Detailed information for compound 1218336

Basic information

Technical information
  • TDR Targets ID: 1218336
  • Name: 2-(cyclohexyl-methylsulfonylamino)-N-(2-methy lpropyl)acetamide
  • MW: 290.422 | Formula: C13H26N2O3S
  • H donors: 1 H acceptors: 3 LogP: 2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CNC(=O)CN(S(=O)(=O)C)C1CCCCC1)C
  • InChi: 1S/C13H26N2O3S/c1-11(2)9-14-13(16)10-15(19(3,17)18)12-7-5-4-6-8-12/h11-12H,4-10H2,1-3H3,(H,14,16)
  • InChiKey: XXBXHIZBGAKJAP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(cyclohexyl-methylsulfonyl-amino)-N-isobutyl-acetamide
  • 2-(cyclohexyl-methylsulfonylamino)-N-isobutylacetamide
  • 2-(cyclohexyl-mesyl-amino)-N-isobutyl-acetamide
  • 2-(cyclohexyl-methylsulfonyl-amino)-N-(2-methylpropyl)ethanamide
  • ZINC02179536
  • AO-081/42297805
  • MLS000051969
  • N~2~-cyclohexyl-N~1~-isobutyl-N~2~-(methylsulfonyl)glycinamide
  • SMR000081180

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.006 0.0306 0.0626
Schistosoma mansoni tar DNA-binding protein 0.0503 0.3514 0.7357
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0048 0.0215 0.0428
Schistosoma mansoni hypothetical protein 0.0041 0.0162 0.0298
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0133 0.0579
Brugia malayi beta-lactamase family protein 0.0113 0.0687 0.1464
Brugia malayi mbt repeat family protein 0.0058 0.0285 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0426 0.078
Leishmania major hypothetical protein, conserved 0.0113 0.0687 0.7832
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0186 0.0165
Schistosoma mansoni hypothetical protein 0.0355 0.2437 0.5089
Schistosoma mansoni coup transcription factor 0.0021 0.0022 0.0003
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0031 0.0021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0138 0.0871 0.1672
Brugia malayi hypothetical protein 0.0028 0.0068 0.0104
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.019 0.0355
Brugia malayi hypothetical protein 0.0023 0.0031 0.0022
Toxoplasma gondii thioredoxin reductase 0.0138 0.0871 0.4394
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0265 0.179 0.1773
Brugia malayi Hhat protein 0.0048 0.0219 0.0435
Treponema pallidum alginate O-acetylation protein (algI) 0.0048 0.0219 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0786 0.161
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0031 0.0051
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0031 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0231 0.021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0048 0.0215 0.2288
Schistosoma mansoni hypothetical protein 0.0042 0.0173 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0503 0.3514 0.7357
Toxoplasma gondii exonuclease III APE 0.0023 0.0032 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0022 0.0003
Plasmodium falciparum thioredoxin reductase 0.0138 0.0871 0.4394
Echinococcus multilocularis chromobox protein 1 0.0138 0.0864 0.0845
Loa Loa (eye worm) hypothetical protein 0.0048 0.0219 0.0435
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0381 0.0361
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0031 0.0019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.037 0.4932
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0022 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0231 0.021
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0727 0.1486
Schistosoma mansoni lamin 0.0055 0.0267 0.0518
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0018 0.021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0687 0.1402
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0022 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0223 0.2375
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0223 0.0444
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.037 0.4932
Brugia malayi ecdysteroid receptor 0.0021 0.0022 0.0003
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0031 0.001
Trypanosoma brucei glycerol uptake protein, putative 0.0048 0.0219 0.2512
Echinococcus multilocularis tumor protein p63 0.1399 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0617 0.1256
Echinococcus granulosus chromobox protein 1 0.0138 0.0864 0.0845
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0223 0.0444
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.037 0.0685
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.3665 0.7011
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0022 0.0255
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0186 0.0347
Loa Loa (eye worm) hypothetical protein 0.024 0.1604 0.3482
Trypanosoma brucei unspecified product 0.0021 0.0022 0.0255
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0687 0.1309
Echinococcus multilocularis zinc finger protein 0.0039 0.0147 0.0127
Onchocerca volvulus 0.0113 0.0687 0.1306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0121 0.0192
Brugia malayi RNA recognition motif domain containing protein 0.0503 0.3514 0.7682
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0316 0.2155 0.8833
Brugia malayi steroid hormone receptor 0.0021 0.0022 0.0003
Mycobacterium tuberculosis Conserved protein 0.0113 0.0687 0.1309
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0022 0.0001
Schistosoma mansoni hypothetical protein 0.0265 0.179 0.3726
Echinococcus granulosus microtubule associated protein 2 0.0677 0.4769 0.4758
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0687 0.1281
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0022 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.3665 0.7011
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0022 0.0002
Trypanosoma cruzi GUP1, putative 0.0048 0.0219 0.2327
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0031 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0022 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.1014 0.2185
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0022 0.0014
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0022 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0031 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0186 0.0317
Loa Loa (eye worm) hypothetical protein 0.0113 0.0687 0.1464
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0031 0.0051
Echinococcus granulosus o acyltransferase membrane bound domain 0.0048 0.0219 0.0198
Brugia malayi RNA, U transporter 1 0.0082 0.0459 0.0964
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0068 0.0244
Loa Loa (eye worm) hypothetical protein 0.0205 0.1351 0.2925
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0288 0.1955 1
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0285 0.0265
Echinococcus granulosus geminin 0.0205 0.135 0.1332
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0022 0.0031
Plasmodium falciparum glutathione reductase 0.0138 0.0871 0.4394
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0048 0.0215 0.1005
Plasmodium vivax importin-beta 2, putative 0.0029 0.0076 0.0284
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0267 0.0541
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0687 0.1281
Onchocerca volvulus 0.0739 0.5218 1
Mycobacterium tuberculosis Conserved protein 0.0113 0.0687 0.1309
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0246
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0223 0.2847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0139 0.0228
Brugia malayi beta-lactamase family protein 0.0113 0.0687 0.1464
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0246
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0022 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.1243 0.2687
Schistosoma mansoni sterol O-acyltransferase 1 0.0048 0.0219 0.0416
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0031 0.0019
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0288 0.1955 0.4253
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.2359 0.4499
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0048 0.0219 0.0198
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0285 0.0556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1243 0.2573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0022 0.0003
Onchocerca volvulus 0.0205 0.1351 0.2581
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0022 0.0001
Brugia malayi mbt repeat family protein 0.0058 0.0285 0.0581
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0223 0.3449
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1243 0.1224
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0031 0.0022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0407 0.0387
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0517 0.0497
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0003
Leishmania major glycerol uptake protein, putative 0.0048 0.0219 0.2327
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0048 0.0215 0.2288
Loa Loa (eye worm) hypothetical protein 0.0049 0.0223 0.0444
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0048 0.0219 0.0416
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0031 0.017
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0864 0.1622
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0032 0.0134
Mycobacterium ulcerans hypothetical protein 0.0049 0.0223 0.2847
Plasmodium falciparum glutathione reductase 0.0048 0.0215 0.1005
Onchocerca volvulus 0.006 0.0306 0.0575
Echinococcus multilocularis Chromo domain 0.0023 0.0031 0.001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0048 0.0215 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0161
Brugia malayi MH2 domain containing protein 0.0235 0.1567 0.3399
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0032 0.0022
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0048 0.0219 0.0416
Leishmania major hypothetical protein, conserved 0.0028 0.0068 0.0555
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0121 0.1179
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0288 0.1955 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0223 0.0444
Schistosoma mansoni intermediate filament proteins 0.0055 0.0267 0.0518
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0048 0.0215 0.1005
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0022 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0426 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0121 0.0192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1243 0.1224
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0231 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0119 0.019
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0032 0.0145
Loa Loa (eye worm) hypothetical protein 0.0108 0.0652 0.1387
Schistosoma mansoni cellular tumor antigen P53 0.0205 0.1351 0.2801
Mycobacterium tuberculosis Conserved protein 0.0113 0.0687 0.1309
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.4769 0.4758
Brugia malayi MBOAT family protein 0.0048 0.0219 0.0435
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0031 0.0019
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0031 0.017
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0022 0.0003
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0285 0.0265
Echinococcus multilocularis musashi 0.0055 0.0267 0.0247
Loa Loa (eye worm) hypothetical protein 0.0113 0.0687 0.1464
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0116 0.0705 0.1441
Mycobacterium tuberculosis Probable reductase 0.0316 0.2155 0.4203
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0031 0.0019
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0606 0.0586
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0727 0.0707
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0031 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0031 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.3665 0.7011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.1014 0.2185
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0185 0.036
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0048 0.0219 0.0198
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0215 0.2288
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0263 0.0466
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1243 0.1224
Toxoplasma gondii hypothetical protein 0.0048 0.0219 0.1022
Brugia malayi Pre-SET motif family protein 0.0093 0.0542 0.1146
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0032 0.0372
Brugia malayi TAR-binding protein 0.0503 0.3514 0.7682
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0022 0.0001
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0048 0.0219 0.0435
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0186 0.1941
Echinococcus granulosus expressed conserved protein 0.0096 0.0561 0.0541
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.2359 0.4499
Loa Loa (eye worm) glutathione reductase 0.0138 0.0871 0.1869
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0285 0.0265
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0469 0.0861
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0032 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0687 0.3441
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0071
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0048 0.0215 0.0195
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0022
Echinococcus multilocularis geminin 0.0205 0.135 0.1332
Echinococcus granulosus importin subunit beta 1 0.0029 0.0076 0.0055
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0265 0.179 0.1773
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0068 0.0555
Mycobacterium leprae Probable lipase LipE 0.0113 0.0687 0.212
Plasmodium vivax SET domain protein, putative 0.0093 0.0542 0.2694
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0048 0.0219 0.0416
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0031 0.001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0111 0.019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1243 0.2573
Brugia malayi follicle stimulating hormone receptor 0.028 0.1894 0.4118
Trypanosoma cruzi ISWI complex protein 0.003 0.0086 0.0768
Loa Loa (eye worm) MBOAT family protein 0.0048 0.0219 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0185 0.0315
Loa Loa (eye worm) hypothetical protein 0.0048 0.0219 0.0435
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Echinococcus multilocularis protein dispatched 1 0.005 0.0229 0.0209
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0022 0.0003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0118 0.072 0.0701
Leishmania major trypanothione reductase 0.0138 0.0871 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0687 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0161
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0068 0.0555
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0288 0.1955 0.4073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0022
Echinococcus multilocularis expressed conserved protein 0.0096 0.0561 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0035
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0186 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0022 0.0003
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.037 0.0349
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0048 0.0219 0.3379
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.2359 0.4499
Brugia malayi beta-lactamase 0.0113 0.0687 0.1464
Entamoeba histolytica hypothetical protein 0.0023 0.0031 0.017
Loa Loa (eye worm) hypothetical protein 0.0076 0.0416 0.0868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0022 0.0003
Schistosoma mansoni hypothetical protein 0.0042 0.0173 0.0321
Entamoeba histolytica hypothetical protein 0.0023 0.0037 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0121 0.0192
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0223 0.2375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0022 0.0003
Brugia malayi MBOAT family protein 0.0048 0.0219 0.0435
Brugia malayi nuclear receptor NHR-88 0.0021 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0219 0.0435
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0864 0.1622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0056 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0351 0.2411 0.4706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0121 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0219 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0219 0.038
Echinococcus multilocularis GPCR, family 2 0.005 0.0231 0.021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0223 0.2847
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0407 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0031 0.0019
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0343 0.0708
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0048 0.0215 0.2474
Schistosoma mansoni hypothetical protein 0.0205 0.135 0.2799
Schistosoma mansoni ap endonuclease 0.0023 0.0032 0.0024
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.005 0.0231 0.0461
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0022 0.0001
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0022 0.0031
Loa Loa (eye worm) MBOAT family protein 0.0048 0.0219 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0058 0.0071
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0285 0.0556
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0022 0.0014
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0343 0.0323
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0082 0.0134
Entamoeba histolytica hypothetical protein 0.0048 0.0219 0.3379
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0215 0.2288
Loa Loa (eye worm) hypothetical protein 0.0048 0.0219 0.0435
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0606 0.0586
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.3665 0.7011
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0068 0.0244
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.3665 0.7011
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0727 0.3649
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0031 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0186 0.0317
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0113 0.0687 0.1464
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0022 0.0001
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0524 0.3665 0.8013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.003
Onchocerca volvulus Glucosylceramidase homolog 0.0344 0.2359 0.4515
Schistosoma mansoni zinc finger protein 0.0048 0.0219 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0287 0.1945 0.4051
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.037 0.0767
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0032 0.0195
Loa Loa (eye worm) hypothetical protein 0.0113 0.0687 0.1464
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0032 0.0134
Trypanosoma cruzi glycerol uptake protein, putative 0.0048 0.0219 0.2327
Loa Loa (eye worm) hypothetical protein 0.0139 0.0877 0.1883
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0031 0.001
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0121 0.1179
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0022 0.0014
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0022 0.0003
Schistosoma mansoni hypothetical protein 0.0048 0.0219 0.0416
Plasmodium falciparum thioredoxin reductase 0.0048 0.0215 0.1005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0287 0.1945 0.1928
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0058 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0649 0.4568 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0068 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0022 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0048 0.0215 0.1005
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0185 0.0164
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0606 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0031 0.0019
Echinococcus granulosus lamin dm0 0.0055 0.0267 0.0247
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0687 0.1281
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0256 0.0517
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0048 0.0215 0.2288
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0022 0.0255
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0031 0.0019
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0469 0.0888
Leishmania major importin beta-1 subunit, putative 0.0023 0.0037 0.0183
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0923 0.0904
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.004 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0542 0.0522
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0031 0.0019
Trypanosoma brucei trypanothione reductase 0.0138 0.0871 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0022 0.0001
Schistosoma mansoni hypothetical protein 0.0205 0.135 0.2799
Trypanosoma cruzi GUP1, putative 0.0048 0.0219 0.2327
Echinococcus multilocularis lamin dm0 0.0055 0.0267 0.0247
Brugia malayi Protein cec-1. 0.0023 0.0031 0.0022
Loa Loa (eye worm) heterochromatin protein 1 0.0138 0.0864 0.1854
Onchocerca volvulus 0.0021 0.0022 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0022 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0215 0.2288
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0267 0.0541
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.1567 0.3399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0161
Plasmodium vivax glutathione reductase, putative 0.0138 0.0871 0.4394
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0687 0.1281
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0316 0.2155 0.4203
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0037 0.003
Echinococcus granulosus sterol O acyltransferase 1 0.0048 0.0219 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0003
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0048 0.0219 0.0198
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0032 0.0134
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0048 0.0215 0.0381
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0076 0.0872
Trypanosoma brucei ISWI complex protein 0.003 0.0086 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0219 0.038
Brugia malayi CHE-14 protein 0.0044 0.0185 0.036
Echinococcus granulosus zinc finger protein 0.0039 0.0147 0.0127
Loa Loa (eye worm) hypothetical protein 0.0102 0.0606 0.1286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1243 0.2573
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.5631 0.5621
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0031 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.004 0.0036
Entamoeba histolytica vacuolar protein sorting 26 0.0048 0.0219 0.3379
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0288 0.1955 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0316 0.2155 0.4203
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.1545 0.1527
Trichomonas vaginalis porcupine, putative 0.0048 0.0219 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0031 0.0019
Trichomonas vaginalis glutathione reductase, putative 0.0048 0.0215 0.0374
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.3665 0.7011
Trypanosoma cruzi ISWI complex protein 0.003 0.0086 0.0768
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0022 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0056 0.0067
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0048 0.0219 0.0198
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0048 0.0219 0.3379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0022 0.0003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0061 0.004
Brugia malayi nuclear hormone receptor 0.0021 0.0022 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0231 0.021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0022
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0048 0.0219 0.0416
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0032 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0022 0.0003
Plasmodium falciparum importin beta, putative 0.0029 0.0076 0.0284
Brugia malayi Bromodomain containing protein 0.0075 0.0415 0.0866
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0048 0.0215 0.2474
Schistosoma mansoni hypothetical protein 0.0108 0.0652 0.1328
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0082 0.0134
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0021 0.0241
Loa Loa (eye worm) thioredoxin reductase 0.0138 0.0871 0.1869
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0022 0.0001
Brugia malayi RNA binding protein 0.0503 0.3514 0.7682
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0231 0.0461
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0048 0.0215 0.0409
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.1894 0.4118
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0687 0.7832
Echinococcus multilocularis protein patched 0.0044 0.0185 0.0164
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0223 0.0395
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0119 0.019
Echinococcus multilocularis dna polymerase eta 0.0021 0.0022 0.0001
Echinococcus granulosus GPCR family 2 0.005 0.0231 0.021
Onchocerca volvulus 0.0113 0.0687 0.1306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0186 0.0317
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0186 0.2136
Loa Loa (eye worm) MBCTL1 0.0066 0.0343 0.0708
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0022 0.0001
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0031 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0022 0.0003
Brugia malayi diacylglycerol acyltransferase 0.0288 0.1955 0.4253
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0231 0.0461
Leishmania major DNA polymerase eta, putative 0.0021 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0121
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0035 0.0123 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0687 0.1402
Loa Loa (eye worm) RNA binding protein 0.0503 0.3514 0.7682
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0022
Echinococcus granulosus chromobox protein 2 0.0023 0.0031 0.001
Toxoplasma gondii NADPH-glutathione reductase 0.0048 0.0215 0.1005
Echinococcus granulosus o acyltransferase membrane bound domain 0.0048 0.0219 0.0198
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0186 0.282
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0031 0.0019
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.019 0.0169
Brugia malayi CHD4 protein 0.0026 0.0058 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0786 0.0766
Leishmania major DNA polymerase kappa, putative 0.0021 0.0022 0.0014
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0035 0.0123 0.0225
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0068 0.0244
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0022 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0022 0.0003
Brugia malayi intermediate filament protein 0.0055 0.0267 0.0541
Echinococcus granulosus dna polymerase eta 0.0021 0.0022 0.0001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0542 0.2694
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0186 0.1941
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0246
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0786 0.0766
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0186 0.1941
Echinococcus granulosus chromobox protein 1 0.0138 0.0864 0.0845
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0037 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0503 0.3514 0.7357
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Treponema pallidum NADH oxidase 0.0048 0.0215 0.9823
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0022 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0058 0.0071
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0022 0.0001
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0343 0.0323
Schistosoma mansoni chromobox protein 0.0023 0.0031 0.0021
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0031 0.0019
Loa Loa (eye worm) TAR-binding protein 0.0503 0.3514 0.7682
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0687 0.1309
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0003
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0048 0.0219 0.0416
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0022 0.0014
Leishmania major glycerol uptake protein, putative 0.0048 0.0219 0.2327
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.0426 0.0807
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0652 0.1387
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0727 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0426 0.0891
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0048 0.0215 0.2288
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0223 0.3449
Echinococcus granulosus Chromo domain 0.0023 0.0031 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0223 0.2375
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0048 0.0215 0.2288
Echinococcus granulosus intermediate filament protein 0.0055 0.0267 0.0247
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0032 0.0059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0186 0.0363
Loa Loa (eye worm) hypothetical protein 0.0049 0.0223 0.0444
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0022 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1243 0.1224
Echinococcus multilocularis chromobox protein 1 0.0138 0.0864 0.0845
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0003
Giardia lamblia DINP protein human, muc B family 0.0021 0.0022 0.0061
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0285 0.0556
Onchocerca volvulus 0.0116 0.0705 0.1342
Loa Loa (eye worm) hhat protein 0.0048 0.0219 0.0435
Onchocerca volvulus 0.0055 0.0267 0.0501
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.1545 0.1527
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0048 0.0219 0.0198
Brugia malayi hypothetical protein 0.0074 0.0407 0.0849
Brugia malayi Heterochromatin protein 1 0.0138 0.0864 0.1854
Trichomonas vaginalis glucosylceramidase, putative 0.0362 0.2493 0.4757
Plasmodium vivax thioredoxin reductase, putative 0.0138 0.0871 0.4394
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0351 0.2411 1
Entamoeba histolytica hypothetical protein 0.0023 0.0031 0.017
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0032 0.0025
Brugia malayi glutathione reductase 0.0138 0.0871 0.1869
Schistosoma mansoni chromobox protein 0.0138 0.0864 0.1775
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0503 0.3514 0.7682
Schistosoma mansoni hypothetical protein 0.005 0.0231 0.0442
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0048 0.0219 0.0198
Schistosoma mansoni lamin 0.0055 0.0267 0.0518
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0687 0.1464
Loa Loa (eye worm) beta-lactamase 0.0113 0.0687 0.1464
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0687 0.7832
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0786 0.161
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0048 0.0215 0.2743
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0003
Mycobacterium ulcerans lipase LipD 0.0113 0.0687 0.943
Schistosoma mansoni thyroid hormone receptor 0.0287 0.1945 0.4051
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0185 0.0164
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0186 0.2136
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0022 0.0255
Schistosoma mansoni ap endonuclease 0.0023 0.0032 0.0024
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0111 0.0091
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0048 0.0215 0.2743
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0076 0.0055
Trichomonas vaginalis set domain proteins, putative 0.0739 0.5218 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0022 0.0003
Schistosoma mansoni hypothetical protein 0.0023 0.0031 0.0021
Mycobacterium tuberculosis Probable dehydrogenase 0.0316 0.2155 0.4203
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0186 0.0165
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0022 0.0001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0022 0.0002
Echinococcus granulosus lamin 0.0055 0.0267 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0503 0.3514 0.7357
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0022 0.0003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0048 0.0215 1
Schistosoma mansoni hypothetical protein 0.003 0.0086 0.0137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0031 0.0019
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0031 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0032 0.0025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0022 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0119 0.019
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0727 0.1486
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0687 0.0667
Trichomonas vaginalis esterase, putative 0.0113 0.0687 0.1281
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0003
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0185 0.0164
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0186 0.1941
Loa Loa (eye worm) hypothetical protein 0.0066 0.0343 0.0708
Schistosoma mansoni hypothetical protein 0.0042 0.0173 0.0321
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0032 0.0586
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0687 0.1309
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0048 0.0215 0.2474
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0031 0.0051
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0351 0.2411 0.4706
Echinococcus multilocularis sterol O acyltransferase 1 0.0048 0.0219 0.0198
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0727 0.8305
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0343 0.0678
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.2359 0.4499
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0133 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0022 0.0003
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0343 0.0323
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0215 0.2288
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0923 0.0904
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0031 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0121 0.0192
Brugia malayi PHD-finger family protein 0.0049 0.0223 0.0445
Trypanosoma cruzi glycerol uptake protein, putative 0.0048 0.0219 0.2327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0074 0.0103
Leishmania major glycerol uptake protein, putative 0.0048 0.0219 0.2327
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0246
Echinococcus granulosus tar DNA binding protein 0.0503 0.3514 0.3501
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0111 0.0091
Schistosoma mansoni hypothetical protein 0.0042 0.0173 0.0321
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0133 0.1574
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0058 0.0082
Echinococcus multilocularis snurportin 1 0.0307 0.2089 0.2072
Loa Loa (eye worm) MBOAT family protein 0.0048 0.0219 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0031 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0032 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0022 0.0003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0032 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0687 0.1281
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.037 0.0734
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0048 0.0219 0.0198
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0118 0.072 0.0701
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0104 0.0432
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0076 0.0872
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0687 0.1309
Leishmania major glycerol uptake protein, putative 0.0048 0.0219 0.2327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.004 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Echinococcus granulosus o acyltransferase membrane bound domain 0.0048 0.0219 0.0198
Loa Loa (eye worm) hypothetical protein 0.0055 0.0267 0.0541
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0687 0.212
Leishmania major hypothetical protein, conserved 0.003 0.0086 0.0768
Schistosoma mansoni zinc finger protein 0.003 0.0086 0.0137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0022 0.0001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0022
Trypanosoma brucei glycerol uptake protein, putative 0.0048 0.0219 0.2512
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0048 0.0219 0.0198
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0032 0.0022
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0022 0.002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0316 0.2155 0.4203
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.012 0.0218
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0048 0.0215 0.2474
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.037 0.4103
Echinococcus granulosus dna polymerase kappa 0.0021 0.0022 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Brugia malayi Pre-SET motif family protein 0.0649 0.4568 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0022 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0215 0.2288
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0288 0.1955 0.1938
Trichomonas vaginalis hypothetical protein 0.0023 0.0031 0.0019
Echinococcus multilocularis lamin 0.0055 0.0267 0.0247
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0022 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0407 0.0813
Loa Loa (eye worm) hypothetical protein 0.0158 0.1014 0.2185
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0223 0.3449
Onchocerca volvulus 0.0048 0.0219 0.0408
Loa Loa (eye worm) helicase 0.0023 0.0031 0.0022
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0048 0.0219 0.0198
Schistosoma mansoni hypothetical protein 0.0074 0.0407 0.0813
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0219 0.3379
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0223 0.2847
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0022 0.0003
Echinococcus granulosus Chromobox protein 3 0.0023 0.0031 0.001
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0031 0.0051
Loa Loa (eye worm) hypothetical protein 0.0127 0.0786 0.1681
Brugia malayi MBOAT family protein 0.0048 0.0219 0.0435
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0727 1
Entamoeba histolytica hypothetical protein 0.0023 0.0031 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0031 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0022 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0022 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0022 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0031 0.0019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0687 0.1309
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0223 0.2847
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0068 0.0783
Loa Loa (eye worm) hypothetical protein 0.0058 0.0285 0.0581
Brugia malayi Thioredoxin reductase 0.0138 0.0871 0.1869
Leishmania major glycerol uptake protein, putative 0.0048 0.0219 0.2327
Schistosoma mansoni chromobox protein 0.0023 0.0031 0.0021
Entamoeba histolytica hypothetical protein 0.0074 0.0407 0.6598
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0316 0.2155 0.4203
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0022 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0022 0.0003
Entamoeba histolytica hypothetical protein 0.0074 0.0407 0.6598
Schistosoma mansoni chromobox protein 0.0138 0.0864 0.1775
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0068 0.0244
Trichomonas vaginalis mercuric reductase, putative 0.0048 0.0215 0.0374
Echinococcus multilocularis thioredoxin glutathione reductase 0.0139 0.0874 0.0855
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0048 0.0215 0.1005
Mycobacterium ulcerans beta-lactamase 0.0113 0.0687 0.943
Schistosoma mansoni tar DNA-binding protein 0.0503 0.3514 0.7357
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Echinococcus granulosus snurportin 1 0.0307 0.2089 0.2072
Loa Loa (eye worm) hypothetical protein 0.0084 0.0477 0.1002
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0058 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0081 0.0116
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0048 0.0219 0.3379
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0031 0.0019
Onchocerca volvulus 0.0113 0.0687 0.1306
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0285 0.0265
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0687 0.1464
Loa Loa (eye worm) hypothetical protein 0.0044 0.0185 0.036
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0048 0.0215 1
Trichomonas vaginalis glucosylceramidase, putative 0.0362 0.2493 0.4757
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0031 0.0051
Mycobacterium ulcerans hypothetical protein 0.0113 0.0687 0.943
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0022 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0113 0.0687 0.1464
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0469 0.0861
Brugia malayi MBOAT family protein 0.0048 0.0219 0.0435
Brugia malayi SET domain containing protein 0.0026 0.0056 0.0076
Brugia malayi Latrophilin receptor protein 2 0.005 0.0231 0.0461
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0111 0.019
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0687 0.1309
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.2359 0.4499
Toxoplasma gondii ABC1 family protein 0.0113 0.0687 0.3441
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0031 0.0019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0722 0.5098 1
Trypanosoma cruzi trypanothione reductase, putative 0.0138 0.0871 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0119 0.019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0031 0.0019
Schistosoma mansoni DNA polymerase eta 0.0021 0.0022 0.0003
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0288 0.1955 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0285 0.0536
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0031 0.017
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0267 0.0541
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0061 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0263 0.0466
Schistosoma mansoni importin beta-1 0.0029 0.0076 0.0116
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0031 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0022 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0031 0.0019
Schistosoma mansoni hypothetical protein 0.005 0.0231 0.0442
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.2089 0.4547
Giardia lamblia NADH oxidase lateral transfer candidate 0.0048 0.0215 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0022 0.0003
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0022 0.0031
Entamoeba histolytica hypothetical protein 0.0074 0.0407 0.6598
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.037 0.0349
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0048 0.0215 0.0195
Brugia malayi chromobox protein homolog 3 0.0077 0.0426 0.0891
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.2359 0.4499
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.1567 0.3399
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.1014 0.2185
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.2359 0.4499
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0031 0.0051
Onchocerca volvulus 0.0055 0.0267 0.0501
Onchocerca volvulus 0.0058 0.0285 0.0536
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.019 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0022 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0223 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0161
Loa Loa (eye worm) hypothetical protein 0.0049 0.0223 0.0444
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0687 0.7885
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0687 0.1309
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.4769 1
Loa Loa (eye worm) hhat protein 0.0048 0.0219 0.0435
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0076 0.0284
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.1243 0.2687
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0031 0.0019
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0727 0.0707
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0022 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0215 0.2288
Onchocerca volvulus 0.0049 0.0223 0.0416
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0687 0.943
Brugia malayi Bromodomain containing protein 0.0148 0.0939 0.2018
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0223 0.2847
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0727 0.1388
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0022 0.0003
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0048 0.0215 0.2743
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0058 0.0078
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0031 0.0021
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0048 0.0219 0.0198
Trypanosoma cruzi glycerol uptake protein, putative 0.0048 0.0219 0.2327
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0343 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0022 0.0255
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0048 0.0219 0.0198
Leishmania major hypothetical protein, conserved 0.0048 0.0219 0.2327
Schistosoma mansoni hypothetical protein 0.0307 0.2089 0.4354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0161
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0162 0.0311
Brugia malayi Importin beta-1 subunit 0.0029 0.0076 0.0121
Trichomonas vaginalis transmembrane protein nessy, putative 0.0048 0.0219 0.038
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0186 0.282
Echinococcus multilocularis chromobox protein 2 0.0023 0.0031 0.001
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0288 0.1955 0.1938
Loa Loa (eye worm) hypothetical protein 0.008 0.0449 0.0942
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0727 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0133 0.0218
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0606 0.1286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0058 0.0071
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0022 0.0255
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0687 0.943
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0048 0.0215 0.1005
Schistosoma mansoni hypothetical protein 0.005 0.0231 0.0442
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0381 0.0361
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0022 0.0003
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0121 0.1391
Echinococcus multilocularis tar DNA binding protein 0.0503 0.3514 0.3501
Entamoeba histolytica hypothetical protein 0.0074 0.0407 0.6598
Brugia malayi MBOAT family protein 0.0048 0.0219 0.0435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0215 0.2288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0542 0.1097
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0223 0.2847
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0285 0.0581
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0336 0.0692
Loa Loa (eye worm) hypothetical protein 0.0113 0.0687 0.1464
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0031 0.0022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0048 0.0215 0.2288
Schistosoma mansoni bromodomain containing protein 0.0125 0.0771 0.158
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0524 0.3665 0.8013
Echinococcus granulosus thioredoxin glutathione reductase 0.0139 0.0874 0.0855
Onchocerca volvulus 0.0023 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0054 0.026 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.004 0.0036
Schistosoma mansoni patched 1 0.0044 0.0185 0.0345
Schistosoma mansoni zinc finger protein 0.0039 0.0147 0.0266
Schistosoma mansoni hypothetical protein 0.005 0.0231 0.0442
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0022 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0223 0.2847
Onchocerca volvulus 0.0023 0.0031 0.0048
Giardia lamblia GTOR 0.0044 0.0186 0.8486
Mycobacterium tuberculosis Probable oxidoreductase 0.0351 0.2411 0.4706
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0022 0.0001

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 1.4581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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