Detailed information for compound 1222827

Basic information

Technical information
  • TDR Targets ID: 1222827
  • Name: 1-cyclohexyloxy-3-(3-methyl-2-propylbenzimida zol-3-ium-1-yl)propan-2-ol iodide
  • MW: 458.377 | Formula: C20H31IN2O2
  • H donors: 1 H acceptors: 1 LogP: 4.6 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1n(CC(COC2CCCCC2)O)c2c([n+]1C)cccc2.[I-]
  • InChi: 1S/C20H31N2O2.HI/c1-3-9-20-21(2)18-12-7-8-13-19(18)22(20)14-16(23)15-24-17-10-5-4-6-11-17;/h7-8,12-13,16-17,23H,3-6,9-11,14-15H2,1-2H3;1H/q+1;/p-1
  • InChiKey: XNXFIRBCAFTONW-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 1-(cyclohexoxy)-3-(3-methyl-2-propyl-benzimidazol-3-ium-1-yl)propan-2-ol iodide
  • 1-(cyclohexoxy)-3-(3-methyl-2-propyl-1-benzimidazol-3-iumyl)propan-2-ol iodide
  • 1-cyclohexyloxy-3-(3-methyl-2-propyl-benzimidazol-3-ium-1-yl)propan-2-ol iodide
  • MLS000687715
  • SMR000283687

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0039 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0039 0.0124
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0335 0.4608
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.1076 0.2217
Schistosoma mansoni hypothetical protein 0.0182 0.1704 0.4363
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.099 0.2535
Onchocerca volvulus 0.0076 0.0597 0.1564
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0341 0.0341
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0341 0.4691
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0123 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0174 0.2387
Schistosoma mansoni hypothetical protein 0.0182 0.1704 0.4363
Brugia malayi hypothetical protein 0.0365 0.3606 0.6214
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0044 0.0731
Loa Loa (eye worm) hypothetical protein 0.0064 0.0473 0.0753
Echinococcus granulosus replication factor c subunit 1 0.0064 0.0473 0.149
Brugia malayi latrophilin 2 splice variant baaae 0.0394 0.3906 0.6731
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0039 0.01
Loa Loa (eye worm) hypothetical protein 0.0079 0.0633 0.103
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0044 0.0731
Loa Loa (eye worm) glutathione reductase 0.0053 0.0363 0.0563
Brugia malayi jmjC domain containing protein 0.003 0.0123 0.0211
Schistosoma mansoni topbp1 0.0064 0.0473 0.1211
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0044 0.0044
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0123 0.0386
Brugia malayi hypothetical protein 0.0064 0.0473 0.0815
Giardia lamblia Replication factor C, subunit 1 0.0064 0.0473 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0039 0.01
Mycobacterium leprae Probable lipase LipE 0.0076 0.0597 0.4324
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0345 0.0531
Loa Loa (eye worm) hypothetical protein 0.0076 0.0597 0.0968
Onchocerca volvulus 0.0076 0.0597 0.1564
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0345 0.0884
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0044 0.0159
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0597 0.0597
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0335 0.5616
Toxoplasma gondii ABC1 family protein 0.0076 0.0597 0.8205
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0039 0.0068
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.0728 0.1863
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0123 0.2054
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0728 1
Brugia malayi jmjC domain containing protein 0.003 0.0123 0.0211
Mycobacterium ulcerans beta-lactamase 0.0076 0.0597 0.2182
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0064 0.0473 0.0815
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.1218 0.2509
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0182 0.1704 0.5369
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0039 0.0039
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0039 0.0124
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0576 0.5803 1
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0335 0.4608
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.1218 0.2509
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0363 0.0749
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0728 0.2659
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0564 0.091
Plasmodium vivax glutathione reductase, putative 0.0053 0.0363 0.4994
Plasmodium falciparum replication factor C subunit 1, putative 0.0064 0.0473 0.6501
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0039 0.0039
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.1076 0.2217
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0182 0.1704 0.5369
Echinococcus granulosus tar DNA binding protein 0.0324 0.3175 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0039 0.0124
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0341 0.0341
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0728 1
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0039 0.01
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0124 0.1709
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0039 0.0124
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0039 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3175 0.8127
Brugia malayi isocitrate dehydrogenase 0.0051 0.0341 0.0588
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0039 0.0068
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0039 0.01
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0341 0.0874
Schistosoma mansoni DNA ligase IV 0.0064 0.0473 0.1211
Echinococcus multilocularis peregrin 0.0035 0.0174 0.0174
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0123 0.1685
Toxoplasma gondii hypothetical protein 0.003 0.0124 0.1709
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0345 0.1088
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0597 0.1881
Brugia malayi jmjC domain containing protein 0.003 0.0123 0.0211
Mycobacterium ulcerans hypothetical protein 0.0076 0.0597 0.2182
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3175 0.8127
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0597 0.2182
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0363 0.4994
Brugia malayi TAR-binding protein 0.0324 0.3175 0.547
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0044 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1037 0.1731
Brugia malayi N-terminal motif family protein 0.0204 0.1932 0.333
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0123 0.1685
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0145
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0728 0.2659
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0044 0.0044
Echinococcus granulosus lysine specific demethylase 5A 0.0114 0.099 0.3119
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0123 0.0145
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0341 0.4691
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0597 0.2182
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0039 0.0039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0039 0.0068
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0124 0.1709
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0039 0.0124
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0341 0.4691
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0039 0.0068
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0044 0.0139
Schistosoma mansoni topbp1 0.0064 0.0473 0.1211
Mycobacterium tuberculosis Conserved protein 0.0076 0.0597 0.123
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0411 0.0411
Mycobacterium ulcerans lipase LipD 0.0076 0.0597 0.2182
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0341 0.5717
Brugia malayi nuclear hormone receptor 0.0022 0.0039 0.0068
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0597 0.0968
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.1076 0.8705
Plasmodium falciparum glutathione reductase 0.0053 0.0363 0.4994
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0064 0.0473 0.7923
Brugia malayi jmjC domain containing protein 0.0186 0.1747 0.301
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0475 0.1736
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0044 0.0008
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0341 0.0703
Giardia lamblia PHD finger protein 15 0.0035 0.0174 0.3671
Schistosoma mansoni ap endonuclease 0.0023 0.0044 0.0112
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0597 0.1029
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0335 0.5616
Echinococcus granulosus GPCR family 2 0.0182 0.1704 0.5369
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0597 0.123
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0039 0.0068
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0044 0.0137
Onchocerca volvulus 0.0076 0.0597 0.1564
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.1932 0.5308
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0039 0.0068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0039 0.0068
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0335 0.4608
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0363 0.0363
Loa Loa (eye worm) glutaminase 2 0.0281 0.2737 0.4681
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0039 0.0068
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0044 0.06
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0341 0.0341
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0597 1
Plasmodium vivax JmjC domain containing protein 0.003 0.0123 0.1685
Onchocerca volvulus 0.0064 0.0473 0.1217
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0039 0.01
Schistosoma mansoni hypothetical protein 0.0182 0.1704 0.4363
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0345 0.0345
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0341 0.0341
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.0728 0.2293
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0039 0.0068
Onchocerca volvulus Alhambra homolog 0.0035 0.0174 0.0377
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0039 0.01
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0174 0.0445
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0174 0.0547
Echinococcus multilocularis nibrin 0.0064 0.0473 0.0473
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0064 0.0473 0.6501
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0411 0.0846
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0252 0.2427 0.4143
Trypanosoma brucei trypanothione reductase 0.0053 0.0363 0.6087
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0363 0.6087
Brugia malayi Latrophilin receptor protein 2 0.0182 0.1704 0.2937
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0064 0.0475 0.1736
Loa Loa (eye worm) RNA binding protein 0.0324 0.3175 0.544
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3175 0.8127
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0485 0.4854 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0345 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0039 0.0068
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0123 0.1685
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.1218 0.2509
Echinococcus granulosus peregrin 0.0035 0.0174 0.0547
Loa Loa (eye worm) hypothetical protein 0.0076 0.0597 0.0968
Loa Loa (eye worm) hypothetical protein 0.0064 0.0473 0.0753
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0186 0.1747 0.1747
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0064 0.0473 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0123 0.0386
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3175 0.8127
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0123 0.0123
Schistosoma mansoni jumonji domain containing protein 0.0163 0.15 0.384
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0039 0.0124
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0597 0.123
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1037 0.1731
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0341 0.5717
Schistosoma mansoni phd/f-box containing protein 0.003 0.0123 0.0314
Trichomonas vaginalis replication factor C large subunit, putative 0.0064 0.0473 0.1729
Brugia malayi Probable ClpP-like protease 0.0088 0.0728 0.1254
Schistosoma mansoni hypothetical protein 0.0035 0.0174 0.0445
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.1076 0.2217
Loa Loa (eye worm) hypothetical protein 0.0182 0.1704 0.2889
Brugia malayi nuclear receptor NHR-88 0.0022 0.0039 0.0068
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0174 0.2387
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0597 0.123
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.0728 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0039 0.0124
Schistosoma mansoni hypothetical protein 0.0023 0.0044 0.0113
Brugia malayi hypothetical protein 0.0051 0.0335 0.0578
Brugia malayi Calcitonin receptor-like protein seb-1 0.0576 0.5803 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0345 0.0884
Trichomonas vaginalis glutaminase, putative 0.0281 0.2737 1
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0597 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0044 0.06
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0039 0.0068
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0044 0.0159
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0182 0.1704 0.1704
Brugia malayi jmjC domain containing protein 0.003 0.0123 0.0211
Plasmodium falciparum phd finger protein, putative 0.0035 0.0174 0.2387
Trypanosoma cruzi FHA domain containing protein, putative 0.0064 0.0473 0.7923
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.0728 0.5519
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0064 0.0473 0.1729
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0039 0.0124
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0174 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0473 0.1729
Echinococcus granulosus phd:f box containing protein 0.003 0.0123 0.0386
Echinococcus granulosus nibrin 0.0064 0.0473 0.149
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.1076 0.2217
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0044 0.0922
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0039 0.0068
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0341 0.5717
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0186 0.1747 0.5502
Brugia malayi beta-lactamase family protein 0.0076 0.0597 0.1029
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0341 0.0524
Brugia malayi hypothetical protein 0.0252 0.2427 0.4182
Mycobacterium tuberculosis Conserved protein 0.0076 0.0597 0.123
Schistosoma mansoni jumonji domain containing protein 0.003 0.0123 0.0314
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0728 1
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0597 0.123
Brugia malayi steroid hormone receptor 0.0022 0.0039 0.0068
Schistosoma mansoni chromosome transmission fidelity factor 0.0064 0.0473 0.1211
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0317 0.0999
Brugia malayi Thioredoxin reductase 0.0053 0.0363 0.0626
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0182 0.1704 0.2937
Brugia malayi hypothetical protein 0.0033 0.0148 0.0255
Loa Loa (eye worm) hypothetical protein 0.0394 0.3906 0.6709
Brugia malayi RNA recognition motif domain containing protein 0.0324 0.3175 0.547
Plasmodium falciparum thioredoxin reductase 0.0053 0.0363 0.4994
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0039 0.01
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0123 0.0314
Chlamydia trachomatis DNA ligase 0.0064 0.0473 0.6501
Loa Loa (eye worm) hypothetical protein 0.0064 0.0473 0.0753
Echinococcus multilocularis GPCR, family 2 0.0182 0.1704 0.1704
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0039 0.0068
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0341 0.5717
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0039 0.0039
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0064 0.0473 0.1729
Trichomonas vaginalis esterase, putative 0.0076 0.0597 0.2182
Loa Loa (eye worm) TAR-binding protein 0.0324 0.3175 0.544
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0597 0.2182
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0473 0.7923
Leishmania major trypanothione reductase 0.0053 0.0363 0.6087
Entamoeba histolytica hypothetical protein 0.0064 0.0473 1
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0123 0.0386
Loa Loa (eye worm) hypothetical protein 0.0088 0.0728 0.1195
Echinococcus multilocularis replication factor c subunit 1 0.0064 0.0473 0.0473
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0039 0.0068
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0039 0.01
Loa Loa (eye worm) glutaminase 0.0281 0.2737 0.4681
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0123 0.0145
Brugia malayi ecdysteroid receptor 0.0022 0.0039 0.0068
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0345 0.0595
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0182 0.1704 0.1704
Brugia malayi glutathione reductase 0.0053 0.0363 0.0626
Schistosoma mansoni hypothetical protein 0.0182 0.1704 0.4363
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0597 0.4324
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0039 0.01
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.0233
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0341 0.1075
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0039 0.0039
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0728 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0473 0.0753
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0363 0.1145
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.1218 1
Loa Loa (eye worm) hypothetical protein 0.0365 0.3606 0.6188
Brugia malayi jmjC domain containing protein 0.0114 0.099 0.1706
Brugia malayi topoisomerase 0.0064 0.0473 0.0815
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0174 0.2387
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0341 0.4691
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0044 0.06
Schistosoma mansoni glutaminase 0.0281 0.2737 0.7008
Brugia malayi DKFZp564C0469 protein 0.0064 0.0473 0.0815
Brugia malayi Bromodomain containing protein 0.0035 0.0174 0.0299
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0473 0.7923
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0597 0.1529
Plasmodium vivax replication factor C subunit 1, putative 0.0064 0.0473 0.6501
Onchocerca volvulus Huntingtin homolog 0.0252 0.2427 0.6694
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0174 0.0174
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0597 0.123
Schistosoma mansoni protein phosphatase 2C 0.003 0.0123 0.0314
Loa Loa (eye worm) hypothetical protein 0.0064 0.0473 0.0753
Brugia malayi beta-lactamase family protein 0.0076 0.0597 0.1029
Loa Loa (eye worm) jmjC domain-containing protein 0.0114 0.099 0.165
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.1076 0.2217
Schistosoma mansoni coup transcription factor 0.0022 0.0039 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0123 0.0145
Loa Loa (eye worm) hypothetical protein 0.0076 0.0597 0.0968
Onchocerca volvulus Huntingtin homolog 0.0252 0.2427 0.6694
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0597 0.8205
Loa Loa (eye worm) hypothetical protein 0.0076 0.0597 0.0968
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0324 0.3175 0.544
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0411 0.2618
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0345 0.0884
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0341 0.5717
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0039 0.01
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0123 0.0386
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0597 0.2182
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0123 0.0123
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0064 0.0473 0.319
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0597 0.123
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0044 0.009
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0341 0.0341
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0123 0.2054
Brugia malayi beta-lactamase 0.0076 0.0597 0.1029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0039 0.0124
Toxoplasma gondii thioredoxin reductase 0.0053 0.0363 0.4994
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0597 0.123
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0317 0.0317
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0576 0.5803 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0044 0.0159
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0335 0.4608
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0335 0.5616
Toxoplasma gondii exonuclease III APE 0.0023 0.0044 0.06
Schistosoma mansoni tar DNA-binding protein 0.0324 0.3175 0.8127
Loa Loa (eye worm) hypothetical protein 0.0051 0.0335 0.0514
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0064 0.0475 0.1736
Brugia malayi RNA binding protein 0.0324 0.3175 0.547
Onchocerca volvulus 0.0365 0.3606 1
Brugia malayi glutaminase DH11.1 0.0281 0.2737 0.4717
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0411 0.1294
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.099 0.2535
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0473 0.1729
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0044 0.0731
Brugia malayi Pax transcription activation domain interacting protein 0.0064 0.0473 0.0815
Schistosoma mansoni ap endonuclease 0.0023 0.0044 0.0112
Echinococcus multilocularis tar DNA binding protein 0.0324 0.3175 0.3175
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0363 0.0563
Loa Loa (eye worm) latrophilin receptor protein 2 0.0182 0.1704 0.2889
Leishmania major hypothetical protein, conserved 0.0076 0.0597 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0411 0.0846
Echinococcus multilocularis lysine specific demethylase 5A 0.0114 0.099 0.099
Schistosoma mansoni hypothetical protein 0.0394 0.3906 1
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0341 0.0588
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0044 0.06
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0728 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0597 0.1529
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0597 0.2182
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0123 0.2054
Brugia malayi PHD-finger family protein 0.0035 0.0174 0.0299
Loa Loa (eye worm) hypothetical protein 0.0064 0.0475 0.0756
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0473 0.1729
Leishmania major hypothetical protein, conserved 0.0051 0.0335 0.5616
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0345 0.0345
Mycobacterium tuberculosis Conserved protein 0.0076 0.0597 0.123
Loa Loa (eye worm) hypothetical protein 0.0076 0.0597 0.0968
Loa Loa (eye worm) hypothetical protein 0.0252 0.2427 0.4143
Loa Loa (eye worm) hypothetical protein 0.0204 0.1932 0.3284
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0039 0.0068
Leishmania major hypothetical protein, conserved 0.003 0.0123 0.2054
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0039 0.01
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.0728 0.0728
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.0728 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0728 1
Echinococcus multilocularis phd:f box containing protein 0.003 0.0123 0.0123
Mycobacterium tuberculosis Probable reductase 0.0122 0.1076 0.2217
Loa Loa (eye worm) hypothetical protein 0.0076 0.0597 0.0968
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0124 0.1709
Loa Loa (eye worm) beta-lactamase 0.0076 0.0597 0.0968
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0597 0.2182
Mycobacterium ulcerans glutaminase 0.0281 0.2737 1
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0123 0.0314
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0039 0.01
Toxoplasma gondii ATPase, AAA family protein 0.0064 0.0473 0.6501
Brugia malayi hypothetical protein 0.0064 0.0473 0.0815
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0473 0.1729
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0064 0.0473 0.6501
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0123 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0597 0.2182
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0597 1
Loa Loa (eye worm) hypothetical protein 0.0576 0.5803 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0064 0.0473 0.1729
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0044 0.0731
Treponema pallidum DNA ligase (lig) 0.0064 0.0473 0.6501
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0039 0.0039
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0064 0.0473 0.7923
Brugia malayi MH2 domain containing protein 0.0118 0.1037 0.1787

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 14.34 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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