Detailed information for compound 1223301

Basic information

Technical information
  • TDR Targets ID: 1223301
  • Name: 2-amino-N-(2,6-dimethylphenyl)acetamide hydro chloride
  • MW: 214.692 | Formula: C10H15ClN2O
  • H donors: 2 H acceptors: 1 LogP: 1.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(=O)Nc1c(C)cccc1C.Cl
  • InChi: 1S/C10H14N2O.ClH/c1-7-4-3-5-8(2)10(7)12-9(13)6-11;/h3-5H,6,11H2,1-2H3,(H,12,13);1H
  • InChiKey: HPVGPNNVMZBKIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-N-(2,6-dimethylphenyl)ethanamide hydrochloride
  • MLS000772773
  • T5230802
  • SMR000377326

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0057 0.1542 0.1542
Toxoplasma gondii cathepsin CPC2 0.0009 0.0042 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0009 0.0042 0.0042
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.0182 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0042 0.0042
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0387 0.0632
Plasmodium vivax vivapain-3 0.0016 0.0283 0.0486
Brugia malayi Cytochrome P450 family protein 0.0013 0.0174 0.0174
Entamoeba histolytica cysteine proteinase 1, putative 0.0016 0.0283 0.5171
Echinococcus multilocularis cathepsin L 0.0009 0.0042 0.0068
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0387 0.0387
Plasmodium falciparum serine repeat antigen 4 0.0009 0.0042 0.0072
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0016 0.0283 0.0623
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0195 0.5812 0.5812
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Schistosoma mansoni cathepsin B (C01 family) 0.0009 0.0042 0.0042
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0174 0.0174
Onchocerca volvulus 0.0009 0.0042 0.0056
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0145 0.0319
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0892 0.1966
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0009 0.0042 0.0072
Onchocerca volvulus 0.0025 0.0547 0.0728
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.0623
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0364 0.0364
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0182
Plasmodium vivax serine-repeat antigen (SERA) 0.0009 0.0042 0.0072
Loa Loa (eye worm) oxidoreductase 0.0013 0.0182 0.0182
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0182 0.0401
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0364 0.0364
Plasmodium falciparum enoyl-acyl carrier reductase 0.0195 0.5812 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0042
Brugia malayi Cathepsin L-like precursor 0.0009 0.0042 0.0042
Schistosoma mansoni DNA helicase recq1 0.0009 0.006 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0547 0.0547
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0547 0.0547
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.0283
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0009 0.0042 0.0072
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0013 0.0182 0.0313
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.0623
Giardia lamblia Cathepsin B precursor 0.0052 0.1386 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0747 0.1285
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0283 0.0462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0319 0.055
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0547 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0364 0.0364
Trypanosoma cruzi cysteine proteinase, putative 0.0016 0.0283 0.0623
Trypanosoma cruzi cysteine peptidase, putative 0.0008 0.0014 0.003
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.0283
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0182 0.0182
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0364 0.0802
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0154 0.4539 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0328 0.0328
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0013 0.0182 0.0313
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0387 0.0665
Echinococcus multilocularis carbonic anhydrase 0.0057 0.1542 0.2523
Onchocerca volvulus 0.0013 0.0182 0.0242
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0027 0.0595 0.0974
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.006 0.0104
Leishmania major oxidoreductase-like protein 0.0013 0.0182 0.0401
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0431 0.0431
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0387 0.7073
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0387 0.0387
Echinococcus granulosus cathepsin l1 0.0016 0.0283 0.0462
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Echinococcus multilocularis carbonic anhydrase II 0.0154 0.4539 0.7425
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0027 0.0595 0.0974
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0747 0.0747
Entamoeba histolytica cysteine protease, putative 0.0009 0.0042 0.0764
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0283 0.0283
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0283 0.0486
Loa Loa (eye worm) hypothetical protein 0.0057 0.1542 0.1542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Onchocerca volvulus 0.0016 0.0283 0.0377
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.4389 0.4389
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0154 0.4539 0.4539
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0714 0.1228
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0892 0.1966
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0283 0.5171
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Schistosoma mansoni cathepsin C 0.0009 0.0042 0.0042
Echinococcus granulosus lysine specific demethylase 5A 0.0083 0.2335 0.3821
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0182 0.0182
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0154 0.4539 0.4539
Brugia malayi glutaminase DH11.1 0.033 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0009 0.0042 0.0072
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0013 0.0182 0.0313
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.006 0.0104
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0182 0.0182
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0283 0.5171
Brugia malayi Cathepsin L-like cysteine proteinase 0.0009 0.0042 0.0042
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Toxoplasma gondii cathepsin CPL 0.0016 0.0283 0.0486
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.0892 0.0892
Plasmodium falciparum serine repeat antigen 1 0.0009 0.0042 0.0072
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0149 0.4389 0.9671
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Brugia malayi cathepsin B-like cysteine proteinase 0.0149 0.4389 0.4389
Loa Loa (eye worm) hypothetical protein 0.0025 0.0547 0.0547
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0013 0.0182 0.0297
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0145 0.265
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0009 0.0042 0.0042
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0387 0.0632
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0009 0.0042 0.0042
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0431 0.0431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Loa Loa (eye worm) hypothetical protein 0.0025 0.0547 0.0547
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0009 0.0042 0.0072
Toxoplasma gondii exonuclease III APE 0.002 0.0387 0.0665
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0009 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0009 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0009 0.0042 0.0764
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0182 0.0313
Loa Loa (eye worm) hypothetical protein 0.0021 0.0431 0.0431
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0387 0.0665
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0547 0.0547
Trypanosoma brucei pteridine reductase 1 0.0013 0.0182 0.0401
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0283 0.5171
Onchocerca volvulus 0.0016 0.0283 0.0377
Trichomonas vaginalis hypothetical protein 0.0195 0.5812 0.5812
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0042 0.0042
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0013 0.0182 0.0182
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.006 0.006
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0009 0.0042 0.0042
Mycobacterium ulcerans endonuclease IV 0.0081 0.2274 0.2274
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.006 0.0104
Plasmodium falciparum serine repeat antigen 7 0.0009 0.0042 0.0072
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.6565 0.6565
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0081 0.2274 0.2274
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0174 0.0174
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0009 0.0042 0.0072
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Entamoeba histolytica cysteine protease, putative 0.0009 0.0042 0.0764
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.0283
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.2335 0.2335
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.0042 0.0042
Mycobacterium ulcerans hypothetical protein 0.0021 0.0431 0.0431
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0547 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0547 0.0547
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0013 0.0182 0.0313
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0283 0.0462
Schistosoma mansoni cathepsin s 0.0008 0.0014 0.0014
Onchocerca volvulus 0.0016 0.0283 0.0377
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0283 0.5171
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0182 0.0313
Onchocerca volvulus 0.0016 0.0283 0.0377
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0892 0.1966
Echinococcus granulosus cathepsin L 0.0016 0.0283 0.0462
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0283 0.0283
Trypanosoma cruzi cysteine proteinase, putative 0.0016 0.0283 0.0623
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.0623
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0711 0.1164
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0031 0.0747 0.0747
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0105 0.3017 0.4936
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0283 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Brugia malayi cathepsin F-like cysteine proteinase 0.0008 0.0014 0.0014
Trypanosoma cruzi cruzipain precursor, putative 0.0008 0.0014 0.003
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0283 0.0283
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0469 0.0768
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0154 0.4539 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0387 0.0852
Schistosoma mansoni ap endonuclease 0.002 0.0387 0.0387
Mycobacterium ulcerans epimerase 0.0021 0.0431 0.0431
Schistosoma mansoni cathepsin F (C01 family) 0.0009 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Echinococcus granulosus cysteine protease 0.0016 0.0283 0.0462
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.0283
Schistosoma mansoni DNA helicase recq5 0.0009 0.006 0.006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0364 0.0595
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0009 0.0042 0.0042
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.2274 0.3913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0547 0.094
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.0892 0.146
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0283 0.0283
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.006 0.006
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0364 0.0595
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0154 0.4539 0.4539
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0174 0.0384
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.0283
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0081 0.2274 0.3913
Onchocerca volvulus 0.0016 0.0283 0.0377
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.006 0.0138
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0009 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.006 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0042 0.0764
Onchocerca volvulus Cathepsin L homolog 0.0009 0.0042 0.0056
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0008 0.0014 0.0014
Toxoplasma gondii hypothetical protein 0.0027 0.0601 0.1034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0081 0.2274 0.2274
Trypanosoma cruzi cysteine protease, putative 0.0016 0.0283 0.0623
Echinococcus granulosus cathepsin L 0.0009 0.0042 0.0068
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0182 0.0182
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0364 0.0595
Trichomonas vaginalis glutaminase, putative 0.033 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0351 0.0351
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0469 0.0469
Echinococcus granulosus cathepsin b 0.0149 0.4389 0.7181
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0042 0.0042
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0547 0.0547
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0387 0.0387
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.0283
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0013 0.0182 0.0313
Plasmodium falciparum serine repeat antigen 9 0.0009 0.0042 0.0072
Plasmodium falciparum cysteine proteinase falcipain 1 0.0016 0.0283 0.0486
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0009 0.0042 0.0072
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0052 0.1386 0.3054
Brugia malayi Pre-SET motif family protein 0.0219 0.6565 0.6565
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0042
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0283 0.0377
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0547 0.0547
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0547 0.1204
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0283 0.0623
Echinococcus granulosus cathepsin b 0.0149 0.4389 0.7181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Loa Loa (eye worm) fibroinase 0.0016 0.0283 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0892 0.1535
Toxoplasma gondii hypothetical protein 0.0057 0.1542 0.2654
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0149 0.4389 0.4389
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0323 0.0323
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0283 0.0283
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.2274 0.3913
Leishmania major pteridine reductase 1 0.0013 0.0182 0.0401
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0042
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0009 0.0042 0.0042
Brugia malayi cathepsin L-like precursor 0.0009 0.0042 0.0042
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0013 0.0182 0.0313
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.0283
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0182 0.0401
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0547 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0283 0.0462
Leishmania major hypothetical protein, conserved 0.0036 0.0892 0.1966
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0042
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0313
Plasmodium vivax vivapain-1 0.0016 0.0283 0.0486
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0182 0.0182
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0387 0.0387
Toxoplasma gondii preprocathepsin c precursor, putative 0.0009 0.0042 0.0072
Brugia malayi cathepsin L-like cysteine proteinase 0.0009 0.0042 0.0042
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0547 0.0547
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0364 0.0802
Entamoeba histolytica cysteine protease, putative 0.0009 0.0042 0.0764
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0364 0.0626
Echinococcus multilocularis lysine specific demethylase 5A 0.0081 0.2282 0.3733
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0009 0.0042 0.0042
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0182
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0008 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0149 0.4389 0.4389
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0042 0.0042
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0283 0.0283
Echinococcus granulosus geminin 0.0205 0.6112 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0547 0.0547
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0145 0.0319
Brugia malayi cathepsin F-like cysteine proteinase 0.0009 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0009 0.0042 0.0764
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0892 0.1535
Brugia malayi isocitrate dehydrogenase 0.0019 0.0364 0.0364
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.0283
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0547 0.1204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0283 0.0623
Loa Loa (eye worm) ctsf protein 0.0016 0.0283 0.0283
Trypanosoma brucei carbonic anhydrase-like protein 0.0154 0.4539 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.006 0.0099
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0283 0.0283
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0174 0.0174
Onchocerca volvulus 0.0013 0.0182 0.0242
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Echinococcus multilocularis carbonic anhydrase 0.0057 0.1542 0.2523
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0547 0.0547
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0182 0.0182
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.082 0.1411
Plasmodium vivax unspecified product 0.0008 0.0014 0.0024
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0154 0.4539 0.4539
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0009 0.0042 0.0072
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0385 0.0662
Plasmodium vivax SET domain protein, putative 0.0031 0.0747 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0042 0.0042
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0387 0.0852
Plasmodium falciparum serine repeat antigen 3 0.0009 0.0042 0.0072
Brugia malayi cathepsin Z-like cysteine proteinase 0.0009 0.0042 0.0042
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Loa Loa (eye worm) carbonic anhydrase 3 0.0154 0.4539 0.4539
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0319 0.055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.0283
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0009 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0283 0.0623
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Trypanosoma cruzi cruzipain precursor, putative 0.0016 0.0283 0.0623
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.006 0.0099
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0364 0.0802
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0747 0.1222
Mycobacterium ulcerans glutaminase 0.033 1 1
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0013 0.0182 0.0313
Loa Loa (eye worm) hypothetical protein 0.0025 0.0547 0.0547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0283 0.0283
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0387 0.2565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.0623
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0747 0.0747
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.0892 0.146
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0154 0.4539 0.4539
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0013 0.0182 0.0313
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0009 0.0042 0.0042
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0182 0.0401
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0469 0.0469
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0013 0.0182 0.0401
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0892 0.1535
Trichomonas vaginalis set domain proteins, putative 0.025 0.7504 0.7504
Plasmodium falciparum carbonic anhydrase 0.0057 0.1542 0.2654
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0364 0.0626
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.2335 0.2335
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0195 0.5812 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0387 0.0665
Loa Loa (eye worm) RecQ helicase 0.0022 0.0469 0.0469
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.1542 0.1542
Echinococcus multilocularis geminin 0.0205 0.6112 1
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0145 0.0145
Toxoplasma gondii cathepsin CPC1 0.0009 0.0042 0.0072
Leishmania major carbonic anhydrase-like protein 0.0154 0.4539 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0469 0.0469
Onchocerca volvulus 0.0009 0.0042 0.0056
Brugia malayi cathepsin L precursor 0.0009 0.0042 0.0042
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0431 0.0574
Brugia malayi cathepsin Z-like cysteine proteinase 0.0009 0.0042 0.0042
Echinococcus multilocularis cathepsin L 0.0016 0.0283 0.0462
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.006 0.006
Loa Loa (eye worm) glutaminase 0.033 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0387 0.0852
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0013 0.0182 0.0182
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0052 0.1386 0.3054
Schistosoma mansoni ap endonuclease 0.002 0.0387 0.0387
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0042 0.0042
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0313
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0595 0.0595
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0057 0.1542 0.1542
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0081 0.2274 0.3913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0057 0.1542 0.1542
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0364 0.0595
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0182 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0042 0.0042
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0013 0.0182 0.3327
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0283 0.0283
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Plasmodium vivax vivapain-2 0.0016 0.0283 0.0486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0283 0.0377
Plasmodium vivax JmjC domain containing protein 0.003 0.0714 0.1228
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0364 0.0626
Echinococcus granulosus cathepsin L cysteine protease 0.0016 0.0283 0.0462
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.1386 0.1386
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0182 0.0401
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0182 0.0182
Toxoplasma gondii PLU-1 family protein 0.0046 0.1195 0.2055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Echinococcus multilocularis cathepsin b 0.0149 0.4389 0.7181
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.1542 0.1542
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.0283
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0057 0.1542 0.1542
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0351 0.0604
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0547 0.094
Schistosoma mansoni hypothetical protein 0.0054 0.1461 0.1461
Toxoplasma gondii cathepsin B 0.0052 0.1386 0.2385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0009 0.0042 0.0072
Plasmodium falciparum serine repeat antigen 6 0.0009 0.0042 0.0072
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0351 0.0351
Plasmodium vivax vivapain-2 0.0016 0.0283 0.0486
Echinococcus granulosus carbonic anhydrase 0.0057 0.1542 0.2523
Plasmodium falciparum serine repeat antigen 2 0.0009 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0009 0.0042 0.0042
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0182 0.0313
Echinococcus granulosus carbonic anhydrase 0.0057 0.1542 0.2523
Loa Loa (eye worm) hypothetical protein 0.0013 0.0182 0.0182
Giardia lamblia Cathepsin B precursor 0.0052 0.1386 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0174 0.0384
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0364 0.0802
Brugia malayi Augmenter of liver regeneration 0.0036 0.0892 0.0892
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0009 0.0042 0.0072
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0195 0.5812 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0547 0.0547
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0009 0.0042 0.0042
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0182
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0105 0.3017 0.4936
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0547 0.094
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0431 0.0741
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0283 0.5171
Loa Loa (eye worm) hypothetical protein 0.0019 0.0351 0.0351
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0013 0.0182 0.0401
Onchocerca volvulus 0.025 0.7504 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0009 0.0042 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0387 0.0852
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.1542 0.1542
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0042
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0351 0.0351
Schistosoma mansoni cathepsin S (C01 family) 0.0009 0.0042 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0547 0.1204
Echinococcus granulosus carbonic anhydrase 0.0057 0.1542 0.2523
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Brugia malayi jmjC domain containing protein 0.0129 0.3757 0.3757
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0747 0.1222
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0364 0.0626
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0009 0.0042 0.0042
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0351 0.03
Entamoeba histolytica cysteine protease, putative 0.0009 0.0042 0.0764
Echinococcus granulosus carbonic anhydrase II 0.0154 0.4539 0.7425
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.0623
Loa Loa (eye worm) hypothetical protein 0.0019 0.0351 0.0351
Entamoeba histolytica cysteine protease, putative 0.0009 0.0042 0.0764
Toxoplasma gondii endonuclease IV APN 0.0081 0.2274 0.3913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0042 0.0042
Entamoeba histolytica cysteine proteinase 2 0.0016 0.0283 0.5171
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0182
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0009 0.0042 0.0072
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0364 0.0802
Onchocerca volvulus 0.0031 0.0747 0.0996
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0547 0.0547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0042 0.0042
Loa Loa (eye worm) cysteine protease 0.0016 0.0283 0.0283
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0283 0.5171
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0009 0.0042 0.0042
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.006 0.0099
Plasmodium vivax unspecified product 0.0016 0.0283 0.0486
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0042
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.1542 0.1542
Loa Loa (eye worm) cathepsin B 0.0052 0.1386 0.1386
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0283 0.0486
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0009 0.0042 0.0072
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.0623
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.4389 0.4389
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0283 0.0623
Echinococcus multilocularis cysteine protease 0.0016 0.0283 0.0462
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0182
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0009 0.0042 0.0042
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0747 0.1222
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0009 0.0042 0.0072
Plasmodium vivax serine-repeat antigen (SERA) 0.0009 0.0042 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.0283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0319 0.055
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.4389 0.4389
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0387 0.0364
Trypanosoma cruzi major cysteine proteinase, putative 0.0009 0.0042 0.0092
Onchocerca volvulus 0.0016 0.0283 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Plasmodium vivax unspecified product 0.0009 0.0042 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0174 0.0174
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.1386 0.1386
Onchocerca volvulus 0.0016 0.0283 0.0377
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0283 0.0623
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0283 0.0462
Echinococcus multilocularis cysteine protease 0.0016 0.0283 0.0462
Echinococcus granulosus bloom syndrome protein 0.0022 0.0469 0.0768
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Schistosoma mansoni carbonic anhydrase 0.0057 0.1542 0.1542
Plasmodium falciparum serine repeat antigen 5 0.0009 0.0042 0.0072
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0892 0.1535
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0013 0.0182 0.0313
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0195 0.5812 1
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0431 0.0741
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0182
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0009 0.0042 0.0764
Echinococcus multilocularis cathepsin b 0.0149 0.4389 0.7181
Brugia malayi Cytochrome P450 family protein 0.0013 0.0174 0.0174
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0547 0.094
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0283 0.0377
Trypanosoma brucei oxidoreductase-like protein 0.0013 0.0182 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0009 0.0042 0.0042
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0195 0.5812 1
Schistosoma mansoni hypothetical protein 0.0205 0.6112 0.6112
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0364 0.0595
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0387 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0283 0.0623
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0174 0.0384
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0351 0.0604
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0145 0.0319
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0009 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0205 0.6112 0.6112
Mycobacterium ulcerans oxidoreductase 0.0013 0.0182 0.0182
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0009 0.0042 0.0092
Echinococcus multilocularis carbonic anhydrase 0.0057 0.1542 0.2523
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0283 0.0486
Chlamydia trachomatis endonuclease IV 0.0081 0.2274 0.3716
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0387 0.0387
Brugia malayi jmjC domain containing protein 0.0027 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.0009 0.0059 0.0059
Brugia malayi fibroinase precursor 0.0009 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0057 0.1542 0.1542
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.5171
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0182 0.0182
Leishmania major cytochrome p450-like protein 0.0013 0.0174 0.0384
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.0283
Trypanosoma brucei cysteine peptidase C (CPC) 0.0052 0.1386 0.3054
Brugia malayi Pre-SET motif family protein 0.0031 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0014
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0364 0.0626
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0019 0.0351 0.0351
Echinococcus granulosus cathepsin l1 0.0009 0.0042 0.0068
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0892 0.1966
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0057 0.1542 0.1542
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0195 0.5812 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0244 0.0419
Entamoeba histolytica cysteine protease, putative 0.0009 0.0042 0.0764
Loa Loa (eye worm) jmjC domain-containing protein 0.0129 0.3757 0.3757
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0182
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.1542 0.1542
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0364 0.0595
Giardia lamblia Cathepsin B precursor 0.0052 0.1386 1
Brugia malayi Cathepsin L-like precursor 0.0009 0.0042 0.0042
Schistosoma mansoni glutaminase 0.033 1 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0182 0.0401
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0013 0.0182 0.0297
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0238 0.041
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0009 0.0042 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0009 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0042 0.0042
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0283 0.0283
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0182 0.0182
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.1542 0.1542
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0351 0.0604
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0195 0.5812 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0042
Brugia malayi Cathepsin L-like precursor 0.0008 0.0014 0.0014
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0283 0.0462
Loa Loa (eye worm) retinol dehydrogenase 12 0.0013 0.0182 0.0182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0319 0.055
Plasmodium falciparum serine repeat antigen 8 0.0009 0.0042 0.0072
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0013 0.0182 0.0313
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.0623
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0182 0.0313
Trypanosoma cruzi major cysteine proteinase, putative 0.0009 0.0042 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0042

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 10 % Antiarrhythmic activity in Swiss albino mouse assessed as protection against chloroform-induced fibrillation at 100 mg/kg, sc relative to control ChEMBL. 513064
Potency (functional) 10.3225 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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