Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | karyopherin (importin) beta 1 | No references | |
Homo sapiens | snurportin 1 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.3397 | 0.3397 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0596 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0596 | 0.2436 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0596 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0596 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.033 | 0.1349 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0596 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0596 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0596 | 0.0596 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.033 | 0.033 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0596 | 0.2436 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.033 | 0.033 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.033 | 0.033 |
Brugia malayi | RNA, U transporter 1 | 0.0099 | 0.2187 | 0.8939 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0596 | 0.0596 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0596 | 0.0596 |
Onchocerca volvulus | 0.0043 | 0.0596 | 1 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0596 | 0.2436 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0596 | 0.0596 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0596 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0596 | 0.0596 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0596 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0108 | 0.2447 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0035 | 0.0348 | 0.0348 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.033 | 0.033 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0141 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0596 | 0.0596 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0141 | 0.3397 | 0.3397 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0108 | 0.2447 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.033 | 0.033 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.033 | 0.033 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0596 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0596 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0596 | 0.0596 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0596 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0596 | 0.0596 |
Echinococcus multilocularis | snurportin 1 | 0.0372 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.4047 | 0.4047 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0596 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0596 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0035 | 0.0348 | 0.1422 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.9875 | 0.9875 |
Onchocerca volvulus | 0.0043 | 0.0596 | 1 | |
Echinococcus multilocularis | importin subunit beta 1 | 0.0035 | 0.0348 | 0.0348 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0596 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0372 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0596 | 0.0596 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0596 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0596 | 0.0596 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0596 | 0.2436 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.033 | 0.033 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0159 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0108 | 0.2447 | 0.2447 |
Plasmodium falciparum | importin beta, putative | 0.0035 | 0.0348 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2447 | 0.2447 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.1467 | 0.5996 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0348 | 0.0348 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0596 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0596 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.1467 | 0.1467 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0596 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.033 | 0.033 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.033 | 0.033 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0596 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0596 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0035 | 0.0348 | 0.0348 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0596 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.4047 | 0.4047 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.033 | 0.1349 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1467 | 0.1467 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0596 | 0.0596 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.033 | 0.033 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0596 | 0.0596 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.4047 | 0.4047 |
Echinococcus multilocularis | geminin | 0.0367 | 0.9875 | 0.9875 |
Echinococcus granulosus | geminin | 0.0367 | 0.9875 | 0.9875 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.7308 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.9875 | 0.9875 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.5623 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 0.7943 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.