Detailed information for compound 1219529

Basic information

Technical information
  • TDR Targets ID: 1219529
  • Name: N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2 -(1-propylimidazol-2-yl)sulfanylacetamide
  • MW: 385.483 | Formula: C19H23N5O2S
  • H donors: 1 H acceptors: 3 LogP: 2.86 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1ccnc1SCC(=O)Nc1c(C)n(n(c1=O)c1ccccc1)C
  • InChi: 1S/C19H23N5O2S/c1-4-11-23-12-10-20-19(23)27-13-16(25)21-17-14(2)22(3)24(18(17)26)15-8-6-5-7-9-15/h5-10,12H,4,11,13H2,1-3H3,(H,21,25)
  • InChiKey: VSJIVIFOYJHYHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-2-(1-propylimidazol-2-yl)sulfanyl-acetamide
  • N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-2-[(1-propyl-2-imidazolyl)thio]acetamide
  • N-(3-keto-1,5-dimethyl-2-phenyl-pyrazol-4-yl)-2-[(1-propylimidazol-2-yl)thio]acetamide
  • N-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-2-(1-propylimidazol-2-yl)sulfanyl-ethanamide
  • ZINC08128837
  • T5574472

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0189 1
Schistosoma mansoni nuclear receptor 0.0015 0.0026 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0101 0.0093
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0026 0.0067
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0049 0.0041
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0242 0.0208
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0189 0.0189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0206 0.0528
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0034 0.0034
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0101 0.0362
Leishmania major trypanothione reductase 0.0049 0.018 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0206 0.0508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0101 0.0362
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0519 0.0485
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0566
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0463 0.0429
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0189 0.0397
Brugia malayi nuclear hormone receptor 0.0015 0.0026 0.0018
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0026 0.0018
Brugia malayi hypothetical protein 0.0076 0.0299 0.0291
Echinococcus multilocularis importin subunit beta 1 0.003 0.0094 0.0231
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0101 0.0101
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0101 0.0093
Schistosoma mansoni hypothetical protein 0.0321 0.1397 0.1397
Plasmodium falciparum dihydroorotate dehydrogenase 0.2244 1 1
Brugia malayi RNA, U transporter 1 0.0086 0.0342 0.0334
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0206 0.0198
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0049 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0049 0.0028
Echinococcus granulosus snurportin 1 0.0321 0.1397 0.3581
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0108 0.0443 0.0423
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0101 0.025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0101 0.0101
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0034 0.0084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0101 0.0722
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Loa Loa (eye worm) DR-78 0.0015 0.0026 0.0067
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0566
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0068 0.0085
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0094 0.0073
Schistosoma mansoni cpg binding protein 0.0034 0.0112 0.0112
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0094 0.0058
Mycobacterium tuberculosis Conserved protein 0.0043 0.0153 0.0118
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0049 0.0121
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.2244 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0242 0.0208
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0055 0.0142
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0153 0.0305
Mycobacterium ulcerans hypothetical protein 0.0043 0.0153 0.0118
Onchocerca volvulus 0.0032 0.0101 0.0722
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0026 0.0067
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0049 0.0014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0101 0.025
Brugia malayi CXXC zinc finger family protein 0.0032 0.0104 0.0096
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0026 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0101 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0153 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0101 0.0362
Leishmania major importin beta-1 subunit, putative 0.0024 0.0068 0.0033
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0035 0.0087
Leishmania major DNA polymerase eta, putative 0.002 0.0049 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0362
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0049 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0099
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0876 0.388 0.9947
Echinococcus multilocularis geminin 0.0366 0.1597 0.394
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0055 0.0136
Chlamydia trachomatis cytosol aminopeptidase 0.0108 0.0443 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0091 0.0056
Brugia malayi tailless protein 0.0015 0.0026 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0091 0.0056
Schistosoma mansoni importin beta-1 0.003 0.0094 0.0094
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0189 0.0154
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0881 0.39 0.9621
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0206 0.0206
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.018 0.0145
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.2244 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0101 0.026
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0463 0.0314
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.2244 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0362
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0239 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0101 0.0362
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0018 0.0045
Echinococcus granulosus dna polymerase kappa 0.002 0.0049 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Brugia malayi hypothetical protein 0.0017 0.0034 0.0026
Brugia malayi nuclear receptor NHR-88 0.0015 0.0026 0.0018
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0026 0.0067
Brugia malayi ecdysteroid receptor 0.0032 0.0101 0.0093
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0881 0.39 0.9621
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0068 0.0085
Entamoeba histolytica hypothetical protein 0.0076 0.0299 0.0648
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0049 0.0014
Brugia malayi hypothetical protein 0.0019 0.0044 0.0036
Echinococcus granulosus leucine aminopeptidase protein 0.0108 0.0443 0.1135
Trichomonas vaginalis set domain proteins, putative 0.0248 0.1069 0.2673
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0026 0.0026
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0101 0.026
Plasmodium falciparum glutathione reductase 0.0049 0.018 0.0145
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0566
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0101 0.0101
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0055 0.0136
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.002
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0101 0.025
Schistosoma mansoni hypothetical protein 0.0366 0.1597 0.1597
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0153 0.0305
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0153 0.0118
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0189 0.0154
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0068 0.0033
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0157
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0101 0.025
Echinococcus granulosus dnaJ subfamily B 0.0461 0.2024 0.5191
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0101 0.025
Onchocerca volvulus 0.0248 0.1069 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0189 0.0154
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0026 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0049 0.0014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0035 0.0035
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0189 0.0154
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0091 0.0056
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0049 0.0014
Echinococcus multilocularis dna polymerase eta 0.002 0.0049 0.0121
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0049 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0242 0.0208
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0108 0.0443 0.0409
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.002
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0101 0.025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0206 0.0206
Echinococcus granulosus importin subunit beta 1 0.003 0.0094 0.024
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0101 0.0101
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0035 0.0014
Loa Loa (eye worm) glutathione reductase 0.0049 0.018 0.0669
Schistosoma mansoni zinc finger protein 0.0015 0.0026 0.0026
Trypanosoma brucei trypanothione reductase 0.0049 0.018 0.0159
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0362
Mycobacterium tuberculosis Probable reductase 0.0113 0.0463 0.0429
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0055 0.0136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0101 0.025
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0035 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0049 0.0014
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0101 0.026
Brugia malayi beta-lactamase family protein 0.0043 0.0153 0.0145
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0189 0.0154
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0463 0.0429
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0101 0.0093
Brugia malayi ecdysone receptor 0.0015 0.0026 0.0018
Brugia malayi Thioredoxin reductase 0.0049 0.018 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0153 0.0305
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0101 0.026
Leishmania major dihydroorotate dehydrogenase 0.2244 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.1397 0.5434
Onchocerca volvulus 0.0043 0.0153 0.1222
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2244 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0881 0.39 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0101 0.026
Giardia lamblia DINP protein human, muc B family 0.002 0.0049 0.0888
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0068 0.0085
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0362
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0026 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0035 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0463 0.0429
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0026 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0206 0.0528
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0101 0.0066
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0321
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0153 0.0118
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0108 0.0443 0.0409
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0026 0.0064
Schistosoma mansoni hypothetical protein 0.0366 0.1597 0.1597
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0101 0.0093
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0153 0.0118
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0881 0.39 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0153 0.0118
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0024 0.0068 0.005
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0101 0.0093
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0272 0.0272
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0049 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0026 0.0067
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0519 0.0485
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0362
Schistosoma mansoni nuclear receptor 0.0015 0.0026 0.0026
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0876 0.388 0.9947
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0101 0.0722
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0055 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0101 0.0362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0206 0.0206
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0049 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Echinococcus multilocularis cpg binding protein 0.0034 0.0112 0.0277
Schistosoma mansoni cpg binding protein 0.0034 0.0112 0.0112
Loa Loa (eye worm) glutaminase 2 0.0582 0.2563 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0049 0.0035
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0101 0.0101
Toxoplasma gondii ABC1 family protein 0.0043 0.0153 0.0118
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0101 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0101 0.0362
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0035 0.0014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0153 0.0153
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0101 0.026
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0101 0.0093
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0108 0.0443 0.0294
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0055 0.0182
Trichomonas vaginalis esterase, putative 0.0043 0.0153 0.0305
Brugia malayi nuclear receptor NHR-67 0.0015 0.0026 0.0018
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0153 0.0393
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0153 0.0305
Treponema pallidum NADH oxidase 0.0017 0.0035 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0299 0.0737
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0026 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0153 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0206 0.0508
Schistosoma mansoni hypothetical protein 0.0076 0.0299 0.0299
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0055 0.0142
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0101 0.0093
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0101 0.026
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0026 0.0067
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.018 0.0145
Echinococcus granulosus geminin 0.0366 0.1597 0.4096
Schistosoma mansoni cpg binding protein 0.0032 0.0104 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0091 0.007
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0242 0.0622
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0101 0.025
Brugia malayi nuclear receptor RXR 0.0015 0.0026 0.0018
Schistosoma mansoni hypothetical protein 0.0461 0.2024 0.2024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0026 0.0026
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.2244 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0101 0.0362
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0242 0.0208
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0035 0.0091
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.0034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0101 0.025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0299 0.0766
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0101 0.0093
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0242 0.0208
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0108 0.0443 0.0409
Echinococcus granulosus dna polymerase eta 0.002 0.0049 0.0126
Echinococcus multilocularis snurportin 1 0.0321 0.1397 0.3446
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0101 0.0101
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0026 0.0026
Trypanosoma brucei aminopeptidase, putative 0.0022 0.0055 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Loa Loa (eye worm) glutaminase 0.0582 0.2563 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0189 0.0397
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0099
Brugia malayi conserved hypotetical protein 0.0015 0.0026 0.0018
Plasmodium falciparum importin beta, putative 0.003 0.0094 0.0058
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0055 0.0047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0934 0.3623
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0519 0.0371
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0362
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0049 0.0157
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0189 0.0397
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1202 0.1171
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0101 0.0093
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0049 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0104 0.0372
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0049 0.0126
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0153 0.0133
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0049 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0101 0.0101
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0876 0.388 0.3858
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0034 0.0034
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0463 0.0429
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0362
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0566
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.2244 1 1
Mycobacterium ulcerans leucyl aminopeptidase 0.0108 0.0443 0.0409
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0299 0.0299
Brugia malayi nuclear hormone receptor 0.0032 0.0101 0.0093
Leishmania major DNA polymerase kappa, putative 0.002 0.0049 0.0014
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0034 0.0099
Mycobacterium tuberculosis Conserved protein 0.0043 0.0153 0.0118
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0049 0.0014
Onchocerca volvulus 0.0032 0.0101 0.0724
Mycobacterium ulcerans beta-lactamase 0.0043 0.0153 0.0118
Brugia malayi Pre-SET motif family protein 0.0218 0.0934 0.0927
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0093 0.0239
Onchocerca volvulus 0.0043 0.0153 0.1222
Brugia malayi Pre-SET motif family protein 0.0032 0.0101 0.0093
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0463 0.0429
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2244 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0026 0.0064
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0881 0.39 1
Brugia malayi hypothetical protein 0.0017 0.0034 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0363
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0153 0.0118
Brugia malayi nuclear receptor RXR 0.0017 0.0034 0.0026
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0026 0.0067
Brugia malayi nuclear receptor NHR-88 0.0032 0.0101 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0242 0.0208
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0026 0.0064
Mycobacterium tuberculosis Conserved protein 0.0043 0.0153 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0101 0.0093
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0049 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0206 0.0772
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0009 0.0023
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0153 0.0118
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0915 0.4054 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.018 0.0461
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0362
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0101 0.0101
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0049 0.0049
Plasmodium vivax importin-beta 2, putative 0.003 0.0094 0.0058
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0189 0.0704
Brugia malayi MAP kinase sur-1 0.0051 0.0189 0.0181
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0026 0.0064
Plasmodium vivax glutathione reductase, putative 0.0049 0.018 0.0145
Mycobacterium ulcerans glutaminase 0.0582 0.2563 0.2537
Leishmania major hypothetical protein, conserved 0.0029 0.0091 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0026 0.0064
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0881 0.39 1
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0101 0.0722
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0101 0.0101
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0189 0.0397
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2244 1 1
Onchocerca volvulus 0.0032 0.0104 0.0747
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0101 0.0093
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0055 0.0055
Brugia malayi hypothetical protein 0.0015 0.0026 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0881 0.39 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.0034
Brugia malayi steroid hormone receptor 0.0032 0.0101 0.0093
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0153 0.0566
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0055 0.0182
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0189 0.0465
Brugia malayi Importin beta-1 subunit 0.003 0.0094 0.0085
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0015 0.0007
Brugia malayi glutathione reductase 0.0049 0.018 0.0172
Plasmodium falciparum thioredoxin reductase 0.0049 0.018 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0026 0.0064
Plasmodium vivax SET domain protein, putative 0.0032 0.0101 0.0066
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0091 0.0056
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0189 0.0465
Loa Loa (eye worm) beta-lactamase 0.0043 0.0153 0.0566
Trichomonas vaginalis glutaminase, putative 0.0582 0.2563 0.654
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0055 0.0047
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0101 0.0101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0101 0.026
Brugia malayi beta-lactamase family protein 0.0043 0.0153 0.0145
Schistosoma mansoni hypothetical protein 0.0013 0.0018 0.0018
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0034 0.0087
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0101 0.0093
Brugia malayi Zinc finger, C2H2 type family protein 0.0876 0.388 0.3875
Onchocerca volvulus 0.0043 0.0153 0.1222
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.018 0.0443
Trypanosoma brucei unspecified product 0.002 0.0049 0.0028
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0108 0.0443 0.0409
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0091 0.0056
Toxoplasma gondii leucyl aminopeptidase LAP 0.0108 0.0443 0.0409
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0034 0.0026
Trypanosoma brucei protein kinase, putative 0.0051 0.0189 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0101 0.0101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0026 0.0067
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0026 0.0067
Brugia malayi hypothetical protein 0.0015 0.0026 0.0018
Brugia malayi hypothetical protein 0.0029 0.0091 0.0083
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0153 0.0145
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0189 0.0154
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0101 0.0093
Entamoeba histolytica hypothetical protein 0.0076 0.0299 0.0648
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0108 0.0443 0.0409
Schistosoma mansoni coup transcription factor 0.0032 0.0101 0.0101
Entamoeba histolytica hypothetical protein 0.0076 0.0299 0.0648
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0091 0.0056
Brugia malayi glutaminase DH11.1 0.0582 0.2563 0.2557
Schistosoma mansoni DNA polymerase eta 0.002 0.0049 0.0049
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0189 0.0154
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.018 0.0145
Schistosoma mansoni glutaminase 0.0582 0.2563 0.2563
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0189 0.0168
Echinococcus multilocularis dnaJ subfamily B 0.0461 0.2024 0.4994
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0101 0.0093
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0026 0.0018
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0189 0.0484
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0101 0.0362
Entamoeba histolytica hypothetical protein 0.0076 0.0299 0.0648
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Echinococcus multilocularis dna polymerase kappa 0.002 0.0049 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0101 0.0093
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0034 0.0026
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0018 0.0046
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Mycobacterium ulcerans lipase LipD 0.0043 0.0153 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0028
Plasmodium falciparum M17 leucyl aminopeptidase 0.0108 0.0443 0.0409
Leishmania major hypothetical protein, conserved 0.0043 0.0153 0.0118
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.2244 1 1
Toxoplasma gondii thioredoxin reductase 0.0049 0.018 0.0145
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0566
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0055 0.0142
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0153 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0153 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0153 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0332
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0566
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0035 0.0027
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2244 1 1
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.002
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0099
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0153 0.0118
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.018 0.0669
Echinococcus granulosus cpg binding protein 0.0034 0.0112 0.0288
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.2244 1 1
Echinococcus multilocularis leucine aminopeptidase protein 0.0108 0.0443 0.1092
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0101 0.025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0101 0.026
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0519 0.0485
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0101 0.025
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0876 0.388 0.9947
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0153 0.0379
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0099
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0101 0.026
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0108 0.0443 0.0409
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0153 0.0153
Schistosoma mansoni dihydroorotate dehydrogenase 0.2244 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0876 0.388 0.9947
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Brugia malayi beta-lactamase 0.0043 0.0153 0.0145
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0153 0.0118
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0242 0.0598
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0189 0.0484
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0242 0.0242
Brugia malayi cytosol aminopeptidase 0.0022 0.0055 0.0047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0067
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0015 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0026 0.0026
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0094 0.0073

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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