Detailed information for compound 1223865

Basic information

Technical information
  • TDR Targets ID: 1223865
  • Name: N-(2,6-dimethylphenyl)-2-[2-[(4-methylphenyl) sulfanylmethyl]benzimidazol-1-yl]acetamide
  • MW: 415.551 | Formula: C25H25N3OS
  • H donors: 1 H acceptors: 2 LogP: 5.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)SCc1nc2c(n1CC(=O)Nc1c(C)cccc1C)cccc2
  • InChi: 1S/C25H25N3OS/c1-17-11-13-20(14-12-17)30-16-23-26-21-9-4-5-10-22(21)28(23)15-24(29)27-25-18(2)7-6-8-19(25)3/h4-14H,15-16H2,1-3H3,(H,27,29)
  • InChiKey: UXVDFSNUMMFECO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,6-dimethylphenyl)-2-[2-[[(4-methylphenyl)thio]methyl]-1-benzimidazolyl]acetamide
  • N-(2,6-dimethylphenyl)-2-[2-[[(4-methylphenyl)thio]methyl]benzimidazol-1-yl]acetamide
  • N-(2,6-dimethylphenyl)-2-[2-[(4-methylphenyl)sulfanylmethyl]benzimidazol-1-yl]ethanamide
  • MLS000325550
  • N-(2,6-dimethylphenyl)-2-(2-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,3-benzimidazol-1-yl)acetamide
  • SMR000169902
  • Oprea1_358797
  • 8J-308S

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0513 0.1362
Loa Loa (eye worm) hypothetical protein 0.0043 0.0513 0.137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0178 0.0474
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0036 0.006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0051 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0178 0.0474
Toxoplasma gondii LsmAD domain-containing protein 0.0034 0.0375 0.5014
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0021 0.0203 0.0539
Brugia malayi mbt repeat family protein 0.0022 0.0217 0.058
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0051 0.0137
Loa Loa (eye worm) Smad1 0.0011 0.006 0.0161
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0269 0.1263
Mycobacterium tuberculosis Probable aminotransferase 0.0152 0.202 0.5365
Onchocerca volvulus 0.0019 0.0178 0.0638
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0178 0.0291
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0015 0.0119 0.0112
Plasmodium falciparum ornithine aminotransferase 0.0022 0.021 0.5412
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0036 0.0407 0.0523
Mycobacterium ulcerans hypothetical protein 0.0026 0.0269 0.1263
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0269 0.1263
Schistosoma mansoni hypothetical protein 0.0028 0.0298 0.0488
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0269 0.4534
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0036 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0036 0.0039
Loa Loa (eye worm) RNA binding protein 0.0063 0.0789 0.2107
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0298 0.0794
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0017 0.0151 0.0145
Onchocerca volvulus 0.0043 0.0513 0.1846
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1236 0.123
Mycobacterium ulcerans lipase LipD 0.0043 0.0513 0.2484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1236 0.2029
Brugia malayi beta-lactamase 0.0043 0.0513 0.137
Echinococcus multilocularis Aminotransferase class III 0.0022 0.021 0.0203
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0178 0.0291
Schistosoma mansoni transcription factor LCR-F1 0.0048 0.0574 0.0942
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0475
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0475
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0474
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0178 0.0291
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0152 0.202 0.5365
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0178 0.0474
Mycobacterium tuberculosis Conserved protein 0.0043 0.0513 0.1362
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0513 0.1362
Loa Loa (eye worm) hypothetical protein 0.0008 0.0026 0.0069
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0036 0.0039
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0021 0.0203 0.0197
Brugia malayi hypothetical protein 0.0009 0.0036 0.0097
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0298 0.038
Onchocerca volvulus 0.0008 0.0015 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0178 0.0474
Onchocerca volvulus 0.0008 0.0015 0.0055
Trypanosoma brucei DNA polymerase IV, putative 0.0008 0.0026 0.0213
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0178 0.0474
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0789 0.0783
Brugia malayi ecdysteroid receptor 0.0019 0.0178 0.0474
Trypanosoma cruzi DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0036 0.003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0269 0.1263
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0513 0.251
Onchocerca volvulus 0.0009 0.0036 0.0131
Schistosoma mansoni hypothetical protein 0.0037 0.0417 0.0685
Brugia malayi hypothetical protein 0.0009 0.0036 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0036 0.003
Echinococcus granulosus ornithine aminotransferase 0.0022 0.021 0.0266
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0008 0.0026 0.0025
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0017 0.0139 0.2485
Loa Loa (eye worm) hypothetical protein 0.0207 0.2781 0.7424
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0513 1
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0015 0.0025
Schistosoma mansoni Smad4 0.0011 0.006 0.0099
Schistosoma mansoni nuclear receptor 0.0009 0.0036 0.006
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0017 0.0151 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Loa Loa (eye worm) MH2 domain-containing protein 0.0159 0.2112 0.5638
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0269 0.1263
Onchocerca volvulus 0.0022 0.0217 0.0782
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0178 0.0474
Plasmodium vivax ataxin-2 like protein, putative 0.0034 0.0375 0.7224
Echinococcus multilocularis SAM and MBT domain containing protein 0.0022 0.0217 0.0211
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0017 0.0139 0.344
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0269 0.4534
Echinococcus multilocularis dna polymerase kappa 0.0008 0.0026 0.0019
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0017 0.0139 0.2485
Loa Loa (eye worm) hypothetical protein 0.0028 0.0298 0.0794
Trichomonas vaginalis DNA polymerase eta, putative 0.0008 0.0026 0.0087
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0015 0.0039
Brugia malayi ecdysone receptor 0.0009 0.0036 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.007 0.0886 0.088
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0036 0.0097
Brugia malayi MH2 domain containing protein 0.0159 0.2112 0.5638
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0036 0.0097
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0017 0.0139 0.2485
Mycobacterium ulcerans DNA polymerase IV 0.0008 0.0026 0.0053
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0178 0.0223
Echinococcus granulosus Aminotransferase class III 0.0022 0.021 0.0266
Echinococcus multilocularis Smad4 0.0011 0.006 0.0053
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Brugia malayi TAR-binding protein 0.0063 0.0789 0.2107
Echinococcus granulosus smad 0.0011 0.006 0.007
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.03 0.4075 0.4071
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0015 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0008 0.0026 0.0213
Echinococcus granulosus GPCR family 2 0.0028 0.0298 0.038
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0021 0.0203 0.3776
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0178 0.0291
Echinococcus granulosus intestinal type alkaline phosphatase 0.007 0.0886 0.115
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0017 0.0151 0.0248
Onchocerca volvulus 0.0007 0.0007 0.0024
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0178 0.0223
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0017 0.0151 0.2435
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0152 0.202 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0178 0.0474
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0036 0.006
Echinococcus multilocularis intestinal type alkaline phosphatase 0.007 0.0886 0.088
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0018 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0015 0.0039
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.7657 0.7655
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0015 0.0039
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0017 0.0151 0.0189
Loa Loa (eye worm) apoptosis regulator protein 0.0036 0.0407 0.1087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1236 0.1607
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0022 0.021 0.0971
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0017 0.0151 0.273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1236 0.2029
Schistosoma mansoni smad1 5 8 and 0.0011 0.006 0.0099
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0178 0.0291
Loa Loa (eye worm) hypothetical protein 0.0043 0.0513 0.137
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0051 0.0084
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0022 0.021 0.0556
Loa Loa (eye worm) DR-78 0.0009 0.0036 0.0097
Schistosoma mansoni hypothetical protein 0.0028 0.0298 0.0488
Schistosoma mansoni hypothetical protein 0.0036 0.0407 0.0668
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0015 0.0039
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0017 0.0139 0.0649
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0298 0.038
Loa Loa (eye worm) isocitrate dehydrogenase 0.0021 0.0203 0.0543
Brugia malayi nuclear receptor RXR 0.0009 0.0036 0.0097
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0036 0.0039
Schistosoma mansoni hypothetical protein 0.0028 0.0298 0.0488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0178 0.0474
Echinococcus multilocularis GPCR, family 2 0.0028 0.0298 0.0291
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0036 0.003
Brugia malayi isocitrate dehydrogenase 0.0021 0.0203 0.0543
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0269 0.0717
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0269 0.1263
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1236 0.2029
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0269 0.5085
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0152 0.202 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0137
Toxoplasma gondii ABC1 family protein 0.0043 0.0513 0.6941
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0163 0.0432
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.0034 0.0375 0.1001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0163 0.0432
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0015 0.0009
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0008 0.0026 0.0087
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0022 0.0217 0.0357
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.007 0.0886 0.088
Schistosoma mansoni terminal deoxycytidyl transferase 0.0008 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0018
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0015 0.0034
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0178 0.0474
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0041
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0178 0.0291
Schistosoma mansoni alkaline phosphatase 0.007 0.0886 0.1454
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0017 0.0139 0.0371
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0178 0.0474
Schistosoma mansoni hypothetical protein 0.0446 0.6094 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0269 0.5085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0088 0.1135 0.3029
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0344 0.0919
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0018 0.0015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0178 0.0171
Loa Loa (eye worm) oxidoreductase 0.0008 0.0015 0.0041
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0017 0.0151 0.071
Brugia malayi hypothetical protein 0.0022 0.021 0.0561
Echinococcus granulosus tar DNA binding protein 0.0063 0.0789 0.1023
Toxoplasma gondii isocitrate dehydrogenase 0.0021 0.0203 0.2621
Brugia malayi conserved hypotetical protein 0.0009 0.0036 0.0097
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0513 1
Brugia malayi hypothetical protein 0.0007 0.0007 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0178 0.0474
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0017 0.0139 0.0371
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0017 0.0151 0.273
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0022 0.021 0.0971
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0036 0.0407 0.0401
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0036 0.0407 0.1087
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0178 0.0474
Loa Loa (eye worm) beta-lactamase 0.0043 0.0513 0.137
Echinococcus granulosus SAM and MBT domain containing protein 0.0022 0.0217 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0178 0.0474
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0178 0.0291
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.007 0.0886 0.115
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0022 0.021 0.0971
Schistosoma mansoni smad1 5 8 and 0.0011 0.006 0.0099
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0513 0.1362
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0513 0.0507
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.021 0.0203
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0475
Schistosoma mansoni cpg binding protein 0.0033 0.0369 0.0606
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.0021 0.0203 0.2621
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0015 0.0041
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0011 0.006 0.0053
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0015 0.0034
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0269 0.1263
Schistosoma mansoni hypothetical protein 0.0036 0.0407 0.0668
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Loa Loa (eye worm) hypothetical protein 0.0025 0.026 0.0694
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.021 0.2714
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0475
Schistosoma mansoni zinc finger protein 0.0009 0.0036 0.006
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0017 0.0151 0.0248
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0789 0.2107
Schistosoma mansoni sex comb on midleg homolog 0.0022 0.0217 0.0357
Entamoeba histolytica deoxycytidyl transferase, putative 0.0008 0.0026 0.019
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0036 0.0039
Onchocerca volvulus 0.0009 0.0036 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0178 0.0474
Loa Loa (eye worm) hypothetical protein 0.0043 0.0513 0.137
Echinococcus multilocularis geminin 0.0227 0.3055 0.305
Schistosoma mansoni smad1 5 8 and 0.0011 0.006 0.0099
Schistosoma mansoni hypothetical protein 0.0036 0.0407 0.0668
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0036 0.006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1236 0.33
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0178 0.0291
Brugia malayi Protein kinase domain containing protein 0.0007 0.0007 0.0018
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0178 0.0474
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0178 0.0474
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0017 0.0139 0.1725
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.021 0.0345
Echinococcus granulosus tumor protein p63 0.0157 0.2087 0.2719
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0015 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0021 0.0203 0.0197
Plasmodium falciparum ataxin-2 like protein, putative 0.0034 0.0375 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0021 0.0203 0.3776
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0178 0.0223
Loa Loa (eye worm) hypothetical protein 0.0023 0.0229 0.0611
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0513 1
Mycobacterium ulcerans DNA polymerase IV 0.0008 0.0026 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0178 0.0474
Echinococcus granulosus nuclear receptor co repressor related ncor 0.03 0.4075 0.5319
Plasmodium falciparum ataxin-2 like protein, putative 0.0034 0.0375 1
Leishmania major hypothetical protein, conserved 0.0034 0.0375 0.7224
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0178 0.0223
Onchocerca volvulus 0.0008 0.0015 0.0055
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0178 0.0223
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0036 0.0097
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0269 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0178 0.0474
Brugia malayi hypothetical protein 0.001 0.0051 0.0137
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0036 0.0407 0.0523
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0513 0.251
Entamoeba histolytica hypothetical protein 0.0048 0.0574 1
Loa Loa (eye worm) mbt repeat family protein 0.0022 0.0217 0.058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0088 0.1135 0.3029
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0017 0.0139 0.0371
Mycobacterium ulcerans L-lysine aminotransferase 0.0022 0.021 0.0971
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.021 0.0561
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0021 0.0203 0.3776
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0178 0.0474
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0087 0.1121 0.1115
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0043 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0036 0.006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0008 0.0026 0.0067
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0831 0.1364
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0051 0.0058
Trypanosoma cruzi DNA polymerase eta, putative 0.0008 0.0026 0.0213
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0017 0.0139 0.2216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0407 0.1087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0178 0.0223
Loa Loa (eye worm) hypothetical protein 0.0043 0.0513 0.137
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0022 0.021 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0137
Loa Loa (eye worm) hypothetical protein 0.0017 0.0151 0.0404
Mycobacterium leprae Probable lipase LipE 0.0043 0.0513 0.2484
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0051 0.0137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Onchocerca volvulus 0.0031 0.0344 0.1238
Echinococcus multilocularis tumor protein p63 0.0157 0.2087 0.2081
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0036 0.0097
Echinococcus granulosus cpg binding protein 0.0033 0.0369 0.0474
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Schistosoma mansoni cpg binding protein 0.0031 0.0344 0.0565
Brugia malayi hypothetical protein 0.0048 0.0574 0.1532
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0036 0.0039
Brugia malayi photoreceptor-specific nuclear receptor 0.0277 0.3746 1
Schistosoma mansoni hypothetical protein 0.0227 0.3055 0.5014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0269 0.0717
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.6094 0.6091
Schistosoma mansoni hypothetical protein 0.006 0.0747 0.1226
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0269 0.1263
Echinococcus multilocularis alkaline phosphatase 0.007 0.0886 0.088
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0269 0.4534
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0178 0.0171
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0015 0.0041
Schistosoma mansoni hypothetical protein 0.0015 0.0119 0.0195
Brugia malayi MH1 domain containing protein 0.0011 0.006 0.0161
Trichomonas vaginalis esterase, putative 0.0043 0.0513 0.251
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0036 0.0131
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0298 0.0794
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0178 0.0638
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0036 0.0097
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.7657 0.7655
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0298 0.0794
Brugia malayi ImpB/MucB/SamB family protein 0.0008 0.0026 0.0069
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0022 0.0217 0.0782
Schistosoma mansoni smad 0.0011 0.006 0.0099
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0513 0.1362
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0789 0.2107
Entamoeba histolytica hypothetical protein 0.0048 0.0574 1
Brugia malayi Isocitrate dehydrogenase 0.0021 0.0203 0.0543
Schistosoma mansoni hypothetical protein 0.0048 0.0574 0.0942
Mycobacterium tuberculosis Conserved protein 0.0043 0.0513 0.1362
Loa Loa (eye worm) TK/ALK protein kinase 0.0007 0.0007 0.0018
Brugia malayi nuclear receptor NHR-88 0.0009 0.0036 0.0097
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0036 0.0407 0.0401
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0017 0.0139 0.2485
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0017 0.0139 0.2485
Brugia malayi latrophilin 2 splice variant baaae 0.006 0.0747 0.1995
Mycobacterium ulcerans acetylornithine aminotransferase 0.0022 0.021 0.0971
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0021 0.0203 0.3776
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0269 0.5085
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Brugia malayi tailless protein 0.0009 0.0036 0.0097
Mycobacterium ulcerans hypothetical protein 0.0152 0.202 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0021 0.0203 0.0197
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0017 0.0151 0.0404
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0513 0.1362
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1236 0.33
Schistosoma mansoni hypothetical protein 0.0028 0.0298 0.0488
Brugia malayi nuclear receptor NHR-88 0.0019 0.0178 0.0474
Loa Loa (eye worm) hypothetical protein 0.0026 0.0269 0.0717
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0178 0.0171
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0036 0.0407 0.0668
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0474
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0022 0.021 1
Brugia malayi ImpB/MucB/SamB family protein 0.0008 0.0026 0.0069
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0022 0.021 0.0971
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0178 0.0291
Onchocerca volvulus 0.0043 0.0513 0.1846
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0269 0.0717
Echinococcus granulosus neuropeptide s receptor 0.0558 0.7657 1
Echinococcus multilocularis smad 0.0011 0.006 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0022 0.021 0.0556
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0178 0.0291
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0513 0.1362
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0513 0.2484
Schistosoma mansoni hypothetical protein 0.0135 0.1778 0.2918
Brugia malayi nuclear hormone receptor 0.0009 0.0036 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0178 0.0474
Plasmodium vivax ornithine aminotransferase, putative 0.0022 0.021 0.391
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0178 0.0171
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0017 0.0139 0.0649
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0036 0.003
Schistosoma mansoni hypothetical protein 0.0227 0.3055 0.5014
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0513 0.251
Schistosoma mansoni apoptosis regulator bax 0.0036 0.0407 0.0668
Echinococcus multilocularis histone acetyltransferase MYST2 0.0025 0.026 0.0253
Brugia malayi MH2 domain containing protein 0.0011 0.006 0.0161
Loa Loa (eye worm) hypothetical protein 0.0043 0.0513 0.137
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0036 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0178 0.0291
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0021 0.0203 0.3776
Echinococcus granulosus dnaJ subfamily B 0.0446 0.6094 0.7957
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0137
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0025 0.026 0.0253
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.007 0.0886 0.115
Trypanosoma cruzi PAB1-binding protein , putative 0.0034 0.0375 0.7224
Brugia malayi CXXC zinc finger family protein 0.0031 0.0344 0.0919
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0178 0.0291
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0048 0.0574 0.0741
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0475
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0008 0.0026 0.0213
Echinococcus multilocularis cpg binding protein 0.0033 0.0369 0.0363
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0017 0.0151 0.071
Onchocerca volvulus 0.0023 0.0229 0.0822
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0008 0.0026 0.0069
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0269 0.0712
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0733 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0015 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0178 0.0171
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0152 0.202 1
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0022 0.021 0.0556
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0018 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0021 0.0203 0.0197
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0513 0.2484
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0087 0.1121 0.1456
Echinococcus granulosus histone acetyltransferase MYST2 0.0025 0.026 0.0331
Schistosoma mansoni nuclear receptor 0.0009 0.0036 0.006
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0178 0.452
Echinococcus granulosus ubiquitin specific protease 41 0.0017 0.0151 0.0189
Leishmania major hypothetical protein, conserved 0.0043 0.0513 1
Brugia malayi MH2 domain containing protein 0.0011 0.006 0.0161
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0178 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0036 0.0097
Echinococcus multilocularis isocitrate dehydrogenase 0.0021 0.0203 0.0197
Onchocerca volvulus 0.0007 0.0007 0.0024
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0021 0.0203 0.0257
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0513 0.251
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0513 0.2484
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0021 0.0203 0.3776
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0017 0.0151 0.0189
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0088 0.1135 0.3029
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0789 0.2107
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0044 0.0038
Echinococcus granulosus mothers against decapentaplegic 5 0.0011 0.006 0.007
Echinococcus granulosus polycomb protein SCMH1 0.0022 0.0217 0.0275
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.021 0.0203
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0513 0.137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0474
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0178 0.0811
Brugia malayi beta-lactamase family protein 0.0043 0.0513 0.137
Brugia malayi nuclear receptor NHR-67 0.0009 0.0036 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Echinococcus granulosus Smad4 0.0011 0.006 0.007
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.021 0.0971
Trypanosoma brucei PAB1-binding protein , putative 0.0034 0.0375 0.7224
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0513 0.137
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0269 0.1263
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0015 0.0041
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0017 0.0151 0.0145
Entamoeba histolytica hypothetical protein 0.0048 0.0574 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0178 0.0223
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0178 0.0638
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0789 0.1295
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0008 0.0026 0.0067
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0021 0.0203 0.5227
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0021 0.0203 0.0334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0018 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0163 0.0432
Trypanosoma brucei DNA polymerase IV, putative 0.0008 0.0026 0.0213
Echinococcus multilocularis polycomb protein SCMH1 0.0022 0.0217 0.0211
Schistosoma mansoni coup transcription factor 0.0019 0.0178 0.0291
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0178 0.0171
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0474
Brugia malayi Smad1 0.0011 0.006 0.0161
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0022 0.021 0.0971
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0513 0.0842
Trypanosoma cruzi DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.006 0.0161
Loa Loa (eye worm) hypothetical protein 0.0088 0.1135 0.3029
Echinococcus granulosus geminin 0.0227 0.3055 0.3985
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0298 0.0291
Trypanosoma brucei DNA polymerase eta, putative 0.0008 0.0026 0.0213
Loa Loa (eye worm) hypothetical protein 0.0043 0.0513 0.137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0044 0.0049
Schistosoma mansoni cpg binding protein 0.0033 0.0369 0.0606
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.021 0.0971
Brugia malayi RNA binding protein 0.0063 0.0789 0.2107
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0008 0.0026 0.0019
Onchocerca volvulus 0.0207 0.2781 1
Loa Loa (eye worm) hypothetical protein 0.0277 0.3746 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0025 0.026 0.0331
Brugia malayi steroid hormone receptor 0.0019 0.0178 0.0474
Loa Loa (eye worm) histone methyltransferase 0.001 0.0044 0.0119
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0036 0.0097
Trypanosoma cruzi PAB1-binding protein , putative 0.0034 0.0375 0.7224
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0008 0.0026 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0269 0.0717
Mycobacterium ulcerans hypothetical protein 0.0043 0.0513 0.2484
Brugia malayi hypothetical protein 0.0034 0.0375 0.1001
Schistosoma mansoni sex comb on midleg homolog 0.0022 0.0217 0.0357
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0017 0.0139 0.0173
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0036 0.003
Loa Loa (eye worm) MBCTL1 0.0025 0.026 0.0694
Echinococcus multilocularis dna polymerase eta 0.0008 0.0026 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0789 0.1295
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0178 0.0474
Loa Loa (eye worm) hypothetical protein 0.006 0.0747 0.1995
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0015 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0513 0.0842
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0015 0.0039
Brugia malayi nuclear hormone receptor 0.0019 0.0178 0.0474
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0163 0.0432
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0036 0.0097
Leishmania major DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Mycobacterium ulcerans beta-lactamase 0.0043 0.0513 0.2484
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0178 0.0638
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0151 0.071
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0178 0.3265
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0178 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0017 0.0139 0.0371
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1236 0.1607
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0022 0.021 0.0556
Schistosoma mansoni hypothetical protein 0.0007 0.0007 0.0011
Onchocerca volvulus 0.0026 0.0269 0.0966
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1236 0.123
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0178 0.0471
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Schistosoma mansoni alkaline phosphatase 0.007 0.0886 0.1454
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0017 0.0151 0.273
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0789 0.1295
Leishmania major DNA polymerase eta, putative 0.0008 0.0026 0.0213
Brugia malayi hypothetical protein 0.0207 0.2781 0.7424
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0017 0.0139 0.0132
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0178 0.0171
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0048 0.0574 0.0567
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0036 0.003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0017 0.0151 0.273
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.006 0.0161
Trypanosoma brucei unspecified product 0.0008 0.0026 0.0213
Brugia malayi hypothetical protein 0.001 0.0051 0.0137
Brugia malayi nuclear receptor RXR 0.001 0.0051 0.0137
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.7657 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0513 0.0662
Schistosoma mansoni myelin transcription factor 1 myt1 0.0025 0.026 0.0427
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0097
Loa Loa (eye worm) transcription factor SMAD2 0.0159 0.2112 0.5638
Brugia malayi beta-lactamase family protein 0.0043 0.0513 0.137
Echinococcus granulosus dna polymerase kappa 0.0008 0.0026 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0269 0.1263
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0789 0.1295
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0011 0.006 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0178 0.0474
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0015 0.0041
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0178 0.0171
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0015 0.0119 0.0146
Schistosoma mansoni DNA polymerase eta 0.0008 0.0026 0.0043
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0015 0.0039
Echinococcus multilocularis mothers against decapentaplegic 5 0.0011 0.006 0.0053
Loa Loa (eye worm) hypothetical protein 0.0022 0.0217 0.058
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0015 0.0039
Brugia malayi MH1 domain containing protein 0.0011 0.006 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0474
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0025 0.026 0.0694
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0036 0.0131
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0474
Loa Loa (eye worm) hypothetical protein 0.0026 0.0269 0.0717
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0178 0.0171
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0018 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0789 0.1295
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0017 0.0139 0.0228
Echinococcus multilocularis ubiquitin specific protease 41 0.0017 0.0151 0.0145
Echinococcus granulosus TGF beta signal transducer SmadC 0.0011 0.006 0.007
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0015 0.0041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3763 1
Onchocerca volvulus 0.0043 0.0513 0.1846
Echinococcus granulosus dna polymerase eta 0.0008 0.0026 0.0025
Entamoeba histolytica hypothetical protein 0.0048 0.0574 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0474
Onchocerca volvulus 0.0008 0.0015 0.0055
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0036 0.0097
Echinococcus granulosus alkaline phosphatase 0.007 0.0886 0.115
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0298 0.0291
Mycobacterium tuberculosis Conserved protein 0.0043 0.0513 0.1362
Schistosoma mansoni cellular tumor antigen P53 0.0023 0.0229 0.0375
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0513 0.251
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0026 0.0213
Schistosoma mansoni hypothetical protein 0.0007 0.0007 0.0011
Brugia malayi mbt repeat family protein 0.0022 0.0217 0.058
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0513 0.1362
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0178 0.0474
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0051 0.0137
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0513 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0928 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5104 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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