Detailed information for compound 1221597

Basic information

Technical information
  • TDR Targets ID: 1221597
  • Name: 4,5-di(phenyl)-2-propan-2-yl-1H-imidazole
  • MW: 262.349 | Formula: C18H18N2
  • H donors: 1 H acceptors: 1 LogP: 4.55 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1nc(c([nH]1)c1ccccc1)c1ccccc1)C
  • InChi: 1S/C18H18N2/c1-13(2)18-19-16(14-9-5-3-6-10-14)17(20-18)15-11-7-4-8-12-15/h3-13H,1-2H3,(H,19,20)
  • InChiKey: KDPMUOQKEHXSOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-isopropyl-4,5-di(phenyl)-1H-imidazole
  • 13682-25-2
  • NSC163276
  • MLS000567402
  • SMR000154123
  • T5337386

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1936 0.2639
Echinococcus granulosus bloom syndrome protein 0.0023 0.0419 0.0482
Brugia malayi beta-lactamase 0.007 0.1471 0.5709
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0107 0.0054
Mycobacterium leprae Probable lipase LipE 0.007 0.1471 1
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1471 1
Mycobacterium ulcerans lipase LipD 0.007 0.1471 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0158
Schistosoma mansoni hypothetical protein 0.0033 0.0641 0.0874
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0237 0.0232
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1471 0.2005
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0237 0.0687
Schistosoma mansoni smad1 5 8 and 0.0008 0.0068 0.0093
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0898 0.6105
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0419 0.1901
Brugia malayi Inositol-1 0.0045 0.0898 0.3378
Echinococcus granulosus geminin 0.0329 0.7337 1
Mycobacterium ulcerans hypothetical protein 0.007 0.1471 1
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1471 1
Schistosoma mansoni hypothetical protein 0.0015 0.0237 0.0323
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0898 0.559
Loa Loa (eye worm) hypothetical protein 0.0015 0.0237 0.0678
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0307 0.1043
Schistosoma mansoni inositol monophosphatase 0.0045 0.0898 0.1224
Mycobacterium tuberculosis Conserved protein 0.007 0.1471 0.1201
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0307 0.0329
Schistosoma mansoni hypothetical protein 0.0329 0.7337 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0307 0.1043
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0898 1
Echinococcus multilocularis geminin 0.0329 0.7337 1
Echinococcus granulosus GPCR family 2 0.0015 0.0237 0.0232
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.1471 1
Schistosoma mansoni ap endonuclease 0.0018 0.0307 0.0419
Loa Loa (eye worm) hypothetical protein 0.007 0.1471 0.5636
Loa Loa (eye worm) RecQ helicase 0.0023 0.0419 0.1408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1936 0.2639
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1936 0.257
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0898 0.559
Loa Loa (eye worm) hypothetical protein 0.007 0.1471 0.5636
Loa Loa (eye worm) inositol-1 0.0045 0.0898 0.3334
Onchocerca volvulus 0.007 0.1471 0.5
Schistosoma mansoni smad1 5 8 and 0.0008 0.0068 0.0093
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0307 0.096
Leishmania major hypothetical protein, conserved 0.007 0.1471 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0898 0.5077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1936 0.7602
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0307 0.8093
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.1471 0.193
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0307 0.1043
Loa Loa (eye worm) hypothetical protein 0.0118 0.2558 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0307 0.0492
Schistosoma mansoni DNA helicase recq1 0.001 0.0107 0.0146
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0898 0.559
Loa Loa (eye worm) hypothetical protein 0.007 0.1471 0.5636
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0107 0.016
Mycobacterium leprae conserved hypothetical protein 0.007 0.1471 1
Trichomonas vaginalis esterase, putative 0.007 0.1471 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1433 0.1952
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0237 0.0232
Loa Loa (eye worm) RNA binding protein 0.0068 0.1433 0.5481
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0419 0.1901
Toxoplasma gondii exonuclease III APE 0.0018 0.0307 0.2088
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.099 0.375
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.1471 0.193
Schistosoma mansoni smad 0.0008 0.0068 0.0093
Mycobacterium ulcerans beta-lactamase 0.007 0.1471 1
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.1433 0.5552
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0237 0.0687
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0107 0.073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1936 0.257
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1433 0.1952
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1936 0.257
Loa Loa (eye worm) hypothetical protein 0.007 0.1471 0.5636
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0307 0.0419
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.1433 0.5481
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0898 0.559
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1471 1
Echinococcus granulosus tar DNA binding protein 0.0068 0.1433 0.1877
Schistosoma mansoni Smad4 0.0008 0.0068 0.0093
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0307 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0307 0.1043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1936 0.2639
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0172 0.1912
Loa Loa (eye worm) beta-lactamase 0.007 0.1471 0.5636
Loa Loa (eye worm) hypothetical protein 0.007 0.1471 0.5636
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0641 0.2332
Schistosoma mansoni hypothetical protein 0.0015 0.0237 0.0323
Loa Loa (eye worm) hypothetical protein 0.0049 0.099 0.3702
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.099 0.375
Brugia malayi beta-lactamase family protein 0.007 0.1471 0.5709
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.1471 0.5636
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0419 0.0482
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.1471 0.1201
Loa Loa (eye worm) hypothetical protein 0.007 0.1471 0.5636
Toxoplasma gondii ABC1 family protein 0.007 0.1471 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0307 0.0329
Brugia malayi TAR-binding protein 0.0068 0.1433 0.5552
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0243 0.165
Brugia malayi MH2 domain containing protein 0.0116 0.2525 1
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.1471 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0898 0.559
Mycobacterium tuberculosis Conserved protein 0.007 0.1471 0.1201
Schistosoma mansoni DNA helicase recq5 0.001 0.0107 0.0146
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0898 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2525 0.9871
Schistosoma mansoni hypothetical protein 0.0015 0.0237 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1471 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0307 0.1043
Brugia malayi beta-lactamase family protein 0.007 0.1471 0.5709
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0898 0.559
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0898 0.559
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0237 0.0678
Mycobacterium tuberculosis Conserved protein 0.007 0.1471 0.1201
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0307 0.0973
Echinococcus multilocularis GPCR, family 2 0.0015 0.0237 0.0232
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0354 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0641 0.2302
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1471 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0898 0.1142
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.1471 0.1201
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.1471 0.1201
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.1471 0.1201
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0307 0.342
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0898 0.1142
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.1471 0.1201
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0237 0.0232
Schistosoma mansoni inositol monophosphatase 0.0045 0.0898 0.1224
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.099 0.3702
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0107 0.073
Loa Loa (eye worm) TAR-binding protein 0.0068 0.1433 0.5481
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0419 0.1427
Plasmodium vivax hypothetical protein, conserved 0.007 0.1471 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0307 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1936 0.7504
Mycobacterium tuberculosis Probable hydrolase 0.007 0.1471 0.1201
Schistosoma mansoni ap endonuclease 0.0018 0.0307 0.0419
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0107 0.0054
Schistosoma mansoni hypothetical protein 0.0015 0.0237 0.0323
Onchocerca volvulus 0.007 0.1471 0.5
Brugia malayi RNA binding protein 0.0068 0.1433 0.5552
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1471 0.2005
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1433 0.1952
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0307 0.1043
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1471 1
Schistosoma mansoni hypothetical protein 0.0329 0.7337 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0068 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1433 0.1952
Echinococcus multilocularis tar DNA binding protein 0.0068 0.1433 0.1877
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2525 0.9871
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0107 0.016
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0107 0.0158
Onchocerca volvulus 0.007 0.1471 0.5
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1433 0.1952
Schistosoma mansoni smad1 5 8 and 0.0008 0.0068 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.007 0.1471 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0792 0.0501
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0237 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1936 0.257
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0107 0.0054
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1471 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0107 0.0054
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.1471 0.5709
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.1471 0.1201

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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