TDR Targets

Basic information

Technical information

TDR Targets ID: 1220436
Name: N-(4-ethylphenyl)-2-[2,4,6-trioxo-3,5-di(prop -2-enyl)-1,3,5-triazinan-1-yl]acetamide
MW: 370.402 | Formula: C19H22N4O4
H donors: 1 H acceptors: 4 LogP: 2.36 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)NC(=O)Cn1c(=O)n(CC=C)c(=O)n(c1=O)CC=C
InChi: 1S/C19H22N4O4/c1-4-11-21-17(25)22(12-5-2)19(27)23(18(21)26)13-16(24)20-15-9-7-14(6-3)8-10-15/h4-5,7-10H,1-2,6,11-13H2,3H3,(H,20,24)
InChiKey: FHKGGBAYPWLBML-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(3,5-diallyl-2,4,6-trioxo-1,3,5-triazinan-1-yl)-N-(4-ethylphenyl)acetamide
2-(3,5-diallyl-2,4,6-triketo-1,3,5-triazinan-1-yl)-N-(4-ethylphenyl)acetamide
N-(4-ethylphenyl)-2-[2,4,6-trioxo-3,5-di(prop-2-enyl)-1,3,5-triazinan-1-yl]ethanamide
SMR000352757
T5301726
ZINC03441337
MLS001007828

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0098	0.0083
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0344	0.0434
Schistosoma mansoni	hypothetical protein	0.0173	0.5058	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0429	0.0848
Treponema pallidum	ribonuclease Z	0.0173	0.5058	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.114	0.2254
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0788	0.1539
Mycobacterium ulcerans	hydrolase	0.0173	0.5058	1
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0444	0.0878
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0168	0.487	0.4863
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.0316
Mycobacterium tuberculosis	Conserved protein	0.0173	0.5058	1
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.5058	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0098	0.0077
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0016	0.0109	0.0024
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0173	0.5058	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0098	0.0193
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0168	0.487	0.4863
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2648	0.5236
Echinococcus multilocularis	tumor protein p63	0.0331	1	1
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0344	0.0376
Schistosoma mansoni	alkaline phosphatase	0.0168	0.487	0.9623
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0098	0.0083
Loa Loa (eye worm)	phosphatidylinositol 3	0.0047	0.1089	0.2153
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1135	0.2245
Echinococcus granulosus	alkaline phosphatase	0.0168	0.487	0.4863
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0173	0.5058	1
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0173	0.5058	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0016	0.0109	0.0094
Schistosoma mansoni	lamin	0.0026	0.0444	0.0698
Entamoeba histolytica	type A flavoprotein, putative	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0496	0.0961
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0168	0.487	0.4863
Echinococcus granulosus	ETHE1 protein	0.0173	0.5058	0.505
Echinococcus granulosus	lamin	0.0026	0.0444	0.0429
Mycobacterium tuberculosis	Conserved protein	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0109	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0444	0.0878
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.0316
Onchocerca volvulus	Putative hydrolase PNKD	0.0173	0.5058	1
Trypanosoma cruzi	glyoxalase II	0.0173	0.5058	1
Chlamydia trachomatis	ribonuclease Z	0.0173	0.5058	1
Trypanosoma cruzi	glyoxalase II	0.0173	0.5058	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0344	0.068
Loa Loa (eye worm)	hypothetical protein	0.0173	0.5058	1
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.1135	0.2092
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0047	0.1089	0.1999
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0098	0.0077
Onchocerca volvulus		0.0048	0.1135	0.1679
Schistosoma mansoni	alkaline phosphatase	0.0168	0.487	0.9623
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0604	0.1175
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0047	0.1089	0.1581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0411	0.0793
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0109	0.0196
Mycobacterium leprae	POSSIBLE HYDROLASE	0.0173	0.5058	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.114	0.2163
Loa Loa (eye worm)	hypothetical protein	0.0049	0.114	0.2254
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0097	0.2648	0.518
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.1089	0.2137
Echinococcus granulosus	zinc phosphodiesterase	0.0173	0.5058	0.505
Loa Loa (eye worm)	hypothetical protein	0.0173	0.5058	1
Mycobacterium leprae	conserved hypothetical protein	0.0173	0.5058	1
Trypanosoma brucei	metallo-beta-lactamase-like protein, putative	0.0173	0.5058	1
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.5058	1
Schistosoma mansoni	hypothetical protein	0.0087	0.2346	0.4533
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0344	0.068
Trypanosoma brucei	glyoxalase II	0.0173	0.5058	1
Plasmodium falciparum	cytosolic glyoxalase II	0.0173	0.5058	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0344	0.0376
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0344	0.0376
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0016	0.0109	0.0094
Entamoeba histolytica	type A flavoprotein, putative	0.0173	0.5058	1
Entamoeba histolytica	alkyl sulfatase, putative	0.0173	0.5058	1
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.5058	1
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0173	0.5058	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0173	0.5058	1
Echinococcus multilocularis	zinc phosphodiesterase	0.0173	0.5058	0.505
Entamoeba histolytica	heat shock transcription factor, putative	0.0097	0.2648	0.4889
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.041	0.0791
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0788	0.1539
Mycobacterium ulcerans	glyoxalase II, GloB	0.0173	0.5058	1
Entamoeba histolytica	hypothetical protein, conserved	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0487	0.0944
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.114	0.2163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0487	0.0944
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0788	0.1539
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0173	0.5058	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0658	0.13
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0098	0.0193
Mycobacterium leprae	Beta-lactamase-like protein	0.0173	0.5058	1
Brugia malayi	ethe1-prov protein	0.0173	0.5058	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0173	0.5058	1
Trichomonas vaginalis	A-type flavoprotein	0.0173	0.5058	1
Onchocerca volvulus		0.0026	0.0444	0.0212
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0658	0.1197
Onchocerca volvulus		0.0026	0.0444	0.0212
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.1389
Mycobacterium ulcerans	beta lactamase-like protein	0.0173	0.5058	1
Echinococcus granulosus	intermediate filament protein	0.0026	0.0444	0.0429
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0344	0.0474
Onchocerca volvulus		0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0411	0.0793
Mycobacterium ulcerans	hypothetical protein	0.0173	0.5058	1
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0173	0.5058	1
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0173	0.5058	1
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0173	0.5058	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.0316
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0059	0.0117
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0444	0.0878
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0047	0.1089	0.198
Echinococcus multilocularis	lamin	0.0026	0.0444	0.0429
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.1089	0.2137
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0173	0.5058	0.505
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.5058	1
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.1389
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0109	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.041	0.0791
Brugia malayi	hypothetical protein	0.0173	0.5058	1
Plasmodium vivax	unspecified product	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0411	0.0793
Schistosoma mansoni	zinc phosphodiesterase	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0788	0.1539
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.0316
Entamoeba histolytica	alkyl sulfatase, putative	0.0173	0.5058	1
Echinococcus multilocularis	lamin dm0	0.0026	0.0444	0.0429
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.1389
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0047	0.1089	0.1581
Brugia malayi	intermediate filament protein	0.0026	0.0444	0.077
Schistosoma mansoni	hypothetical protein	0.0033	0.0658	0.1129
Mycobacterium tuberculosis	Conserved protein	0.0173	0.5058	1
Echinococcus multilocularis	alkaline phosphatase	0.0168	0.487	0.4863
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0173	0.5058	1
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0572	0.1112
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0173	0.5058	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0015	0.003
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0168	0.487	0.4863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.1389
Leishmania major	cleavage and polyadenylation specificity factor, putative	0.0173	0.5058	1
Trypanosoma cruzi	glyoxalase II	0.0173	0.5058	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0344	0.0376
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0047	0.1089	0.198
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0047	0.1089	0.198
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0344	0.0474
Mycobacterium tuberculosis	Beta lactamase like protein	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0496	0.0961
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0097	0.2648	0.4889
Trichomonas vaginalis	beta lactamase domain, putative	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0496	0.0961
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0411	0.0793
Mycobacterium ulcerans	hydrolase	0.0173	0.5058	1
Toxoplasma gondii	metallo-beta-lactamase domain-containing protein	0.0173	0.5058	1
Leishmania major	hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0874	0.171
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0173	0.5058	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.002	0.0227	0.0238
Leishmania major	metallo-beta-lactamase family protein-like protein	0.0173	0.5058	1
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0173	0.5058	1
Mycobacterium ulcerans	Zn-dependent glyoxylase	0.0173	0.5058	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0047	0.1089	0.198
Entamoeba histolytica	heat shock transcription factor, putative	0.0097	0.2648	0.4889
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0098	0.0083
Loa Loa (eye worm)	phosphatidylinositol 3	0.0016	0.0109	0.0216
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0173	0.5058	1
Mycobacterium ulcerans	hypothetical protein	0.0173	0.5058	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0344	0.0434
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0173	0.5058	1
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0173	0.5058	0.505
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0109	0.0196
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0173	0.5058	0.505
Loa Loa (eye worm)	hypothetical protein	0.0173	0.5058	1
Mycobacterium leprae	conserved hypothetical protein	0.0173	0.5058	1
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0098	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.0316
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0173	0.5058	1
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0173	0.5058	0.505
Plasmodium vivax	hydroxyacyl glutathione hydrolase, putative	0.0173	0.5058	1
Trypanosoma brucei	cleavage and polyadenylation specificity factor subunit, putative	0.0173	0.5058	1
Leishmania major	hypothetical protein, conserved	0.0173	0.5058	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0047	0.1089	0.1076
Echinococcus granulosus	lamin dm0	0.0026	0.0444	0.0429
Schistosoma mansoni	lamin	0.0026	0.0444	0.0698
Mycobacterium tuberculosis	Possible hydrolase	0.0173	0.5058	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0344	0.0474
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0037	0.0789	0.1373
Entamoeba histolytica	heat shock transcription factor, putative	0.0097	0.2648	0.4889
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0037	0.0789	0.1373
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0173	0.5058	0.505
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0173	0.5058	1
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0173	0.5058	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0344	0.068
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0344	0.0376
Onchocerca volvulus		0.0173	0.5058	1
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0168	0.487	0.4863
Trypanosoma cruzi	target of rapamycin kinase 3	0.0037	0.0789	0.1373
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.016	0.006
Onchocerca volvulus	Hydroxyacylglutathione hydrolase, mitochondrial homolog	0.0173	0.5058	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0344	0.0569
Schistosoma mansoni	zinc phosphodiesterase	0.0173	0.5058	1
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0173	0.5058	0.505
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0016	0.0109	0.0101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.1389
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0173	0.5058	1
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.5058	1
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0444	0.0698
Mycobacterium ulcerans	hypothetical protein	0.0173	0.5058	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0344	0.0376
Mycobacterium ulcerans	hydrolase	0.0173	0.5058	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0788	0.1539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.041	0.0791
Trichomonas vaginalis	beta lactamase domain, putative	0.0173	0.5058	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0047	0.1089	0.198
Echinococcus granulosus	GPCR family 2	0.0015	0.0098	0.0083
Mycobacterium tuberculosis	Possible hydrolase	0.0173	0.5058	1
Schistosoma mansoni	hypothetical protein	0.0173	0.5058	1
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0168	0.487	0.4863
Leishmania major	metallo-beta-lactamase family-like protein	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.1389
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0173	0.5058	1
Wolbachia endosymbiont of Brugia malayi	metallo-beta-lactamase superfamily hydrolase	0.0173	0.5058	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0344	0.0376
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0047	0.1089	0.2061
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0344	0.0569
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0312	0.041
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0173	0.5058	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0173	0.5058	1
Schistosoma mansoni	hypothetical protein	0.0173	0.5058	1
Giardia lamblia	Metallo-beta-lactamase superfamily protein	0.0173	0.5058	1
Mycobacterium ulcerans	hypothetical protein	0.0173	0.5058	1
Trypanosoma brucei	hydroxyacylglutathione hydrolase, putative	0.0173	0.5058	1
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0173	0.5058	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0344	0.0569
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0173	0.5058	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0711	0.1389
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0109	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.1089	0.2137
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0173	0.5058	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0173	0.5058	1
Echinococcus multilocularis	musashi	0.0026	0.0444	0.0429
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0444	0.077
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0098	0.0083
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0047	0.1089	0.198
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0344	0.0376
Echinococcus multilocularis	ETHE1 protein	0.0173	0.5058	0.505
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0047	0.1089	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0173	0.5058	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1367435

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1220436