Detailed information for compound 1224655

Basic information

Technical information
  • TDR Targets ID: 1224655
  • Name: N-[3-[(4-ethylpiperazin-1-yl)-pyridin-3-ylmet hyl]-4,5-dimethylthiophen-2-yl]furan-2-carbox amide
  • MW: 424.559 | Formula: C23H28N4O2S
  • H donors: 1 H acceptors: 2 LogP: 3.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)C(c1c(sc(c1C)C)NC(=O)c1ccco1)c1cccnc1
  • InChi: 1S/C23H28N4O2S/c1-4-26-10-12-27(13-11-26)21(18-7-5-9-24-15-18)20-16(2)17(3)30-23(20)25-22(28)19-8-6-14-29-19/h5-9,14-15,21H,4,10-13H2,1-3H3,(H,25,28)
  • InChiKey: GQQYPACXCGWKJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[3-[(4-ethylpiperazin-1-yl)-(3-pyridyl)methyl]-4,5-dimethyl-2-thienyl]furan-2-carboxamide
  • N-[3-[(4-ethyl-1-piperazinyl)-(3-pyridyl)methyl]-4,5-dimethyl-2-thienyl]-2-furancarboxamide
  • N-[3-[(4-ethylpiperazin-1-yl)-(3-pyridyl)methyl]-4,5-dimethyl-2-thienyl]-2-furamide
  • N-[3-[(4-ethylpiperazin-1-yl)-pyridin-3-yl-methyl]-4,5-dimethyl-thiophen-2-yl]furan-2-carboxamide
  • T5473218
  • EU-0047491

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0099 0.2775
Leishmania major trypanothione reductase 0.0103 0.0337 0.9432
Loa Loa (eye worm) hypothetical protein 0.003 0.007 0.0607
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0099 0.9054
Leishmania major cysteinyl-tRNA synthetase, putative 0.004 0.0105 0.26
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0016 0.0019 0.0002
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0117 0.0388 0.4635
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0018 0.0075
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0017 0.0019
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0018 0.0021
Trypanosoma brucei unspecified product 0.0023 0.0044 0.0815
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0111 0.1771
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0412 0.1475 0.6053
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0111 0.3127
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.0836 0.7264
Echinococcus granulosus importin subunit beta 1 0.003 0.007 0.0288
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.009 0.7621
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.0918 0.0903
Loa Loa (eye worm) hypothetical protein 0.0108 0.0356 0.3096
Onchocerca volvulus 0.0013 0.0005 0.0075
Echinococcus granulosus GPCR family 2 0.0048 0.0134 0.0551
Echinococcus multilocularis neuropeptide s receptor 0.0565 0.2038 0.2287
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0044 0.0026
Echinococcus granulosus leucyl tRNA synthetase 0.004 0.0105 0.0431
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0049 0.1369
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0016 0.0019 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.009 0.215
Mycobacterium tuberculosis Conserved protein 0.0108 0.0356 0.034
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0018 0.0021
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0012 0.0013
Leishmania major hypothetical protein, conserved 0.0108 0.0356 1
Plasmodium falciparum importin beta, putative 0.003 0.007 0.2083
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0044 0.0815
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0049 0.1377
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0017 0.0467
Onchocerca volvulus 0.0108 0.0356 0.5665
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0087 0.2446
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0177 0.0725
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.009 0.0368
Schistosoma mansoni hypothetical protein 0.0324 0.1151 0.4722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0632 0.2594
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0356 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Brugia malayi mbt repeat family protein 0.0103 0.0336 0.4011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0415 0.1704
Echinococcus multilocularis neuropeptide receptor A26 0.0565 0.2038 0.2287
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0356 1
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0087 0.2378
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0019 0.0062
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0117 0.0388 0.0436
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0177 0.0158
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.004 0.0105 0.26
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0016 0.0019 0.0002
Plasmodium vivax importin-beta 2, putative 0.003 0.007 0.197
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.004 0.0105 1
Echinococcus granulosus transcription factor btf3 0.0035 0.0087 0.0358
Schistosoma mansoni cytochrome P450 0.0016 0.0019 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0101 0.2824
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0049 0.1377
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0134 0.0551
Schistosoma mansoni Smad4 0.0016 0.0018 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0356 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.009 0.0368
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0134 0.1602
Echinococcus multilocularis SAM and MBT domain containing protein 0.0103 0.0336 0.0377
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.004
Schistosoma mansoni hypothetical protein 0.0048 0.0134 0.0551
Schistosoma mansoni chromobox protein 0.0069 0.0212 0.087
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0041 0.1111
Echinococcus granulosus geminin 0.0673 0.2437 1
Schistosoma mansoni hypothetical protein 0.0048 0.0134 0.0551
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.009 0.107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0134 0.0551
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.0632 0.7544
Brugia malayi MH2 domain containing protein 0.0238 0.0836 0.9975
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0356 0.4251
Brugia malayi MH1 domain containing protein 0.0016 0.0018 0.0218
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0044 0.005
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0051 0.1011
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0099 0.118
Loa Loa (eye worm) cytochrome P450 0.0016 0.0019 0.0163
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0016 0.0019 0.0002
Echinococcus multilocularis lamin 0.0027 0.0058 0.0065
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0117 0.0388 0.1594
Echinococcus multilocularis musashi 0.0027 0.0058 0.0065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0514 0.6134
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0019 0.0077
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0058 0.0689
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0049 0.1369
Brugia malayi Heterochromatin protein 1 0.0069 0.0212 0.253
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0356 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.0918 0.0903
Brugia malayi hypothetical protein 0.0036 0.009 0.1071
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0454
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0016 0.0019 0.0002
Schistosoma mansoni hypothetical protein 0.0631 0.2282 0.9367
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0018 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Echinococcus multilocularis snurportin 1 0.0324 0.1151 0.1292
Loa Loa (eye worm) hypothetical protein 0.0108 0.0356 0.3096
Brugia malayi MH2 domain containing protein 0.0016 0.0018 0.0218
Schistosoma mansoni cpg binding protein 0.0062 0.0186 0.0764
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0016 0.0019 0.0002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0058 0.0502
Brugia malayi Cytochrome P450 family protein 0.0016 0.0019 0.0224
Onchocerca volvulus 0.003 0.007 0.1112
Trypanosoma brucei unspecified product 0.0016 0.0018 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0019
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.007 0.1577
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0016 0.0019 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.0632 0.2594
Echinococcus multilocularis smad 0.0016 0.0018 0.0021
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.009 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0005 0.0019
Schistosoma mansoni hypothetical protein 0.0673 0.2437 1
Echinococcus multilocularis Smad4 0.0016 0.0018 0.0021
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0212 0.1842
Schistosoma mansoni intermediate filament proteins 0.0027 0.0058 0.0237
Mycobacterium tuberculosis Probable reductase 0.0234 0.0822 0.0807
Brugia malayi beta-lactamase 0.0108 0.0356 0.4251
Echinococcus granulosus snurportin 1 0.0324 0.1151 0.4722
Echinococcus granulosus neuropeptide receptor A26 0.0565 0.2038 0.8362
Echinococcus granulosus lamin 0.0027 0.0058 0.0237
Echinococcus granulosus lamin dm0 0.0027 0.0058 0.0237
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0356 0.1462
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0019 0.0062
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0087 0.2076
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0016 0.0019 0.0002
Brugia malayi RNA binding protein 0.0063 0.0192 0.2286
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.009 0.215
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0205
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0016 0.0019 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0174 0.1511
Echinococcus multilocularis polycomb protein SCMH1 0.0103 0.0336 0.0377
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.1477 0.1658
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Loa Loa (eye worm) RNA binding protein 0.0063 0.0192 0.1665
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0356 0.034
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0041 0.0709
Echinococcus multilocularis geminin 0.0673 0.2437 0.2735
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0099 0.2421
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0016 0.0019 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.004
Brugia malayi Cytochrome P450 family protein 0.0025 0.0051 0.0608
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0012 0.0049
Brugia malayi beta-NAC-like protein 0.0035 0.0087 0.104
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0041 0.1143
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0103 0.0336 0.138
Schistosoma mansoni smad 0.0016 0.0018 0.0075
Toxoplasma gondii thioredoxin reductase 0.0103 0.0337 0.9196
Leishmania major cytochrome p450-like protein 0.0016 0.0019 0.0062
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.009 0.2517
Echinococcus multilocularis lamin dm0 0.0027 0.0058 0.0065
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.0629 1
Echinococcus granulosus dna polymerase eta 0.0023 0.0044 0.0182
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.009 0.215
Loa Loa (eye worm) hypothetical protein 0.0151 0.0514 0.4467
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0101 0.16
Brugia malayi beta-lactamase family protein 0.0108 0.0356 0.4251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0632 0.2594
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0099 0.0111
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.0822 0.0807
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0412 0.1475 0.1656
Schistosoma mansoni transcription factor btf3 0.0035 0.0087 0.0358
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.007 0.1577
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.009 0.215
Plasmodium vivax glutathione reductase, putative 0.0103 0.0337 0.9459
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.007 0.1915
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.1208
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0205
Entamoeba histolytica Ran family GTPase 0.0022 0.0041 0.3879
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0099 0.2775
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Onchocerca volvulus 0.0058 0.0174 0.2764
Onchocerca volvulus 0.0108 0.0356 0.5665
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0025 0.0028
Schistosoma mansoni hypothetical protein 0.0048 0.0134 0.0551
Loa Loa (eye worm) hypothetical protein 0.0182 0.0629 0.5465
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0205
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.0822 0.0807
Echinococcus multilocularis chromobox protein 1 0.0069 0.0212 0.0238
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0356 0.1462
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0017 0.0145
Loa Loa (eye worm) hypothetical protein 0.0117 0.0388 0.3375
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0101 0.2824
Brugia malayi CXXC zinc finger family protein 0.0058 0.0174 0.2074
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0099 0.2775
Loa Loa (eye worm) hypothetical protein 0.0108 0.0356 0.3096
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0044 0.0028
Echinococcus multilocularis cpg binding protein 0.0062 0.0186 0.0209
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0044 0.4224
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0087 0.2076
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0102 0.0334 0.0375
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0049 0.0955
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.004 0.0105 0.0912
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0177 0.0158
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0018 0.0159
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0177 0.0198
Entamoeba histolytica hypothetical protein 0.0025 0.0049 0.4675
Loa Loa (eye worm) MBCTL1 0.0117 0.0388 0.3375
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0339 0.1392
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0212 0.595
Schistosoma mansoni ap endonuclease 0.0038 0.0099 0.0406
Leishmania major DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0051 0.0032
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.0918 0.0901
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.009 0.215
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0055 0.0655
Schistosoma mansoni hypothetical protein 0.0103 0.0338 0.1388
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0337 0.9432
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0049 0.1369
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0087 0.2446
Brugia malayi glutathione reductase 0.0103 0.0337 0.4021
Brugia malayi Cytochrome P450 family protein 0.0062 0.0188 0.2249
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0017 0.0068
Giardia lamblia DINP protein human, muc B family 0.0023 0.0044 0.0564
Schistosoma mansoni lamin 0.0027 0.0058 0.0237
Echinococcus multilocularis cysteinyl tRNA synthetase 0.004 0.0105 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0205
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0051 0.0443
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0019
Entamoeba histolytica hypothetical protein 0.0036 0.009 0.855
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.2727 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0026 0.0735
Trichomonas vaginalis ran, putative 0.0022 0.0041 0.1143
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0177 0.4713
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.009 0.215
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Giardia lamblia Cysteinyl-tRNA synthetase 0.004 0.0105 1
Brugia malayi N-terminal motif family protein 0.0182 0.0629 0.7504
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0099 0.2421
Trichomonas vaginalis helicase, putative 0.0013 0.0007 0.0205
Schistosoma mansoni importin beta-1 0.003 0.007 0.0288
Echinococcus granulosus chromobox protein 1 0.0069 0.0212 0.087
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0385
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0016 0.0019 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.009 0.215
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0205
Brugia malayi SET domain containing protein 0.0013 0.0005 0.0056
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.009 0.0101
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0106 0.0349 0.1432
Entamoeba histolytica hypothetical protein 0.0035 0.0087 0.8302
Brugia malayi intermediate filament protein 0.0027 0.0058 0.0689
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0018 0.0159
Trypanosoma brucei trypanothione reductase 0.0103 0.0337 0.9432
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.004 0.0105 0.26
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0099 0.0859
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.009 0.215
Echinococcus granulosus Smad4 0.0016 0.0018 0.0075
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0077
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0502
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0075
Brugia malayi cytochrome P450 0.0016 0.0019 0.0224
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.0822 0.0807
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.009 0.2447
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0016 0.0019 0.0002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0006 0.0007
Schistosoma mansoni cpg binding protein 0.0062 0.0186 0.0764
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0026 0.0735
Loa Loa (eye worm) hypothetical protein 0.004 0.0105 0.0912
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0016 0.0019 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0049 0.1369
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.004 0.0105 1
Leishmania major GTP-binding protein, putative 0.0022 0.0041 0.0709
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.0822 0.0805
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0177 0.0158
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0192 0.2286
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.009 0.215
Schistosoma mansoni hypothetical protein 0.0048 0.0134 0.0551
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0177 0.0725
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0068
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0356 0.034
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0016 0.0019 0.0002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0044 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0205
Mycobacterium leprae Probable lipase LipE 0.0108 0.0356 0.0338
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0016 0.0019 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.009 0.215
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.1659
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0051 0.0443
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0049 0.1369
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0019
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0012 0.005
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.004 0.0105 0.26
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0087 0.8302
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.1151 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0103 0.0336 0.138
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0044 0.0182
Schistosoma mansoni lamin 0.0027 0.0058 0.0237
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0041 0.0709
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0049 0.1369
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0041 0.0046
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0356 0.034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.009 0.215
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.009 0.0071
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0044 0.0529
Onchocerca volvulus 0.0108 0.0356 0.5665
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Echinococcus granulosus smad 0.0016 0.0018 0.0075
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0044 0.0815
Schistosoma mansoni retinoic acid receptor RXR 0.0106 0.0349 0.1432
Schistosoma mansoni cpg binding protein 0.0058 0.0174 0.0713
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0786
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0337 0.9459
Schistosoma mansoni DNA polymerase eta 0.0023 0.0044 0.0182
Loa Loa (eye worm) hypothetical protein 0.0108 0.0356 0.3096
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0017 0.0019
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0356 0.0338
Loa Loa (eye worm) mbt repeat family protein 0.0103 0.0336 0.2921
Schistosoma mansoni cysteinyl-tRNA synthetase 0.004 0.0105 0.0431
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0177 0.016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.009 0.215
Plasmodium vivax cysteine--tRNA ligase, putative 0.004 0.0105 0.2946
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Loa Loa (eye worm) hypothetical protein 0.0103 0.0336 0.2921
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0044 0.005
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0336 0.138
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0058 0.0502
Schistosoma mansoni hypothetical protein 0.0673 0.2437 1
Plasmodium falciparum cysteine--tRNA ligase 0.004 0.0105 0.3114
Leishmania major cytochrome p450-like protein 0.0025 0.0051 0.1011
Schistosoma mansoni hypothetical protein 0.0036 0.009 0.0368
Brugia malayi Smad1 0.0016 0.0018 0.0218
Echinococcus granulosus dnaJ subfamily B 0.0412 0.1477 0.6063
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0075
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0108 0.0356 0.3096
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.009 0.2447
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0337 0.0321
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0099 0.2421
Brugia malayi Cytochrome P450 family protein 0.0025 0.0051 0.0608
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.004 0.0105 0.2946
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0356 0.0338
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0486
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0188 0.1638
Plasmodium falciparum cysteine--tRNA ligase 0.004 0.0105 0.3114
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0192 0.1665
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0786
Loa Loa (eye worm) hypothetical protein 0.0048 0.0134 0.1167
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.0822 0.0807
Brugia malayi cysteinyl tRNA synthetase protein 1 0.004 0.0105 0.1252
Echinococcus granulosus intermediate filament protein 0.0027 0.0058 0.0237
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0044 0.0529
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0055 0.0655
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0012 0.0139
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.0918 0.0903
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0514 0.6134
Leishmania major importin beta-1 subunit, putative 0.0025 0.0049 0.0955
Loa Loa (eye worm) hypothetical protein 0.0108 0.0356 0.3096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.0632 0.2594
Loa Loa (eye worm) hypothetical protein 0.003 0.007 0.061
Schistosoma mansoni myelin transcription factor 1 myt1 0.0117 0.0388 0.1594
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0454
Echinococcus granulosus cysteinyl tRNA synthetase 0.004 0.0105 0.0431
Onchocerca volvulus 0.0103 0.0336 0.5345
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.009 0.215
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0019 0.0062
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0134 0.1167
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0018 0.0075
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0099 0.0082
Entamoeba histolytica hypothetical protein 0.0036 0.009 0.855
Onchocerca volvulus 0.0027 0.0058 0.0918
Brugia malayi follicle stimulating hormone receptor 0.0239 0.0838 1
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0025 0.0218
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0016 0.0019 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0044 0.0815
Brugia malayi Thioredoxin reductase 0.0103 0.0337 0.4021
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0019 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0205
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0044 0.0182
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.009 0.2517
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0177 0.0725
Chlamydia trachomatis cysteine--tRNA ligase 0.004 0.0105 1
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0356 0.0338
Brugia malayi CHD4 protein 0.0015 0.0012 0.0146
Loa Loa (eye worm) hypothetical protein 0.0039 0.0101 0.0874
Echinococcus multilocularis transcription factor btf3 0.0035 0.0087 0.0098
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.0838 0.7283
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0016 0.0019 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0024 0.029
Echinococcus multilocularis GPCR, family 2 0.0048 0.0134 0.0151
Leishmania major basic transcription factor 3a, putative 0.0035 0.0087 0.2076
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0012 0.0049
Echinococcus multilocularis dna polymerase eta 0.0023 0.0044 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.1659
Schistosoma mansoni ap endonuclease 0.0038 0.0099 0.0406
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0018 0.0075
Onchocerca volvulus 0.0027 0.0058 0.0918
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.009 0.215
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0041 0.0709
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0049 0.1369
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.004 0.0105 0.2864
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0099 0.008
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0111 0.3127
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0012 0.0013
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0041 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0786
Brugia malayi chromobox protein homolog 3 0.0039 0.0101 0.12
Echinococcus granulosus histone acetyltransferase MYST2 0.0117 0.0388 0.1594
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.0836 0.7264
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0087 0.2586
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0356 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0017 0.0494
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.0354
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.2727 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0356 0.3096
Loa Loa (eye worm) beta-lactamase 0.0108 0.0356 0.3096
Brugia malayi beta-lactamase family protein 0.0108 0.0356 0.4251
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0049 0.1377
Entamoeba histolytica hypothetical protein 0.0036 0.009 0.855
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0356 1
Echinococcus granulosus chromobox protein 1 0.0069 0.0212 0.087
Mycobacterium ulcerans hypothetical protein 0.0108 0.0356 0.0338
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0087 0.2446
Mycobacterium tuberculosis Conserved protein 0.0108 0.0356 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0205
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0099 0.9421
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Toxoplasma gondii ABC1 family protein 0.0108 0.0356 0.9722
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0205
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0017 0.0198
Brugia malayi MH1 domain containing protein 0.0016 0.0018 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.009 0.215
Brugia malayi Importin beta-1 subunit 0.003 0.007 0.0838
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0019 0.0062
Onchocerca volvulus 0.004 0.0105 0.1669
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0044 0.0028
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.009 0.2661
Trichomonas vaginalis esterase, putative 0.0108 0.0356 1
Echinococcus granulosus cpg binding protein 0.0062 0.0186 0.0764
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0134 0.0151
Mycobacterium ulcerans lipase LipD 0.0108 0.0356 0.0338
Brugia malayi mbt repeat family protein 0.0103 0.0336 0.4011
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0044 0.1244
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0356 0.034
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0356 0.034
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0099 0.2934
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0099 0.6023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.009 0.0071
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0356 0.034
Plasmodium falciparum thioredoxin reductase 0.0103 0.0337 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0044 0.0815
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.0486
Echinococcus granulosus polycomb protein SCMH1 0.0103 0.0336 0.138
Echinococcus multilocularis 0.0016 0.0019 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0018 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.009 0.0101
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.009 0.0368
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0338 0.4037
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0044 0.1244
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0337 0.2929
Echinococcus multilocularis importin subunit beta 1 0.003 0.007 0.0079
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.009 0.215
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.0632 0.071
Entamoeba histolytica hypothetical protein 0.0036 0.009 0.855
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0025 0.0103
Schistosoma mansoni chromobox protein 0.0069 0.0212 0.087
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0012 0.005
Plasmodium falciparum thioredoxin reductase 0.0036 0.009 0.2661
Brugia malayi isocitrate dehydrogenase 0.0016 0.0017 0.0198
Toxoplasma gondii exonuclease III APE 0.0038 0.0099 0.2698
Plasmodium falciparum glutathione reductase 0.0036 0.009 0.2661
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0103 0.0336 0.5345
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0016 0.0019 0.0002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0356 0.034
Brugia malayi MH2 domain containing protein 0.0016 0.0018 0.0218
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0044 0.0815
Echinococcus multilocularis histone acetyltransferase MYST2 0.0117 0.0388 0.0436
Schistosoma mansoni cysteinyl-tRNA synthetase 0.004 0.0105 0.0431
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0044 0.0815
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0134 0.1602
Schistosoma mansoni hypothetical protein 0.0412 0.1477 0.6063
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0366 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0632 0.2594
Echinococcus granulosus dna polymerase kappa 0.0023 0.0044 0.0182
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.009 0.2661
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0339 0.0381
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0051 0.0443
Trypanosoma brucei unspecified product 0.0016 0.0018 0.0031
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0012 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0018 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0356 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0356 0.1462
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0087 0.2076
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.0822 0.0807
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0099 0.2421
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0016 0.0019 0.0002
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.009 0.2517
Mycobacterium ulcerans beta-lactamase 0.0108 0.0356 0.0338
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0012 0.0049
Schistosoma mansoni ran 0.0022 0.0041 0.0167
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0356 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0044 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0023 0.0635
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.009 0.0368
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0012 0.0101
Leishmania major DNA polymerase eta, putative 0.0023 0.0044 0.0815
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0177 0.4822
Leishmania major cytochrome p450-like protein 0.0016 0.0019 0.0062
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.009 0.2517
Echinococcus granulosus neuropeptide s receptor 0.0565 0.2038 0.8362
Loa Loa (eye worm) hypothetical protein 0.0103 0.0338 0.294
Brugia malayi TAR-binding protein 0.0063 0.0192 0.2286
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0212 0.595
Plasmodium falciparum glutathione reductase 0.0103 0.0337 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0786
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0087 0.0757
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0099 0.0406
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0075
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0192 0.0215
Schistosoma mansoni ran 0.0022 0.0041 0.0167
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.0632 0.5494
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0099 0.6023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0356 0.04
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.009 0.215
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.009 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0016 0.0019 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0087 0.2446
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0192 0.1665
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0336 0.138
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0134 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0356 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0815
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.0632 0.071
Loa Loa (eye worm) glutathione reductase 0.0103 0.0337 0.2929
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.0019 0.0511
Echinococcus multilocularis chromobox protein 1 0.0069 0.0212 0.0238
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0044 0.0385
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0051 0.1011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0049 0.1369
Brugia malayi RNA, U transporter 1 0.0086 0.0276 0.3295
Loa Loa (eye worm) Smad1 0.0016 0.0018 0.0159
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.004 0.0105 0.0086
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0051 0.1011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.069 0.25 0.2487
Echinococcus granulosus tar DNA binding protein 0.0063 0.0192 0.0786
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2431 0.8909 1
Mycobacterium tuberculosis Conserved protein 0.0108 0.0356 0.034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0514 0.4467
Treponema pallidum cysteinyl-tRNA synthetase 0.004 0.0105 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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