Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0038 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0038 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0038 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0038 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0038 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0038 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0038 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0038 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 1 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0038 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0038 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0038 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0038 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Schistosoma mansoni | ap endonuclease | 0.0038 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0038 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.2642 | 0.2642 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.2642 | 0.2642 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.2642 | 0.2642 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.2642 | 0.2642 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.2642 | 0.2642 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.2642 | 0.2642 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.