Detailed information for compound 1214760

Basic information

Technical information
  • TDR Targets ID: 1214760
  • Name: T0504-0917
  • MW: 497.587 | Formula: C24H23N3O5S2
  • H donors: 1 H acceptors: 4 LogP: 3.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1OC(C)CN(C1)S(=O)(=O)c1ccc(cc1)C(=O)Nc1scc(n1)c1cc2c(o1)cccc2
  • InChi: 1S/C24H23N3O5S2/c1-15-12-27(13-16(2)31-15)34(29,30)19-9-7-17(8-10-19)23(28)26-24-25-20(14-33-24)22-11-18-5-3-4-6-21(18)32-22/h3-11,14-16H,12-13H2,1-2H3,(H,25,26,28)
  • InChiKey: XBLLCQYFZUQTGB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • MLS000374456
  • SMR000242372

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Mus musculus DNA-damage inducible transcript 3 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Mus musculus wingless-type MMTV integration site family, member 3A Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Mus musculus GLI-Kruppel family member GLI1 Starlite/ChEMBL No references
Homo sapiens X-box binding protein 1 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134980 All targets in OG5_134980
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus zinc finger transcription factor gli2 Get druggable targets OG5_130785 All targets in OG5_130785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis zinc finger transcription factor gli2 Get druggable targets OG5_130785 All targets in OG5_130785
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Zinc finger, C2H2 type family protein Get druggable targets OG5_130785 All targets in OG5_130785
Loa Loa (eye worm) zinc finger protein Get druggable targets OG5_130785 All targets in OG5_130785
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Wnt-2 protein precursor wingless-type MMTV integration site family, member 3A 352 aa 355 aa 39.7 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis protein patched 0.0051 0.0209 0.0307
Loa Loa (eye worm) ctsf protein 0.002 0.0008 0.0024
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0123 0.068 0.2173
Brugia malayi MH1 domain containing protein 0.0034 0.0097 0.031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0283
Schistosoma mansoni sulfide quinone reductase 0.0044 0.0166 0.0166
Schistosoma mansoni smad1 5 8 and 0.0034 0.0097 0.0097
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1225 0.7895 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.0606 0.0891
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0044 0.0166 0.0523
Brugia malayi glutamate synthase 0.0044 0.0166 0.0531
Brugia malayi Cathepsin L-like precursor 0.002 0.0008 0.0024
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0044 0.0166 0.2456
Brugia malayi MH2 domain containing protein 0.0498 0.3132 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0044 0.0166 0.0523
Echinococcus multilocularis cysteine protease 0.002 0.0008 0.0011
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0123 0.068 0.2173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.038 0.1227
Trypanosoma brucei trypanothione reductase 0.0483 0.3038 1
Brugia malayi Smad1 0.0034 0.0097 0.031
Loa Loa (eye worm) MH2 domain-containing protein 0.0498 0.3132 1
Trichomonas vaginalis glutamate synthase, putative 0.0044 0.0166 0.1646
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0044 0.0166 0.0523
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0044 0.0166 0.2456
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0097 0.0143
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0653 1
Plasmodium vivax ferrodoxin reductase, putative 0.0044 0.0166 0.0523
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0069 0.022
Echinococcus granulosus lamin dm0 0.0055 0.0237 0.0348
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.038 0.1227
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0167 0.0971 0.318
Schistosoma mansoni smad 0.0034 0.0097 0.0097
Trichomonas vaginalis mercuric reductase, putative 0.0167 0.0971 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0008 0.0024
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0044 0.0166 0.1646
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0044 0.0166 0.0244
Loa Loa (eye worm) hypothetical protein 0.0051 0.0209 0.0668
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0209 0.0307
Trypanosoma cruzi trypanothione reductase, putative 0.0483 0.3038 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0044 0.0166 0.2456
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0653 0.2086
Echinococcus multilocularis lamin dm0 0.0055 0.0237 0.0348
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0483 0.3038 0.3716
Schistosoma mansoni hypothetical protein 0.0049 0.0197 0.0197
Echinococcus multilocularis lamin 0.0055 0.0237 0.0348
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0209 0.0668
Schistosoma mansoni smad1 5 8 and 0.0034 0.0097 0.0097
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0209 0.0307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0167 0.0971 0.318
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0237 0.0755
Loa Loa (eye worm) hypothetical protein 0.0054 0.023 0.0734
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0167 0.0971 0.0971
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0237 0.0755
Leishmania major cathepsin L-like protease 0.0077 0.038 0.1227
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1225 0.7895 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0008 0.0024
Plasmodium vivax glutathione reductase, putative 0.0483 0.3038 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Loa Loa (eye worm) zinc finger protein 0.0373 0.232 0.7406
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0044 0.0166 0.2456
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0044 0.0166 0.0244
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0665 0.0665
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0167 0.0971 0.1042
Entamoeba histolytica hypothetical protein 0.0043 0.016 0.2354
Schistosoma mansoni hypothetical protein 0.0041 0.0145 0.0145
Leishmania major cathepsin L-like protease 0.0077 0.038 0.1227
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0167 0.0971 0.318
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0167 0.0971 0.318
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.016 0.016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0167 0.0971 1
Brugia malayi Thioredoxin reductase 0.0483 0.3038 0.9701
Echinococcus multilocularis Smad4 0.0034 0.0097 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0167 0.0971 0.1427
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0653 0.096
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0167 0.0971 1
Echinococcus multilocularis cysteine protease 0.002 0.0008 0.0011
Brugia malayi MH2 domain containing protein 0.0034 0.0097 0.031
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0166 0.1646
Schistosoma mansoni lamin 0.0055 0.0237 0.0237
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0283
Brugia malayi glutathione reductase 0.0483 0.3038 0.9701
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0044 0.0166 0.0523
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0257 0.0819
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0044 0.0166 0.1646
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0167 0.0971 1
Echinococcus multilocularis musashi 0.0055 0.0237 0.0348
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1102 0.709 0.8958
Loa Loa (eye worm) glutathione reductase 0.0483 0.3038 0.9701
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0008 0.0024
Echinococcus granulosus neuropeptide s receptor 0.0558 0.353 0.5187
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0049 0.0197 0.0197
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0044 0.0166 0.0531
Loa Loa (eye worm) RNA binding protein 0.0062 0.0283 0.0904
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0167 0.0971 0.3101
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1102 0.709 0.8958
Echinococcus multilocularis glutamate synthase 0.0044 0.0166 0.0244
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0044 0.0166 0.0531
Brugia malayi Muscleblind-like protein 0.018 0.1056 0.3372
Echinococcus granulosus tar DNA binding protein 0.0062 0.0283 0.0416
Schistosoma mansoni glutamate synthase 0.0044 0.0166 0.0166
Echinococcus multilocularis X box binding protein 1 0.0348 0.2152 0.3162
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0097 0.031
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0167 0.0971 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0166 0.0523
Plasmodium falciparum thioredoxin reductase 0.0483 0.3038 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0269 0.086
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0167 0.0971 0.318
Loa Loa (eye worm) hypothetical protein 0.0148 0.0844 0.2694
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0008 0.0024
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0044 0.0166 0.0244
Loa Loa (eye worm) programmed cell death 8 0.0044 0.0166 0.0531
Schistosoma mansoni lamin 0.0055 0.0237 0.0237
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0283
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0167 0.0971 0.318
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0237 0.0755
Echinococcus granulosus Smad4 0.0034 0.0097 0.0143
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0044 0.0166 0.0244
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0167 0.0971 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0008 0.0011
Onchocerca volvulus 0.0055 0.0237 0.2595
Echinococcus granulosus cathepsin l1 0.002 0.0008 0.0011
Leishmania major trypanothione reductase 0.0483 0.3038 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.038 0.1227
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0097 0.0143
Schistosoma mansoni hypothetical protein 0.0205 0.1215 0.1215
Brugia malayi Cathepsin L-like precursor 0.002 0.0008 0.0024
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0044 0.0166 0.2456
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0167 0.0971 0.318
Trichomonas vaginalis glutamate synthase, putative 0.0044 0.0166 0.1646
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0166 0.1646
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0167 0.0971 0.318
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0167 0.0971 0.318
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1744 0.2563
Mycobacterium tuberculosis Probable oxidoreductase 0.1225 0.7895 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0044 0.0166 0.0523
Brugia malayi Cathepsin L-like precursor 0.002 0.0008 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0167 0.0971 0.2803
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0044 0.0166 0.0523
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0167 0.0971 0.318
Schistosoma mansoni sulfide quinone reductase 0.0044 0.0166 0.0166
Echinococcus multilocularis protein dispatched 1 0.0058 0.0256 0.0377
Toxoplasma gondii NADPH-glutathione reductase 0.0167 0.0971 0.318
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0044 0.0166 0.0523
Schistosoma mansoni patched 1 0.0051 0.0209 0.0209
Mycobacterium tuberculosis Probable dehydrogenase 0.1102 0.709 0.8958
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0167 0.0971 1
Echinococcus granulosus lamin 0.0055 0.0237 0.0348
Entamoeba histolytica hypothetical protein 0.0043 0.016 0.2354
Loa Loa (eye worm) thioredoxin reductase 0.0483 0.3038 0.9701
Loa Loa (eye worm) hypothetical protein 0.018 0.1056 0.3372
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0044 0.0166 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Brugia malayi hypothetical protein 0.0286 0.1744 0.5569
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0166 0.1646
Leishmania major hypothetical protein, conserved 0.0044 0.0166 0.0523
Brugia malayi RNA binding protein 0.0062 0.0283 0.0904
Entamoeba histolytica disulphide oxidoreductase, putative 0.0044 0.0166 0.2456
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.353 0.5187
Brugia malayi CHE-14 protein 0.0051 0.0209 0.0668
Onchocerca volvulus 0.0155 0.089 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0283 0.0416
Brugia malayi intermediate filament protein 0.0055 0.0237 0.0755
Leishmania major hypothetical protein, conserved 0.0044 0.0166 0.0523
Brugia malayi hypothetical protein 0.0043 0.016 0.051
Trypanosoma cruzi trypanothione reductase, putative 0.0167 0.0971 0.318
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.016
Echinococcus granulosus muscleblind protein 0.018 0.1056 0.1551
Mycobacterium tuberculosis Probable reductase 0.1102 0.709 0.8958
Echinococcus granulosus thioredoxin glutathione reductase 0.0489 0.3076 0.4519
Leishmania major hypothetical protein, conserved 0.0044 0.0166 0.0523
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0283
Echinococcus granulosus geminin 0.0205 0.1215 0.1785
Schistosoma mansoni Smad4 0.0034 0.0097 0.0097
Schistosoma mansoni intermediate filament proteins 0.0055 0.0237 0.0237
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0044 0.0166 0.1646
Echinococcus multilocularis geminin 0.0205 0.1215 0.1785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Loa Loa (eye worm) fibroinase 0.002 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0119 0.0653 0.2086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0137
Schistosoma mansoni glutamate synthase 0.0044 0.0166 0.0166
Echinococcus multilocularis zinc finger transcription factor gli2 0.0373 0.232 0.3408
Loa Loa (eye worm) cysteine protease 0.002 0.0008 0.0024
Trypanosoma cruzi NADH dehydrogenase, putative 0.0044 0.0166 0.0523
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0209 0.0307
Echinococcus granulosus zinc finger transcription factor gli2 0.0373 0.232 0.3408
Onchocerca volvulus 0.0058 0.0257 0.2821
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.016 0.0235
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0024
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0008 0.0011
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0044 0.0166 0.0244
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0044 0.0166 0.0531
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0283 0.0904
Echinococcus granulosus expressed conserved protein 0.0112 0.0606 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Toxoplasma gondii selenide, water dikinase 0.0044 0.0166 0.0523
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0283 0.0904
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0044 0.0166 0.0523
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0167 0.0971 0.1427
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0167 0.0971 0.2803
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0008 0.0008
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0167 0.0971 0.318
Schistosoma mansoni glutamate synthase 0.0044 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0155 0.089 0.2841
Echinococcus multilocularis smad 0.0034 0.0097 0.0143
Loa Loa (eye worm) Smad1 0.0034 0.0097 0.031
Schistosoma mansoni hypothetical protein 0.0348 0.2152 0.2152
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0097 0.0143
Echinococcus granulosus intermediate filament protein 0.0055 0.0237 0.0348
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0462
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.353 0.5187
Loa Loa (eye worm) hypothetical protein 0.018 0.1056 0.3372
Loa Loa (eye worm) hypothetical protein 0.0148 0.0844 0.2694
Echinococcus granulosus glutamate synthase 0.0044 0.0166 0.0244
Brugia malayi MH1 domain containing protein 0.0034 0.0097 0.031
Schistosoma mansoni survival motor neuron protein 0.0058 0.0257 0.0257
Plasmodium falciparum thioredoxin reductase 0.0167 0.0971 0.318
Schistosoma mansoni hypothetical protein 0.0058 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0044 0.0166 0.0531
Echinococcus multilocularis tumor protein p63 0.1059 0.6806 1
Echinococcus granulosus X box binding protein 1 0.0348 0.2152 0.3162
Loa Loa (eye worm) transcription factor SMAD2 0.0498 0.3132 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1102 0.709 0.8958
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0166 0.0523
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0069 0.022
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0044 0.0166 0.0244
Treponema pallidum NADH oxidase 0.0167 0.0971 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.0044 0.0166 0.1646
Leishmania major cathepsin L-like protease 0.0077 0.038 0.1227
Brugia malayi TAR-binding protein 0.0062 0.0283 0.0904
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0044 0.0166 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0755
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0166 0.1646
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0044 0.0166 0.1646
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0166 0.1646
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.0166 0.1646
Plasmodium falciparum glutathione reductase 0.0483 0.3038 1
Entamoeba histolytica thioredoxin reductase, putative 0.0044 0.0166 0.2456
Toxoplasma gondii thioredoxin reductase 0.0483 0.3038 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0008 0.0024
Onchocerca volvulus Huntingtin homolog 0.0148 0.0844 0.9477
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0044 0.0166 0.0523
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0272 0.0871
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0159
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0167 0.0971 0.2803
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0044 0.0166 0.0244
Echinococcus multilocularis muscleblind protein 0.018 0.1056 0.1551
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0044 0.0166 0.0523
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.038 0.1227
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0097 0.0143
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0167 0.0971 0.318
Echinococcus multilocularis muscleblind protein 1 0.018 0.1056 0.1551
Onchocerca volvulus 0.0055 0.0237 0.2595
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0987 0.1451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Onchocerca volvulus Huntingtin homolog 0.0148 0.0844 0.9477
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0044 0.0166 0.0523
Loa Loa (eye worm) hypothetical protein 0.0062 0.0284 0.0908
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0044 0.0166 0.0523
Schistosoma mansoni cellular tumor antigen P53 0.0155 0.089 0.089
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0008 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0653 0.096
Schistosoma mansoni hypothetical protein 0.0044 0.0166 0.0166
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0145 0.0462
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0167 0.0971 0.318
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1102 0.709 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0167 0.0971 0.318
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0008 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0269 0.086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0269 0.086
Schistosoma mansoni disulfide oxidoreductase 0.0044 0.0166 0.0166
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0209 0.2092
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0097 0.0097
Echinococcus granulosus smad 0.0034 0.0097 0.0143
Schistosoma mansoni hypothetical protein 0.0049 0.0197 0.0197
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0283
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0167 0.0971 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0167 0.0971 0.318
Loa Loa (eye worm) hypothetical protein 0.0286 0.1744 0.5569
Plasmodium falciparum glutathione reductase 0.0167 0.0971 0.318
Onchocerca volvulus 0.0044 0.0166 0.1798
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0044 0.0166 0.0244
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0044 0.0166 0.0244
Entamoeba histolytica hypothetical protein 0.0043 0.016 0.2354
Entamoeba histolytica hypothetical protein 0.0043 0.016 0.2354
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1744 0.2563
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1102 0.709 0.8958
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.038 0.0743
Schistosoma mansoni smad1 5 8 and 0.0034 0.0097 0.0097
Echinococcus multilocularis thioredoxin glutathione reductase 0.0489 0.3076 0.4519
Brugia malayi hypothetical protein 0.0148 0.0844 0.2694
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0336 0.1083
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0044 0.0166 0.0531
Echinococcus granulosus tumor protein p63 0.1059 0.6806 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0373 0.232 0.7406
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0008 0.0011
Trichomonas vaginalis glutathione reductase, putative 0.0167 0.0971 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0097 0.031
Brugia malayi MH2 domain containing protein 0.0034 0.0097 0.031
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0044 0.0166 0.0523
Plasmodium vivax thioredoxin reductase, putative 0.0483 0.3038 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0044 0.0166 0.0244
Brugia malayi Cathepsin L-like precursor 0.002 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.006 0.0269 0.086
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0044 0.0166 0.0244
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.016 0.0235
Leishmania major NADH dehydrogenase, putative 0.0044 0.0166 0.0523
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.005 0.0073
Giardia lamblia NADH oxidase lateral transfer candidate 0.0167 0.0971 1
Schistosoma mansoni hypothetical protein 0.0205 0.1215 0.1215
Trypanosoma cruzi NADH dehydrogenase, putative 0.0044 0.0166 0.0523
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0283 0.0904
Schistosoma mansoni hypothetical protein 0.0049 0.0197 0.0197
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0044 0.0166 0.0523
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.353 0.5187
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.005 0.0073
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0167 0.0971 0.318
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1225 0.7895 1
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0987 0.1451
Plasmodium falciparum ferrodoxin reductase-like protein 0.0044 0.0166 0.0523
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0044 0.0166 0.0244
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0167 0.0971 0.318

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 1.26 uM PubChem BioAssay. Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 1.28 uM PubChem BioAssay. Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 9.56 uM PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (functional) = 10 uM PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 1.9953 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 2.0596 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 3.6626 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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