Detailed information for compound 1222973

Basic information

Technical information
  • TDR Targets ID: 1222973
  • Name: 1-(amino-nitramidomethylidene)-3-ethylthioure a
  • MW: 191.212 | Formula: C4H9N5O2S
  • H donors: 2 H acceptors: 2 LogP: 0.25 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN=C(N=C(N[N+](=O)[O-])N)S
  • InChi: 1S/C4H9N5O2S/c1-2-6-4(12)7-3(5)8-9(10)11/h2H2,1H3,(H4,5,6,7,8,12)
  • InChiKey: HXGHHLVCSUYOKY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (1E)-1-(amino-nitramidomethylidene)-3-ethylthiourea
  • 1-(amino-nitramido-methylene)-3-ethyl-thiourea
  • (1E)-1-(amino-nitramido-methylene)-3-ethyl-thiourea
  • (1E)-1-(amino-nitramidomethylene)-3-ethylthiourea
  • 1-(amino-nitramidomethylene)-3-ethylthiourea
  • (1E)-1-(amino-nitramido-methylidene)-3-ethyl-thiourea
  • 1-(amino-nitramido-methylidene)-3-ethyl-thiourea
  • MLS000764226
  • SMR000335057
  • 6N-712
  • 1-nitro 3-(N-ethyl thiocarbamoyl) guanidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serotonin receptor 0.007 0.3642 0.3642
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0083 0.0084
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0597 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0083 0.0083
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.3642 0.3642
Echinococcus granulosus hypothetical protein 0.007 0.3642 0.3642
Schistosoma mansoni ferritin 0.001 0.0019 0.0019
Echinococcus granulosus neuropeptide Y receptor 0.007 0.3642 0.3642
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.007 0.3642 0.3667
Schistosoma mansoni biogenic amine receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0083 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.3642 0.3642
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0084
Schistosoma mansoni neuropeptide receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0084
Schistosoma mansoni biogenic amine receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus g-protein coupled receptor 0.007 0.3642 0.3642
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0083 0.0084
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.3642 0.3642
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.007 0.3642 0.3642
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.3642 0.3642
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.3642 0.3642
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.3642 0.3642
Loa Loa (eye worm) follicle stimulating hormone receptor 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.3642 0.3642
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.3642 0.3667
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.7894 0.7948
Brugia malayi Muscleblind-like protein 0.0174 0.9932 1
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0084
Schistosoma mansoni ap endonuclease 0.0019 0.0597 0.0597
Brugia malayi G-protein coupled receptor 0.007 0.3642 0.3667
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0083 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0083 0.0084
Echinococcus granulosus allatostatin A receptor 0.007 0.3642 0.3642
Echinococcus multilocularis serotonin receptor 0.007 0.3642 0.3642
Echinococcus granulosus neuropeptides capa receptor 0.007 0.3642 0.3642
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.1171 0.1171
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.3642 0.3642
Echinococcus granulosus neuropeptide FF receptor 2 0.007 0.3642 0.3642
Schistosoma mansoni ferritin light chain 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Onchocerca volvulus 0.006 0.3045 0.8323
Echinococcus multilocularis lamin dm0 0.006 0.3045 0.3045
Echinococcus multilocularis dro:myosuppressin receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.0029 0.1171 0.1179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0083 0.0084
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0083 0.0083
Brugia malayi nuclear hormone receptor 0.0011 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus G protein coupled receptor 139 0.007 0.3642 0.3642
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0597 0.5
Brugia malayi larval opioid receptor 0.007 0.3642 0.3667
Echinococcus multilocularis G-protein coupled receptor, putative 0.007 0.3642 0.3642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.2413 0.2413
Schistosoma mansoni amine GPCR 0.007 0.3642 0.3642
Brugia malayi steroid hormone receptor 0.0011 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.3642 0.3642
Brugia malayi RE15519p 0.007 0.3642 0.3667
Echinococcus granulosus g protein coupled receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0597 0.0601
Brugia malayi neuropeptide F receptor 0.007 0.3642 0.3667
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0083 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.007 0.3642 0.3642
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.3642 0.3667
Onchocerca volvulus 0.007 0.3642 1
Brugia malayi intermediate filament protein 0.006 0.3045 0.3066
Schistosoma mansoni ap endonuclease 0.0019 0.0597 0.0597
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0597 0.5
Brugia malayi Dopamine receptor protein 1 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni opsin-like receptor 0.007 0.3642 0.3642
Echinococcus multilocularis G protein coupled receptor 139 0.007 0.3642 0.3642
Onchocerca volvulus 0.007 0.3642 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0597 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0083 0.0084
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0083 0.0083
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi Tachykinin-like peptides receptor 99D 0.007 0.3642 0.3667
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.3642 0.3642
Onchocerca volvulus 0.007 0.3642 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0083 0.0084
Onchocerca volvulus 0.007 0.3642 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0083 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.3642 0.3642
Echinococcus multilocularis geminin 0.0175 1 1
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Brugia malayi Melatonin receptor type 1A 0.007 0.3642 0.3667
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0084
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0083 0.0083
Schistosoma mansoni apoferritin-2 0.001 0.0019 0.0019
Brugia malayi sulfakinin receptor protein 0.007 0.3642 0.3667
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0083 0.0084
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.007 0.3642 0.3667
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0597 0.0597
Echinococcus granulosus neuropeptide Y receptor 0.007 0.3642 0.3642
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0083 0.0083
Echinococcus granulosus serotonin receptor 0.007 0.3642 0.3642
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni hypothetical protein 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi putative neuropeptide receptor NPR1 0.007 0.3642 0.3667
Brugia malayi GnHR receptor homolog 0.007 0.3642 0.3667
Schistosoma mansoni coup transcription factor 0.0011 0.0083 0.0083
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.007 0.3642 0.3642
Schistosoma mansoni opsin-like receptor 0.007 0.3642 0.3642
Schistosoma mansoni intermediate filament proteins 0.006 0.3045 0.3045
Schistosoma mansoni apoferritin-2 0.001 0.0019 0.0019
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0597 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0083 0.0084
Brugia malayi nuclear receptor NHR-88 0.0011 0.0083 0.0084
Brugia malayi Dopamine receptor protein 2 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0084
Loa Loa (eye worm) melatonin receptor type 1A 0.007 0.3642 0.3667
Echinococcus multilocularis expressed protein 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0083 0.0084
Echinococcus granulosus alpha 1A adrenergic receptor 0.007 0.3642 0.3642
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.1171 0.1171
Loa Loa (eye worm) hypothetical protein 0.0028 0.1105 0.1112
Onchocerca volvulus 0.007 0.3642 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.2413 0.2413
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.3642 0.3642
Echinococcus multilocularis fmrfamide receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni biogenic amine receptor 0.007 0.3642 0.3642
Schistosoma mansoni hypothetical protein 0.007 0.3642 0.3642
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.3045 0.3066
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.7894 0.7948
Echinococcus granulosus thyrotropin releasing hormone receptor 0.007 0.3642 0.3642
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.3642 0.3642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0083 0.0084
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0083 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni opsin-like receptor 0.007 0.3642 0.3642
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0083 0.0084
Brugia malayi Dopamine receptor 0.007 0.3642 0.3667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.3642 0.3642
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0597 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.2413 0.2413
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.3045 0.3066
Schistosoma mansoni peptide (allatostatin)-like receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0174 0.9932 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.007 0.3642 0.3642
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0083 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.3642 0.3642
Echinococcus multilocularis biogenic amine (5HT) receptor 0.007 0.3642 0.3642
Schistosoma mansoni alpha-1 adrenergic receptor 0.007 0.3642 0.3642
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0597 0.5
Onchocerca volvulus 0.007 0.3642 1
Schistosoma mansoni adenoreceptor 0.007 0.3642 0.3642
Schistosoma mansoni lamin 0.006 0.3045 0.3045
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0083 0.0084
Echinococcus granulosus neuropeptide receptor A26 0.007 0.3642 0.3642
Onchocerca volvulus 0.007 0.3642 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.3642 0.3642
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0083 0.0083
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Echinococcus multilocularis allatostatin A receptor 0.007 0.3642 0.3642
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.007 0.3642 0.3667
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.007 0.3642 0.3642
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0597 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.007 0.3642 0.3642
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.007 0.3642 0.3642
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.007 0.3642 0.3642
Onchocerca volvulus 0.007 0.3642 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.2413 0.2413
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.3642 0.3642
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0597 1
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni ferritin 0.001 0.0019 0.0019
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0597 1
Schistosoma mansoni amine GPCR 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni neuropeptide receptor 0.007 0.3642 0.3642
Brugia malayi AKH receptor 0.007 0.3642 0.3667
Echinococcus multilocularis muscleblind protein 1 0.0174 0.9932 0.9932
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.3642 0.3642
Echinococcus granulosus orexin receptor type 2 0.007 0.3642 0.3642
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi G protein-coupled receptor 0.007 0.3642 0.3667
Echinococcus granulosus ferritin 0.001 0.0019 0.0019
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus multilocularis neuropeptide receptor 0.007 0.3642 0.3642
Brugia malayi MH2 domain containing protein 0.014 0.7894 0.7948
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus neuropeptide s receptor 0.007 0.3642 0.3642
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.007 0.3642 0.3642
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.3642 0.3642
Echinococcus multilocularis tachykinin peptides receptor 99D 0.007 0.3642 0.3642
Onchocerca volvulus 0.007 0.3642 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.007 0.3642 0.3642
Toxoplasma gondii exonuclease III APE 0.0019 0.0597 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.2979 0.2999
Onchocerca volvulus 0.007 0.3642 1
Onchocerca volvulus 0.006 0.3045 0.8323
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.3642 0.3642
Loa Loa (eye worm) intermediate filament protein 0.006 0.3045 0.3066
Echinococcus granulosus fmrfamide receptor 0.007 0.3642 0.3642
Echinococcus granulosus neuropeptides capa receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.0028 0.1105 0.1112
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0083 0.0083
Onchocerca volvulus 0.007 0.3642 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Onchocerca volvulus 0.007 0.3642 1
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi gonadotropin-releasing hormone receptor 2 0.007 0.3642 0.3667
Brugia malayi G-protein coupled receptor 0.007 0.3642 0.3667
Echinococcus multilocularis neuropeptide receptor 0.007 0.3642 0.3642
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0083 0.0083
Echinococcus granulosus neuropeptide receptor 0.007 0.3642 0.3642
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0083 0.0083
Echinococcus granulosus intermediate filament protein 0.006 0.3045 0.3045
Echinococcus granulosus expressed protein 0.001 0.0019 0.0019
Echinococcus multilocularis orexin receptor type 2 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0083 0.0084
Echinococcus granulosus somatostatin receptor 0.007 0.3642 0.3642
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.3642 0.3642
Schistosoma mansoni hypothetical protein 0.0175 1 1
Echinococcus multilocularis neuropeptide s receptor 0.007 0.3642 0.3642
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.007 0.3642 0.3642
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0083 0.0084
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.007 0.3642 0.3642
Schistosoma mansoni growth hormone secretagogue receptor 0.007 0.3642 0.3642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.2413 0.2413
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.3642 0.3642
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.3642 0.3642
Echinococcus multilocularis ferritin 0.001 0.0019 0.0019
Onchocerca volvulus 0.007 0.3642 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0597 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.3642 0.3642
Brugia malayi Serotonin/octopamine receptor family protein 7 0.007 0.3642 0.3667
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi Serotonin receptor 0.007 0.3642 0.3667
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0083 0.0084
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.3642 0.3667
Echinococcus granulosus tachykinin peptides receptor 99D 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0084
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.2413 0.2429
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.3642 0.3642
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0083 0.0083
Onchocerca volvulus 0.007 0.3642 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.007 0.3642 0.3642
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0597 0.0597
Echinococcus granulosus neuropeptide receptor 0.007 0.3642 0.3642
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.007 0.3642 0.3667
Schistosoma mansoni myosin xvIII 0.007 0.3642 0.3642
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0083 0.0084
Echinococcus multilocularis lamin 0.006 0.3045 0.3045
Echinococcus multilocularis neuropeptide receptor A26 0.007 0.3642 0.3642
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.007 0.3642 1
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.1363 0.1373
Schistosoma mansoni ferritin light chain 0.001 0.0019 0.0019
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni hypothetical protein 0.0175 1 1
Onchocerca volvulus 0.007 0.3642 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.3642 0.3642
Schistosoma mansoni neuropeptide f receptor 76f 0.007 0.3642 0.3642
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.3642 0.3642
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0083 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0083 0.0084
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.3642 0.3642
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0597 0.5
Brugia malayi Serotonin receptor 0.007 0.3642 0.3667
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.007 0.3642 0.3642
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0597 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.2413 0.2413
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni neuropeptide receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.2413 0.2429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0083 0.0084
Brugia malayi follicle stimulating hormone receptor 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus peptide allatostatin:somatostatin 0.007 0.3642 0.3642
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.2413 0.2413
Echinococcus multilocularis fmrfamide receptor 0.007 0.3642 0.3642
Echinococcus granulosus lamin dm0 0.006 0.3045 0.3045
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.0174 0.9932 1
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0083 0.0083
Brugia malayi putative neuropeptide receptor 0.007 0.3642 0.3667
Echinococcus multilocularis somatostatin receptor 0.007 0.3642 0.3642
Schistosoma mansoni ferritin 0.001 0.0019 0.0019
Echinococcus multilocularis musashi 0.006 0.3045 0.3045
Echinococcus multilocularis sex peptide receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni hypothetical protein 0.007 0.3642 0.3642
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.3642 0.3642
Echinococcus multilocularis g-protein coupled receptor 0.007 0.3642 0.3642
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.3642 0.3642
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.3642 0.3642
Brugia malayi ORL1-like opioid receptor 0.007 0.3642 0.3667
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0083 0.0083
Onchocerca volvulus 0.007 0.3642 1
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus g protein coupled receptor 0.007 0.3642 0.3642
Brugia malayi ecdysteroid receptor 0.0011 0.0083 0.0084
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0083 0.0084
Echinococcus multilocularis alpha 1A adrenergic receptor 0.007 0.3642 0.3642
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0083 0.0083
Echinococcus granulosus lamin 0.006 0.3045 0.3045
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.3642 0.3642
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0083 0.0083
Brugia malayi neuropeptide F receptor 0.007 0.3642 0.3667
Schistosoma mansoni amine GPCR 0.007 0.3642 0.3642
Echinococcus granulosus muscleblind protein 0.0174 0.9932 0.9932
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.007 0.3642 0.3667
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.007 0.3642 0.3642
Echinococcus granulosus sex peptide receptor 0.007 0.3642 0.3642
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0083 0.0083
Schistosoma mansoni ferritin 0.001 0.0019 0.0019
Echinococcus multilocularis g protein coupled receptor 0.007 0.3642 0.3642
Echinococcus multilocularis muscleblind protein 0.0174 0.9932 0.9932
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0083 0.0083
Onchocerca volvulus Neuropeptide F receptor homolog 0.007 0.3642 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0597 0.5
Brugia malayi hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus g protein coupled receptor 0.007 0.3642 0.3642
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.007 0.3642 0.3642
Schistosoma mansoni amine GPCR 0.007 0.3642 0.3642
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.3642 0.3642
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.3642 0.3642
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.007 0.3642 0.3667
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0083 0.0084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.3642 0.3642
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0083 0.0083
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0083 0.0084
Onchocerca volvulus 0.007 0.3642 1
Schistosoma mansoni lamin 0.006 0.3045 0.3045
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0597 1
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.3642 0.3642
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.3642 0.3642
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.006 0.3045 0.3066
Schistosoma mansoni amine GPCR 0.007 0.3642 0.3642
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.007 0.3642 0.3642
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0083 0.0083
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.3642 0.3642
Schistosoma mansoni neuropeptide receptor 0.007 0.3642 0.3642
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus multilocularis g protein coupled receptor 0.007 0.3642 0.3642
Echinococcus multilocularis g protein coupled receptor 0.007 0.3642 0.3642
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.3642 0.3642
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0083 0.0083
Schistosoma mansoni histamine h1 receptor 0.007 0.3642 0.3642
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) TYRA-2 protein 0.007 0.3642 0.3667
Loa Loa (eye worm) hypothetical protein 0.007 0.3642 0.3667
Echinococcus granulosus 7tm_1 domain containing protein 0.007 0.3642 0.3642
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0083 0.0084
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.3642 0.3642
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.1363 0.1373
Brugia malayi G protein-coupled receptor F59B2.13 0.007 0.3642 0.3667
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.3642 0.3667

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.