Detailed information for compound 1216382

Basic information

Technical information
  • TDR Targets ID: 1216382
  • Name: 6-oxo-1-(phenylmethyl)-3,5-dihydro-2H-pyrrolo [2,3-d]pyridine-7-carbonitrile
  • MW: 251.283 | Formula: C15H13N3O
  • H donors: 1 H acceptors: 3 LogP: 2.75 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(O)ncc2c1N(CC2)Cc1ccccc1
  • InChi: 1S/C15H13N3O/c16-8-13-14-12(9-17-15(13)19)6-7-18(14)10-11-4-2-1-3-5-11/h1-5,9H,6-7,10H2,(H,17,19)
  • InChiKey: NWZQCFJWPZRDRH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(benzyl)-6-keto-3,5-dihydro-2H-pyrrolo[2,3-d]pyridine-7-carbonitrile
  • ZINC00190347
  • 1-benzyl-6-oxo-2,3,5,6-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile
  • MLS000549945
  • SMR000113380

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.2105 0.4656
Schistosoma mansoni hypothetical protein 0.0033 0.1229 0.1501
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0198 0.8724 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0015 0.0402 0.0431
Brugia malayi Guanylyl cyclase protein 23 0.0015 0.0402 0.0331
Loa Loa (eye worm) hypothetical protein 0.0026 0.0902 0.0834
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.2391 0.2951
Echinococcus granulosus glutamate receptor 2 0.0015 0.0402 0.0431
Mycobacterium ulcerans DNA polymerase IV 0.004 0.1517 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.3865 0.4792
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5508 0.6844
Loa Loa (eye worm) hypothetical protein 0.0015 0.0402 0.0331
Echinococcus multilocularis tyrosine kinase 0.0015 0.0402 0.0431
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0015 0.0402 0.0431
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.0402 0.0431
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.4207 1
Echinococcus granulosus tyrosine kinase 0.0015 0.0402 0.0431
Brugia malayi Latrophilin receptor protein 2 0.0033 0.1229 0.1164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.1229 0.1164
Entamoeba histolytica hypothetical protein 0.0037 0.1407 0.9019
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0976 0.0909
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.4503 0.4462
Schistosoma mansoni metabotropic glutamate receptor 0.0079 0.3281 0.4063
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.1517 0.5
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.1517 0.1453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.3865 0.4792
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.1229 0.1382
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0074 0.0053
Trypanosoma brucei unspecified product 0.004 0.1517 0.316
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1517 0.316
Schistosoma mansoni smad1 5 8 and 0.0008 0.0074 0.0058
Loa Loa (eye worm) hypothetical protein 0.0012 0.0273 0.0201
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5508 0.6844
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0183 0.8036 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0099 0.4207 1
Echinococcus multilocularis mitogen activated protein kinase 0.0099 0.4207 0.4806
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.4207 0.5219
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0026 0.0902 0.8709
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0402 0.0431
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.5508 0.5475
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.1407 0.1586
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.4207 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0402 0.0331
Leishmania major extracellular receptor, putative 0.0015 0.0402 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0957 0.1738
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0402 0.0331
Schistosoma mansoni protein kinase 0.0015 0.0402 0.0468
Echinococcus multilocularis dna polymerase kappa 0.004 0.1517 0.1712
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1517 0.316
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0099 0.4207 0.4164
Echinococcus granulosus Smad4 0.0008 0.0074 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0402 0.0331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.3865 0.4792
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.1517 0.316
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0074 0.0053
Brugia malayi Receptor family ligand binding region containing protein 0.0041 0.159 0.1528
Loa Loa (eye worm) glutamate receptor 0.0161 0.7033 0.7011
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0402 0.0331
Echinococcus granulosus GPCR family 2 0.0033 0.1229 0.1382
Loa Loa (eye worm) hypothetical protein 0.0015 0.0402 0.0331
Echinococcus multilocularis tar DNA binding protein 0.0128 0.5508 0.6302
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0957 0.1738
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.4503 0.4462
Schistosoma mansoni metabotropic glutamate receptor 0.0135 0.5845 0.7264
Schistosoma mansoni hypothetical protein 0.0026 0.0902 0.1092
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.1517 0.316
Echinococcus granulosus dna polymerase kappa 0.004 0.1517 0.1712
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0015 0.0402 0.0331
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0402 0.0431
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.4995 0.4958
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5508 0.6844
Echinococcus granulosus GPCR family 3 C terminal 0.0026 0.0902 0.1005
Echinococcus multilocularis mitogen activated protein kinase 3 0.0099 0.4207 0.4806
Loa Loa (eye worm) TAR-binding protein 0.0128 0.5508 0.5475
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.1407 0.1723
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.1517 0.3605
Echinococcus granulosus atrial natriuretic peptide receptor 0.0015 0.0402 0.0431
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.1517 0.1712
Echinococcus multilocularis GPCR, family 2 0.0033 0.1229 0.1382
Entamoeba histolytica hypothetical protein 0.0037 0.1407 0.9019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.1229 0.1382
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0099 0.4207 1
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.1517 0.316
Echinococcus granulosus receptor type guanylyl cyclase 0.0015 0.0402 0.0431
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0074 0.0053
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.5508 0.5475
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0015 0.0402 0.0431
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0026 0.0902 0.0834
Loa Loa (eye worm) hypothetical protein 0.0105 0.4503 0.4462
Schistosoma mansoni hypothetical protein 0.0033 0.1229 0.1501
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0402 0.0331
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0099 0.4207 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.1407 0.1586
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.1517 0.1453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.3865 0.4413
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0041 0.159 0.1528
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0105 0.0088
Loa Loa (eye worm) hypothetical protein 0.0072 0.2988 0.2936
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.1229 0.1164
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.1229 0.1382
Loa Loa (eye worm) hypothetical protein 0.0033 0.1229 0.1164
Mycobacterium ulcerans DNA polymerase IV 0.004 0.1517 1
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0402 0.0431
Schistosoma mansoni cpg binding protein 0.0028 0.0976 0.1184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0402 0.0331
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1517 0.316
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0099 0.4207 1
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0402 0.0331
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1517 0.316
Brugia malayi MH2 domain containing protein 0.0116 0.4995 0.4958
Loa Loa (eye worm) hypothetical protein 0.0015 0.0402 0.0331
Echinococcus multilocularis dna polymerase eta 0.004 0.1517 0.1712
Brugia malayi hypothetical protein 0.0015 0.0402 0.0331
Echinococcus multilocularis smad 0.0008 0.0074 0.0053
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0041 0.159 0.1528
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.1517 0.1712
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Echinococcus granulosus metabotropic glutamate receptor 2 0.0135 0.5845 0.6689
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.0402 0.0431
Loa Loa (eye worm) hypothetical protein 0.0041 0.159 0.1528
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.01 0.0026
Trypanosoma brucei protein kinase, putative 0.0099 0.4207 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.3865 0.3819
Onchocerca volvulus Poor gastrulation protein homolog 0.0026 0.0902 0.8709
Loa Loa (eye worm) hypothetical protein 0.0015 0.0402 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5508 0.6844
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.1229 0.1382
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.1517 0.1453
Echinococcus granulosus tar DNA binding protein 0.0128 0.5508 0.6302
Echinococcus granulosus dna polymerase eta 0.004 0.1517 0.1712
Entamoeba histolytica hypothetical protein 0.0037 0.1407 0.9019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0105 0.0088
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0074 0.0053
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.1517 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0099 0.4207 1
Trypanosoma brucei unspecified product 0.0027 0.0957 0.1738
Brugia malayi MAP kinase sur-1 0.0099 0.4207 0.4164
Echinococcus granulosus smad 0.0008 0.0074 0.0053
Brugia malayi TAR-binding protein 0.0128 0.5508 0.5475
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.4995 0.4958
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0402 0.0431
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.1517 0.316
Giardia lamblia DINP protein human, muc B family 0.004 0.1517 0.316
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0402 0.0468
Brugia malayi RNA binding protein 0.0128 0.5508 0.5475
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0105 0.0031
Schistosoma mansoni hypothetical protein 0.0033 0.1229 0.1501
Schistosoma mansoni tar DNA-binding protein 0.0128 0.5508 0.6844
Leishmania major DNA polymerase kappa, putative 0.004 0.1517 0.316
Schistosoma mansoni tyrosine kinase 0.0015 0.0402 0.0468
Echinococcus granulosus glutamate receptor 2 0.0015 0.0402 0.0431
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0273 0.5
Echinococcus granulosus cpg binding protein 0.0029 0.1048 0.1173
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0099 0.4207 1
Onchocerca volvulus 0.0028 0.0976 1
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.2988 0.2936
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0402 0.0431
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0273 0.0307
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.1517 1
Echinococcus granulosus mitogen activated protein kinase 0.0099 0.4207 0.4806
Brugia malayi CXXC zinc finger family protein 0.0028 0.0976 0.0909
Brugia malayi polk-prov protein 0.0012 0.0273 0.0201
Schistosoma mansoni smad1 5 8 and 0.0008 0.0074 0.0058
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.3865 0.3819
Echinococcus granulosus metabotropic glutamate receptor 5 0.0198 0.8724 1
Loa Loa (eye worm) RNA binding protein 0.0128 0.5508 0.5475
Brugia malayi Metabotropic glutamate receptor precursor. 0.0161 0.7033 0.7011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.3865 0.4413
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.3865 0.4413
Trypanosoma cruzi extracellular receptor, putative 0.0015 0.0402 0.0327
Loa Loa (eye worm) hypothetical protein 0.0015 0.0402 0.0331
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.3865 0.4413
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.1517 0.316
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.1517 0.1859
Trypanosoma brucei unspecified product 0.0027 0.0957 0.1738
Giardia lamblia Kinase, CMGC MAPK 0.0099 0.4207 1
Schistosoma mansoni Smad4 0.0008 0.0074 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Brugia malayi hypothetical protein 0.0037 0.1407 0.1343
Schistosoma mansoni cpg binding protein 0.0029 0.1048 0.1274
Echinococcus granulosus mitogen activated protein kinase 3 0.0099 0.4207 0.4806
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.1517 0.316
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0402 0.0431
Brugia malayi metabotropic glutamate receptor type 2 0.0079 0.3281 0.3231
Schistosoma mansoni tyrosine kinase 0.0015 0.0402 0.0468
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.1517 0.1859
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Schistosoma mansoni smad 0.0008 0.0074 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Schistosoma mansoni hypothetical protein 0.0033 0.1229 0.1501
Schistosoma mansoni cpg binding protein 0.0029 0.1048 0.1274
Schistosoma mansoni smad1 5 8 and 0.0008 0.0074 0.0058
Schistosoma mansoni DNA polymerase eta 0.004 0.1517 0.1859
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0402 0.0431
Entamoeba histolytica hypothetical protein 0.0037 0.1407 0.9019
Echinococcus multilocularis cpg binding protein 0.0029 0.1048 0.1173
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0402 0.0431
Echinococcus multilocularis receptor type guanylyl cyclase 0.0015 0.0402 0.0431
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.4207 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0273 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0957 0.1738
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.1407 0.1723
Echinococcus multilocularis GPCR, family 3, C terminal 0.0026 0.0902 0.1005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.4503 0.4462
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0146 0.6345 0.6317
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Echinococcus multilocularis Smad4 0.0008 0.0074 0.0053
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0135 0.5845 0.6689
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0099 0.4207 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.8724 0.8715
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.4207 1
Schistosoma mansoni hypothetical protein 0.0072 0.2988 0.3697
Leishmania major DNA polymerase eta, putative 0.004 0.1517 0.316
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0074 0.0058
Loa Loa (eye worm) glutamate receptor 0.0063 0.2593 0.2538
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0099 0.4207 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1517 0.316
Loa Loa (eye worm) hypothetical protein 0.004 0.1517 0.1453
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.1517 0.3605

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) 199.5262 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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