Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0376 | 0.0376 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0257 | 0.0257 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3368 | 0.3193 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.3368 | 0.3193 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0038 | 0.0717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0717 | 0.0717 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0376 | 0.0121 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0038 | 0.0717 | 0.0472 |
Echinococcus granulosus | solute carrier family 5 | 0.0038 | 0.0717 | 0.0472 |
Brugia malayi | RNA binding protein | 0.0125 | 0.3368 | 0.3368 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0038 | 0.0717 | 0.0472 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.3368 | 0.3368 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3368 | 0.3193 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0361 | 0.0361 |
Schistosoma mansoni | high-affinity choline transporter | 0.0343 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0376 | 0.0376 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0376 | 0.0121 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.3368 | 0.3368 |
Echinococcus granulosus | lamin | 0.0027 | 0.0376 | 0.0121 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0492 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0038 | 0.0717 | 0.0472 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.3368 | 0.3193 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3368 | 0.3193 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0376 | 0.0376 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0492 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0257 | 0.5 |
Brugia malayi | hypothetical protein | 0.002 | 0.0164 | 0.0164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3368 | 0.3193 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0343 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0257 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.3368 | 0.3368 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0038 | 0.0717 | 0.0472 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0492 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.3368 | 0.3368 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0492 | 1 |
Schistosoma mansoni | inositol transporter | 0.0038 | 0.0717 | 0.0472 |
Echinococcus multilocularis | solute carrier family 5 | 0.0038 | 0.0717 | 0.0472 |
Onchocerca volvulus | 0.0038 | 0.0717 | 1 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0257 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0257 | 0.0257 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0376 | 0.0121 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0376 | 0.0121 |
Schistosoma mansoni | inositol transporter | 0.0038 | 0.0717 | 0.0472 |
Schistosoma mansoni | sodium/solute symporter | 0.0038 | 0.0717 | 0.0472 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3368 | 0.3193 |
Schistosoma mansoni | lamin | 0.0027 | 0.0376 | 0.0121 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0257 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0257 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0257 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0376 | 0.0121 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0492 | 0.5106 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0257 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0038 | 0.0717 | 0.0472 |
Brugia malayi | hypothetical protein | 0.003 | 0.0492 | 0.0492 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.3368 | 0.3368 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0376 | 0.0376 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0492 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0492 | 0.0492 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0343 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0492 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0376 | 0.0121 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0376 | 0.0121 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0038 | 0.0717 | 0.0472 |
Brugia malayi | Sodium:solute symporter family protein | 0.0038 | 0.0717 | 0.0717 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0492 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0038 | 0.0717 | 0.0472 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0257 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2818 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.