Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2136 | 0.2136 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2136 | 0.2136 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2136 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2136 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2136 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0125 | 0.8906 | 0.8906 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2136 | 0.2136 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0125 | 0.8906 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2136 | 0.2136 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2136 | 0.2136 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.8906 | 0.8906 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2136 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2136 | 0.2136 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2136 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2136 | 0.2399 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2136 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5131 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.