Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.5 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.5 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.5 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.5 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.5 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.5 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.5 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.5 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.5 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.5 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.5 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.5 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.5 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.