Detailed information for compound 1215636

Basic information

Technical information
  • TDR Targets ID: 1215636
  • Name: 5-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-2- chloro-N,N-diethylbenzenesulfonamide
  • MW: 470.768 | Formula: C18H17BrClN3O3S
  • H donors: 0 H acceptors: 4 LogP: 4.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1cc(ccc1Cl)c1nnc(o1)c1ccc(cc1)Br)CC
  • InChi: 1S/C18H17BrClN3O3S/c1-3-23(4-2)27(24,25)16-11-13(7-10-15(16)20)18-22-21-17(26-18)12-5-8-14(19)9-6-12/h5-11H,3-4H2,1-2H3
  • InChiKey: LMZMURZVCYYPQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-2-chloro-N,N-diethyl-benzenesulfonamide
  • Oprea1_412010
  • Oprea1_364370
  • A0854/0040034
  • MLS000108765
  • SMR000104716
  • ZINC00712311

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0148 0.1363 0.2611
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0161 0.0309
Plasmodium falciparum plasmepsin X 0.0022 0.006 0.0699
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0027 0.003
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0809 0.5925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0235 0.0476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0159 0.0305
Schistosoma mansoni neuropeptide F-like receptor 0.0108 0.0948 0.1061
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0003 0.0003
Brugia malayi Pre-SET motif family protein 0.0062 0.0467 0.0896
Loa Loa (eye worm) hypothetical protein 0.0112 0.0987 0.1891
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0098
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0006 0.0017
Giardia lamblia DINP protein human, muc B family 0.0019 0.0027 0.026
Brugia malayi nuclear hormone receptor 0.0032 0.0159 0.0305
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0342 0.1046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Schistosoma mansoni opsin-like receptor 0.0108 0.0948 0.1061
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0291 0.2847 0.3188
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0004 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.0392 0.4818
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0032 0.0161 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0112 0.0987 0.1891
Plasmodium falciparum thioredoxin reductase 0.0017 0.0006 0.0028
Echinococcus granulosus 7TM GPCR rhodopsin 0.0108 0.0948 0.1061
Schistosoma mansoni coup transcription factor 0.0032 0.0159 0.0179
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0809 0.5614
Onchocerca volvulus 0.0108 0.0948 0.1944
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0027 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0007
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0159 0.0179
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.07
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0046 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0161 0.0324
Echinococcus multilocularis geminin 0.0876 0.8929 0.8929
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.167 0.3433
Loa Loa (eye worm) hypothetical protein 0.0033 0.0166 0.0318
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Onchocerca volvulus 0.0054 0.0392 0.08
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0006 0.0005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0069 0.0134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0467 0.0524
Leishmania major hypothetical protein, conserved 0.0148 0.1363 0.4198
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108 0.0948 0.1061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0392 0.08
Plasmodium vivax aspartyl protease, putative 0.0022 0.006 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.167 0.3433
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0159 0.0159
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0159 0.0179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0948 0.1061
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.006 0.0067
Onchocerca volvulus 0.0108 0.0948 0.1944
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0007
Loa Loa (eye worm) glutathione reductase 0.0049 0.0342 0.0655
Giardia lamblia Cathepsin B precursor 0.0102 0.0883 1
Plasmodium falciparum thioredoxin reductase 0.0049 0.0342 0.4194
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0319 0.0357
Mycobacterium tuberculosis Conserved protein 0.0148 0.1363 0.1409
Leishmania major importin beta-1 subunit, putative 0.0023 0.0069 0.0194
Echinococcus granulosus dna polymerase eta 0.0044 0.0289 0.0324
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0006 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108 0.0948 0.1061
Onchocerca volvulus 0.0108 0.0948 0.1944
Plasmodium falciparum cysteine proteinase falcipain 1 0.0032 0.0161 0.1953
Loa Loa (eye worm) latrophilin receptor protein 2 0.0164 0.1533 0.2938
Schistosoma mansoni hypothetical protein 0.0876 0.8929 1
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0392 0.0752
Schistosoma mansoni hypothetical protein 0.0305 0.2998 0.3357
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0392 0.1202
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0342 0.2489
Echinococcus multilocularis musashi 0.0033 0.0166 0.0166
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.006 0.0067
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0397 0.3951 0.3951
Toxoplasma gondii thioredoxin reductase 0.0049 0.0342 0.2489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0392 0.08
Loa Loa (eye worm) hypothetical protein 0.0148 0.1363 0.2611
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0159 0.0305
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0809 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Echinococcus granulosus dna polymerase kappa 0.0019 0.0027 0.003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0307 0.0939
Mycobacterium ulcerans hydrolase 0.0026 0.01 0.054
Trichomonas vaginalis esterase, putative 0.0148 0.1363 0.28
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Leishmania major DNA polymerase eta, putative 0.0031 0.0152 0.0451
Schistosoma mansoni cpg binding protein 0.0029 0.0128 0.0143
Echinococcus multilocularis fmrfamide receptor 0.0108 0.0948 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0387 0.0742
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0809 0.5925
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.0392 0.0439
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0342 0.0349
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0046 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0948 0.0948
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0612 0.6183 0.6183
Brugia malayi cathepsin L precursor 0.0017 0.0004 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0159 0.0305
Brugia malayi Probable ClpP-like protease 0.0094 0.0809 0.155
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1 0.7132
Echinococcus granulosus neuropeptide receptor 0.0108 0.0948 0.1061
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpB 0.0185 0.1747 1
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.2355 0.4513
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0027 0.0021
Schistosoma mansoni cpg binding protein 0.0031 0.0145 0.0163
Brugia malayi ecdysteroid receptor 0.0032 0.0159 0.0305
Echinococcus multilocularis neuropeptide receptor 0.0108 0.0948 0.0948
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0159 0.0305
Loa Loa (eye worm) hypothetical protein 0.0313 0.3082 0.5907
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.1363 0.1409
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0948 0.1061
Schistosoma mansoni intermediate filament proteins 0.0033 0.0166 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0098
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Brugia malayi Cathepsin L-like precursor 0.0054 0.0392 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Entamoeba histolytica Ran family GTPase 0.0021 0.0046 0.0662
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0323 0.0659
Echinococcus granulosus cathepsin l1 0.0054 0.0392 0.0439
Echinococcus multilocularis lamin dm0 0.0033 0.0166 0.0166
Plasmodium vivax SET domain protein, putative 0.0062 0.0467 0.3413
Plasmodium falciparum importin beta, putative 0.0029 0.0125 0.1501
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.042 0.3063
Onchocerca volvulus 0.0031 0.0145 0.029
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2635 0.5422
Onchocerca volvulus 0.0062 0.0467 0.0955
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0392 0.08
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Brugia malayi latrophilin 2 splice variant baaae 0.0355 0.3513 0.6732
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0392 0.0392
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0948 0.0948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0159 0.0305
Plasmodium vivax vivapain-3 0.0032 0.0161 0.1159
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0342 0.0342
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0365 0.0409
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0166 0.0318
Brugia malayi Cathepsin L-like precursor 0.0054 0.0392 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0161 0.2444
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0166 0.0521
Entamoeba histolytica hypothetical protein 0.0079 0.0648 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0235 0.045
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0648 0.0726
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0289 0.0554
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0003 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.0392 0.1202
Onchocerca volvulus 0.0108 0.0948 0.1944
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.1363 0.1409
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0159 0.0179
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Trypanosoma brucei unspecified product 0.0019 0.0027 0.0064
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0078 0.064 0.0717
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Entamoeba histolytica phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative 0.0053 0.038 0.5837
Leishmania major cathepsin L-like protease 0.0054 0.0392 0.1195
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0161 0.0487
Trypanosoma brucei cysteine peptidase C (CPC) 0.0102 0.0883 0.2714
Brugia malayi hypothetical protein 0.0079 0.0648 0.1242
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0948 0.1061
Echinococcus multilocularis cysteine protease 0.0054 0.0392 0.0392
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.3238 1
Brugia malayi RNA, U transporter 1 0.0081 0.0672 0.1288
Brugia malayi aspartic protease BmAsp-2, identical 0.0022 0.006 0.0115
Mycobacterium tuberculosis Probable reductase 0.0113 0.1 0.1033
Echinococcus multilocularis serotonin receptor 0.0108 0.0948 0.0948
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0017 0.0004 0.0004
Echinococcus granulosus 7tm_1 domain containing protein 0.0108 0.0948 0.1061
Brugia malayi hypothetical protein 0.0022 0.006 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0667 0.8227
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0948 0.1061
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0319 0.0319
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0095 0.081 0.081
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0159 0.0321
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0108 0.0948 0.1816
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0159 0.0305
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0006 0.0017
Entamoeba histolytica hypothetical protein 0.0023 0.0069 0.1007
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0159 0.0179
Schistosoma mansoni neuropeptide F-like receptor 0.0108 0.0948 0.1061
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0667 0.4882
Brugia malayi Cathepsin L-like precursor 0.0054 0.0392 0.0752
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0006 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108 0.0948 0.1061
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0159 0.0179
Brugia malayi steroid hormone receptor 0.0032 0.0159 0.0305
Loa Loa (eye worm) MBCTL1 0.0054 0.0387 0.0742
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0159 0.0179
Loa Loa (eye worm) hypothetical protein 0.0094 0.0809 0.155
Echinococcus multilocularis neuropeptide Y receptor 0.0108 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0948 0.0948
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.7042 0.7042
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0161 0.0487
Loa Loa (eye worm) hypothetical protein 0.0148 0.1363 0.2611
Onchocerca volvulus 0.0108 0.0948 0.1944
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0305
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0164 0.1533 0.1717
Loa Loa (eye worm) hypothetical protein 0.0519 0.5218 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.0027
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.2998 0.5744
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0006 0.0017
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0108 0.0948 0.1816
Onchocerca volvulus 0.0148 0.1363 0.28
Echinococcus multilocularis muscleblind protein 0.0148 0.1366 0.1366
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.1363 0.1409
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0667 0.2052
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.006 0.0067
Toxoplasma gondii cathepsin CPL 0.0054 0.0392 0.2859
Loa Loa (eye worm) TYRA-2 protein 0.0108 0.0948 0.1816
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0471 0.2937
Schistosoma mansoni hypothetical protein 0.0287 0.2814 0.3151
Plasmodium falciparum plasmepsin IX 0.0022 0.006 0.0699
Brugia malayi ORL1-like opioid receptor 0.0108 0.0948 0.1816
Loa Loa (eye worm) hypothetical protein 0.0054 0.0392 0.0752
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0471 0.0483
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.0064
Brugia malayi Dopamine receptor protein 1 0.0108 0.0948 0.1816
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0387 0.0387
Echinococcus granulosus snurportin 1 0.0305 0.2998 0.3357
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1 0.1033
Schistosoma mansoni hypothetical protein 0.0108 0.0948 0.1061
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0108 0.0948 0.0948
Echinococcus granulosus biogenic amine 5HT receptor 0.0108 0.0948 0.1061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0305
Onchocerca volvulus 0.0108 0.0948 0.1944
Echinococcus granulosus g protein coupled receptor 0.0108 0.0948 0.1061
Schistosoma mansoni myosin xvIII 0.0108 0.0948 0.1061
Echinococcus multilocularis neuropeptide s receptor 0.0663 0.6719 0.6719
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0159 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0102 0.0883 0.1811
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0027 0.0355
Echinococcus granulosus g protein coupled receptor 0.0108 0.0948 0.1061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0161 0.048
Schistosoma mansoni hypothetical protein 0.0876 0.8929 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0948 0.1061
Schistosoma mansoni opsin-like receptor 0.0108 0.0948 0.1061
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.0004 0.0007
Onchocerca volvulus 0.0108 0.0948 0.1944
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0809 0.9983
Echinococcus multilocularis lamin 0.0033 0.0166 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1363 0.4202
Loa Loa (eye worm) matrix metalloproteinase 0.0022 0.0051 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0112 0.0987 0.1891
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0648 0.0648
Brugia malayi cathepsin L-like cysteine proteinase 0.0017 0.0004 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0159 0.0179
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Brugia malayi putative neuropeptide receptor NPR1 0.0108 0.0948 0.1816
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Schistosoma mansoni memapsin-2 (A01 family) 0.0022 0.006 0.0067
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1363 0.28
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0467 0.0467
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0071
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0161 0.0487
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108 0.0948 0.0948
Onchocerca volvulus 0.0029 0.0128 0.0256
Echinococcus granulosus G protein coupled receptor 139 0.0108 0.0948 0.1061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0319 0.0611
Brugia malayi G protein-coupled receptor F59B2.13 0.0108 0.0948 0.1816
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.0392 0.4818
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.1363 0.1409
Schistosoma mansoni cathepsin S (C01 family) 0.0017 0.0004 0.0004
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0108 0.0948 0.1061
Brugia malayi hypothetical protein 0.0017 0.0003 0.0006
Echinococcus multilocularis cathepsin b 0.0291 0.2847 0.2847
Echinococcus granulosus orexin receptor type 2 0.0108 0.0948 0.1061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0161 0.048
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1769 0.3637
Brugia malayi follicle stimulating hormone receptor 0.0386 0.3833 0.7345
Schistosoma mansoni amine GPCR 0.0108 0.0948 0.1061
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.01 0.0192
Schistosoma mansoni biogenic amine receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.045
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.0064
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0392 0.1202
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0392 0.08
Brugia malayi hypothetical protein 0.0108 0.0948 0.1816
Mycobacterium ulcerans beta-lactamase 0.0148 0.1363 0.7792
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Brugia malayi neuropeptide F receptor 0.0108 0.0948 0.1816
Echinococcus granulosus hypothetical protein 0.0108 0.0948 0.1061
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0948 0.1061
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0095 0.081 0.1661
Brugia malayi Hemopexin family protein 0.0031 0.0145 0.0277
Onchocerca volvulus 0.0033 0.0166 0.0335
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0027 0.0021
Toxoplasma gondii aspartyl protease ASP1 0.0095 0.081 0.5935
Brugia malayi Matrixin family protein 0.0022 0.0051 0.0098
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0392 0.1202
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2794 0.3129
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0392 0.1202
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0108 0.0948 0.1061
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0069 0.0201
Brugia malayi mbt repeat family protein 0.0047 0.0319 0.0611
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1363 0.28
Onchocerca volvulus 0.0058 0.0433 0.0884
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Loa Loa (eye worm) hypothetical protein 0.0044 0.0289 0.0554
Brugia malayi Serotonin receptor 0.0108 0.0948 0.1816
Plasmodium falciparum plasmepsin IV 0.0095 0.081 1
Brugia malayi Serotonin receptor 0.0108 0.0948 0.1816
Brugia malayi nuclear receptor RXR 0.0017 0.0003 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0392 0.08
Schistosoma mansoni ran 0.0021 0.0046 0.0052
Echinococcus granulosus cysteine protease 0.0032 0.0161 0.0181
Plasmodium falciparum plasmepsin I 0.0095 0.081 1
Echinococcus granulosus tumor protein p63 0.0354 0.3501 0.3922
Toxoplasma gondii aspartyl protease ASP3 0.0022 0.006 0.0415
Leishmania major mitochondrial DNA polymerase beta 0.0328 0.3238 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0667 0.2052
Toxoplasma gondii ABC1 family protein 0.0148 0.1363 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0004 0.0007
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0809 0.5925
Echinococcus multilocularis tumor protein p63 0.0354 0.3501 0.3501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0948 0.1061
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0022 0.006 0.0415
Leishmania major hypothetical protein, unknown function 0.0053 0.038 0.1157
Echinococcus granulosus neuropeptide receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) matrixin family protein 0.0052 0.0368 0.0705
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0392 0.08
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0098
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0392 0.08
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0944 0.9634 1
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0159 0.0305
Loa Loa (eye worm) hypothetical protein 0.0029 0.0125 0.0239
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0471 0.0471
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.1442 0.4442
Schistosoma mansoni cathepsin D (A01 family) 0.0279 0.2724 0.3051
Echinococcus multilocularis dna polymerase eta 0.0044 0.0289 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2635 0.5422
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0027 0.0064
Brugia malayi Melatonin receptor type 1A 0.0108 0.0948 0.1816
Schistosoma mansoni growth hormone secretagogue receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Plasmodium falciparum plasmepsin VI 0.0095 0.081 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0007
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0809 1
Onchocerca volvulus 0.0108 0.0948 0.1944
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0161 0.0309
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.1363 0.2611
Brugia malayi Calcitonin receptor-like protein seb-1 0.0519 0.5218 1
Brugia malayi RE15519p 0.0108 0.0948 0.1816
Onchocerca volvulus 0.0022 0.006 0.0116
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0027 0.003
Onchocerca volvulus Cathepsin F homolog 0.0054 0.0392 0.08
Echinococcus multilocularis somatostatin receptor 0.0108 0.0948 0.0948
Onchocerca volvulus 0.0108 0.0948 0.1944
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Brugia malayi Cathepsin L-like precursor 0.0054 0.0392 0.0752
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0809 0.0906
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0071
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0004 0.0007
Trichomonas vaginalis set domain proteins, putative 0.0484 0.4858 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0159 0.0305
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0809 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1131 0.1169
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1769 0.3637
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0307 0.0932
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.01 0.0192
Brugia malayi Tachykinin-like peptides receptor 99D 0.0108 0.0948 0.1816
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0286 0.2799 0.2799
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0071
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0046 0.0089
Schistosoma mansoni neuropeptide receptor 0.0108 0.0948 0.1061
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.0392 0.0439
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0235 0.3584
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0392 0.08
Echinococcus granulosus cathepsin b 0.0291 0.2847 0.3188
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0152 0.109
Echinococcus multilocularis neuropeptide receptor 0.0108 0.0948 0.0948
Echinococcus multilocularis g protein coupled receptor 0.0108 0.0948 0.0948
Echinococcus multilocularis G protein coupled receptor 139 0.0108 0.0948 0.0948
Echinococcus multilocularis g-protein coupled receptor 0.0108 0.0948 0.0948
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0159 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0095 0.081 0.0907
Onchocerca volvulus 0.0108 0.0948 0.1944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Schistosoma mansoni importin beta-1 0.0029 0.0125 0.014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0159 0.0305
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0328 0.3238 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1363 0.2611
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1131 0.1169
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2635 0.5422
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0166 0.0318
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0027 0.0047
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0004 0.0007
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0046 0.0052
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0305
Schistosoma mansoni neuropeptide receptor 0.0108 0.0948 0.1061
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1 0.1033
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0004 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0007
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0027 0.0118
Brugia malayi hypothetical protein 0.0108 0.0948 0.1816
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0125 0.0368
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.1763 0.1763
Schistosoma mansoni biogenic amine receptor 0.0108 0.0948 0.1061
Echinococcus granulosus neuropeptides capa receptor 0.0108 0.0948 0.1061
Echinococcus multilocularis cpg binding protein 0.0031 0.0145 0.0145
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0006 0.0026
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0319 0.0357
Loa Loa (eye worm) fibroinase 0.0054 0.0392 0.0752
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0235 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.167 0.3433
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0386 0.3833 0.7345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0948 0.0948
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0159 0.0179
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0108 0.0948 0.1061
Plasmodium vivax vivapain-1 0.0032 0.0161 0.1159
Leishmania major cathepsin L-like protease 0.0054 0.0392 0.1195
Echinococcus granulosus lamin dm0 0.0033 0.0166 0.0186
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0667 0.8227
Brugia malayi hypothetical protein 0.0017 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0108 0.0948 0.1061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2635 0.5422
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0159 0.0179
Loa Loa (eye worm) neuropeptide F receptor 0.0108 0.0948 0.1816
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0027 0.0118
Giardia lamblia Cathepsin B precursor 0.0102 0.0883 1
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.167 0.3433
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Schistosoma mansoni hypothetical protein 0.0058 0.0433 0.0485
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0948 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0948 0.1061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0004 0.0004
Echinococcus multilocularis sex peptide receptor 0.0108 0.0948 0.0948
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.006 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Brugia malayi larval opioid receptor 0.0108 0.0948 0.1816
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0166 0.201
Toxoplasma gondii aspartyl protease 0.0022 0.006 0.0415
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0392 0.0439
Echinococcus multilocularis serotonin receptor 0.0108 0.0948 0.0948
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0809 0.4611
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0125 0.0125
Echinococcus multilocularis neuropeptides capa receptor 0.0108 0.0948 0.0948
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0948 0.1061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0319 0.0357
Echinococcus granulosus neuropeptide FF receptor 2 0.0108 0.0948 0.1061
Schistosoma mansoni ran 0.0021 0.0046 0.0052
Entamoeba histolytica hypothetical protein 0.0079 0.0648 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0159 0.0179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0519 0.5218 1
Echinococcus multilocularis g protein coupled receptor 0.0108 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0062 0.0467 0.0896
Loa Loa (eye worm) melatonin receptor type 1A 0.0108 0.0948 0.1816
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2635 0.5422
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0017 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0036 0.0204 0.0229
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108 0.0948 0.1061
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0046 0.0125
Loa Loa (eye worm) hypothetical protein 0.0148 0.1363 0.2611
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0471 0.0527
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0152 0.0458
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0164 0.1533 0.1533
Brugia malayi hypothetical protein 0.0286 0.2794 0.5354
Echinococcus granulosus neuropeptide Y receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) matrixin family protein 0.0048 0.0323 0.062
Echinococcus granulosus biogenic amine 5HT receptor 0.0108 0.0948 0.1061
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0102 0.0883 0.2719
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) 0.0185 0.1747 0.1809
Schistosoma mansoni amine GPCR 0.0108 0.0948 0.1061
Loa Loa (eye worm) cysteine protease 0.0054 0.0392 0.0752
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1 0.1033
Brugia malayi Dopamine receptor 0.0108 0.0948 0.1816
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0519 0.5218 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0291 0.2847 0.3188
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0108 0.0948 0.1061
Plasmodium vivax plasmepsin IV, putative 0.0095 0.081 0.5935
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0159 0.0305
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.167 0.3433
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0159 0.0305
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.167 0.3433
Loa Loa (eye worm) hypothetical protein 0.0291 0.2847 0.5455
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.1363 0.7792
Echinococcus granulosus cpg binding protein 0.0031 0.0145 0.0163
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0307 0.0939
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0112 0.0987 0.0987
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0387 0.0433
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0204 0.0204
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0004 0.0007
Onchocerca volvulus 0.0108 0.0948 0.1944
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.2799 0.3135
Echinococcus granulosus somatostatin receptor 0.0108 0.0948 0.1061
Echinococcus granulosus sex peptide receptor 0.0108 0.0948 0.1061
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.4248 0.8141
Schistosoma mansoni biogenic amine receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) hypothetical protein 0.0148 0.1363 0.2611
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0159 0.0159
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0166 0.1193
Loa Loa (eye worm) hypothetical protein 0.0054 0.0387 0.0742
Echinococcus granulosus cathepsin l1 0.0039 0.0235 0.0263
Echinococcus multilocularis cysteine protease 0.0054 0.0392 0.0392
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0392 0.0752
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Brugia malayi glutathione reductase 0.0049 0.0342 0.0655
Loa Loa (eye worm) aspartyl protease 6 0.0022 0.006 0.0115
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0289 0.0875
Schistosoma mansoni cathepsin B (C01 family) 0.0017 0.0004 0.0004
Brugia malayi Matrixin family protein 0.0022 0.0051 0.0098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1363 0.1526
Echinococcus granulosus cathepsin L 0.0032 0.0161 0.0181
Plasmodium falciparum plasmepsin VII 0.0022 0.006 0.0699
Echinococcus granulosus GPCR family 2 0.0164 0.1533 0.1717
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0467 0.0524
Leishmania major hypothetical protein, conserved 0.0081 0.0667 0.2046
Brugia malayi aspartic protease BmAsp-1, identical 0.0022 0.006 0.0115
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.0392 0.4818
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0046 0.0314
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0166 0.0318
Leishmania major cathepsin L-like protease 0.0054 0.0392 0.1195
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Onchocerca volvulus 0.0108 0.0948 0.1944
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0286 0.2799 0.3135
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0159 0.0321
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.3238 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0148 0.1363 0.2611
Schistosoma mansoni hypothetical protein 0.0164 0.1533 0.1717
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.1763 0.1975
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Schistosoma mansoni hypothetical protein 0.0164 0.1533 0.1717
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0007
Brugia malayi MH2 domain containing protein 0.0243 0.2355 0.4513
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0161 0.2444
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0291 0.2847 0.3188
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0108 0.0948 0.1061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0948 0.0948
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0948 0.1061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0161 0.0324
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0108 0.0948 0.1816
Brugia malayi hypothetical protein 0.0108 0.0948 0.1816
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0286 0.2799 0.2799
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Leishmania major cysteine peptidase A (CPA) 0.0054 0.0392 0.1195
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0648 0.0726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0108 0.0948 0.1061
Echinococcus multilocularis fmrfamide receptor 0.0108 0.0948 0.0948
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0003 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.006 0.0067
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0159 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Echinococcus granulosus tm gpcr rhodopsin 0.0612 0.6183 0.6925
Echinococcus granulosus tachykinin peptides receptor 99D 0.0397 0.3951 0.4425
Echinococcus multilocularis FTZ F1 alpha 0.0112 0.0987 0.0987
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0159 0.0179
Mycobacterium leprae Probable lipase LipE 0.0148 0.1363 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.1533 0.2938
Schistosoma mansoni cathepsin D (A01 family) 0.0279 0.2724 0.3051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0159 0.0179
Loa Loa (eye worm) hypothetical protein 0.0355 0.3513 0.6732
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Echinococcus multilocularis neuropeptide FF receptor 2 0.0108 0.0948 0.0948
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0286 0.2799 0.5364
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0467 0.0467
Onchocerca volvulus 0.0054 0.0392 0.08
Echinococcus granulosus fmrfamide receptor 0.0108 0.0948 0.1061
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2635 0.5422
Brugia malayi GnHR receptor homolog 0.0108 0.0948 0.1816
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0027 0.0051
Plasmodium falciparum glutathione reductase 0.0017 0.0006 0.0028
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0164 0.1533 0.2938
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0046 0.0485
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108 0.0948 0.1061
Echinococcus granulosus neuropeptides capa receptor 0.0108 0.0948 0.1061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Loa Loa (eye worm) G-protein coupled receptor 0.0108 0.0948 0.1816
Schistosoma mansoni hypothetical protein 0.0108 0.0948 0.1061
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108 0.0948 0.0948
Mycobacterium tuberculosis Conserved protein 0.0148 0.1363 0.1409
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.1363 0.2611
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0488 0.0546
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0387 0.0433
Brugia malayi cathepsin B-like cysteine proteinase 0.0291 0.2847 0.5455
Brugia malayi Thioredoxin reductase 0.0049 0.0342 0.0655
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.1363 0.1409
Echinococcus multilocularis GPCR, family 2 0.0164 0.1533 0.1533
Toxoplasma gondii hypothetical protein 0.0053 0.0378 0.2753
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0108 0.0948 0.1816
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0108 0.0948 0.1944
Brugia malayi Dopamine receptor protein 2 0.0108 0.0948 0.1816
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0039 0.0235 0.0714
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.006 0.0067
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Brugia malayi hypothetical protein 0.0108 0.0948 0.1816
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0342 0.0383
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0948 0.1061
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0392 0.08
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0095 0.081 0.5935
Loa Loa (eye worm) hypothetical protein 0.0032 0.016 0.0306
Onchocerca volvulus 0.0484 0.4858 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0009 0.0017
Mycobacterium ulcerans hypothetical protein 0.0173 0.1624 0.9292
Echinococcus granulosus peptide allatostatin:somatostatin 0.0108 0.0948 0.1061
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0948 0.1061
Echinococcus granulosus FTZ F1 alpha 0.0407 0.4056 0.4543
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0467 0.3413
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0161 0.0181
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0392 0.0392
Echinococcus granulosus lamin 0.0033 0.0166 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0467 0.0524
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Loa Loa (eye worm) neuropeptide F receptor 0.0108 0.0948 0.1816
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0159 0.0179
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0809 0.4611
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0342 0.0655
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0159 0.0179
Onchocerca volvulus 0.0052 0.0365 0.0745
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Echinococcus granulosus tm gpcr rhodopsin 0.0108 0.0948 0.1061
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0108 0.0948 0.1061
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1131 0.8168
Schistosoma mansoni hypothetical protein 0.0031 0.0145 0.0162
Loa Loa (eye worm) cathepsin B 0.0102 0.0883 0.1692
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0108 0.0948 0.1061
Schistosoma mansoni neuropeptide receptor 0.0108 0.0948 0.1061
Brugia malayi beta-lactamase 0.0148 0.1363 0.2611
Onchocerca volvulus 0.0108 0.0948 0.1944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0159 0.0305
Plasmodium falciparum plasmepsin VIII, putative 0.0022 0.006 0.0699
Brugia malayi nuclear receptor NHR-88 0.0032 0.0159 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0159 0.0305
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.1363 0.1526
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0307 0.0939
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0159 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.2799 0.3135
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1363 0.28
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0948 0.0948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.2799 0.3135
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Plasmodium vivax unspecified product 0.0032 0.0161 0.1159
Schistosoma mansoni amine GPCR 0.0108 0.0948 0.1061
Trypanosoma brucei trypanothione reductase 0.0049 0.0342 0.104
Mycobacterium tuberculosis Conserved protein 0.0148 0.1363 0.1409
Trichomonas vaginalis ran, putative 0.0021 0.0046 0.0088
Plasmodium falciparum plasmepsin II 0.0095 0.081 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0112 0.0987 0.1105
Schistosoma mansoni hypothetical protein 0.008 0.0655 0.0734
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0022 0.0051 0.0057
Brugia malayi hypothetical protein 0.0108 0.0948 0.1816
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0159 0.0159
Brugia malayi hypothetical protein 0.0108 0.0948 0.1816
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0006
Brugia malayi CXXC zinc finger family protein 0.0029 0.0128 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0159 0.0305
Brugia malayi cathepsin L-like precursor 0.0039 0.0235 0.045
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0809 1
Onchocerca volvulus 0.0054 0.0392 0.08
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108 0.0948 0.1061
Leishmania major GTP-binding protein, putative 0.0021 0.0046 0.0125
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0006
Brugia malayi putative neuropeptide receptor 0.0108 0.0948 0.1816
Entamoeba histolytica hypothetical protein 0.0079 0.0648 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0319 0.065
Brugia malayi G-protein coupled receptor 0.0108 0.0948 0.1816
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0108 0.0948 0.0948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0392 0.08
Schistosoma mansoni survival motor neuron protein 0.0058 0.0433 0.0485
Echinococcus multilocularis neuropeptide Y receptor 0.0108 0.0948 0.0948
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0159 0.0305
Plasmodium vivax importin-beta 2, putative 0.0029 0.0125 0.0891
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0948 0.1061
Echinococcus multilocularis snurportin 1 0.0305 0.2998 0.2998
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0161 0.0181
Echinococcus granulosus neuropeptide Y receptor 0.0108 0.0948 0.1061
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0467 0.0524
Plasmodium falciparum plasmepsin V 0.0022 0.006 0.0699
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0026 0.01 0.0098
Onchocerca volvulus Matrilysin homolog 0.0022 0.0051 0.0098
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0069 0.0134
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.1442 0.4446
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0071
Loa Loa (eye worm) beta-lactamase 0.0148 0.1363 0.2611
Onchocerca volvulus 0.0022 0.006 0.0116
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0006 0.0028
Toxoplasma gondii cathepsin B 0.0102 0.0883 0.647
Echinococcus multilocularis neuropeptides capa receptor 0.0108 0.0948 0.0948
Plasmodium vivax aspartyl proteinase, putative 0.0095 0.081 0.5935
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.006 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1363 0.1526
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0392 0.08
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.045
Echinococcus multilocularis cathepsin b 0.0291 0.2847 0.2847
Leishmania major cathepsin L-like protease 0.0054 0.0392 0.1195
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.0392 0.0752
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0305
Brugia malayi hypothetical protein 0.0081 0.0667 0.1278
Brugia malayi mbt repeat family protein 0.0047 0.0319 0.0611
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Brugia malayi Cathepsin L-like precursor 0.0039 0.0235 0.045
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0159 0.0179
Plasmodium falciparum plasmepsin III 0.0022 0.006 0.0699
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0004 0.0004
Onchocerca volvulus 0.0054 0.0392 0.08
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0289 0.0882
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0433 0.0829
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0004 0.0004
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.1363 0.1409
Brugia malayi intermediate filament protein 0.0033 0.0166 0.0318
Schistosoma mansoni hypothetical protein 0.0355 0.3513 0.3934
Echinococcus granulosus neuropeptide receptor A26 0.0663 0.6719 0.7525
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1 0.1033
Entamoeba histolytica cysteine protease, putative 0.0054 0.0392 0.6028
Schistosoma mansoni amine GPCR 0.0108 0.0948 0.1061
Echinococcus multilocularis cathepsin L 0.0032 0.0161 0.0161
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0148 0.1363 1
Mycobacterium leprae conserved hypothetical protein 0.0148 0.1363 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0809 0.0809
Plasmodium vivax vivapain-2 0.0054 0.0392 0.2859
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0006 0.0028
Mycobacterium ulcerans lipase LipD 0.0148 0.1363 0.7792
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0286 0.2799 0.3135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.1363 0.7792
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.1363 0.1363
Brugia malayi Muscleblind-like protein 0.0148 0.1366 0.2618
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0095 0.081 0.0907
Brugia malayi hypothetical protein 0.0313 0.3082 0.5907
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0046 0.0132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.1624 0.168
Echinococcus granulosus importin subunit beta 1 0.0029 0.0125 0.014
Plasmodium vivax glutathione reductase, putative 0.0049 0.0342 0.2489
Echinococcus multilocularis orexin receptor type 2 0.0108 0.0948 0.0948
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.1747 0.3592
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.0115
Schistosoma mansoni lamin 0.0033 0.0166 0.0186
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0102 0.0883 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0235 0.0476
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0159 0.0305
Echinococcus granulosus g-protein coupled receptor 0.0108 0.0948 0.1061
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0392 0.6028
Plasmodium vivax aspartyl protease, putative 0.0022 0.006 0.0415
Schistosoma mansoni hypothetical protein 0.0079 0.0648 0.0726
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0007
Schistosoma mansoni DNA polymerase eta 0.0044 0.0289 0.0324
Onchocerca volvulus Matrilysin homolog 0.0048 0.0323 0.0659
Brugia malayi fibroinase precursor 0.0017 0.0004 0.0007
Entamoeba histolytica hypothetical protein, conserved 0.0053 0.038 0.5837
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1363 0.28
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0319 0.0357
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0392 0.08
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.1363 0.4198
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0102 0.0883 0.2714
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0809 0.0906
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0392 0.0439
Trypanosoma cruzi tyrosine phosphatase, putative 0.0053 0.038 0.1163
Schistosoma mansoni opsin-like receptor 0.0108 0.0948 0.1061
Brugia malayi hypothetical protein 0.0022 0.006 0.0115
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0069 0.0134
Plasmodium vivax aspartyl proteinase, putative 0.0022 0.006 0.0415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Onchocerca volvulus 0.0108 0.0948 0.1944
Plasmodium falciparum glutathione reductase 0.0049 0.0342 0.4194
Leishmania major phosphoinositide phosphatase 0.0185 0.1747 0.5388
Brugia malayi Eukaryotic aspartyl protease family protein 0.0022 0.006 0.0115
Brugia malayi beta-lactamase family protein 0.0148 0.1363 0.2611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0125 0.0368
Onchocerca volvulus 0.0039 0.0235 0.0476
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2794 0.2794
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0108 0.0948 0.1816
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0003 0.0006
Brugia malayi hypothetical protein 0.0108 0.0948 0.1816
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0108 0.0948 0.1061
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1131 0.1169
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1 0.1033
Plasmodium vivax plasmepsin V, putative 0.0022 0.006 0.0415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0948 0.1061
Echinococcus multilocularis neuropeptide receptor A26 0.0663 0.6719 0.6719
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.045
Brugia malayi hypothetical protein 0.0052 0.037 0.0708
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.0064
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0046 0.0314
Loa Loa (eye worm) hypothetical protein 0.0081 0.0667 0.1278
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0006 0.0007
Echinococcus granulosus intermediate filament protein 0.0033 0.0166 0.0186
Onchocerca volvulus 0.0108 0.0948 0.1944
Leishmania major trypanothione reductase 0.0049 0.0342 0.104
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0467 0.0524
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0108 0.0948 0.0948
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0948 0.1061
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0108 0.0948 0.0948
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0667 0.2046
Schistosoma mansoni amine GPCR 0.0108 0.0948 0.1061
Brugia malayi AKH receptor 0.0108 0.0948 0.1816
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0291 0.2847 0.3188
Onchocerca volvulus 0.0022 0.0051 0.0098
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0078 0.064 0.064
Entamoeba histolytica cysteine proteinase 1, putative 0.0032 0.0161 0.2444
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0108 0.0948 0.0948
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0009 0.0017
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0108 0.0948 0.1816
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Brugia malayi neuropeptide F receptor 0.0108 0.0948 0.1816
Schistosoma mansoni adenoreceptor 0.0108 0.0948 0.1061
Echinococcus granulosus serotonin receptor 0.0108 0.0948 0.1061
Schistosoma mansoni histamine h1 receptor 0.0108 0.0948 0.1061
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0159 0.0159
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Onchocerca volvulus 0.0047 0.0319 0.065
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0108 0.0948 0.1816
Schistosoma mansoni cpg binding protein 0.0031 0.0145 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Trypanosoma cruzi cysteine protease, putative 0.0032 0.0161 0.0487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Brugia malayi Pepsin A precursor 0.0022 0.006 0.0115
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.1442 0.4442
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0305
Echinococcus granulosus cathepsin b 0.0291 0.2847 0.3188
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0438 0.049
Brugia malayi Cathepsin L-like precursor 0.0054 0.0392 0.0752
Loa Loa (eye worm) hypothetical protein 0.0047 0.0319 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0948 0.1061
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1363 0.28
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0159 0.0305
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0319 0.0357
Echinococcus granulosus dro:myosuppressin receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) hypothetical protein 0.0148 0.1366 0.2618
Giardia lamblia Cathepsin B precursor 0.0102 0.0883 1
Loa Loa (eye worm) ctsf protein 0.0054 0.0392 0.0752
Echinococcus granulosus alpha 1A adrenergic receptor 0.0108 0.0948 0.1061
Entamoeba histolytica hypothetical protein 0.0079 0.0648 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0006 0.0011
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0166 0.1991
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0159 0.0179
Schistosoma mansoni cathepsin C 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.0115
Echinococcus multilocularis cathepsin L 0.0017 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0054 0.0392 0.0752
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0108 0.0948 0.0948
Entamoeba histolytica cysteine proteinase 2 0.0032 0.0161 0.2444
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108 0.0948 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0159 0.0305
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Loa Loa (eye worm) hypothetical protein 0.0148 0.1366 0.2618
Leishmania major DNA polymerase eta, putative 0.0044 0.0289 0.0875
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Onchocerca volvulus 0.0054 0.0392 0.08
Echinococcus multilocularis allatostatin A receptor 0.0108 0.0948 0.0948
Echinococcus granulosus allatostatin A receptor 0.0108 0.0948 0.1061
Echinococcus granulosus tm gpcr rhodopsin 0.0108 0.0948 0.1061
Onchocerca volvulus 0.0148 0.1363 0.28
Leishmania major cathepsin L-like protease 0.0054 0.0392 0.1195
Brugia malayi sulfakinin receptor protein 0.0313 0.3082 0.5907
Schistosoma mansoni hypothetical protein 0.0108 0.0948 0.1061
Plasmodium vivax aspartyl protease, putative 0.0022 0.006 0.0415
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Loa Loa (eye worm) hypothetical protein 0.0286 0.2794 0.5354
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0387 0.0387
Loa Loa (eye worm) G-protein coupled receptor 0.0108 0.0948 0.1816
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0108 0.0948 0.1816
Brugia malayi Pre-SET motif family protein 0.0426 0.4248 0.8141
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0392 0.08
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0392 0.6028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0161 0.0181
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1366 0.1366
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0159 0.0159
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0159 0.0305
Brugia malayi Matrixin family protein 0.0022 0.0051 0.0098
Brugia malayi hypothetical protein 0.0108 0.0948 0.1816
Onchocerca volvulus 0.0032 0.0159 0.0321
Brugia malayi Importin beta-1 subunit 0.0029 0.0125 0.0239
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0161 0.2444
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0305
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0164 0.1533 0.1717
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0392 0.1195
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0412 0.1263
Brugia malayi G-protein coupled receptor 0.0108 0.0948 0.1816
Mycobacterium ulcerans hypothetical protein 0.0148 0.1363 0.7792
Onchocerca volvulus 0.0054 0.0392 0.08
Loa Loa (eye worm) hypothetical protein 0.0095 0.081 0.1553
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Echinococcus granulosus cathepsin L cysteine protease 0.0032 0.0161 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0159 0.0305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0006
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.7042 0.7887
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0128 0.0245
Onchocerca volvulus 0.0148 0.1363 0.28
Echinococcus multilocularis G-protein coupled receptor, putative 0.0108 0.0948 0.0948
Onchocerca volvulus 0.0108 0.0948 0.1944
Plasmodium vivax vivapain-2 0.0054 0.0392 0.2859
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0006 0.0005
Leishmania major cathepsin L-like protease 0.0054 0.0392 0.1195
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0291 0.2847 0.8791
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0046 0.0132
Onchocerca volvulus 0.0054 0.0392 0.08
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.006 0.0067
Schistosoma mansoni hypothetical protein 0.0164 0.1533 0.1717
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0112 0.0987 0.1105
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.167 0.3433
Onchocerca volvulus 0.0033 0.0166 0.0335
Brugia malayi Cathepsin L-like precursor 0.0039 0.0235 0.045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108 0.0948 0.0948
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0204 0.0229
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.2635 0.505
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0006 0.0017
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0095 0.081 0.1553
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0004 0.0004
Toxoplasma gondii hypothetical protein 0.0033 0.0166 0.1193
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0305
Echinococcus multilocularis g protein coupled receptor 0.0108 0.0948 0.0948
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108 0.0948 0.1061
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Echinococcus multilocularis dro:myosuppressin receptor 0.0108 0.0948 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Schistosoma mansoni neuropeptide f receptor 76f 0.0108 0.0948 0.1061
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.2635 0.505
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0108 0.0948 0.0948
Brugia malayi Matrixin family protein 0.0052 0.0368 0.0705
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0004 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0286 0.2799 0.5364
Loa Loa (eye worm) hypothetical protein 0.0108 0.0948 0.1816
Schistosoma mansoni neuropeptide receptor 0.0108 0.0948 0.1061
Echinococcus granulosus neuropeptide s receptor 0.0663 0.6719 0.7525
Leishmania major cathepsin L-like protease 0.0054 0.0392 0.1195
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0667 0.4882
Echinococcus granulosus g protein coupled receptor 0.0108 0.0948 0.1061
Onchocerca volvulus 0.0108 0.0948 0.1944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.2355 0.4513
Brugia malayi Latrophilin receptor protein 2 0.0164 0.1533 0.2938
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0046 0.0529
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108 0.0948 0.1061
Schistosoma mansoni hypothetical protein 0.0164 0.1533 0.1717
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0003 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0164 0.1533 0.1533
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0022 0.006 0.0115
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0017 0.0004 0.0007
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0108 0.0948 0.0948
Leishmania major DNA polymerase kappa, putative 0.0019 0.0027 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0392 0.08
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0387 0.0433
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0948 0.0948
Echinococcus granulosus microtubule associated protein 2 0.0694 0.7042 0.7887
Echinococcus granulosus muscleblind protein 0.0148 0.1366 0.153
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0471 0.0483
Schistosoma mansoni alpha-1 adrenergic receptor 0.0108 0.0948 0.1061
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0161 0.2444
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.1363 0.1409
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0159 0.0179
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0108 0.0948 0.1816
Entamoeba histolytica cysteine protease, putative 0.0032 0.0161 0.2444
Onchocerca volvulus Neuropeptide F receptor homolog 0.0108 0.0948 0.1944
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0125 0.0891
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1363 0.4202
Brugia malayi hypothetical protein 0.0108 0.0948 0.1816
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.167 0.3433
Leishmania major cathepsin L-like protease 0.0054 0.0392 0.1195
Brugia malayi Matrixin family protein 0.0022 0.0051 0.0098
Schistosoma mansoni lamin 0.0033 0.0166 0.0186
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0003 0.0003
Echinococcus granulosus geminin 0.0876 0.8929 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0159 0.0179
Echinococcus granulosus cathepsin L 0.0017 0.0004 0.0004
Brugia malayi G protein-coupled receptor 0.0108 0.0948 0.1816

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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