Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosyl-DNA phosphodiesterase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0054 | 0.0888 | 0.5 | |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.0888 | 0.173 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.3124 | 0.3124 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0046 | 0.0559 | 0.0559 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.008 | 0.2018 | 0.2018 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.008 | 0.2018 | 0.3928 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2018 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.2018 | 0.2018 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.1678 | 0.3267 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.2018 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0046 | 0.0559 | 0.0559 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.008 | 0.2018 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.2018 | 0.2018 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2018 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0295 | 0.0295 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0295 | 0.0575 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0295 | 0.0295 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.3124 | 0.3124 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.3721 | 0.3721 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.3124 | 0.3124 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2018 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.0888 | 0.0888 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3124 | 0.3124 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.3721 | 0.3721 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0888 | 0.173 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.3721 | 0.3721 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1678 | 0.1678 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0263 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.008 | 0.2018 | 0.2018 |
Brugia malayi | hypothetical protein | 0.004 | 0.0295 | 0.0295 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0151 | 0.5137 | 0.5137 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0263 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 0.5137 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.014 | 0.4648 | 0.4648 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.014 | 0.4648 | 0.4648 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0295 | 0.0575 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 0.5137 | 1 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.4648 | 0.9048 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.