TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.413 | Formula: C17H15N7S
H donors: 1 H acceptors: 3 LogP: 3.15 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(n(n1)c1nnc2n1N=C(CS2)c1c[nH]c2c1cccc2)C
InChi: 1S/C17H15N7S/c1-10-7-11(2)23(21-10)16-19-20-17-24(16)22-15(9-25-17)13-8-18-14-6-4-3-5-12(13)14/h3-8,18H,9H2,1-2H3
InChiKey: CQWIVLGOZCPJOL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references
Homo sapiens	signal transducer and activator of transcription 3 (acute-phase response factor)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.038	0.0591
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0092	0.0092
Echinococcus multilocularis	muscleblind protein 1	0.0457	0.6427	0.6427
Loa Loa (eye worm)	nuclear hormone receptor	0.002	0.0058	0.009
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.0842	0.1273
Echinococcus granulosus	nuclear receptor nhr 48	0.002	0.0058	0.0058
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0421	0.5002
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0421	0.0421
Plasmodium falciparum	phd finger protein, putative	0.003	0.0203	0.3945
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0042	0.038	0.0591
Schistosoma mansoni	hypothetical protein	0.0049	0.0485	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0042	0.038	0.0591
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0092	0.0144
Echinococcus multilocularis	peregrin	0.003	0.0203	0.0203
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0317	0.3764
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0048	0.0075
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0372	0.0372
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.0842	0.1311
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0842	0.1273
Loa Loa (eye worm)	nuclear receptor NHR-67	0.002	0.0058	0.009
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Schistosoma mansoni	alpha-glucosidase	0.0145	0.1891	0.1891
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0842	0.0842
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0042	0.038	0.038
Schistosoma mansoni	alpha-glucosidase	0.0145	0.1891	0.1891
Echinococcus granulosus	FTZ F1 alpha	0.0442	0.6218	0.6218
Onchocerca volvulus		0.0033	0.0245	0.0372
Brugia malayi	hypothetical protein	0.0033	0.025	0.0389
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0648	0.1008
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0842	0.5
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0203	0.2404
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0127	0.162	0.252
Brugia malayi	ecdysteroid receptor	0.0042	0.038	0.0591
Brugia malayi	hypothetical protein	0.0125	0.1586	0.2469
Brugia malayi	hypothetical protein	0.0051	0.0513	0.0799
Leishmania major	hypothetical protein, conserved	0.0074	0.0842	1
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.038	0.038
Schistosoma mansoni	nuclear receptor	0.002	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0672	0.1045
Mycobacterium ulcerans	lipase LipD	0.0074	0.0842	0.5
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0048	0.0048
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0042	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0236	0.0368
Echinococcus multilocularis	nuclear receptor nhr 48	0.002	0.0058	0.0058
Brugia malayi	beta-lactamase	0.0074	0.0842	0.1311
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0842	0.1311
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.0319	0.0319
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0048	0.0048
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.0895	0.0895
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1872	0.2913
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0485	0.0485
Brugia malayi	nuclear hormone receptor	0.0042	0.038	0.0591
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.038	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0092	0.0144
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.0842	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0326	0.0326
Brugia malayi	nuclear hormone receptor family member nhr-6	0.002	0.0058	0.009
Echinococcus multilocularis	geminin	0.0348	0.4849	0.4849
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.002	0.0058	0.009
Brugia malayi	orphan nuclear receptor NR2E1	0.002	0.0058	0.009
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0042	0.038	0.038
Mycobacterium ulcerans	beta-lactamase	0.0074	0.0842	0.5
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1586	0.2469
Schistosoma mansoni	microtubule-associated protein tau	0.0702	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0042	0.038	0.038
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0513	0.6093
Schistosoma mansoni	hypothetical protein	0.0433	0.6083	0.6083
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0042	0.038	0.038
Schistosoma mansoni	hypothetical protein	0.003	0.0203	0.0203
Brugia malayi	Ets-domain containing protein	0.0072	0.0824	0.1283
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.3276	0.3276
Loa Loa (eye worm)	beta-lactamase	0.0074	0.0842	0.1311
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0203	0.0203
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0104	0.0104
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0187	0.2496	0.2496
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0058	0.009
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0842	1
Brugia malayi	hypothetical protein	0.0038	0.0326	0.0507
Brugia malayi	ecdysone receptor	0.002	0.0058	0.009
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.3276	0.3276
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0048	0.0075
Brugia malayi	hypothetical protein	0.002	0.0058	0.009
Schistosoma mansoni	retinoic acid receptor RXR	0.0042	0.038	0.038
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0092	0.0144
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0058	0.0058
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0372	0.0372
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0421	0.5002
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0293	0.0293
Echinococcus granulosus	intermediate filament protein	0.0033	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0042	0.038	0.0591
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0421	0.0421
Echinococcus multilocularis	GA binding protein alpha chain	0.0072	0.0824	0.0824
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.002	0.0058	0.0058
Trypanosoma brucei	glucosidase, putative	0.0038	0.0317	0.3764
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0047	0.0073
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.002	0.0058	0.009
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0042	0.038	0.038
Onchocerca volvulus		0.0098	0.1195	0.226
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0048	0.0048
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0317	0.0317
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0513	0.6093
Leishmania major	hypothetical protein, conserved	0.0051	0.0513	0.6093
Schistosoma mansoni	alpha glucosidase	0.0038	0.0317	0.0317
Onchocerca volvulus		0.0074	0.0842	0.1559
Loa Loa (eye worm)	hypothetical protein	0.003	0.0203	0.0315
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.002	0.0058	0.0058
Brugia malayi	beta-lactamase family protein	0.0074	0.0842	0.1311
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0092	0.0144
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0842	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0104	0.0104
Brugia malayi	tailless protein	0.002	0.0058	0.009
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.002	0.0058	0.0058
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0058	0.0058
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.0842	0.1311
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0048	0.0048
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.037	0.0576
Brugia malayi	MH2 domain containing protein	0.0144	0.1872	0.2913
Brugia malayi	Ets-domain containing protein	0.0072	0.0824	0.1283
Brugia malayi	nuclear hormone receptor family member odr-7	0.002	0.0058	0.009
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Schistosoma mansoni	hypothetical protein	0.0041	0.037	0.037
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0187	0.2496	0.3883
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0663	0.1031
Brugia malayi	hypothetical protein	0.0022	0.0092	0.0144
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0041	0.037	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0042	0.038	0.0591
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0169	0.2234	0.3476
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0421	1
Onchocerca volvulus		0.0033	0.0245	0.0372
Brugia malayi	hypothetical protein	0.0022	0.0092	0.0144
Echinococcus granulosus	ecdysone induced protein 78C	0.0042	0.038	0.038
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0245	0.0245
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0245	0.0381
Loa Loa (eye worm)	DR-78	0.002	0.0058	0.009
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.0317	0.3764
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0187	0.2496	0.2496
Loa Loa (eye worm)	hypothetical protein	0.0042	0.038	0.0591
Brugia malayi	nuclear hormone receptor	0.002	0.0058	0.009
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0042	0.038	0.0591
Echinococcus granulosus	thyroid hormone receptor alpha	0.002	0.0058	0.0058
Onchocerca volvulus		0.0074	0.0842	0.1559
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0319	0.0496
Brugia malayi	conserved hypotetical protein	0.002	0.0058	0.009
Loa Loa (eye worm)	fli-1 protein	0.022	0.2971	0.4622
Brugia malayi	steroid hormone receptor	0.0042	0.038	0.0591
Brugia malayi	beta-lactamase family protein	0.0074	0.0842	0.1311
Entamoeba histolytica	hypothetical protein	0.0038	0.0326	0.0818
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0127	0.162	0.252
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0042	0.038	0.064
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0421	0.0421
Brugia malayi	nuclear receptor NHR-67	0.002	0.0058	0.009
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.0092	0.0144
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0203	0.0203
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.038	0.038
Schistosoma mansoni	cpg binding protein	0.0032	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0365	0.509	0.7921
Echinococcus granulosus	lysosomal alpha glucosidase	0.0169	0.2234	0.2234
Entamoeba histolytica	hypothetical protein	0.0038	0.0326	0.0818
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0203	0.2404
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0421	0.1985
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1586	0.3037
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.0842	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0092	0.0144
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.038	0.038
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0025	0.0038
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0169	0.2234	0.2234
Echinococcus granulosus	dnaJ subfamily B	0.0433	0.6083	0.6083
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0042	0.038	0.0591
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0421	0.0421
Schistosoma mansoni	hypothetical protein	0.0348	0.4849	0.4849
Echinococcus multilocularis	muscleblind protein	0.0457	0.6427	0.6427
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.038	0.038
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.061	0.7242
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0421	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1586	0.2469
Schistosoma mansoni	lamin	0.0033	0.0245	0.0245
Onchocerca volvulus	Alhambra homolog	0.003	0.0203	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0127	0.162	0.252
Brugia malayi	hypothetical protein	0.002	0.0058	0.009
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0058	0.0058
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0187	0.2496	0.2496
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0648	0.1008
Echinococcus granulosus	lamin	0.0033	0.0245	0.0245
Echinococcus multilocularis	musashi	0.0033	0.0245	0.0245
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0842	0.1273
Schistosoma mansoni	hypothetical protein	0.0085	0.101	0.101
Echinococcus granulosus	GPCR family 2	0.0019	0.0048	0.0048
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0169	0.2234	0.2234
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.0842	0.1273
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0245	0.0381
Brugia malayi	Muscleblind-like protein	0.0457	0.6427	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0042	0.038	0.038
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0048	0.0075
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0842	0.5
Schistosoma mansoni	hypothetical protein	0.0038	0.0326	0.0326
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0203	0.0315
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.0842	0.1273
Onchocerca volvulus	Bile acid receptor homolog	0.0042	0.038	0.064
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0187	0.2496	0.2496
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0317	0.3764
Onchocerca volvulus		0.0049	0.0485	0.0849
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0169	0.2234	0.3476
Schistosoma mansoni	hypothetical protein	0.0019	0.0048	0.0048
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0042	0.038	0.0591
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0421	0.0421
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.0842	0.0842
Onchocerca volvulus		0.0074	0.0842	0.1559
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0058	0.0058
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0048	0.0048
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0421	0.0421
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0842	0.1273
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.038	0.0591
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.1186	0.1186
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0058	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0042	0.038	0.0591
Brugia malayi	CXXC zinc finger family protein	0.003	0.0214	0.0332
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0042	0.038	0.0591
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0048	0.0075
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0317	0.3764
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0042	0.038	0.0591
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.0842	1
Onchocerca volvulus		0.0365	0.509	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0513	0.6093
Schistosoma mansoni	hypothetical protein	0.0019	0.0048	0.0048
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0421	0.5002
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0317	0.0493
Schistosoma mansoni	hypothetical protein	0.0019	0.0048	0.0048
Schistosoma mansoni	cpg binding protein	0.0032	0.0239	0.0239
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.0842	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0042	0.038	0.038
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0042	0.038	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0457	0.6427	1
Loa Loa (eye worm)	hypothetical protein	0.024	0.3276	0.5097
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0017	0.0022	0.0022
Echinococcus multilocularis	lamin dm0	0.0033	0.0245	0.0245
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0127	0.162	0.162
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0421	0.0656
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0127	0.162	0.162
Brugia malayi	Bromodomain containing protein	0.003	0.0203	0.0315
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0421	0.1985
Schistosoma mansoni	zinc finger protein	0.002	0.0058	0.0058
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0042	0.038	0.038
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0421	0.1985
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.0842	0.1273
Entamoeba histolytica	hypothetical protein	0.0038	0.0326	0.0818
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0058	0.009
Brugia malayi	nuclear receptor NHR-88	0.0042	0.038	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0457	0.6427	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0842	1
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1586	0.3037
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Schistosoma mansoni	ets-related	0.022	0.2971	0.2971
Echinococcus granulosus	lamin dm0	0.0033	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.038	0.038
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0072	0.0824	0.1283
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1872	0.2913
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0245	0.0381
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Schistosoma mansoni	coup transcription factor	0.0042	0.038	0.038
Onchocerca volvulus	Protein ultraspiracle homolog	0.0042	0.038	0.064
Echinococcus multilocularis	FTZ F1 alpha	0.0127	0.162	0.162
Brugia malayi	nuclear receptor NHR-88	0.002	0.0058	0.009
Brugia malayi	nuclear receptor RXR	0.0022	0.0092	0.0144
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0042	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0842	0.1311
Brugia malayi	jmjC domain containing protein	0.0038	0.0319	0.0496
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.1186	0.1186
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.002	0.0058	0.0058
Echinococcus granulosus	peregrin	0.003	0.0203	0.0203
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.0842	0.0842
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0513	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0042	0.038	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0245	0.0381
Brugia malayi	Fli-1 protein	0.022	0.2971	0.4622
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0042	0.038	0.0591
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0092	0.0144
Brugia malayi	intermediate filament protein	0.0033	0.0245	0.0381
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.038	0.038
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.038	0.0591
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0187	0.2496	0.2496
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0842	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0513	0.6093
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0326	0.0326
Brugia malayi	PHD-finger family protein	0.003	0.0203	0.0315
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0042	0.038	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0842	0.1311
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.0092	0.0092
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0203	0.0203
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0513	0.6093
Schistosoma mansoni	hypothetical protein	0.0348	0.4849	0.4849
Schistosoma mansoni	nuclear receptor nhr-48	0.002	0.0058	0.0058
Entamoeba histolytica	hypothetical protein	0.0038	0.0326	0.0818
Echinococcus multilocularis	microtubule associated protein 2	0.0702	1	1
Echinococcus granulosus	GA binding protein alpha chain	0.0072	0.0824	0.0824
Loa Loa (eye worm)	steroid hormone receptor	0.0042	0.038	0.0591
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0317	0.0317
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0058	0.0058
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0319	0.0319
Schistosoma mansoni	hypothetical protein	0.0019	0.0048	0.0048
Schistosoma mansoni	cpg binding protein	0.003	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0042	0.038	0.0591
Echinococcus granulosus	geminin	0.0348	0.4849	0.4849
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0842	0.1311
Schistosoma mansoni	gabp alpha	0.0072	0.0824	0.0824
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0513	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0187	0.2496	0.2496
Brugia malayi	nuclear receptor RXR	0.002	0.0058	0.009
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0214	0.0332
Onchocerca volvulus		0.0042	0.038	0.064
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0317	0.0493
Onchocerca volvulus		0.003	0.0214	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0842	0.1311
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0842	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.0842	0.1273
Schistosoma mansoni	nuclear receptor	0.002	0.0058	0.0058
Echinococcus multilocularis	lamin	0.0033	0.0245	0.0245
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0421	0.5002
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0042	0.038	0.0591
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0842	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0421	0.0421
Echinococcus multilocularis	dnaJ subfamily B	0.0433	0.6083	0.6083
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0191	0.2549	0.3966
Brugia malayi	hypothetical protein	0.024	0.3276	0.5097
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0421	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0042	0.038	0.038
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0485	0.0755
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0042	0.038	0.0591
Echinococcus granulosus	muscleblind protein	0.0457	0.6427	0.6427
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0842	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0042	0.038	0.038
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0042	0.038	0.038
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0127	0.162	0.162
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.0092	0.0092
Brugia malayi	hypothetical protein	0.0365	0.509	0.7921
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0092	0.0144
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0042	0.038	0.0591
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0042	0.038	0.0591
Echinococcus multilocularis	ecdysone induced protein 78C	0.0042	0.038	0.038
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0203	0.2404
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0042	0.038	0.0591
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0042	0.038	0.0591
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.038	0.038
Mycobacterium leprae	Probable lipase LipE	0.0074	0.0842	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.038	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0513	0.0799
Brugia malayi	Steroid receptor seven-up type 2	0.0042	0.038	0.0591
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.047	0.6619	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0058	0.0058
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.0842	0.1273
Toxoplasma gondii	ABC1 family protein	0.0074	0.0842	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.002	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Echinococcus granulosus	cpg binding protein	0.0032	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.006	0.0648	0.1008
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0187	0.2496	0.3883
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0187	0.2496	0.2496
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0319	0.0319
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0042	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0842	0.1311
Loa Loa (eye worm)	STAT protein	0.0191	0.2549	0.3966
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.002	0.0058	0.009
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.071	0.071
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0511	0.0796
Echinococcus multilocularis	cpg binding protein	0.0032	0.0239	0.0239
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0648	0.1008
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.0842	0.1273
Trichomonas vaginalis	esterase, putative	0.0074	0.0842	1
Brugia malayi	jmjC domain containing protein	0.0097	0.1186	0.1845
Schistosoma mansoni	lamin	0.0033	0.0245	0.0245

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 55.7 um	PUBCHEM_BIOASSAY: Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation. (Class of assay: confirmatory) [Related pubchem assays: 1267, 871, 932, 1309, 1318 ]	ChEMBL.	No reference
IC50 (functional)	= 14.49 um	PUBCHEM_BIOASSAY: Dose response cell-based assay to measure STAT3 activation. (Class of assay: confirmatory) [Related pubchem assays: 1267, 871, 932, 1309, 1318 ]	ChEMBL.	No reference
Potency (functional)	4.4411 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 4.4668 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	6.2733 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	12.5168 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1369131

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1219496