Detailed information for compound 1216563

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 450.391 | Formula: C21H29BrFN5
  • H donors: 1 H acceptors: 2 LogP: 5.33 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1cc(C)nc(n1)Nc1ccc(cc1F)Br)CCCN1CCCCC1
  • InChi: 1S/C21H29BrFN5/c1-3-28(13-7-12-27-10-5-4-6-11-27)20-14-16(2)24-21(26-20)25-19-9-8-17(22)15-18(19)23/h8-9,14-15H,3-7,10-13H2,1-2H3,(H,24,25,26)
  • InChiKey: FIYVAKWPWARCGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase eta 0.015 0.6472 0.818
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.2416 0.3048
Schistosoma mansoni inositol monophosphatase 0.0036 0.1132 0.1431
Leishmania major DNA polymerase eta, putative 0.0099 0.4098 0.6329
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Trichomonas vaginalis chromobox protein, putative 0.0041 0.137 0.3075
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0504 0.0769
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Trypanosoma cruzi DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Echinococcus multilocularis expressed protein 0.0019 0.0313 0.0387
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0504 0.0769
Loa Loa (eye worm) hypothetical protein 0.0053 0.1909 0.2414
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.444 1
Leishmania major DNA polymerase kappa, putative 0.008 0.3204 0.4946
Echinococcus granulosus chromobox protein 1 0.0068 0.2643 0.3336
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0073 0.2877 0.3638
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0313 0.0387
Brugia malayi beta-lactamase 0.0035 0.1089 0.1674
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1089 0.2441
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0788 0.1761
Echinococcus granulosus DNA ligase 1 0.0023 0.0536 0.0669
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0299 0.066
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0788 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.3204 0.4946
Giardia lamblia DNA damage repair protein 0.0023 0.0504 0.1554
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0299 0.2702
Echinococcus multilocularis GPCR, family 2 0.0017 0.0218 0.0268
Trypanosoma brucei unspecified product 0.0094 0.3869 0.5974
Trichomonas vaginalis DNA ligase IV, putative 0.0023 0.0536 0.1193
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.444 0.5614
Entamoeba histolytica hypothetical protein 0.0019 0.0313 0.0689
Loa Loa (eye worm) hypothetical protein 0.0019 0.0313 0.0395
Entamoeba histolytica hypothetical protein 0.0019 0.0313 0.0689
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0313 0.0395
Schistosoma mansoni hypothetical protein 0.0017 0.0218 0.0276
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.444 0.561
Loa Loa (eye worm) DNA ligase 0.0023 0.0536 0.0678
Mycobacterium ulcerans DNA polymerase IV 0.0101 0.4197 0.9411
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.1089 0.1079
Toxoplasma gondii small ubiquitin family modifier, putative 0.003 0.0848 0.2056
Entamoeba histolytica hypothetical protein 0.0036 0.1106 0.2478
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0299 0.0379
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.1089 0.1079
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.3941 0.4979
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.3941 0.4979
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0299 0.066
Loa Loa (eye worm) hypothetical protein 0.0038 0.1234 0.156
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.444 1
Brugia malayi hypothetical protein 0.0019 0.0313 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0313 0.0689
Schistosoma mansoni serine/threonine protein kinase 0.018 0.7909 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0101 0.4197 0.945
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.1234 0.7399
Echinococcus multilocularis beta adrenergic receptor kinase 0.018 0.7909 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0313 0.0689
Echinococcus granulosus G protein coupled receptor kinase 1 0.0162 0.7033 0.889
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.444 0.5614
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.2416 0.3048
Brugia malayi PXA domain containing protein 0.0019 0.0313 0.0473
Loa Loa (eye worm) hypothetical protein 0.015 0.6472 0.8182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.5912 0.7475
Schistosoma mansoni transient receptor potential channel 0.0063 0.2416 0.3054
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0313 0.0395
Trichomonas vaginalis chromobox protein, putative 0.0041 0.137 0.3075
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0504 0.0769
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0299 0.0288
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1909 0.2943
Echinococcus granulosus expressed protein 0.0019 0.0313 0.0387
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1909 0.2943
Schistosoma mansoni serine/threonine protein kinase 0.018 0.7909 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.1089 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1132 0.174
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0007 0.0009
Echinococcus multilocularis Small ubiquitin modifier 2 0.003 0.0848 0.1064
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.1132 0.2011
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0299 0.0452
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.5912 0.7473
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.5912 0.9135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.5912 0.7473
Entamoeba histolytica hypothetical protein 0.0036 0.1106 0.2478
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.3941 0.4983
Trypanosoma cruzi DNA polymerase eta, putative 0.015 0.6472 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.1106 0.139
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0313 0.0387
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1089 0.1674
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1127 0.1732
Entamoeba histolytica hypothetical protein 0.0019 0.0313 0.0689
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0313 0.0395
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1089 0.1377
Trypanosoma cruzi DNA ligase I, putative 0.0023 0.0536 0.0818
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1132 0.174
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.1132 0.2538
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0788 0.7214
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0313 0.0387
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.1089 0.1377
Trichomonas vaginalis chromobox protein, putative 0.0068 0.2643 0.5947
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.444 1
Schistosoma mansoni DNA ligase I 0.0023 0.0536 0.0678
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0313 0.0395
Schistosoma mansoni ap endonuclease 0.0018 0.0299 0.0379
Mycobacterium tuberculosis Conserved protein 0.0035 0.1089 0.1079
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.1132 0.2538
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.1089 0.1907
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0218 0.0268
Brugia malayi chromobox protein homolog 3 0.0038 0.1234 0.1898
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0313 0.0387
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0504 0.0769
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0313 0.0387
Brugia malayi Inositol-1 0.0036 0.1132 0.174
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1089 0.1674
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0848 0.1897
Brugia malayi Transient-receptor-potential like protein 0.0036 0.1111 0.1708
Trypanosoma brucei DNA polymerase eta, putative 0.015 0.6472 1
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0788 0.1908
Leishmania major hypothetical protein, conserved 0.0035 0.1089 0.1674
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.5912 0.7473
Loa Loa (eye worm) hypothetical protein 0.0035 0.1089 0.1377
Echinococcus granulosus Small ubiquitin modifier 2 0.003 0.0848 0.1064
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.2877 0.2869
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.1111 0.1398
Brugia malayi polk-prov protein 0.0051 0.1823 0.281
Echinococcus granulosus beta-adrenergic receptor kinase 0.018 0.7909 1
Leishmania major DNA ligase I, putative 0.0023 0.0536 0.0818
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0313 0.0387
Brugia malayi hypothetical protein 0.0019 0.0313 0.0473
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.2643 0.3342
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0504 0.0769
Schistosoma mansoni hypothetical protein 0.0017 0.0218 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0709 0.1583
Entamoeba histolytica hypothetical protein 0.0036 0.1106 0.2478
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.1089 0.1079
Trypanosoma brucei unspecified product 0.005 0.1809 0.2788
Trypanosoma brucei DNA polymerase IV, putative 0.0101 0.4197 0.6481
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0334 0.0505
Schistosoma mansoni DNA polymerase eta 0.015 0.6472 0.8182
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.1089 0.1907
Loa Loa (eye worm) SMO-1 protein 0.003 0.0848 0.1072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1909 0.2414
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.008 0.3204 0.4946
Brugia malayi PXA domain containing protein 0.0019 0.0313 0.0473
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.1111 0.1405
Loa Loa (eye worm) hypothetical protein 0.0019 0.0313 0.0395
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0313 0.0473
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0073 0.2877 0.3632
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1089 0.2441
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0313 0.0689
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0788 0.1761
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.1089 0.137
Loa Loa (eye worm) hypothetical protein 0.006 0.2266 0.2865
Mycobacterium ulcerans hypothetical protein 0.0035 0.1089 0.1907
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0334 0.0422
Entamoeba histolytica hypothetical protein 0.0036 0.1106 0.2478
Mycobacterium ulcerans DNA polymerase IV 0.0101 0.4197 0.9411
Mycobacterium tuberculosis Conserved protein 0.0035 0.1089 0.1079
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0504 0.0769
Loa Loa (eye worm) hypothetical protein 0.0035 0.1089 0.1377
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0313 0.0473
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.444 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.1089 0.1907
Brugia malayi Heterochromatin protein 1 0.0068 0.2643 0.4078
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0218 0.0327
Echinococcus multilocularis chromobox protein 1 0.0068 0.2643 0.3336
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0831 0.2014
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0035 0.1089 0.1377
Leishmania major DNA polymerase eta, putative 0.015 0.6472 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0313 0.0473
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0334 0.0422
Mycobacterium ulcerans lipase LipD 0.0035 0.1089 0.1907
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1089 0.2441
Loa Loa (eye worm) hypothetical protein 0.0032 0.0961 0.1215
Schistosoma mansoni chromobox protein 0.0068 0.2643 0.3342
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0313 0.0395
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0504 0.459
Echinococcus granulosus dna polymerase kappa 0.0101 0.4197 0.5302
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.444 0.5614
Brugia malayi 6-phosphofructokinase 0.0106 0.444 0.6858
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0788 0.1761
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.444 0.561
Echinococcus granulosus GPCR family 2 0.0017 0.0218 0.0268
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0313 0.0395
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0218 0.0268
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.444 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.1089 0.137
Loa Loa (eye worm) inositol-1 0.0036 0.1132 0.1431
Schistosoma mansoni DNA ligase I 0.0023 0.0536 0.0678
Echinococcus multilocularis chromobox protein 1 0.0068 0.2643 0.3336
Echinococcus granulosus dna polymerase eta 0.015 0.6472 0.818
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.1132 0.2538
Loa Loa (eye worm) beta-lactamase 0.0035 0.1089 0.1377
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0276
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.444 0.5614
Giardia lamblia DINP protein human, muc B family 0.008 0.3204 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0788 0.1761
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1089 0.2441
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.1089 0.1674
Mycobacterium tuberculosis Conserved protein 0.0035 0.1089 0.1079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Schistosoma mansoni hypothetical protein 0.0017 0.0218 0.0276
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0788 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.1234 0.2767
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.1089 0.1079
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0788 0.1761
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0218 0.0327
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.444 1
Plasmodium falciparum small ubiquitin-related modifier 0.003 0.0848 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0313 0.0689
Schistosoma mansoni hypothetical protein 0.0017 0.0218 0.0276
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0788 0.9282
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.1106 0.1398
Toxoplasma gondii DNA ligase 1, putative 0.0023 0.0536 0.1293
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0313 0.0689
Mycobacterium leprae Probable lipase LipE 0.0035 0.1089 0.0387
Loa Loa (eye worm) hypothetical protein 0.0036 0.1127 0.1425
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.2136 0.3294
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.444 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0299 0.0452
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0313 0.0387
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.444 0.6858
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0313 0.0387
Schistosoma mansoni transient receptor potential channel 0.0096 0.3941 0.4983
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0313 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0709 0.1583
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.1132 1
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.003 0.0848 0.1072
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0788 0.1761
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0504 0.0769
Trypanosoma brucei DNA polymerase IV, putative 0.0101 0.4197 0.6481
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0313 0.0395
Plasmodium vivax DNA ligase I, putative 0.0023 0.0536 0.4887
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0313 0.0395
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.018 0.7909 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.2136 0.3294
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.2136 0.3294
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0313 0.0473
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.444 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.1234 0.2767
Brugia malayi ImpB/MucB/SamB family protein 0.015 0.6472 1
Giardia lamblia DNA ligase 0.0023 0.0536 0.1654
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0299 0.066
Loa Loa (eye worm) hypothetical protein 0.0051 0.1823 0.2305
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0788 0.9282
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0218 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1823 0.281
Schistosoma mansoni hypothetical protein 0.0036 0.1106 0.1398
Plasmodium falciparum DNA ligase I 0.0023 0.0536 0.6288
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.1089 0.1079
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.1132 0.1424
Leishmania major DNA polymerase kappa, putative 0.0023 0.0504 0.0769
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0788 0.1761
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.2877 0.444
Schistosoma mansoni transient receptor potential channel 0.0063 0.2416 0.3054
Brugia malayi DNA ligase 0.0023 0.0536 0.0818
Brugia malayi Ubiquitin-like protein SMT3 0.003 0.0848 0.1301
Entamoeba histolytica ubiquitin like protein 0.003 0.0848 0.1897
Schistosoma mansoni hypothetical protein 0.0036 0.1127 0.1425
Trypanosoma brucei unspecified product 0.005 0.1809 0.2788
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Echinococcus multilocularis dna polymerase kappa 0.0101 0.4197 0.5302
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.3791 0.4789
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.1106 0.139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.5912 0.7475
Brugia malayi beta-lactamase family protein 0.0035 0.1089 0.1674
Loa Loa (eye worm) phosphofructokinase 0.0106 0.444 0.5614
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0299 0.0452
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0313 0.0387
Loa Loa (eye worm) hypothetical protein 0.0035 0.1089 0.1377
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.1132 0.1424
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0313 0.0395
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0218 0.0276
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0504 0.0769
Loa Loa (eye worm) hypothetical protein 0.0019 0.0313 0.0395
Trypanosoma brucei DNA polymerase IV, putative 0.0094 0.3869 0.5974
Loa Loa (eye worm) hypothetical protein 0.0019 0.0313 0.0395
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0073 0.2877 0.3638
Schistosoma mansoni inositol monophosphatase 0.0036 0.1132 0.1431
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.444 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0313 0.0387
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.1111 0.1398
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0313 0.0387
Toxoplasma gondii ABC1 family protein 0.0035 0.1089 0.2645
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.444 0.6858
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0313 0.0387
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0788 0.1908
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0313 0.0395
Mycobacterium ulcerans hypothetical protein 0.0023 0.0504 0.0494
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0299 0.3477
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1089 0.2441
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.1132 0.2538
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0788 0.1761
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0073 0.2877 0.3632
Brugia malayi phosphofructokinase 0.0106 0.444 0.6858
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.444 0.6858
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0954 0.0944
Brugia malayi hypothetical protein 0.0036 0.1106 0.17
Trypanosoma cruzi DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Loa Loa (eye worm) hypothetical protein 0.0035 0.1089 0.1377
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0788 0.7214
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0313 0.0387
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0504 0.5906
Trichomonas vaginalis chromobox protein, putative 0.0068 0.2643 0.5947
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0504 0.0769
Loa Loa (eye worm) hypothetical protein 0.003 0.0845 0.1069
Echinococcus granulosus chromobox protein 1 0.0068 0.2643 0.3336
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.3791 0.4789
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0313 0.0473
Leishmania major DNA damage repair protein, putative 0.0023 0.0504 0.0769
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.5912 0.7475
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.1089 0.1674
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0313 0.0387
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0788 0.2442
Giardia lamblia Sentrin 0.003 0.0848 0.2631
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0313 0.0395
Schistosoma mansoni chromobox protein 0.0068 0.2643 0.3342
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.1089 0.1079
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0313 0.0689
Entamoeba histolytica DNA ligase, putative 0.0023 0.0536 0.1193
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0313 0.0387
Trypanosoma cruzi DNA polymerase eta, putative 0.0099 0.4098 0.6329
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.008 0.3204 0.3197
Trichomonas vaginalis esterase, putative 0.0035 0.1089 0.2441
Echinococcus multilocularis DNA ligase 1 0.0023 0.0536 0.0669
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1089 0.1377
Mycobacterium leprae conserved hypothetical protein 0.0035 0.1089 0.0387
Onchocerca volvulus 0.0035 0.1089 0.4646
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0788 0.1179
Trypanosoma cruzi DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0162 0.7033 0.889
Trypanosoma brucei DNA ligase I, putative 0.0023 0.0536 0.0818
Loa Loa (eye worm) hypothetical protein 0.0096 0.3941 0.4983
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.5912 0.7475
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.444 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0299 0.0452
Loa Loa (eye worm) hypothetical protein 0.0019 0.0313 0.0395
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0299 0.037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0218 0.0268
Brugia malayi beta-lactamase family protein 0.0035 0.1089 0.1674
Plasmodium vivax small ubiquitin-related modifier, putative 0.003 0.0848 0.7772
Schistosoma mansoni terminal deoxycytidyl transferase 0.0073 0.2877 0.3638
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0101 0.4197 0.945
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0299 0.0452
Onchocerca volvulus 0.0035 0.1089 0.4646
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.1089 0.1079
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0299 0.037
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0099 0.4098 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0313 0.0395
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0299 0.0915
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1132 0.174
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.1132 0.275
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0313 0.0395
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0848 0.1301
Entamoeba histolytica deoxycytidyl transferase, putative 0.0073 0.2877 0.6474
Onchocerca volvulus 0.0035 0.1089 0.4646
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.137 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0504 0.0637
Loa Loa (eye worm) hypothetical protein 0.0035 0.1089 0.1377
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.444 0.4434
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0313 0.0387
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0313 0.0395
Schistosoma mansoni ap endonuclease 0.0018 0.0299 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0313 0.0689
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1823 0.281
Mycobacterium ulcerans ATP-dependent DNA ligase 0.0023 0.0536 0.0571
Leishmania major small ubiquitin protein, putative 0.003 0.0848 0.1301
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.2416 0.3048
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1132 0.174
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0848 0.1301
Trypanosoma cruzi DNA ligase I, putative 0.0023 0.0536 0.0818
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.4197 0.6481
Trypanosoma brucei small ubiquitin-related modifier 0.003 0.0848 0.1301
Brugia malayi 6-phosphofructokinase 0.0106 0.444 0.6858
Loa Loa (eye worm) hypothetical protein 0.0019 0.0313 0.0395
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.2416 0.3048
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0504 0.1214
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0788 0.1908
Toxoplasma gondii exonuclease III APE 0.0018 0.0299 0.0715
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.5912 0.7473

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.