TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 478.52 | Formula: C24H22N4O5S
H donors: 1 H acceptors: 7 LogP: 1.49 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C(=C(C(N1Cc1cccnc1)c1ccncc1)C(=O)c1ccc(cc1)S(=O)(=O)N(C)C)O
InChi: 1S/C24H22N4O5S/c1-27(2)34(32,33)19-7-5-18(6-8-19)22(29)20-21(17-9-12-25-13-10-17)28(24(31)23(20)30)15-16-4-3-11-26-14-16/h3-14,21,30H,15H2,1-2H3
InChiKey: PGCCGZQSMVNTHW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	arachidonate 15-lipoxygenase, type B	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing	Get druggable targets OG5_127482	All targets in OG5_127482
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus granulosus	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative	Get druggable targets OG5_127482	All targets in OG5_127482
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	esterase, putative	0.0035	0.0072	0.0307
Brugia malayi	Muscleblind-like protein	0.018	0.063	0.3791
Schistosoma mansoni	hypothetical protein	0.004	0.009	0.009
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0017	0.0017
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0947	0.3579	0.8001
Trichomonas vaginalis	hypothetical protein	0.0022	0.0022	0.0094
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0072	0.0126
Loa Loa (eye worm)	jmjC domain-containing protein	0.0027	0.0038	0.0229
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0078	0.0234	0.0234
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0083	0.0255	0.0538
Onchocerca volvulus		0.0057	0.0155	0.0815
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0054	0.0144	0.0616
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0053	0.0053
Brugia malayi	Heterochromatin protein 1	0.0076	0.0229	0.1379
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0017	0.0017
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.0229	0.098
Plasmodium falciparum	protease, putative	0.0021	0.0016	0.0044
Onchocerca volvulus	Huntingtin homolog	0.0128	0.0428	0.2253
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	0.01	0.0322	0.1375
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0017	0.0017
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.0466	0.0466
Echinococcus multilocularis	musashi	0.0057	0.0155	0.0155
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0053	0.0053
Echinococcus granulosus	lysine specific demethylase 5A	0.011	0.0359	0.0359
Trypanosoma brucei	protein kinase, putative	0.0054	0.0145	0.4316
Echinococcus granulosus	RUN	0.0024	0.0028	0.0028
Brugia malayi	Furin-like cysteine rich region family protein	0.0144	0.0491	0.2956
Giardia lamblia	PHD finger protein 15	0.003	0.0053	0.0128
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.01	0.0322	0.0322
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0028	0.0028
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0083	0.0255	0.0673
Schistosoma mansoni	cpg binding protein	0.0194	0.0683	0.0683
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0053	0.0319
Loa Loa (eye worm)	hypothetical protein	0.003	0.0053	0.0319
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0017	0.0104
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0072	0.0307
Toxoplasma gondii	exonuclease III APE	0.0023	0.0023	0.0182
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0027	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.004	0.009	0.009
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0023	0.0024	0.0024
Echinococcus multilocularis	epidermal growth factor receptor	0.0078	0.0234	0.0234
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.0445	0.0445
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0027	0.0038	0.1183
Schistosoma mansoni	hypothetical protein	0.2615	1	1
Entamoeba histolytica	CAAX amino terminal protease family	0.0021	0.0016	0.0067
Echinococcus multilocularis	survival motor neuron protein 1	0.0252	0.0905	0.0905
Echinococcus granulosus	muscleblind protein	0.018	0.063	0.063
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0072	0.2231
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0411
Echinococcus granulosus	epidermal growth factor receptor	0.0144	0.0491	0.0491
Schistosoma mansoni	hypothetical protein	0.004	0.009	0.009
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.3143	0.3143
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0072	0.0072
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0017	0.0104
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0023	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0411
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0017	0.0104
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.0145	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0017	0.0104
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0023	0.0141
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0072	0.0126
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0072	0.0432
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0218	0.0455
Onchocerca volvulus		0.008	0.0245	0.129
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0023	0.0729
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0624	0.2339	1
Trypanosoma cruzi	CAAX prenyl protease 2, putative	0.01	0.0322	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0054	0.0144	0.0616
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0072	0.0072
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0179	0.0626	0.3295
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0028	0.0166
Brugia malayi	CHD4 protein	0.0023	0.0024	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0626	0.3764
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.0466	0.0466
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.01	0.0529
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0099	0.0099
Loa Loa (eye worm)	jmjC domain-containing protein	0.0027	0.0038	0.0229
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.0145	0.0145
Schistosoma mansoni	jumonji/arid domain-containing protein	0.011	0.0359	0.0359
Brugia malayi	Latrophilin receptor protein 2	0.0084	0.0258	0.1551
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0083	0.0255	0.0713
Echinococcus granulosus	Polycystic kidney disease protein	0.0024	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0631	0.3797
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0023	0.0065
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0017	0.0091
Schistosoma mansoni	tyrosine kinase	0.0077	0.0231	0.0231
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0027	0.0038	0.0894
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.007	0.0299
Toxoplasma gondii	histone lysine methyltransferase SET1	0.035	0.1284	1
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0083	0.0255	0.2073
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0218	0.0455
Entamoeba histolytica	CAAX amino terminal protease family	0.0021	0.0016	0.0067
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0028	0.0028
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0017	0.0104
Brugia malayi	jmjC domain containing protein	0.0027	0.0038	0.0229
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0072	0.0432
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0114	0.0683
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	0.01	0.0322	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0359	0.1318	0.1318
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0095	0.0407
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0028	0.0166
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0145	0.4497
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0197	0.1184
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0046	0.0114	0.0114
Onchocerca volvulus		0.0035	0.0072	0.0378
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0142	0.0484	0.0484
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Loa Loa (eye worm)	hypothetical protein	0.002	0.0015	0.0088
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0054	0.0145	0.4497
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0411
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0059	0.0164	0.0164
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0017	0.0017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0023	0.0023
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0017	0.0017
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0095	0.0095
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0053	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0411
Echinococcus granulosus	epidermal growth factor receptor	0.0078	0.0234	0.0234
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0624	0.2339	1
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0023	0.01
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0947	0.3579	1
Schistosoma mansoni	SET domain protein	0.0017	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0277	0.1664
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0029	0.0046	0.0046
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.3143	0.3143
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0255	0.1535
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.001	0.0044
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0305	0.111	0.2457
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0017	0.0017
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0072	0.037
Brugia malayi	N-terminal motif family protein	0.0179	0.0626	0.3764
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0084	0.0258	0.0258
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0017	0.0104
Onchocerca volvulus	Huntingtin homolog	0.0128	0.0428	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0065	0.039
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0017	0.0104
Onchocerca volvulus		0.0024	0.0028	0.0146
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0264	0.0953	0.5733
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0072	0.0136
Loa Loa (eye worm)	hypothetical protein	0.018	0.063	0.3791
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.0445	0.0445
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0059	0.0164	0.0164
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0178	0.1068
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0142	0.0484	0.0484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0017	0.0104
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.0197	0.0197
Brugia malayi	MAP kinase sur-1	0.0054	0.0145	0.087
Loa Loa (eye worm)	TAR-binding protein	0.0132	0.0445	0.2676
Echinococcus multilocularis	chromobox protein 1	0.0076	0.0229	0.0229
Onchocerca volvulus		0.0035	0.0072	0.0378
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0072	0.0136
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0048	0.0121	0.0121
Mycobacterium ulcerans	lipase LipD	0.0035	0.0072	0.0126
Entamoeba histolytica	CAAX prenyl protease family	0.01	0.0322	0.1375
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0017	0.0104
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0095	0.0573
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.0113	0.0482
Echinococcus granulosus	peregrin	0.003	0.0053	0.0053
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.018	0.559
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0024	0.0028	0.0166
Onchocerca volvulus		0.0158	0.0542	0.2857
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0072	0.0136
Schistosoma mansoni	myst-related protein	0.0022	0.0019	0.0019
Schistosoma mansoni	rab6-interacting	0.0024	0.0028	0.0028
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0048	0.0121	0.0121
Echinococcus multilocularis	muscleblind protein 1	0.018	0.063	0.063
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0057	0.0155	0.0931
Schistosoma mansoni	rab6-interacting	0.0024	0.0028	0.0028
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0072	0.0136
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0218	0.0218
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0054	0.0145	0.4316
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.0445	0.0445
Brugia malayi	hypothetical protein	0.0024	0.0028	0.0166
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0017	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0255	0.1535
Schistosoma mansoni	lipoxygenase	0.0142	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0258	0.1551
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.003	0.0053	0.032
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.0947	0.3579	0.8001
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0017	0.0104
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0017	0.0104
Echinococcus multilocularis	lamin	0.0057	0.0155	0.0155
Schistosoma mansoni	amine oxidase	0.0083	0.0255	0.0255
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0145	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0905	0.5443
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0084	0.0258	0.1551
Schistosoma mansoni	tyrosine kinase	0.0077	0.0231	0.0231
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0017	0.0017
Brugia malayi	SET domain containing protein	0.0019	0.0008	0.0051
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0307	0.0307
Echinococcus multilocularis	tar DNA binding protein	0.0132	0.0445	0.0445
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.3143	0.3143
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0027	0.0038	0.0296
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0025	0.0032	0.0039
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0072	0.0432
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0072	0.0307
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0132	0.0445	0.2676
Onchocerca volvulus	Alhambra homolog	0.003	0.0053	0.0279
Brugia malayi	Intermediate filament tail domain containing protein	0.0057	0.0155	0.0931
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.0229	0.098
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0624	0.2339	1
Brugia malayi	chromobox protein homolog 3	0.0043	0.01	0.0604
Schistosoma mansoni	tyrosine kinase	0.0077	0.0231	0.0231
Brugia malayi	jmjC domain containing protein	0.0027	0.0038	0.0229
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.018	0.559
Echinococcus granulosus	CAAX prenyl protease 2	0.01	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0264	0.0953	0.5733
Onchocerca volvulus		0.0021	0.0017	0.0091
Loa Loa (eye worm)	heterochromatin protein 1	0.0076	0.0229	0.1379
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0017	0.0104
Schistosoma mansoni	hypothetical protein	0.0084	0.0258	0.0258
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.0113	0.0594
Schistosoma mansoni	jumonji domain containing protein	0.0142	0.0481	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0017	0.0104
Schistosoma mansoni	ap endonuclease	0.0023	0.0023	0.0023
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0162	0.056	0.056
Plasmodium falciparum	zinc finger protein, putative	0.0022	0.0019	0.0054
Mycobacterium ulcerans	oxidoreductase	0.0083	0.0255	0.0538
Echinococcus multilocularis	chromobox protein 1	0.0076	0.0229	0.0229
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0072	0.0072
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0017	0.0104
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0025	0.0032	0.007
Schistosoma mansoni	phosphatidylserine receptor	0.0027	0.0038	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.018	0.559
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0072	0.0432
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0624	0.2339	1
Brugia malayi	SWIRM domain containing protein	0.0083	0.0255	0.1535
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0218	0.049
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.0159	0.4932
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0392	0.1444	0.1444
Schistosoma mansoni	protein phosphatase 2C	0.0027	0.0038	0.0038
Plasmodium vivax	hypothetical protein, conserved	0.0083	0.0255	0.0713
Brugia malayi	jmjC domain containing protein	0.011	0.0359	0.2159
Entamoeba histolytica	hypothetical protein	0.0022	0.0019	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0052	0.0224
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0017	0.0017
Entamoeba histolytica	fatty acid elongase, putative	0.0123	0.0409	0.1749
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0072	0.2231
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0162	0.056	0.056
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0037	0.0078	0.0078
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0307	0.0307
Trypanosoma cruzi	ISWI complex protein	0.0019	0.001	0.0318
Giardia lamblia	Kinase, CMGC MAPK	0.0054	0.0145	0.0523
Trichomonas vaginalis	set domain proteins, putative	0.051	0.1899	0.8119
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.025
Brugia malayi	Bromodomain containing protein	0.003	0.0053	0.0319
Brugia malayi	CAAX amino terminal protease family protein	0.01	0.0322	0.1934
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0017	0.0104
Entamoeba histolytica	fatty acid elongase, putative	0.0123	0.0409	0.1749
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.01	0.0429
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0068	0.0197	0.0197
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0017	0.0104
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.0145	0.087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Echinococcus granulosus	expressed conserved protein	0.0091	0.0285	0.0285
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0145	0.0618
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0054	0.0144	0.0616
Brugia malayi	amine oxidase, flavin-containing family protein	0.0083	0.0255	0.1535
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0128	0.3968
Leishmania major	cathepsin L-like protease	0.0063	0.018	0.559
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0017	0.0017
Brugia malayi	beta-lactamase family protein	0.0035	0.0072	0.0432
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0017	0.0017
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.0113	0.0482
Brugia malayi	Pre-SET motif family protein	0.0068	0.0197	0.1184
Schistosoma mansoni	tyrosine kinase	0.0078	0.0234	0.0234
Schistosoma mansoni	jumonji/arid domain-containing protein	0.011	0.0359	0.0359
Echinococcus multilocularis	dnaJ subfamily B	0.2615	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0027	0.0038	0.0229
Chlamydia trachomatis	oxoacyl-ACP synthase III	0.0947	0.3579	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0084	0.0258	0.1551
Brugia malayi	hypothetical protein	0.0158	0.0542	0.3263
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0038	0.0226
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0025	0.0032	0.0046
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0624	0.2339	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0084	0.0258	0.0258
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.0803	0.1905
Brugia malayi	jmjC domain containing protein	0.0162	0.056	0.337
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.1095	0.4149	1
Onchocerca volvulus		0.0083	0.0255	0.1344
Mycobacterium ulcerans	dehydrogenase	0.0083	0.0255	0.0538
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.0947	0.3579	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0053	0.0413
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.001	0.0044
Loa Loa (eye worm)	RNA binding protein	0.0132	0.0445	0.2676
Onchocerca volvulus		0.0017	0.0001	0.0004
Toxoplasma gondii	histone lysine-specific demethylase	0.0083	0.0255	0.1988
Echinococcus granulosus	jumonji domain containing 1A	0.0027	0.0038	0.0038
Toxoplasma gondii	hypothetical protein	0.0021	0.0016	0.0121
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0218	0.17
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0072	0.0432
Schistosoma mansoni	myst-related protein	0.0022	0.0019	0.0019
Echinococcus multilocularis	epidermal growth factor receptor	0.0144	0.0491	0.0491
Schistosoma mansoni	lamin	0.0057	0.0155	0.0155
Brugia malayi	latrophilin 2 splice variant baaae	0.0181	0.0631	0.3797
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0144	0.0491	0.2956
Schistosoma mansoni	lipoxygenase	0.01	0.0319	0.0319
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0072	0.0126
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.0145	0.0145
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0083	0.0255	0.0255
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0023	0.0424
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0025	0.0032	0.0248
Loa Loa (eye worm)	TK/INSR protein kinase	0.0046	0.0114	0.0683
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1693	0.6449	0.6449
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0255	0.1535
Leishmania major	phosphopantetheinyl transferase-like protein	0.0025	0.0032	0.099
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0025	0.0032	0.0248
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0083	0.0255	0.0255
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.0445	0.0445
Brugia malayi	nuclear hormone receptor	0.0021	0.0017	0.0104
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0072	0.0432
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0218	0.0455
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.018	0.559
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0218	0.0218
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0264	0.0953	0.5733
Schistosoma mansoni	patched 1	0.0041	0.0095	0.0095
Brugia malayi	RNA binding protein	0.0132	0.0445	0.2676
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0542	0.3263
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0264	0.0953	0.5733
Brugia malayi	intermediate filament protein	0.0057	0.0155	0.0931
Schistosoma mansoni	lamin	0.0057	0.0155	0.0155
Onchocerca volvulus		0.0051	0.0134	0.0704
Schistosoma mansoni	phd/f-box containing protein	0.0027	0.0038	0.0038
Echinococcus multilocularis	RUN	0.0024	0.0028	0.0028
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0084	0.0258	0.0258
Schistosoma mansoni	hypothetical protein	0.0084	0.0258	0.0258
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0046	0.0114	0.0114
Brugia malayi	RNA recognition motif domain containing protein	0.0132	0.0445	0.2676
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.0947	0.3579	0.8619
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0023	0.01
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0411
Onchocerca volvulus		0.0089	0.0277	0.1457
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0054	0.0144	0.0616
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0083	0.0255	0.0255
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0072	0.0136
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0048	0.0121	0.0121
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.0445	0.0445
Brugia malayi	PHD-finger family protein	0.002	0.0015	0.0088
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0094	0.0298	0.2324
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0017	0.0091
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0072	0.0307
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0095	0.0095
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0017	0.0104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0053	0.0148
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0032	0.0058	0.0249
Onchocerca volvulus		0.0184	0.0643	0.3385
Brugia malayi	PHD-finger family protein	0.003	0.0053	0.0319
Schistosoma mansoni	polycystin 1-related	0.0024	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0038	0.0229
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0023	0.01
Schistosoma mansoni	hypothetical protein	0.004	0.009	0.009
Echinococcus multilocularis	jumonji domain containing 1A	0.0027	0.0038	0.0038
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0017	0.0017
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0218	0.6786
Brugia malayi	CXXC zinc finger family protein	0.0184	0.0643	0.3866
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0017	0.0104
Mycobacterium ulcerans	monoamine oxidase	0.0083	0.0255	0.0538
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0025	0.0032	0.0024
Schistosoma mansoni	tyrosine kinase	0.0078	0.0234	0.0234
Echinococcus granulosus	L aminoadipate semialdehyde	0.0089	0.0277	0.0277
Onchocerca volvulus		0.0035	0.0072	0.0378
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0054	0.0145	0.4497
Brugia malayi	F/Y-rich N-terminus family protein	0.0068	0.0199	0.1198
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0624	0.2339	1
Loa Loa (eye worm)	doublecortin family protein	0.0024	0.0028	0.0166
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0043	0.01	0.0604
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0072	0.0136
Echinococcus granulosus	chromobox protein 1	0.0076	0.0229	0.0229
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Schistosoma mansoni	hypothetical protein	0.0084	0.0258	0.0258
Echinococcus granulosus	lamin	0.0057	0.0155	0.0155
Echinococcus multilocularis	insulin receptor	0.0046	0.0114	0.0114
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.0947	0.3579	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0307	0.1848
Toxoplasma gondii	ABC1 family protein	0.0035	0.0072	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0428	0.2573
Brugia malayi	jmjC domain containing protein	0.0027	0.0038	0.0229
Plasmodium vivax	JmjC domain containing protein	0.0027	0.0038	0.0106
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0017	0.0017
Toxoplasma gondii	CAAX amino terminal protease family protein	0.0021	0.0016	0.0121
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.0145	0.1126
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0017	0.0104
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0054	0.0144	0.0616
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0118	0.0118
Echinococcus granulosus	geminin	0.0359	0.1318	0.1318
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0027	0.0038	0.1183
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.0145	0.0145
Brugia malayi	SET domain containing protein	0.0017	0.0001	0.0005
Echinococcus granulosus	tar DNA binding protein	0.0132	0.0445	0.0445
Plasmodium vivax	SET domain protein, putative	0.0068	0.0197	0.055
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0145	0.0618
Echinococcus multilocularis		0.0045	0.0108	0.0108
Echinococcus multilocularis	protein patched	0.0041	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0072	0.0432
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0068	0.0197	0.1534
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0134	0.0804
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0017	0.0104
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0307	0.1848
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0052	0.0224
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0307	0.1313
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0017	0.0017
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0017	0.0104
Schistosoma mansoni	hypothetical protein	0.0084	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0131	0.0789
Loa Loa (eye worm)	CHromoDomain protein family member	0.0023	0.0024	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0155	0.0931
Loa Loa (eye worm)	jmjC domain-containing protein	0.011	0.0359	0.2159
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0072	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0017	0.0104
Brugia malayi	hypothetical protein	0.0252	0.0905	0.5443
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0201	0.1208
Echinococcus granulosus	histone lysine methyltransferase setb	0.0068	0.0197	0.0197
Giardia lamblia	Hypothetical protein	0.01	0.0322	0.1288
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0411
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0428	0.2573
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0083	0.0255	0.0713
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0624	0.2339	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0053	0.0413
Echinococcus granulosus	chromobox protein 1	0.0076	0.0229	0.0229
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0023	0.0018
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0017	0.0104
Echinococcus granulosus	cpg binding protein	0.0194	0.0683	0.0683
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0095	0.0095
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0084	0.0258	0.0258
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0058	0.0159	0.0159
Schistosoma mansoni	amine oxidase	0.0083	0.0255	0.0255
Schistosoma mansoni	jumonji domain containing protein	0.0027	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.01	0.0429
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0449	0.1662	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0017	0.0104
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0083	0.0255	0.7937
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0017	0.0017
Leishmania major	UDP-galactopyranose mutase	0.0083	0.0255	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0072	0.0432
Schistosoma mansoni	chromobox protein	0.0076	0.0229	0.0229
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0054	0.0144	0.0616
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0017	0.0017
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0028	0.0028
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1178	0.4469	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0305	0.111	0.2647
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0083	0.0255	0.7937
Echinococcus multilocularis	GPCR, family 2	0.0084	0.0258	0.0258
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0017	0.0104
Echinococcus multilocularis	CAAX prenyl protease 2	0.01	0.0322	0.0322
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0017	0.0048
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0032	0.0089
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0184	0.0643	0.3866
Loa Loa (eye worm)	histone methyltransferase	0.0059	0.0164	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0017	0.0104
Loa Loa (eye worm)	intermediate filament protein	0.0057	0.0155	0.0931
Brugia malayi	steroid hormone receptor	0.0021	0.0017	0.0104
Schistosoma mansoni	coup transcription factor	0.0021	0.0017	0.0017
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0023	0.0034
Onchocerca volvulus		0.0057	0.0155	0.0815
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0017	0.0091
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0054	0.0145	0.4497
Schistosoma mansoni	cpg binding protein	0.0184	0.0643	0.0643
Brugia malayi	CHE-14 protein	0.0041	0.0095	0.0573
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0017	0.0017
Echinococcus multilocularis	Polycystic kidney disease protein	0.0024	0.0028	0.0028
Schistosoma mansoni	ap endonuclease	0.0023	0.0023	0.0023
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0035	0.007	0.0299
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1178	0.4469	1
Brugia malayi	ecdysteroid receptor	0.0021	0.0017	0.0104
Echinococcus multilocularis	JmjC domain containing protein 4	0.0027	0.0038	0.0038
Echinococcus granulosus	survival motor neuron protein 1	0.0252	0.0905	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0151	0.0907
Brugia malayi	beta-lactamase	0.0035	0.0072	0.0432
Onchocerca volvulus		0.051	0.1899	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0023	0.0729
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0024	0.0028	0.0028
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0089	0.0277	0.1664
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0255	0.1535
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0027	0.0038	0.0106
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0027	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0255	0.1535
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Leishmania major	hypothetical protein, conserved	0.0027	0.0038	0.1183
Leishmania major	hypothetical protein, conserved	0.0035	0.0072	0.2231
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0083	0.0255	0.0255
Schistosoma mansoni	hypothetical protein	0.0359	0.1318	0.1318
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0072	0.0432
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0089	0.0277	0.0277
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0305	0.111	1
Entamoeba histolytica	hypothetical protein	0.0025	0.0032	0.0136
Brugia malayi	cytoplasmic intermediate filament protein	0.003	0.0053	0.032
Leishmania major	cathepsin L-like protease	0.0063	0.018	0.559
Schistosoma mansoni	tyrosine kinase	0.0046	0.0114	0.0114
Brugia malayi	hypothetical protein	0.0128	0.0428	0.2573
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0028	0.0028
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0072	0.0307
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0072	0.0126
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0023	0.0024	0.0024
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0624	0.2339	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0038	0.0226
Echinococcus multilocularis	cpg binding protein	0.0194	0.0683	0.0683
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0017	0.0017
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0025	0.0032	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0038	0.0229
Schistosoma mansoni	loxhd1	0.0024	0.0028	0.0028
Echinococcus granulosus	insulin receptor	0.0046	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0017	0.0104
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0083	0.0255	0.058
Toxoplasma gondii	hypothetical protein	0.0021	0.0016	0.0121
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.0197	0.0197
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0072	0.0136
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0089	0.0277	0.0277
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0023	0.0024	0.0024
Onchocerca volvulus		0.0024	0.0028	0.0146
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0255	0.1535
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0021	0.0017	0.0048
Echinococcus multilocularis	lamin dm0	0.0057	0.0155	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0411
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0023	0.0729
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0023	0.0019
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0083	0.0255	0.0255
Trichomonas vaginalis	helicase, putative	0.0042	0.0096	0.0411
Plasmodium vivax	protease, putative	0.0021	0.0016	0.0044
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0095	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0017	0.0104
Schistosoma mansoni	cpg binding protein	0.0194	0.0683	0.0683
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0032	0.0694
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0072	0.037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0947	0.3579	0.8001
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0072	0.0136
Schistosoma mansoni	hypothetical protein	0.0181	0.0631	0.0631
Brugia malayi	hypothetical protein	0.0083	0.0255	0.1535
Echinococcus granulosus	lysine specific demethylase 6a	0.0027	0.0038	0.0038
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0145	0.4497
Brugia malayi	Doublecortin family protein	0.0024	0.0028	0.0166
Plasmodium vivax	hypothetical protein, conserved	0.0083	0.0255	0.0713
Plasmodium vivax	multidomain scavenger receptor, putative	0.0024	0.0028	0.0077
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0054	0.0144	0.0616
Echinococcus granulosus	JmjC domain containing protein 4	0.0027	0.0038	0.0038
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.018	0.5445
Schistosoma mansoni	hypothetical protein	0.003	0.0053	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.018	0.063	0.3791
Plasmodium falciparum	LCCL domain-containing protein	0.0024	0.0028	0.0077
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0023	0.0023
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0017	0.0017
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0624	0.2339	1
Plasmodium falciparum	protoporphyrinogen oxidase	0.0083	0.0255	0.0713
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0072	0.0136
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0027	0.0038	0.0038
Echinococcus multilocularis	lysine specific demethylase 6a	0.0027	0.0038	0.0038
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0017	0.0104
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0072	0.1976
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0017	0.0017
Echinococcus multilocularis	lysine specific demethylase 5A	0.0099	0.0319	0.0319
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0023	0.0141
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0032	0.0089
Schistosoma mansoni	intermediate filament proteins	0.0057	0.0155	0.0155
Schistosoma mansoni	chromobox protein	0.0076	0.0229	0.0229
Echinococcus multilocularis	phd:f box containing protein	0.0027	0.0038	0.0038
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0025	0.0032	0.0036
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0313	0.0313
Brugia malayi	jmjC domain containing protein	0.0027	0.0038	0.0229
Entamoeba histolytica	fatty acid elongase, putative	0.0123	0.0409	0.1749
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0017	0.0017
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0624	0.2339	1
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0072	0.0136
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0017	0.0017
Leishmania major	cathepsin L-like protease	0.0063	0.018	0.559
Treponema pallidum	fructose-bisphosphate aldolase	0.0624	0.2339	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0017	0.0104
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0083	0.0255	0.0713
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0072	0.0201
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0218	0.0218
Onchocerca volvulus		0.0033	0.0065	0.0342
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.008	0.0245	0.0245
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0218	0.0218
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0285	0.0285
Brugia malayi	beta-lactamase family protein	0.0035	0.0072	0.0432
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0054	0.0145	0.4497
Schistosoma mansoni	hypothetical protein	0.0051	0.0134	0.0134
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0017	0.0104
Echinococcus multilocularis	peregrin	0.003	0.0053	0.0053
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0054	0.0144	0.0616
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0027	0.0038	0.0296
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0017	0.0104
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0048	0.0121	0.0121
Brugia malayi	TAR-binding protein	0.0132	0.0445	0.2676
Entamoeba histolytica	fatty acid elongase, putative	0.0123	0.0409	0.1749
Echinococcus granulosus	GPCR family 2	0.0084	0.0258	0.0258
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0061	0.0172	0.0172
Echinococcus granulosus	lamin dm0	0.0057	0.0155	0.0155
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0099	0.0099
Schistosoma mansoni	tyrosine kinase	0.0046	0.0114	0.0114
Schistosoma mansoni	tyrosine kinase	0.0144	0.0491	0.0491
Entamoeba histolytica	fatty acid elongase, putative	0.0123	0.0409	0.1749
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0068	0.0197	0.0197
Echinococcus multilocularis	geminin	0.0359	0.1318	0.1318
Brugia malayi	Pre-SET motif family protein	0.0449	0.1662	1
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	0.01	0.0322	1
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.01	0.0322	0.0322
Trypanosoma brucei	CAAX amino terminal protease, putative	0.01	0.0322	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0096	0.0411
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0145	0.0618
Giardia lamblia	Fructose-bisphosphate aldolase	0.0624	0.2339	1
Echinococcus granulosus	intermediate filament protein	0.0057	0.0155	0.0155
Mycobacterium tuberculosis	Possible oxidoreductase	0.0083	0.0255	0.058
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0083	0.0255	0.0255
Echinococcus multilocularis		0.0083	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.01	0.0322	0.1934
Echinococcus multilocularis	muscleblind protein	0.018	0.063	0.063
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0083	0.0255	0.0713
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0037	0.0078	0.0078
Plasmodium falciparum	phd finger protein, putative	0.003	0.0053	0.0148
Echinococcus granulosus	phd:f box containing protein	0.0027	0.0038	0.0038

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.2818 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 1.9953 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	12.5893 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1365691

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1221096