 0.1034
Brugia malayi hypothetical protein 0.0026 0.0233 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0054 0.0643 0.0967
Leishmania major pantothenate kinase subunit, putative 0.0027 0.0257 0.1034
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0041 0.0033
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0507 0.2606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0208 0.0288
Entamoeba histolytica hypothetical protein 0.004 0.0444 0.2295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0208 0.0288
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0241 0.035
Brugia malayi beta-lactamase family protein 0.0037 0.0394 0.058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0233 0.0897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0079 0.0109
Echinococcus multilocularis pyruvate kinase 0.0033 0.0335 0.0327
Toxoplasma gondii exonuclease III APE 0.0135 0.1797 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0233 0.0897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0054 0.0643 0.0967
Schistosoma mansoni Smad4 0.0014 0.0073 0.0065
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0233 0.0225
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0129 0.0443
Mycobacterium tuberculosis Conserved protein 0.0037 0.0394 0.0834
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0054 0.0643 0.0636
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0246 0.0975
Schistosoma mansoni smad1 5 8 and 0.0032 0.0329 0.0321
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.1216 0.1209
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0041 0.005
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0246 0.0086
Echinococcus multilocularis pyruvate kinase 0.0017 0.0107 0.0099
Plasmodium vivax exodeoxyribonuclease III, putative 0.0027 0.0257 0.0885
Schistosoma mansoni hypothetical protein 0.0136 0.1814 0.1808
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0041 0.0033
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0012 0.0041 0.0057
Brugia malayi nuclear receptor NHR-67 0.0026 0.0233 0.0338
Schistosoma mansoni coup transcription factor 0.0054 0.0643 0.0636
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0789 0.1176
Brugia malayi RNA recognition motif domain containing protein 0.0271 0.375 0.5637
Giardia lamblia Pyruvate kinase 0.0033 0.0335 0.1347
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0027 0.0257 0.0249
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0034 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0208 0.0288
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0694 0.1044
Echinococcus multilocularis snurportin 1 0.0313 0.436 0.4356
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0233 0.0897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0208 0.0288
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0801 0.4457
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0233 0.035
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0277 0.0405
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0054 0.0643 0.0636
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.6298 0.6295
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.436 0.656
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1226
Brugia malayi MH1 domain containing protein 0.0032 0.0329 0.0483
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0067 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0394 0.0592
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0135 0.0128
Loa Loa (eye worm) hypothetical protein 0.0029 0.0277 0.0417
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0335 0.0503
Loa Loa (eye worm) hypothetical protein 0.0054 0.0643 0.0967
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0168 0.2277 0.6914
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0027 0.0257 0.1034
Trypanosoma brucei ISWI complex protein 0.0015 0.0081 0.0168
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Echinococcus granulosus traf and tnf receptor associated protein 0.0027 0.0257 0.0249
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0041 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0054 0.0643 0.0956
Loa Loa (eye worm) hypothetical protein 0.0027 0.0257 0.0386
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0801 0.0794
Brugia malayi Bromodomain containing protein 0.0075 0.0943 0.1408
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0054 0.0643 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0277 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0245 0.0339
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0394 0.1554
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0444 0.0437
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0135 0.1797 0.1791
Brugia malayi exodeoxyribonuclease III family protein 0.0135 0.1797 0.2695
Onchocerca volvulus Putative neutral sphingomyelinase 0.0027 0.0257 0.03
Mycobacterium leprae Probable lipase LipE 0.0037 0.0394 0.0641
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0027 0.0257 0.0885
Entamoeba histolytica hypothetical protein 0.004 0.0444 0.2295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0271 0.375 0.5643
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0027 0.0257 0.0885
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0394 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0394 0.1832
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0041 0.0062
Plasmodium falciparum glutathione reductase 0.0074 0.0923 0.4829
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.0233 0.0745
Leishmania major endonuclease/exonuclease protein-like protein 0.0027 0.0257 0.1034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0335 0.0503
Echinococcus granulosus dna polymerase eta 0.0019 0.0135 0.0128
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0394 0.0546
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0394 0.0834
Schistosoma mansoni DNA polymerase eta 0.0019 0.0135 0.0128
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0135 0.033
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0027 0.0257 0.0386
Brugia malayi nuclear hormone receptor 0.0026 0.0233 0.0338
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0027 0.0257 0.1034
Schistosoma mansoni tar DNA-binding protein 0.0271 0.375 0.3745
Trypanosoma brucei protein kinase, putative 0.0058 0.0694 0.3677
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0041 0.0033
Schistosoma mansoni cript-related 0.0027 0.0257 0.0249
Brugia malayi nuclear hormone receptor 0.0054 0.0643 0.0956
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0041 0.0033
Echinococcus granulosus snurportin 1 0.0313 0.436 0.4356
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.037 0.1695
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0079 0.0071
Trichomonas vaginalis ap endonuclease, putative 0.0135 0.1797 0.2491
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0233 0.0225
Loa Loa (eye worm) hypothetical protein 0.0037 0.0394 0.0592
Echinococcus granulosus pyruvate kinase 0.0017 0.0107 0.0099
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0106 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.1859 0.2788
Echinococcus multilocularis cpg binding protein 0.0034 0.0349 0.0341
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.2781 0.4184
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0233 0.0338
Echinococcus multilocularis traf and tnf receptor associated protein 0.0027 0.0257 0.0249
Schistosoma mansoni hypothetical protein 0.0706 1 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0041 0.0062
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0027 0.0257 0.0356
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0135 0.1797 1
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0643 0.0636
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0233 0.1036
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0027 0.0257 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0337 0.0467
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0027 0.0257 0.0386
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0371 0.0363
Brugia malayi hypothetical protein 0.0029 0.0277 0.0405
Loa Loa (eye worm) Smad1 0.0032 0.0329 0.0495
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0233 0.0225
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0329 0.0321
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0135 0.1797 0.2704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0337 0.0467
Schistosoma mansoni hypothetical protein 0.004 0.0444 0.0437
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0027 0.0257 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0245 0.0339
Trypanosoma brucei trypanothione reductase 0.0074 0.0923 0.4992
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0233 0.0225
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3964 0.396
Loa Loa (eye worm) hypothetical protein 0.0019 0.0135 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0054 0.0643 0.0967
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.033
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0233 0.0338
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0335 0.0384
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0233 0.0225
Onchocerca volvulus 0.0027 0.0257 0.03
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0054 0.0643 0.0636
Brugia malayi MH1 domain containing protein 0.0018 0.0122 0.0172
Leishmania major DNA polymerase eta, putative 0.0019 0.0135 0.033
Schistosoma mansoni pyruvate kinase 0.0033 0.0335 0.0327
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0106 0.0098
Giardia lamblia DINP protein human, muc B family 0.0019 0.0135 0.0169
Entamoeba histolytica hypothetical protein 0.004 0.0444 0.2295
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0233 0.0586
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0177 0.0169
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0027 0.0257 0.0249
Loa Loa (eye worm) hypothetical protein 0.0027 0.0257 0.0386
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0208 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0337 0.0467
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0027 0.0257 0.0249
Echinococcus multilocularis mothers against decapentaplegic 6 0.0014 0.0073 0.0065
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0233 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0079 0.0109
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0394 0.0546
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0041 0.0033
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0499 0.2607
Brugia malayi MH1 domain containing protein 0.0032 0.0329 0.0483
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0233 0.0267
Plasmodium falciparum glutathione reductase 0.0026 0.0233 0.0745
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0499 0.2445
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0694 0.386
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0208 0.0752
Echinococcus granulosus mothers against decapentaplegic 2 0.0014 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0277 0.0269
Loa Loa (eye worm) hypothetical protein 0.0054 0.0643 0.0967
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0135 0.0128
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0335 0.0491
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0027 0.0257 0.1034
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.045 0.6325 0.9516
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.037 0.1695
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0136 0.1814 0.1808
Schistosoma mansoni pyruvate kinase 0.0017 0.0107 0.0099
Schistosoma mansoni nocturnin 0.0027 0.0257 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Schistosoma mansoni zinc finger protein 0.0021 0.0166 0.0158
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0335 0.1198
Brugia malayi hypothetical protein 0.0012 0.0041 0.005
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0694 0.3578
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0187 0.2546 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0246 0.0667
Brugia malayi CXXC zinc finger family protein 0.003 0.0298 0.0436
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0135 0.1797 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0499 0.2607
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0027 0.0257 0.0885
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0027 0.0257 0.0374
Leishmania major trypanothione reductase 0.0074 0.0923 0.4914
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0135 0.033
Echinococcus multilocularis thioredoxin glutathione reductase 0.0075 0.0937 0.093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0062
Schistosoma mansoni lamin 0.0026 0.0241 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0208 0.0288
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0135 0.1797 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0499 0.0692
Echinococcus granulosus smad 0.0032 0.0329 0.0321
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0246 0.137
Leishmania major hypothetical protein, conserved 0.0027 0.0257 0.1034
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.1216 0.1209
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0643 0.0956
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Plasmodium vivax glutathione reductase, putative 0.0074 0.0923 0.4829
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0062
Brugia malayi steroid hormone receptor 0.0054 0.0643 0.0956
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0041 0.0033
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0027 0.0257 0.1226
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0233 0.0897
Loa Loa (eye worm) hypothetical protein 0.0064 0.0789 0.1187
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0288 0.028
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0207 0.02
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0041 0.005
Echinococcus granulosus dna polymerase kappa 0.0019 0.0135 0.0128
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0233 0.0225
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0156 0.0235
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.1724 0.1718
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0233 0.0225
Schistosoma mansoni smad1 5 8 and 0.0032 0.0329 0.0321
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0694 0.0961
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.6298 0.6295
Plasmodium falciparum thioredoxin reductase 0.0026 0.0233 0.0745
Schistosoma mansoni thyroid hormone receptor 0.019 0.259 0.2584
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0054 0.0643 0.0967
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0166 0.0651
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0135 0.1797 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.033
Brugia malayi MH2 domain containing protein 0.0472 0.6646 1
Mycobacterium tuberculosis Probable exported protein 0.0027 0.0257 0.0391
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0283 0.3927 0.5904
Trypanosoma brucei RNA editing exonuclease 2 0.0027 0.0257 0.1172
Schistosoma mansoni hypothetical protein 0.0064 0.0789 0.0782
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0246 0.0086
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0041 0.005
Brugia malayi nuclear receptor RXR 0.0029 0.0277 0.0405
Echinococcus granulosus neuropeptide s receptor 0.0448 0.6298 0.6295
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0135 0.0204
Echinococcus multilocularis pyruvate kinase 0.0017 0.0107 0.0099
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0135 0.1797 1
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0233 0.0225
Echinococcus granulosus GPCR family 2 0.0064 0.0789 0.0782
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.1724 0.513
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0335 0.0643
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Schistosoma mansoni hypothetical protein 0.0706 1 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0694 0.3677
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0394 0.0386
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0027 0.0257 0.1226
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0027 0.0257 0.1226
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0694 0.3578
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0027 0.0257 0.0386
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.0478
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0335 0.1861
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0027 0.0257 0.0356
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0499 0.2561
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0694 0.0686
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0041 0.0033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0135 0.1797 0.1791
Mycobacterium tuberculosis Probable reductase 0.0168 0.2277 0.6914
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0507 0.0702
Treponema pallidum exodeoxyribonuclease (exoA) 0.0135 0.1797 1
Toxoplasma gondii thioredoxin reductase 0.0074 0.0923 0.5137
Echinococcus granulosus lamin 0.0026 0.0241 0.0233
Schistosoma mansoni Smad4 0.0014 0.0073 0.0065
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0014 0.0073 0.0045
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0114 0.0172
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0335 0.0409
Onchocerca volvulus 0.0054 0.0643 0.0839
Echinococcus granulosus neutral sphingomyelinase 0.0027 0.0257 0.0249
Brugia malayi nuclear receptor NHR-88 0.0026 0.0233 0.0338
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0012 0.0041 0.0057
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0233 0.0897
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0815 0.1215
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0135 0.1797 0.5366
Chlamydia trachomatis pyruvate kinase 0.0033 0.0335 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.037 0.0512
Trypanosoma cruzi mitochondrial protein 99, putative 0.0027 0.0257 0.1034
Echinococcus granulosus histone lysine methyltransferase setb 0.0082 0.104 0.1033
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0291 0.0403
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0193 0.029
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0233 0.0338
Echinococcus granulosus thioredoxin glutathione reductase 0.0075 0.0937 0.093
Schistosoma mansoni carbon catabolite repressor protein 0.0027 0.0257 0.0249
Onchocerca volvulus 0.0058 0.0703 0.0922
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0277 0.0269
Loa Loa (eye worm) TAR-binding protein 0.0271 0.375 0.5643
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0507 0.2491
Onchocerca volvulus Bile acid receptor homolog 0.0054 0.0643 0.0839
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0061
Echinococcus multilocularis ecdysone induced protein 78C 0.0054 0.0643 0.0636
Echinococcus granulosus pyruvate kinase 0.0033 0.0335 0.0327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.3927 0.3923
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1427
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1427
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0694 0.3578
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0335 0.1347
Trypanosoma cruzi trypanothione reductase, putative 0.0074 0.0923 0.4914
Echinococcus multilocularis geminin 0.0706 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0643 0.0967
Echinococcus granulosus FTZ F1 alpha 0.0054 0.0643 0.0636
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0394 0.0834
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0027 0.0257 0.0249
Loa Loa (eye worm) hypothetical protein 0.0037 0.0394 0.0592
Brugia malayi ecdysteroid receptor 0.0054 0.0643 0.0956
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0177 0.0266
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1226
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0233 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0499 0.0692
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0694 0.3472
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0177 0.0412
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0394 0.0834
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Brugia malayi nuclear receptor NHR-88 0.0054 0.0643 0.0956
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0499 0.2561
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0815 0.4284
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0041 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0054 0.0643 0.0956
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0233 0.0897
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0136 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0394 0.0546
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0074
Trypanosoma cruzi mitochondrial protein 99, putative 0.0027 0.0257 0.1034
Schistosoma mansoni smad 0.0032 0.0329 0.0321
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0135 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.3927 0.3923
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.0478
Loa Loa (eye worm) hypothetical protein 0.0082 0.104 0.1565
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0233 0.0225
Brugia malayi glutathione reductase 0.0074 0.0923 0.1378
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0499 0.0491
Schistosoma mansoni RAR-like nuclear receptor 0.0054 0.0643 0.0636
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0079 0.0153
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0507 0.0499
Onchocerca volvulus 0.003 0.0298 0.0358
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0335 0.0464
Echinococcus multilocularis expressed protein 0.0012 0.0041 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1724 0.9561
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1427
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.037 0.1823
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0815 0.0808
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0233 0.0267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0233 0.0897
Schistosoma mansoni hypothetical protein 0.0313 0.436 0.4356
Loa Loa (eye worm) hypothetical protein 0.0029 0.0277 0.0417
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.1724 0.9594
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0233 0.0897
Echinococcus granulosus ecdysone induced protein 78C 0.0054 0.0643 0.0636
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0499 0.0751
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0789 0.0782
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0789 0.0782
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.2781 0.4177
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0241 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0246 0.0825
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0507 0.0702
Brugia malayi Smad1 0.0032 0.0329 0.0483
Loa Loa (eye worm) MH2 domain-containing protein 0.0472 0.6646 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0054 0.0643 0.0956
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.033
Leishmania major pyruvate kinase 0.0033 0.0335 0.1488
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0233 0.0897
Trichomonas vaginalis ap endonuclease, putative 0.0135 0.1797 0.2491
Brugia malayi CCR4 0.0027 0.0257 0.0374
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0027 0.0257 0.1172
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0694 0.0961
Loa Loa (eye worm) hypothetical protein 0.0037 0.0394 0.0592
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0135 0.1797 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0073 0.011
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0041 0.0062
Schistosoma mansoni hypothetical protein 0.0064 0.0789 0.0782
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0027 0.0257 0.1172
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0027 0.0257 0.1226
Brugia malayi Steroid receptor seven-up type 2 0.0054 0.0643 0.0956
Brugia malayi Importin beta-1 subunit 0.0029 0.0288 0.0421
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0054 0.0643 0.0636
Loa Loa (eye worm) hypothetical protein 0.0203 0.2781 0.4184
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0135 0.0478
Brugia malayi Thioredoxin reductase 0.0074 0.0923 0.1378
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0054 0.0643 0.0839
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0233 0.0225
Brugia malayi Bromodomain containing protein 0.0037 0.0404 0.0596
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0041 0.005
Onchocerca volvulus 0.0026 0.0233 0.0267
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0233 0.1036
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0135 0.0188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.3927 0.3923
Treponema pallidum hypothetical protein 0.0027 0.0257 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0054 0.0643 0.0967
Brugia malayi MH2 domain containing protein 0.0032 0.0329 0.0483
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0027 0.0257 0.0374
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.0478
Brugia malayi nuclear receptor RXR 0.0026 0.0233 0.0338
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0074 0.0923 0.2544
Brugia malayi ecdysone receptor 0.0026 0.0233 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.037 0.0512
Onchocerca volvulus 0.0037 0.0394 0.0491
Mycobacterium tuberculosis Conserved protein 0.0037 0.0394 0.0834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0337 0.0467
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0335 0.0464
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0329 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0407 0.0563
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0135 0.1797 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0233 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0643 0.0636
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0054 0.0643 0.0636
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0135 0.0537
Brugia malayi hypothetical protein 0.0026 0.0233 0.0338
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0041 0.005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0135 0.1797 1
Schistosoma mansoni ran 0.0022 0.0177 0.0169
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0079 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0054 0.0643 0.0636
Schistosoma mansoni hypothetical protein 0.0139 0.1859 0.1853
Brugia malayi TAR-binding protein 0.0271 0.375 0.5637
Trypanosoma brucei unspecified product 0.0019 0.0135 0.0478
Echinococcus granulosus cpg binding protein 0.0034 0.0349 0.0341
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0507 0.1751
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0041 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.1724 0.1718
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0135 0.1797 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0789 0.0782
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0643 0.0636
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0233 0.0586
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0041 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0337 0.0467
Loa Loa (eye worm) hypothetical protein 0.0054 0.0643 0.0967
Schistosoma mansoni ran 0.0022 0.0177 0.0169
Loa Loa (eye worm) hypothetical protein 0.0027 0.0257 0.0386
Loa Loa (eye worm) hypothetical protein 0.0043 0.0489 0.0736
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.1724 0.1718
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0027 0.0257 0.1034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0499 0.0692
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0257 0.0885
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0041 0.0033
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0168 0.2277 0.6914
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0394 0.1957
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0041 0.0033
Schistosoma mansoni ap endonuclease 0.0135 0.1797 0.1791
Onchocerca volvulus 0.0026 0.0233 0.0267
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0027 0.0257 0.1172
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0335 0.1488
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0694 0.0961
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0106 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.033
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0703 0.1046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0241 0.0362
Brugia malayi RNA binding protein 0.0271 0.375 0.5637
Loa Loa (eye worm) nuclear factor I 0.0018 0.0122 0.0184
Schistosoma mansoni zinc finger protein 0.0015 0.0081 0.0074
Onchocerca volvulus 0.0026 0.0241 0.0278
Brugia malayi beta-lactamase 0.0037 0.0394 0.058
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0507 0.2235
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0694 0.3578
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0277 0.0417
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0233 0.0745
Schistosoma mansoni bromodomain containing protein 0.0064 0.0779 0.0771
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0187 0.2546 0.7782
Schistosoma mansoni lamin 0.0026 0.0241 0.0233
Leishmania major hypothetical protein, conserved 0.0027 0.0257 0.1034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0643 0.0636
Trichomonas vaginalis Phospholipase C precursor, putative 0.0027 0.0257 0.0356
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0012 0.0041 0.0057
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0394 0.1554
Schistosoma mansoni Smad4 0.0032 0.0329 0.0321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.3927 0.3923
Schistosoma mansoni steroid hormone receptor ad4bp 0.0054 0.0643 0.0636
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0073 0.011
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0027 0.0257 0.0249
Mycobacterium ulcerans beta-lactamase 0.0037 0.0394 0.1554
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.1216 0.182
Loa Loa (eye worm) hypothetical protein 0.0037 0.0405 0.0609
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0187 0.2546 0.7782
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0233 0.0338
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0233 0.0323
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0177 0.0569
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0233 0.0225
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0444 0.0437
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.0233 0.1296
Leishmania major hypothetical protein, conserved 0.0027 0.0257 0.1034
Loa Loa (eye worm) inositol-1 0.0045 0.0507 0.0762
Brugia malayi conserved hypotetical protein 0.0026 0.0233 0.0338
Echinococcus multilocularis neutral sphingomyelinase 0.0027 0.0257 0.0249
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0499 0.2445
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0027 0.0257 0.0374
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0027 0.0257 0.1172
Schistosoma mansoni zinc finger protein 0.0026 0.0233 0.0225
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0041 0.0033
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0168 0.2277 0.6914
Schistosoma mansoni inositol monophosphatase 0.0045 0.0507 0.0499
Loa Loa (eye worm) thioredoxin reductase 0.0074 0.0923 0.1389
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0135 0.0188
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0041 0.0057
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1226
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0027 0.0257 0.0249
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0027 0.0257 0.0374
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0233 0.1036
Echinococcus granulosus tar DNA binding protein 0.0271 0.375 0.3745
Loa Loa (eye worm) hypothetical protein 0.0054 0.0643 0.0967
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0789 0.1187
Onchocerca volvulus 0.0512 0.7215 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0054 0.0643 0.0636
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0335 0.1619
Brugia malayi mothers against decapentaplegic homolog 3 0.0014 0.0073 0.0098
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0027 0.0257 0.1034
Entamoeba histolytica hypothetical protein 0.004 0.0444 0.2295
Brugia malayi PHD-finger family protein 0.0026 0.0241 0.035
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0815 0.4284
Brugia malayi MH2 domain containing protein 0.0032 0.0329 0.0483
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0815 0.4406
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0041 0.0033
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0335 0.1488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0054 0.0643 0.0967
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0394 0.1696
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0394 0.0834
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1226
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0079 0.0106
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0394 0.0641
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0067 0.0101
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0047 0.0039
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0416 0.0408
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.0233 0.0315
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0499 0.2445
Brugia malayi intermediate filament protein 0.0026 0.0241 0.035
Echinococcus multilocularis mothers against decapentaplegic 2 0.0014 0.0073 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0054 0.0643 0.0967
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.1724 0.9576
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Plasmodium falciparum thioredoxin reductase 0.0074 0.0923 0.4829
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0135 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0079 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0054 0.0643 0.0956
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0241 0.0362
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0054 0.0643 0.0636
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.2781 0.4177
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0041 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.104 0.1033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0337 0.0467
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0027 0.0257 0.0386
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0507 0.0499
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0079 0.0071
Entamoeba histolytica hypothetical protein 0.0026 0.0246 0.1168
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0246 0.0825
Schistosoma mansoni hypothetical protein 0.0064 0.0789 0.0782
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0394 0.0834
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1226
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0027 0.0257 0.1226
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0208 0.0288
Trichomonas vaginalis ran, putative 0.0022 0.0177 0.0245
Echinococcus granulosus mothers against decapentaplegic 6 0.0014 0.0073 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0643 0.0956
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0177 0.0253
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.044 0.0982
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1427
Plasmodium vivax SET domain protein, putative 0.0065 0.0801 0.4107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0643 0.0636
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0694 0.0686
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0027 0.0257 0.1034
Echinococcus granulosus intermediate filament protein 0.0026 0.0241 0.0233
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0335 0.0503
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.011
Trypanosoma cruzi ISWI complex protein 0.0015 0.0081 0.0015
Trypanosoma cruzi ISWI complex protein 0.0015 0.0081 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0168 0.2277 0.6914
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0643 0.0636
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0027 0.0257 0.1034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0122 0.0184
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0041 0.0033
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0371 0.0363
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0288 0.1601
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0394 0.0386
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0233 0.0897
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0288 0.135
Schistosoma mansoni tar DNA-binding protein 0.0271 0.375 0.3745
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.0233 0.1296
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0444 0.0437
Echinococcus multilocularis synaptojanin 1 0.0027 0.0257 0.0249
Leishmania major GTP-binding protein, putative 0.0022 0.0177 0.0569
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0047 0.0039
Loa Loa (eye worm) hypothetical protein 0.0094 0.1216 0.183
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0233 0.1036
Schistosoma mansoni hypothetical protein 0.0027 0.0257 0.0249
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0499 0.2445
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1427
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0277 0.0269
Echinococcus multilocularis lamin dm0 0.0026 0.0241 0.0233
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0815 0.0808
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0329 0.0321
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.6298 0.6295
Trichomonas vaginalis esterase, putative 0.0037 0.0394 0.0546
Brugia malayi Inositol-1 0.0045 0.0507 0.0751
Schistosoma mansoni hypothetical protein 0.0064 0.0789 0.0782
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0643 0.0956
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0079 0.0109
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0135 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0643 0.0956
Echinococcus granulosus pyruvate kinase 0.0033 0.0335 0.0327
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0394 0.1832
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0027 0.0257 0.1034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.3927 0.3923
Brugia malayi photoreceptor-specific nuclear receptor 0.0054 0.0643 0.0956
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0177 0.0569
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0329 0.0495
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0694 0.0686
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.044 0.0841
Onchocerca volvulus 0.0065 0.0801 0.1059
Echinococcus multilocularis dna polymerase eta 0.0019 0.0135 0.0128
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0394 0.0386
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0789 0.0782
Echinococcus multilocularis GPCR, family 2 0.0064 0.0789 0.0782
Loa Loa (eye worm) transcription factor SMAD2 0.0472 0.6646 1
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0027 0.0257 0.0885
Loa Loa (eye worm) hypothetical protein 0.0037 0.0394 0.0592
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1724 0.9561
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0233 0.0225
Plasmodium vivax importin-beta 2, putative 0.0029 0.0288 0.107
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Mycobacterium tuberculosis Conserved protein 0.0037 0.0394 0.0834
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1427
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0507 0.2491
Schistosoma mansoni smad 0.0014 0.0073 0.0065
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0507 0.282
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0079 0.0153
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.3233 1
Onchocerca volvulus 0.0026 0.0241 0.0278
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0394 0.0592
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0054 0.0643 0.0636
Loa Loa (eye worm) RNA binding protein 0.0271 0.375 0.5643
Echinococcus granulosus pyruvate kinase 0.0017 0.0107 0.0099
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0135 0.1797 1
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.1724 0.1718
Brugia malayi G-protein alpha subunit 0.0012 0.0041 0.005
Onchocerca volvulus Protein ultraspiracle homolog 0.0054 0.0643 0.0839
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0034 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0054 0.0643 0.0956
Plasmodium falciparum DNase I-like protein, putative 0.0027 0.0257 0.0885
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0027 0.0257 0.1034
Brugia malayi MH1 domain containing protein 0.0018 0.0122 0.0172
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0027 0.0257 0.0885
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0041 0.0033
Echinococcus multilocularis smad 0.0032 0.0329 0.0321
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0168 0.2277 0.883
Echinococcus granulosus Smad4 0.0032 0.0329 0.0321
Schistosoma mansoni intermediate filament proteins 0.0026 0.0241 0.0233
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0012 0.0041 0.0057
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0041 0.0057
Echinococcus multilocularis Smad4 0.0032 0.0329 0.0321
Loa Loa (eye worm) steroid hormone receptor 0.0054 0.0643 0.0967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0241 0.0334
Mycobacterium ulcerans lipase LipD 0.0037 0.0394 0.1554
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0041 0.005
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0041 0.0033
Leishmania major DNA polymerase kappa, putative 0.0019 0.0135 0.033
Plasmodium falciparum pyruvate kinase 0.0033 0.0335 0.1347
Echinococcus granulosus synaptojanin 1 0.0027 0.0257 0.0249
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.1216 0.1209
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0394 0.0834
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0135 0.0191
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0815 0.0808
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0193 0.0864
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0507 0.2651
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0789 0.1176
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0041 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0394 0.0834
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0177 0.0982
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.104 0.1033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1724 0.9561
Schistosoma mansoni smad1 5 8 and 0.0032 0.0329 0.0321
Giardia lamblia GTOR 0.0044 0.0499 0.2319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0277 0.0384
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0233 0.0338
Echinococcus granulosus expressed protein 0.0012 0.0041 0.0033
Echinococcus multilocularis pyruvate kinase 0.0033 0.0335 0.0327
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0394 0.0386
Onchocerca volvulus 0.0037 0.0394 0.0491
Loa Loa (eye worm) hypothetical protein 0.0026 0.0234 0.0352
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0054 0.0643 0.0636
Entamoeba histolytica Ran family GTPase 0.0022 0.0177 0.0771
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0815 0.4284
Echinococcus granulosus pyruvate kinase 0.0017 0.0107 0.0099
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0054 0.0643 0.0636
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0246 0.132
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0337 0.1875
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0329 0.0495
Schistosoma mansoni hypothetical protein 0.002 0.0156 0.0148
Schistosoma mansoni retinoic acid receptor RXR 0.0054 0.0643 0.0636
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0041 0.0033
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0041 0.0033
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0233 0.035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.3927 0.3923
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0054 0.0643 0.0636
Schistosoma mansoni cpg binding protein 0.003 0.0298 0.029
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0233 0.0225
Brugia malayi hypothetical protein 0.0029 0.0277 0.0405
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0815 0.4371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.037 0.0512
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0694 0.3578
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0136 0.1814 0.1808
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0246 0.137
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0041 0.0033
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0694 0.3578
Schistosoma mansoni survival motor neuron protein 0.0058 0.0703 0.0695
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0758 0.075
Schistosoma mansoni inositol monophosphatase 0.0045 0.0507 0.0499
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0233 0.0897
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0027 0.0257 0.1034
Plasmodium vivax thioredoxin reductase, putative 0.0074 0.0923 0.4829
Loa Loa (eye worm) hypothetical protein 0.0069 0.0858 0.1292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.3927 0.3923
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0177 0.0412
Brugia malayi hypothetical protein 0.004 0.0444 0.0657
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0041 0.0057
Loa Loa (eye worm) beta-lactamase 0.0037 0.0394 0.0592
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0643 0.0956
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0082 0.104 0.1033
Loa Loa (eye worm) glutathione reductase 0.0074 0.0923 0.1389
Echinococcus multilocularis tar DNA binding protein 0.0271 0.375 0.3745
Schistosoma mansoni tar DNA-binding protein 0.0271 0.375 0.3745
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0394 0.0546
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0507 0.0702
Brugia malayi beta-lactamase family protein 0.0037 0.0394 0.058
Schistosoma mansoni ap endonuclease 0.0135 0.1797 0.1791
Echinococcus granulosus lamin dm0 0.0026 0.0241 0.0233
Onchocerca volvulus 0.0027 0.0257 0.03
Brugia malayi MH2 domain containing protein 0.0014 0.0073 0.0098
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0027 0.0257 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0241 0.0334
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0177 0.0412
Loa Loa (eye worm) hypothetical protein 0.0139 0.1859 0.2797
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0499 0.0491
Loa Loa (eye worm) hypothetical protein 0.0054 0.0643 0.0967
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0298 0.0448
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0107 0.0595
Leishmania major importin beta-1 subunit, putative 0.0024 0.0208 0.0752
Loa Loa (eye worm) hypothetical protein 0.004 0.0438 0.0659
Schistosoma mansoni hypothetical protein 0.0058 0.0703 0.0695
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0027 0.0257 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0277 0.0269
Echinococcus multilocularis zinc finger protein 0.0021 0.0166 0.0158
Giardia lamblia hypothetical protein 0.0027 0.0257 0.0885
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0416 0.0408
Brugia malayi MAP kinase sur-1 0.0058 0.0694 0.1033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0277 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.037 0.0512
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0643 0.0956
Echinococcus granulosus zinc finger protein 0.0021 0.0166 0.0158
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0135 0.0128
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0027 0.0257 0.1172
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0233 0.035
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0233 0.0225
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3964 0.396
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0277 0.0405
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0815 0.1226
Brugia malayi RNA, U transporter 1 0.0083 0.1064 0.159
Echinococcus granulosus importin subunit beta 1 0.0029 0.0288 0.028
Leishmania major hypothetical protein, conserved 0.0015 0.0081 0.0015
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0027 0.0257 0.1034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0079 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0208 0.0288
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0054 0.0643 0.0636
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.0478
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0499 0.0739
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0027 0.0257 0.1172
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0815 0.0808
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1226
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0233 0.0745
Entamoeba histolytica hypothetical protein 0.0024 0.0208 0.095
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0027 0.0257 0.1172
Echinococcus multilocularis FTZ F1 alpha 0.0054 0.0643 0.0636
Brugia malayi hypothetical protein 0.0286 0.3964 0.596
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0246 0.1113
Schistosoma mansoni nuclear receptor 0.0026 0.0233 0.0225
Loa Loa (eye worm) hypothetical protein 0.0029 0.0277 0.0417
Leishmania major pyruvate kinase 0.0033 0.0335 0.1488
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0335 0.0491
Echinococcus multilocularis lamin 0.0026 0.0241 0.0233
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0288 0.135
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0728 0.0721
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0041 0.0062
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0335 0.0409
Schistosoma mansoni synaptojanin 0.0027 0.0257 0.0249
Schistosoma mansoni neutral sphingomyelinase 0.0027 0.0257 0.0249
Loa Loa (eye worm) hypothetical protein 0.0027 0.0257 0.0386
Echinococcus multilocularis pyruvate kinase 0.0017 0.0107 0.0099
Schistosoma mansoni cpg binding protein 0.0034 0.0349 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0054 0.0643 0.0956
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0801 0.0794
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0041 0.005
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0041 0.0033
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0233 0.0225
Schistosoma mansoni nuclear receptor 0.0026 0.0233 0.0225
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0246 0.0667
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0136 0.0192
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0233 0.0338
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0694 0.0686
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0177 0.0713
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0394 0.058
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0027 0.0257 0.0374
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0027 0.0257 0.0356
Echinococcus multilocularis deoxyribonuclease 1 2 0.0027 0.0257 0.0249
Mycobacterium tuberculosis Probable oxidoreductase 0.0187 0.2546 0.7782
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0027 0.0257 0.0356
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0027 0.0257 0.0386
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0335 0.0409
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0027 0.0257 0.0386
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0059 0.0077
Loa Loa (eye worm) hypothetical protein 0.0286 0.3964 0.5965
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0329 0.0321
Mycobacterium tuberculosis Probable dehydrogenase 0.0168 0.2277 0.6914
Brugia malayi Pre-SET motif family protein 0.045 0.6325 0.9515
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0041 0.0057
Brugia malayi tailless protein 0.0026 0.0233 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0643 0.0956
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0208 0.0288
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0233 0.0745
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0027 0.0257 0.1034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0337 0.0467
Leishmania major hypothetical protein, conserved 0.0037 0.0394 0.1832
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0207 0.02
Echinococcus multilocularis musashi 0.0026 0.0241 0.0233
Schistosoma mansoni thyroid hormone receptor 0.019 0.259 0.2584
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0071
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0041 0.005
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0027 0.0257 0.1034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0394 0.0592
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0728 0.0721
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0027 0.0257 0.0374
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0027 0.0257 0.0374
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0233 0.0225
Mycobacterium ulcerans hypothetical protein 0.0037 0.0394 0.1554
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0507 0.2491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0233 0.0897
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0233 0.0586
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0027 0.0257 0.0374
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0283 0.3927 0.5909
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0335 0.1619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0208 0.0288
Echinococcus multilocularis thyroid hormone receptor alpha 0.019 0.259 0.2584
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0233 0.0225
Loa Loa (eye worm) hypothetical protein 0.0029 0.0288 0.0433
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0233 0.0745
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0499 0.0491
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0233 0.0338
Echinococcus multilocularis pyruvate kinase 0.0026 0.0236 0.0228
Schistosoma mansoni cpg binding protein 0.0034 0.0349 0.0341
Schistosoma mansoni synaptojanin 0.0027 0.0257 0.0249
Trichomonas vaginalis set domain proteins, putative 0.0512 0.7215 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.035
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0027 0.0257 0.0356
Giardia lamblia Inositol 5-phosphatase 4 0.0027 0.0257 0.0885
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0233 0.0897
Onchocerca volvulus 0.0094 0.1216 0.1638
Onchocerca volvulus 0.0037 0.0394 0.0491
Schistosoma mansoni pyruvate kinase 0.0033 0.0335 0.0327
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0041 0.005
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0027 0.0257 0.1427
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0054 0.0643 0.0636
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0177 0.0169
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0329 0.0321
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0079 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.037 0.0512
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0801 0.0794
Loa Loa (eye worm) hypothetical protein 0.0054 0.0643 0.0967
Schistosoma mansoni tar DNA-binding protein 0.0271 0.375 0.3745
Schistosoma mansoni tar DNA-binding protein 0.0271 0.375 0.3745
Loa Loa (eye worm) hypothetical protein 0.0054 0.0643 0.0967
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0106 0.0098
Loa Loa (eye worm) DR-78 0.0026 0.0233 0.035
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0233 0.0323
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0335 0.0503
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.075 0.4175
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0027 0.0257 0.0885
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0694 0.0686
Schistosoma mansoni importin beta-1 0.0029 0.0288 0.028
Plasmodium falciparum importin beta, putative 0.0029 0.0288 0.107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0245 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0694 0.0961
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0027 0.0257 0.1034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0036 0.005
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0207 0.02
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0246 0.0358
Brugia malayi Pre-SET motif family protein 0.0065 0.0801 0.1194

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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