Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0043 | 0.5657 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5657 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.1658 | 0.2039 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5657 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.5657 | 0.5609 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.5657 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.5657 | 0.5609 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5657 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1658 | 0.2082 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4088 | 0.6876 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5657 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.4088 | 0.6876 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.5657 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.4002 | 0.8868 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0634 | 0.0531 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.4619 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4393 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.4088 | 0.4023 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.4619 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4088 | 0.6876 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4678 | 0.8051 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8867 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.4393 | 1 | |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4088 | 0.6688 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.1658 | 0.2039 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1572 | 0.1833 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4088 | 0.9117 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1572 | 0.1833 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4393 | 0.4331 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4088 | 0.6876 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4088 | 0.6876 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1908 | 0.2086 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4088 | 0.6688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4088 | 0.4023 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4393 | 0.7332 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4088 | 0.9117 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.0607 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1908 | 0.2804 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4088 | 0.9117 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4678 | 0.8051 |
Schistosoma mansoni | lamin | 0.0033 | 0.4088 | 0.4023 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4088 | 0.6876 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 67.547 uM | PubChem BioAssay. Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR).. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.