Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.0055 | 0.05 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0194 | 0.017 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0195 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0275 | 0.3947 | 1 |
Onchocerca volvulus | 0.0085 | 0.0973 | 0.8423 | |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0171 | 0.0371 |
Echinococcus multilocularis | musashi | 0.0085 | 0.0973 | 0.0951 |
Loa Loa (eye worm) | intermediate filament protein | 0.0085 | 0.0973 | 0.2466 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0417 | 0.1056 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0195 | 0.061 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0195 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0085 | 0.0973 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0949 | 0.2404 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0195 | 0.0432 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0195 | 0.061 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0195 | 0.0493 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0283 | 0.0717 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0046 | 0.0354 | 0.0896 |
Brugia malayi | TAR-binding protein | 0.0275 | 0.3947 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0195 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0195 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0493 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0195 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0041 | 0.0283 | 0.0258 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0195 | 1 |
Onchocerca volvulus | 0.0035 | 0.0195 | 0.1684 | |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0195 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0275 | 0.3947 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0195 | 0.061 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0195 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0417 | 0.1056 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0194 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0493 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0973 | 0.2466 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0493 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0195 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1155 | 0.2927 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0195 | 0.0493 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0097 | 0.1155 | 0.2882 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0195 | 0.0493 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0195 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0258 | 0.0655 |
Schistosoma mansoni | intermediate filament proteins | 0.0085 | 0.0973 | 0.2418 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0258 | 0.0655 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0239 | 0.3388 | 0.8583 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0194 | 0.017 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0195 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0195 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0195 | 0.061 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.05 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0275 | 0.3947 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0195 | 0.061 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0417 | 0.1056 |
Onchocerca volvulus | 0.0097 | 0.1155 | 1 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0275 | 0.3947 | 0.3932 |
Schistosoma mansoni | lamin | 0.0085 | 0.0973 | 0.2418 |
Brugia malayi | RNA binding protein | 0.0275 | 0.3947 | 1 |
Echinococcus granulosus | lamin | 0.0085 | 0.0973 | 0.0951 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0195 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.05 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0194 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0275 | 0.3947 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.05 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0194 | 0.0492 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0417 | 0.1056 |
Brugia malayi | MH2 domain containing protein | 0.0239 | 0.3388 | 0.8583 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.05 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0275 | 0.3947 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0195 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0085 | 0.0973 | 0.0951 |
Onchocerca volvulus | 0.0035 | 0.0195 | 0.1684 | |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0055 | 0.05 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0195 | 0.3894 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0195 | 0.061 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0194 | 0.0431 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0195 | 0.0493 |
Onchocerca volvulus | 0.0085 | 0.0973 | 0.8423 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0493 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0195 | 0.017 |
Loa Loa (eye worm) | TAR-binding protein | 0.0275 | 0.3947 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0195 | 0.0493 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0041 | 0.0283 | 0.0258 |
Echinococcus multilocularis | lamin | 0.0085 | 0.0973 | 0.0951 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0195 | 0.0493 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.3189 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0195 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0493 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0046 | 0.0354 | 0.0896 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0055 | 0.05 | 1 |
Brugia malayi | hypothetical protein | 0.0055 | 0.05 | 0.1266 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0239 | 0.3388 | 0.8583 |
Brugia malayi | intermediate filament protein | 0.0085 | 0.0973 | 0.2466 |
Schistosoma mansoni | tar DNA-binding protein | 0.0275 | 0.3947 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0171 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0493 |
Schistosoma mansoni | lamin | 0.0085 | 0.0973 | 0.2418 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0195 | 0.061 |
Echinococcus multilocularis | lamin dm0 | 0.0085 | 0.0973 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.05 | 0.1266 |
Onchocerca volvulus | 0.0035 | 0.0195 | 0.1684 | |
Loa Loa (eye worm) | RNA binding protein | 0.0275 | 0.3947 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0275 | 0.3947 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0275 | 0.3947 | 0.3932 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0085 | 0.0973 | 0.2466 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0195 | 0.061 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0085 | 0.0973 | 0.2466 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.05 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0194 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0195 | 0.0493 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0195 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0195 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0171 | 0.0432 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0194 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0194 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.