Detailed information for compound 1220710

Basic information

Technical information
  • TDR Targets ID: 1220710
  • Name: 8-methyl-6-(2-oxo-2-pyrrolidin-1-ylethyl)pyri do[2,3-b][1,5]benzoxazepin-5-one
  • MW: 337.372 | Formula: C19H19N3O3
  • H donors: 0 H acceptors: 3 LogP: 2.19 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)N(CC(=O)N1CCCC1)C(=O)c1c(O2)nccc1
  • InChi: 1S/C19H19N3O3/c1-13-6-7-16-15(11-13)22(12-17(23)21-9-2-3-10-21)19(24)14-5-4-8-20-18(14)25-16/h4-8,11H,2-3,9-10,12H2,1H3
  • InChiKey: RQSRBRPMFAAJJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-methyl-6-(2-oxo-2-pyrrolidin-1-yl-ethyl)pyrido[2,3-b][1,5]benzoxazepin-5-one
  • 8-methyl-6-(2-oxo-2-1-pyrrolidinylethyl)-5-pyrido[2,3-b][1,5]benzoxazepinone
  • 6-(2-keto-2-pyrrolidin-1-yl-ethyl)-8-methyl-pyrido[2,3-b][1,5]benzoxazepin-5-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0035 0.0558 0.085
Brugia malayi hypothetical protein 0.0025 0.026 0.0397
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1925 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0283 0.3605
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0283 0.3605
Schistosoma mansoni chromobox protein 0.0084 0.1925 0.1925
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0784 0.1065
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0501 0.1327
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2865 0.2865
Schistosoma mansoni retinoic acid receptor RXR 0.0116 0.2817 0.2817
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0887 0.2188
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0283 0.3605
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.2331 0.2331
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0988 0.4293
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0759 0.0759
Brugia malayi hypothetical protein 0.0233 0.6104 0.9301
Leishmania major importin beta-1 subunit, putative 0.0028 0.0356 0.4539
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0784 0.5
Brugia malayi MH2 domain containing protein 0.0118 0.2865 0.4366
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0784 0.3051
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0784 0.3051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0558 0.0558
Schistosoma mansoni ran 0.0026 0.0283 0.0283
Echinococcus multilocularis geminin 0.0167 0.425 0.425
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0541 0.6898
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0283 0.5123
Echinococcus multilocularis snurportin 1 0.0372 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1258 0.1258
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.026 0.332
Brugia malayi Bromodomain containing protein 0.0035 0.0551 0.084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0295 0.0295
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1925 0.1925
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0784 0.5
Echinococcus granulosus importin subunit beta 1 0.0035 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0067 0.1448 0.1448
Loa Loa (eye worm) hypothetical protein 0.0121 0.2952 0.2952
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.6104 0.6104
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0436 0.0664
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0283 0.0283
Onchocerca volvulus Huntingtin homolog 0.0121 0.2952 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0784 0.3051
Leishmania major hypothetical protein, conserved 0.0043 0.0784 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0309 0.0309
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0551 0.7037
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0283 0.3605
Brugia malayi Heterochromatin protein 1 0.0084 0.1925 0.2934
Schistosoma mansoni survival motor neuron protein 0.0048 0.0897 0.0897
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0541 0.6898
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0551 0.7037
Entamoeba histolytica hypothetical protein 0.0028 0.0356 0.2657
Schistosoma mansoni hypothetical protein 0.0167 0.425 0.425
Loa Loa (eye worm) hypothetical protein 0.0043 0.0784 0.0784
Entamoeba histolytica hypothetical protein 0.0035 0.0558 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0784 0.5
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0784 0.1065
Schistosoma mansoni hypothetical protein 0.0031 0.0436 0.0436
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0939 0.0939
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.026 0.332
Loa Loa (eye worm) hypothetical protein 0.0043 0.0784 0.0784
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0784 0.1065
Echinococcus multilocularis GPCR, family 2 0.0031 0.0436 0.0436
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0784 0.0784
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.026 0.4718
Mycobacterium tuberculosis Conserved protein 0.0043 0.0784 0.1065
Loa Loa (eye worm) hypothetical protein 0.0035 0.0541 0.0541
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0551 0.0551
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0784 0.3051
Loa Loa (eye worm) hypothetical protein 0.0043 0.0784 0.0784
Entamoeba histolytica hypothetical protein 0.0035 0.0558 1
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1448 0.2207
Schistosoma mansoni hypothetical protein 0.0031 0.0436 0.0436
Schistosoma mansoni ran 0.0026 0.0283 0.0283
Echinococcus multilocularis chromobox protein 1 0.0084 0.1925 0.1925
Loa Loa (eye worm) hypothetical protein 0.0043 0.0784 0.0784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.2331 0.2331
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0551 0.0551
Onchocerca volvulus 0.0043 0.0784 0.1797
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.2331 0.2331
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.026 0.332
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0784 1
Trichomonas vaginalis esterase, putative 0.0043 0.0784 0.3051
Loa Loa (eye worm) hypothetical protein 0.0025 0.026 0.026
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.6104 0.6104
Schistosoma mansoni chromobox protein 0.0084 0.1925 0.1925
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.7362 1
Echinococcus granulosus chromobox protein 1 0.0084 0.1925 0.1925
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0897 0.1367
Loa Loa (eye worm) hypothetical protein 0.0043 0.0784 0.0784
Brugia malayi beta-lactamase 0.0043 0.0784 0.1194
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0759 0.0759
Schistosoma mansoni jumonji domain containing protein 0.0092 0.2135 0.2135
Schistosoma mansoni hypothetical protein 0.0048 0.0897 0.0897
Loa Loa (eye worm) hypothetical protein 0.0043 0.0784 0.0784
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0356 0.4539
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0551 0.7037
Schistosoma mansoni lamin 0.0027 0.0309 0.0309
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0558 0.0558
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0784 1
Plasmodium falciparum phd finger protein, putative 0.0035 0.0551 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0108 0.2588 0.2588
Mycobacterium ulcerans beta-lactamase 0.0043 0.0784 0.5
Loa Loa (eye worm) hypothetical protein 0.0233 0.6104 0.6104
Echinococcus multilocularis chromobox protein 1 0.0084 0.1925 0.1925
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0283 0.0283
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0784 0.1065
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0939 0.0939
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0784 0.3051
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0988 0.4293
Onchocerca volvulus 0.0037 0.0601 0.1106
Schistosoma mansoni importin beta-1 0.0035 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0037 0.0601 0.0601
Echinococcus multilocularis peregrin 0.0035 0.0551 0.0551
Mycobacterium leprae Probable lipase LipE 0.0043 0.0784 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2801 0.2801
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0784 0.0784
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.026 0.332
Leishmania major GTP-binding protein, putative 0.0026 0.0283 0.3605
Loa Loa (eye worm) hypothetical protein 0.0121 0.2952 0.2952
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0249 0.6562 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.2331 0.2331
Toxoplasma gondii ABC1 family protein 0.0043 0.0784 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.2331 0.2331
Brugia malayi Importin beta-1 subunit 0.0035 0.0541 0.0824
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0309 0.0309
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.2321 0.3536
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0182 0.4677 0.4677
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.026 0.4718
Brugia malayi beta-lactamase family protein 0.0043 0.0784 0.1194
Loa Loa (eye worm) beta-lactamase 0.0043 0.0784 0.0784
Mycobacterium ulcerans hypothetical protein 0.0043 0.0784 0.5
Schistosoma mansoni hypothetical protein 0.0067 0.1448 0.1448
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0887 0.3681
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0436 0.0436
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0551 0.0551
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0887 0.0887
Echinococcus granulosus peregrin 0.0035 0.0551 0.0551
Schistosoma mansoni hypothetical protein 0.0031 0.0436 0.0436
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0436 0.0436
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.2321 0.2321
Schistosoma mansoni intermediate filament proteins 0.0027 0.0309 0.0309
Echinococcus granulosus geminin 0.0167 0.425 0.425
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0436 0.0436
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0436 0.0664
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0356 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0501 0.1327
Echinococcus granulosus lamin dm0 0.0027 0.0309 0.0309
Entamoeba histolytica hypothetical protein 0.0035 0.0558 1
Schistosoma mansoni hypothetical protein 0.0167 0.425 0.425
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1925 1
Leishmania major hypothetical protein, conserved 0.0025 0.026 0.332
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0283 0.0283
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1604 0.1604
Loa Loa (eye worm) hypothetical protein 0.0249 0.6562 0.6562
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0784 0.1065
Mycobacterium tuberculosis Conserved protein 0.0043 0.0784 0.1065
Echinococcus granulosus intermediate filament protein 0.0027 0.0309 0.0309
Onchocerca volvulus Alhambra homolog 0.0035 0.0551 0.0918
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0116 0.2817 0.2817
Schistosoma mansoni lamin 0.0027 0.0309 0.0309
Schistosoma mansoni hypothetical protein 0.0035 0.0558 0.0558
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2865 0.2865
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2801 0.2801
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0182 0.4677 0.4677
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0784 0.1065
Plasmodium falciparum importin beta, putative 0.0035 0.0541 0.9804
Echinococcus multilocularis lamin dm0 0.0027 0.0309 0.0309
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0759 0.0759
Echinococcus granulosus lamin 0.0027 0.0309 0.0309
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0541 0.0541
Entamoeba histolytica hypothetical protein 0.0035 0.0558 1
Echinococcus multilocularis musashi 0.0027 0.0309 0.0309
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.2331 0.2331
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0784 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0784 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0031 0.0436 0.0436
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.026 0.332
Brugia malayi PHD-finger family protein 0.0035 0.0551 0.084
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0558 0.0558
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.2331 0.3552
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0356 0.0446
Brugia malayi RNA, U transporter 1 0.0099 0.2343 0.3571
Brugia malayi beta-lactamase family protein 0.0043 0.0784 0.1194
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0784 0.0784
Echinococcus multilocularis lamin 0.0027 0.0309 0.0309
Onchocerca volvulus Huntingtin homolog 0.0121 0.2952 1
Schistosoma mansoni hypothetical protein 0.0372 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0784 0.1194
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0283 0.0431
Mycobacterium tuberculosis Conserved protein 0.0043 0.0784 0.1065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.2331 0.2331
Brugia malayi hypothetical protein 0.0121 0.2952 0.4498
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0784 0.1065
Schistosoma mansoni hypothetical protein 0.0035 0.0551 0.0551
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0784 0.0784
Echinococcus granulosus chromobox protein 1 0.0084 0.1925 0.1925
Brugia malayi intermediate filament protein 0.0027 0.0309 0.0471
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0759 0.0759
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0551 0.0551
Onchocerca volvulus 0.0043 0.0784 0.1797
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.2331 0.2331
Schistosoma mansoni hypothetical protein 0.0031 0.0436 0.0436
Brugia malayi chromobox protein homolog 3 0.0047 0.0887 0.1352
Brugia malayi hypothetical protein 0.0016 0.0013 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0759 0.0759
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0309 0.0471
Brugia malayi jmjC domain containing protein 0.0115 0.2801 0.4267
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0784 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0356 0.0446
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0541 0.6898
Plasmodium vivax importin-beta 2, putative 0.0035 0.0541 0.6898
Loa Loa (eye worm) hypothetical protein 0.0035 0.0551 0.0551
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0988 0.2569
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0887 0.3681
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0283 0.3605
Onchocerca volvulus 0.0048 0.0897 0.2226
Onchocerca volvulus 0.0043 0.0784 0.1797
Echinococcus granulosus GPCR family 2 0.0031 0.0436 0.0436
Brugia malayi jmjC domain containing protein 0.0043 0.0759 0.1157
Giardia lamblia PHD finger protein 15 0.0035 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0309 0.0309

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2818 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.