Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | pyruvate kinase, muscle | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyruvate kinase | pyruvate kinase, muscle | 605 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.8611 | 1 |
Giardia lamblia | Pyruvate kinase | 0.004 | 0.8611 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.8611 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.004 | 0.8611 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.004 | 0.8611 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.004 | 0.8611 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.004 | 0.8611 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.8611 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.004 | 0.8611 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.8611 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.8611 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.004 | 0.8611 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Leishmania major | pyruvate kinase | 0.004 | 0.8611 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.8611 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.8611 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.8611 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.004 | 0.8611 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.8611 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.4884 | 0.4884 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.004 | 0.8611 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.8611 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.004 | 0.8611 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.004 | 0.8611 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.8611 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.