Detailed information for compound 1221505

Basic information

Technical information
  • TDR Targets ID: 1221505
  • Name: 3-[(4-methoxyphenyl)methyl]-4,10-dihydro-2H-[ 1,3,5]triazino[2,1-b]benzimidazole
  • MW: 294.351 | Formula: C17H18N4O
  • H donors: 1 H acceptors: 1 LogP: 3.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CN1CNc2n(C1)c1ccccc1n2
  • InChi: 1S/C17H18N4O/c1-22-14-8-6-13(7-9-14)10-20-11-18-17-19-15-4-2-3-5-16(15)21(17)12-20/h2-9H,10-12H2,1H3,(H,18,19)
  • InChiKey: FUYOIHZUYLJNMJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-methoxybenzyl)-4,10-dihydro-2H-[1,3,5]triazino[2,1-b]benzimidazole
  • ChemDiv3_006702
  • STOCK4S-57560
  • IDI1_024612
  • 3-(4-Methoxy-benzyl)-1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a][1,3,5]triazine
  • MLS000558434
  • SMR000148950

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase eta, putative 0.0049 0.0939 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0492 0.0492
Trichomonas vaginalis set domain proteins, putative 0.0245 0.5338 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0181 0.391 0.7326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Brugia malayi intermediate filament protein 0.003 0.0503 0.0845
Onchocerca volvulus 0.0008 0.0001 0.0002
Mycobacterium ulcerans hypothetical protein 0.0026 0.0421 0.5226
Schistosoma mansoni hypothetical protein 0.0051 0.0964 0.0964
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.5707 0.5707
Loa Loa (eye worm) RNA binding protein 0.0062 0.123 0.2068
Echinococcus multilocularis geminin 0.0187 0.404 0.404
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0421 0.5226
Onchocerca volvulus 0.0008 0.0001 0.0002
Mycobacterium leprae Probable lipase LipE 0.0043 0.0805 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.0001 0.0001
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) intermediate filament protein 0.003 0.0503 0.0845
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Schistosoma mansoni opsin-like receptor 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0008 0.0001 0.0002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0305 0.0305
Onchocerca volvulus 0.0043 0.0805 0.1509
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0939 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0939 0.1578
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0051 0.0964 0.0964
Echinococcus granulosus neuropeptide receptor A26 0.0008 0.0001 0.0001
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0015 0.0153 0.0153
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0421 0.4483
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0028 0.0028
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0001 0.0001
Onchocerca volvulus 0.003 0.0503 0.0942
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0001 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0421 0.4483
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.6088 1
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0001 0.0001
Brugia malayi steroid hormone receptor 0.0011 0.0076 0.0129
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0805 0.1509
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0421 0.4483
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0076 0.0076
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0218 0.2323
Loa Loa (eye worm) pigment dispersing factor receptor c 0.016 0.3424 0.5756
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0001 0.0001
Brugia malayi neuropeptide F receptor 0.0008 0.0001 0.0001
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0218 0.2323
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0305 0.325
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0421 0.0691
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.3228 0.3228
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0008 0.0001 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0805 0.1323
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Brugia malayi G-protein coupled receptor 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0805 0.1323
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0129
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0964 0.162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0033 0.058 0.058
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0015 0.0153 0.1629
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0805 1
Brugia malayi beta-lactamase 0.0043 0.0805 0.1354
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Brugia malayi follicle stimulating hormone receptor 0.0008 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.3228 0.3228
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0129
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.027 0.0444
Brugia malayi CXXC zinc finger family protein 0.0032 0.0539 0.0907
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0246 0.0404
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0015 0.0153 0.1629
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0421 0.0708
Trypanosoma brucei unspecified product 0.0015 0.0156 0.1663
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0015 0.0153 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.014 0.0235
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0246 0.0404
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0805 0.8578
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0305 0.0305
Echinococcus multilocularis dnaJ subfamily B 0.0451 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0076 0.0129
Schistosoma mansoni amine GPCR 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0008 0.0001 0.0002
Onchocerca volvulus 0.0008 0.0001 0.0002
Brugia malayi hypothetical protein 0.0261 0.5707 0.9594
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0188 0.0316
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0001 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0533 0.0533
Schistosoma mansoni tar DNA-binding protein 0.0062 0.123 0.123
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0015 0.0153 0.0153
Echinococcus granulosus lamin 0.003 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0305 0.3789
Toxoplasma gondii ABC1 family protein 0.0043 0.0805 0.6689
Schistosoma mansoni hypothetical protein 0.0187 0.404 0.404
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0008 0.0001 0.0001
Echinococcus granulosus cpg binding protein 0.0033 0.058 0.058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0076 0.0076
Echinococcus multilocularis neuropeptide FF receptor 2 0.0008 0.0001 0.0001
Echinococcus multilocularis serotonin receptor 0.0008 0.0001 0.0001
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0015 0.0153 0.127
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0805 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0001 0.0001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0305 0.0305
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.016 0.3424 0.5756
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0076 0.0129
Brugia malayi RNA binding protein 0.0062 0.123 0.2068
Mycobacterium tuberculosis Conserved protein 0.0043 0.0805 0.1323
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0218 0.0367
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0001 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0305 0.0305
Echinococcus granulosus 7TM GPCR rhodopsin 0.0008 0.0001 0.0001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0305 0.0572
Schistosoma mansoni intermediate filament proteins 0.003 0.0503 0.0503
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.0001 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0805 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0129
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0421 0.5226
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0051 0.0964 0.0964
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0076 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0305 0.325
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0218 0.8069
Loa Loa (eye worm) hypothetical protein 0.0043 0.0805 0.1354
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0964 0.162
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0076 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0062 0.123 0.123
Loa Loa (eye worm) hypothetical protein 0.0043 0.0805 0.1354
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0218 0.2708
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0305 0.325
Trichomonas vaginalis esterase, putative 0.0043 0.0805 0.1509
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0153 0.1629
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.0454
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0008 0.0001 0.0002
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0129
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0076 0.0076
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0805 0.1323
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0218 0.2323
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0008 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0076 0.0076
Schistosoma mansoni DNA polymerase eta 0.0049 0.0939 0.0939
Echinococcus multilocularis GPCR, family 2 0.0051 0.0964 0.0964
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0076 0.0076
Echinococcus granulosus neuropeptide receptor 0.0008 0.0001 0.0001
Entamoeba histolytica phosphoinositide kinase, putative 0.0015 0.0153 0.3634
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0015 0.0153 0.0153
Loa Loa (eye worm) beta-lactamase 0.0043 0.0805 0.1354
Echinococcus multilocularis allatostatin A receptor 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Brugia malayi G protein-coupled receptor 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Plasmodium vivax SET domain protein, putative 0.0031 0.0533 0.6624
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0805 0.1354
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0072 0.0072
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.027 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0043 0.0805 0.1509
Onchocerca volvulus 0.0008 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0218 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0076 0.0129
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0015 0.0153 0.5659
Schistosoma mansoni adenoreceptor 0.0008 0.0001 0.0001
Brugia malayi isocitrate dehydrogenase 0.0017 0.0218 0.0367
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0218 0.0218
Brugia malayi nuclear hormone receptor 0.0011 0.0076 0.0129
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0008 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0076 0.0129
Onchocerca volvulus 0.0008 0.0001 0.0002
Brugia malayi Pre-SET motif family protein 0.0215 0.467 0.7851
Echinococcus granulosus sex peptide receptor 0.0008 0.0001 0.0001
Brugia malayi Pip kinase protein 2 0.0181 0.391 0.6573
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0305 0.0305
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0008 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0533 0.0533
Schistosoma mansoni hypothetical protein 0.0008 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.0001 0.0001
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0503 0.0845
Echinococcus granulosus geminin 0.0187 0.404 0.404
Onchocerca volvulus 0.0008 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0109 0.2285 0.2285
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.0454
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0503 0.0845
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0964 0.0964
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus somatostatin receptor 0.0008 0.0001 0.0001
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0001 0.0001
Brugia malayi AKH receptor 0.0008 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0805 0.0805
Schistosoma mansoni neuropeptide receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0129
Loa Loa (eye worm) hypothetical protein 0.0043 0.0805 0.1354
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0964 0.0964
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0015 0.0153 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0076 0.0129
Echinococcus multilocularis g-protein coupled receptor 0.0008 0.0001 0.0001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0421 0.5226
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0533 0.0533
Mycobacterium ulcerans hypothetical protein 0.0043 0.0805 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0008 0.0001 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0305 0.0513
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0001 0.0001
Echinococcus granulosus g-protein coupled receptor 0.0008 0.0001 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0964 0.0964
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0076 0.0143
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.027 0.3356
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0305 0.325
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.2285 0.3841
Onchocerca volvulus 0.0026 0.0421 0.0789
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0008 0.0001 0.0001
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0153 0.1629
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0076 0.0076
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0076 0.0076
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0001 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0805 0.8578
Brugia malayi nuclear receptor NHR-88 0.0011 0.0076 0.0129
Brugia malayi Dopamine receptor 0.0008 0.0001 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0076 0.0129
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.3228 0.5426
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0153 0.3634
Onchocerca volvulus 0.0008 0.0001 0.0002
Brugia malayi ORL1-like opioid receptor 0.0008 0.0001 0.0001
Echinococcus granulosus alpha 1A adrenergic receptor 0.0008 0.0001 0.0001
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0076 0.0076
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0001 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0028 0.0028
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0008 0.0001 0.0001
Brugia malayi Melatonin receptor type 1A 0.0008 0.0001 0.0001
Brugia malayi putative neuropeptide receptor 0.0008 0.0001 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0305 0.3789
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0805 0.1509
Schistosoma mansoni hypothetical protein 0.0451 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0964 0.162
Brugia malayi ecdysteroid receptor 0.0011 0.0076 0.0129
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.123 0.2068
Echinococcus granulosus dna polymerase eta 0.0049 0.0939 0.0939
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0076 0.0129
Schistosoma mansoni hypothetical protein 0.0187 0.404 0.404
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0076 0.0076
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0076 0.0129
Schistosoma mansoni myosin xvIII 0.0008 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0028 0.0028
Echinococcus granulosus tachykinin peptides receptor 99D 0.0008 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0001 0.0001
Brugia malayi Serotonin receptor 0.0008 0.0001 0.0001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0152 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Onchocerca volvulus 0.0008 0.0001 0.0002
Onchocerca volvulus 0.0008 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0305 0.325
Brugia malayi beta-lactamase family protein 0.0043 0.0805 0.1354
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0181 0.391 0.391
Echinococcus granulosus G protein coupled receptor 139 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0008 0.0001 0.0002
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0015 0.0153 0.0257
Loa Loa (eye worm) hypothetical protein 0.0051 0.0964 0.162
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0076 0.0076
Echinococcus granulosus fmrfamide receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0076 0.0076
Echinococcus granulosus GPCR family 2 0.0051 0.0964 0.0964
Schistosoma mansoni hypothetical protein 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0245 0.5338 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0015 0.0153 0.0153
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0421 0.5226
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0153 0.1629
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0001 0.0001
Leishmania major DNA polymerase kappa, putative 0.0021 0.0305 0.325
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0043 0.0805 0.8578
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0805 0.0805
Echinococcus granulosus g protein coupled receptor 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0015 0.0153 0.1629
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0805 0.1509
Onchocerca volvulus 0.0043 0.0805 0.1509
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0008 0.0001 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0805 0.0805
Brugia malayi larval opioid receptor 0.0008 0.0001 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0001 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0939 0.1578
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0153 0.1899
Loa Loa (eye worm) TAR-binding protein 0.0062 0.123 0.2068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0421 0.0708
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0421 0.5226
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.016 0.3424 0.5756
Brugia malayi Dopamine receptor protein 2 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0305 0.0501
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0028 0.0028
Onchocerca volvulus 0.0032 0.0539 0.1011
Trypanosoma brucei unspecified product 0.0021 0.0305 0.325
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0305 0.0501
Brugia malayi Serotonin receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0015 0.0153 0.0257
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0015 0.0153 0.0287
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0152 0.0256
Mycobacterium tuberculosis Conserved protein 0.0043 0.0805 0.1323
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0805 0.1354
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0076 0.0129
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0218 0.2323
Loa Loa (eye worm) hypothetical protein 0.0031 0.0533 0.0897
Echinococcus multilocularis dna polymerase eta 0.0049 0.0939 0.0939
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0076 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0076 0.0129
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0015 0.0153 0.127
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.3228 0.5426
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0805 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.3228 0.3228
Plasmodium falciparum acyl-CoA synthetase 0.002 0.027 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0805 0.1323
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0015 0.0153 0.0287
Brugia malayi Calcitonin receptor-like protein seb-1 0.016 0.3424 0.5756
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0076 0.0129
Echinococcus granulosus neuropeptide receptor 0.0008 0.0001 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0805 0.8578
Mycobacterium ulcerans beta-lactamase 0.0043 0.0805 1
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0015 0.0153 0.127
Schistosoma mansoni lamin 0.003 0.0503 0.0503
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0421 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0421 0.0708
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0076 0.0076
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0421 1
Schistosoma mansoni hypothetical protein 0.0051 0.0964 0.0964
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0805 0.1323
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis sex peptide receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0421 0.0708
Echinococcus granulosus neuropeptide FF receptor 2 0.0008 0.0001 0.0001
Loa Loa (eye worm) pip kinase 1 0.0015 0.0153 0.0257
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0156 0.1663
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0001 0.0001
Onchocerca volvulus 0.003 0.0503 0.0942
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0218 0.0218
Echinococcus multilocularis G protein coupled receptor 139 0.0008 0.0001 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0964 0.0964
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0156 0.1663
Schistosoma mansoni biogenic amine receptor 0.0008 0.0001 0.0001
Echinococcus granulosus allatostatin A receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0011 0.0076 0.0143
Onchocerca volvulus 0.0008 0.0001 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0001 0.0001
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0421 0.5226
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0181 0.391 0.391
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0001 0.0001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0001 0.0001
Leishmania major DNA polymerase eta, putative 0.0035 0.0608 0.6473
Schistosoma mansoni hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0015 0.0153 0.1629
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0008 0.0001 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0805 0.1509
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0608 0.6473
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0181 0.391 0.391
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus g protein coupled receptor 0.0008 0.0001 0.0001
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0218 0.0218
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0076 0.0076
Echinococcus multilocularis serotonin receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) pip kinase 2 0.0181 0.391 0.6573
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0076 0.0076
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0001 0.0001
Echinococcus granulosus 7tm_1 domain containing protein 0.0008 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0062 0.123 0.123
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0076 0.0129
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0421 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.0454
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0072 0.0072
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Echinococcus multilocularis lamin dm0 0.003 0.0503 0.0503
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0076 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0076 0.0129
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0015 0.0153 0.1629
Echinococcus granulosus lamin dm0 0.003 0.0503 0.0503
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0076 0.0129
Schistosoma mansoni amine GPCR 0.0008 0.0001 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.123 0.2068
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0072 0.012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0008 0.0001 0.0002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0246 0.0404
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.5707 0.5707
Onchocerca volvulus 0.0053 0.1025 0.192
Onchocerca volvulus 0.0008 0.0001 0.0002
Echinococcus granulosus dro:myosuppressin receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0001 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0272 0.5949 1
Schistosoma mansoni coup transcription factor 0.0011 0.0076 0.0076
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0153 0.1899
Schistosoma mansoni tar DNA-binding protein 0.0062 0.123 0.123
Echinococcus multilocularis G-protein coupled receptor, putative 0.0008 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.3228 0.3228
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0076 0.0076
Schistosoma mansoni biogenic amine receptor 0.0008 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0421 0.0691
Echinococcus multilocularis musashi 0.003 0.0503 0.0503
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0001 0.0001
Schistosoma mansoni lamin 0.003 0.0503 0.0503
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0001 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0076 0.0076
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0218 0.1811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.3228 0.3228
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0109 0.2285 0.3841
Schistosoma mansoni cpg binding protein 0.0032 0.0539 0.0539
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0076 0.0143
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0218 0.0218
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0001 0.0001
Echinococcus multilocularis orexin receptor type 2 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0008 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0805 0.1354
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0076 0.0129
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0805 0.1509
Schistosoma mansoni histamine h1 receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0076 0.0076
Brugia malayi RE15519p 0.0008 0.0001 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0421 0.5226
Loa Loa (eye worm) hypothetical protein 0.0181 0.391 0.6573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0076 0.0129
Echinococcus multilocularis tar DNA binding protein 0.0062 0.123 0.123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0001 0.0001
Echinococcus granulosus serotonin receptor 0.0008 0.0001 0.0001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0305 0.325
Onchocerca volvulus 0.0031 0.0533 0.0999
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.003 0.0503 0.0503
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0008 0.0001 0.0001
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0218 0.2323
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0069 0.0116
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.3228 0.3228
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0421 0.5226
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0421 0.0708
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0015 0.0153 0.0153
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0305 0.0513
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0076 0.0076
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1366 0.1366
Loa Loa (eye worm) hypothetical protein 0.003 0.0503 0.0845
Echinococcus granulosus dna polymerase kappa 0.0021 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0272 0.5949 1
Schistosoma mansoni neuropeptide receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis somatostatin receptor 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0805 0.1323
Schistosoma mansoni hypothetical protein 0.0053 0.1025 0.1025
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0218 0.0358
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0015 0.0153 0.1629
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0153 0.1629
Schistosoma mansoni opsin-like receptor 0.0008 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0008 0.0001 0.0001
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0015 0.0153 0.1629
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1204 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.0454
Loa Loa (eye worm) hypothetical protein 0.0043 0.0805 0.1354
Schistosoma mansoni amine GPCR 0.0008 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0015 0.0153 0.1629
Brugia malayi Pip kinase protein 1 0.0015 0.0153 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0076 0.0129
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0156 0.1663
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0076 0.0143
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0305 0.7249
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0076 0.0129
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0608 0.5047
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0033 0.058 0.058
Brugia malayi Dopamine receptor protein 1 0.0008 0.0001 0.0001
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.014 0.0235
Echinococcus multilocularis lamin 0.003 0.0503 0.0503
Brugia malayi GnHR receptor homolog 0.0008 0.0001 0.0001
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0188 0.0316
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0001 0.0001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0805 0.1323
Giardia lamblia DINP protein human, muc B family 0.0021 0.0305 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.123 0.123
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Mycobacterium tuberculosis Conserved protein 0.0043 0.0805 0.1323
Echinococcus multilocularis neuropeptide s receptor 0.0008 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0076 0.0129
Echinococcus granulosus neuropeptide s receptor 0.0008 0.0001 0.0001
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0305 0.0572
Schistosoma mansoni survival motor neuron protein 0.0053 0.1025 0.1025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Echinococcus multilocularis dro:myosuppressin receptor 0.0008 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0533 0.0533
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0421 0.0708
Loa Loa (eye worm) FYVE zinc finger family protein 0.0015 0.0153 0.0257
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.027 0.3356
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.0001 0.0001
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0181 0.391 0.391
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0076 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0305 0.325
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0076 0.0076
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0533 0.443
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0015 0.0153 0.1629
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0218 0.0367
Echinococcus multilocularis cpg binding protein 0.0033 0.058 0.058
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0008 0.0001 0.0002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.467 0.7851
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0001 0.0001
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0153 0.1629
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0001 0.0001
Onchocerca volvulus Neuropeptide F receptor homolog 0.0008 0.0001 0.0002
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0805 0.0805
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0015 0.0153 0.1629
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.3228 0.3228
Brugia malayi G-protein coupled receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0076 0.0076
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0246 0.0404
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0305 0.325
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0939 1
Brugia malayi beta-lactamase family protein 0.0043 0.0805 0.1354
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0076 0.0129
Echinococcus granulosus tar DNA binding protein 0.0062 0.123 0.123
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0305 0.325
Brugia malayi TAR-binding protein 0.0062 0.123 0.2068
Schistosoma mansoni opsin-like receptor 0.0008 0.0001 0.0001
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0218 0.1811
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0015 0.0153 0.1629
Schistosoma mansoni biogenic amine receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0001 0.0001
Trypanosoma brucei unspecified product 0.0015 0.0156 0.1663
Loa Loa (eye worm) hypothetical protein 0.0261 0.5707 0.9594
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0076 0.0129
Echinococcus granulosus g protein coupled receptor 0.0008 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0008 0.0001 0.0001
Mycobacterium ulcerans lipase LipD 0.0043 0.0805 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0076 0.0076
Brugia malayi Pre-SET motif family protein 0.0031 0.0533 0.0897
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0824
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0533 0.0533
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0421 0.5226
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0015 0.0153 0.0153
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0539 0.0907
Schistosoma mansoni neuropeptide receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0805 0.1354
Loa Loa (eye worm) hypothetical protein 0.0011 0.0076 0.0129
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0076 0.0076
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0076 0.0129
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0001 0.0001
Brugia malayi neuropeptide F receptor 0.0008 0.0001 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0218 0.0218
Brugia malayi sulfakinin receptor protein 0.0008 0.0001 0.0001
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.1025 0.1723
Echinococcus granulosus hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0001 0.0001
Echinococcus granulosus orexin receptor type 2 0.0008 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.6611 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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